CN203469137U - White blood cell removing system - Google Patents
White blood cell removing system Download PDFInfo
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- CN203469137U CN203469137U CN201320404137.4U CN201320404137U CN203469137U CN 203469137 U CN203469137 U CN 203469137U CN 201320404137 U CN201320404137 U CN 201320404137U CN 203469137 U CN203469137 U CN 203469137U
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Abstract
The utility model provides a white blood cell removing system for removing white blood cells from blood platelet preparations or plasma preparations. The white blood cell removing system is characterized by comprising a blood guiding-in part, a white blood cell removing filter and a flow control device. In the white blood cell removing system, the flow control device is utilized to control the flow velocity of blood preparations. Therefore, the flow velocity of the blood platelet preparations or the plasma preparations can be prevented from being too fast when the white blood cells are removed from the blood platelet preparations or the plasma preparations with lower viscosity, and the leakage of the white blood cells can be inhibited.
Description
Technical field
This utility model relates to a kind of Blood Preparations for the use of certainly transfusing blood and removes leukocytic leukocyte removal system.In detail, relate to and a kind ofly from take cell that platelet transfusion, blood plasma preparation be representative, swim in liquid and remove efficiently leukocytic leukocyte removal system.
Background technology
Conventionally, in the field of blood transfusion, the whole blood of taking from blood donor is separated into erythrocyte preparation, platelet transfusion, blood plasma preparation etc. storage, afterwards for blood transfusion.In addition, contained small condensation product, the leukocyte of above-mentioned Blood Preparations is the reason that causes various blood transfusion side effect, and the situation of therefore removed above-mentioned undesirable constituents before blood transfusion, transfusing blood again afterwards increases.In recent years, particularly remove leukocytic necessity and obtained extensive understanding, the blood transfusion to all is increased with the country that is used further to the situation legalization of blood transfusion after Blood Preparations enforcement leukocyte Transformatin.As removing leukocytic method in autoblood preparation, for example, the most generally with leukocyte, remove the filter filtering blood preparation of use.As leukocyte, remove the filter of use, the filters that the filter member consisting of non-woven fabrics, porous plastid are accommodated in to the type in container that use more.
Utility model content
the problem that utility model will solve
But, when using leukocyte as above to remove with filter, blood to be filtered, have because of viscosity compared with low platelet transfusion or blood plasma preparation the too fast hidden danger that causes leukocyte to spill of flow velocity when removing leukocyte.
In view of the above problems, the purpose of this utility model is to provide a kind of flow velocity can remove leukocyte by control time to suppress the leukocytic leukocyte spilling and removes system.
for the scheme of dealing with problems
Leukocyte removal system of the present utility model is used for removing leukocyte from platelet transfusion or blood plasma preparation, it is characterized in that, this leukocyte removal system comprises blood introduction part, leukocyte removal filter and volume control device.
In this leukocyte removal system, utilize volume control device to control the flow velocity of Blood Preparations.Thus, even lower platelet transfusion or the blood plasma preparation of viscosity also can prevent that its flow velocity when removing leukocyte is too fast, can suppress leukocytic spilling.
In addition, of the present utility model being characterised in that, leukocyte is removed filter and is had: the filter member of lamellar, it is for removing the leukocyte of blood, and entrance side container and outlet side container, both configure relatively across filter member for this, filter member is to form by stacked the 1st filter course consisting of one or more layers non-woven fabrics and the 2nd filter course that consists of one or more layers non-woven fabrics, the 1st filter course is between the entrance of entrance side container and the outlet of outlet side container, position than the 2nd filter course by entrance side, the fiber diameter that forms the non-woven fabrics of the 2nd filter course is less than the fiber diameter of the non-woven fabrics that forms the 1st filter course, the fiber diameter that forms the non-woven fabrics of the 1st filter course is 3 μ m～60 μ m, form the fiber diameter of non-woven fabrics of the 2nd filter course for being less than 3 μ m.
Because the 1st filter course of filter member is disposed at the position by upstream side (entrance side) than the 2nd filter course, and the fiber diameter that forms the non-woven fabrics of the 2nd filter course is less than the fiber diameter of the non-woven fabrics that forms the 1st filter course, even thereby in blood, produce the in the situation that of having condensation product, also can be by utilizing the non-woven fabrics of the 1st filter course of the upstream side that mesh is larger to catch the condensation product that condensation product reduces the non-woven fabrics of the 2nd filter course that arrives the downstream that mesh is less.Thereby the mesh that can suppress the filter member that condensation product causes stops up.Owing to forming the fiber diameter of the non-woven fabrics of the 1st filter course, be particularly 3 μ m～60 μ m, therefore it is effective for the mesh that suppresses filter member, stopping up, in addition,, because the fiber diameter of the non-woven fabrics of the 2nd filter course is less than 3 μ m, therefore can prevent that leukocyte removal capacity from declining.
And then, in this utility model, due to when the fiber diameter that forms the non-woven fabrics of the 1st filter course is made as to 4 μ m～40 μ m, can seek more reliably to suppress the effect that the mesh of filter member stops up, be therefore preferred.In addition, when forming the fiber diameter of the non-woven fabrics of the 2nd filter course, be that 0.3 μ m is when above, can prevent that the mesh causing because of leukocyte etc. from stopping up, therefore be preferred, particularly, from aspects such as leukocyte removal capacities, the fiber diameter that is more preferably the non-woven fabrics that forms the 2nd filter course is 0.5 μ m～2.5 μ m.
In addition, can be also that, in this utility model, the end of blood introduction part is more than one pricker.By the end of blood introduction part is made as to pricker, being connected between bags of blood and blood introduction part becomes easy.
In addition, can be also that, in this utility model, the end of blood introduction part is more than one airtight loop.By the end of blood introduction part is made as to airtight loop, can carry out SCD connection, can maintain aseptic condition.
In addition, can be also that, in this utility model, the end of blood introduction part is more than one breather filter (air vent filter).Thus, EOG sterilizing becomes easily, and can utilize SCD to connect to maintain aseptic condition.
In addition, can be also that, in this utility model, the aeration resistance that leukocyte is removed filter is 20Pa～4900Pa.Thus, can carry out rightly the filtration of low viscous Blood Preparations.
In addition, can be also, in this utility model, to utilize hydrophilic macromolecule coating leukocyte to remove the filter member of filter.Thus, can improve the response rate of platelet or plasma protein.In addition, by remove the filter member of filter with hydrophilic macromolecule coating leukocyte, can improve wettability.
In addition, can be also that, in this utility model, volume control device is loop diameters control device.Thus, can carry out rightly flow-control, can suppress leukocytic the spilling causing because forming high flow rate.Particularly, when directly the blood after filtering being transfused blood to patient, the dropping speed in the time of can coordinating blood transfusion carries out flow adjustment.
In addition, can be also, in this utility model, volume control device be loop, thin footpath, and net sectional area is 0.1mm
2～5.0mm
2, length/net sectional area is 3mm/mm
2～400mm/mm
2.Thus, can carry out rightly flow-control, can suppress leukocytic the spilling causing because forming high flow rate.In the time of particularly in the bags of blood that the blood after filtering is stored in to one end, can keep easily best (shortening filtration time when guaranteeing leukocyte removal capacity) rate of filtration.
In addition, can be also that, in this utility model, volume control device is arranged at the downstream that leukocyte is removed filter.Thus, can maintain blood and start the flow velocity while annotating, can start equably filling, can effectively utilize filter material.
In addition, can be also, in this utility model, between blood introduction part and leukocyte removal filter, to there is net chamber (mesh chamber).Thus, can effectively remove aggregation, the mesh that suppresses filter member stops up.
In addition, can be also, in this utility model, between blood introduction part and leukocyte removal filter, to have for storing the reservoir bag of the blood before filtration.Thus, can concentrate the blood before the filtration of a plurality of bags of blood to remove leukocyte.In addition, by the buffy coat of complex unit is stored in this bag, can also after centrifugalize, utilize filter member to filter the platelet of supernatant.
In addition, can be also that, in this utility model, the downstream of removing filter at leukocyte has for reclaiming the reclaiming bag of the blood after filtration.Thus, can be in the situation that directly the blood after filtering not be transfused blood and is temporarily reclaimed this blood and transport to patient.
In addition, can be also that, in this utility model, this leukocyte removal system has for connecting the shunt loop between blood introduction part and leukocyte removal filter and between leukocyte removal filter and reclaiming bag.Thus, can utilize the upstream side that loop is removed filter by the air being blended in reclaiming bag to leukocyte along separate routes to extrude, can reclaim efficiently leukocyte and remove the blood in filter.
In addition, can be also, in this utility model, in shunt loop, have in check-valves and fixture at least any one.Thus, can suppress unfiltered Blood Preparations is blended in reclaiming bag.
In addition, can be also that, in this utility model, this leukocyte removal system has at least more than one son bag.Thus, this sub-bag can be blended into the air in reclaiming bag and sample with blood to checking for Blood Preparations, the discharge of cutting apart after filtration.
In addition, can be also that, in this utility model, the downstream of removing filter at leukocyte has blood transfusion needle adapter.Thus, can directly the blood after filtering be transfused blood to patient.
In addition, can be also, in this utility model, at leukocyte, to remove between filter and blood transfusion needle adapter and there is dropping funnel.Thus, the management of blood transfusion flow velocity becomes and is more prone to.
the effect of utility model
Adopt this utility model, can provide a kind of flow velocity can remove leukocyte by controls time to suppress the leukocytic leukocyte removal system spilling.
Accompanying drawing explanation
Fig. 1 means the front view of the leukocyte removal system of the 1st embodiment of the present utility model.
Fig. 2 is that the leukocyte of biopsy cavity marker devices the 1st embodiment is removed the front view after the filter that system used.
Fig. 3 is the cutaway view along the III-III line of Fig. 2.
Fig. 4 is the cutaway view along the IV-IV line of Fig. 2.
Fig. 5 means the front view of the leukocyte removal system of the 2nd embodiment of the present utility model.
Fig. 6 means the front view of the leukocyte removal system of the 3rd embodiment of the present utility model.
Fig. 7 means the front view of the leukocyte removal system of the 4th embodiment of the present utility model.
Fig. 8 represents the back side of the leukocyte removal filter of present embodiment, means the figure of the state after biopsy cavity marker devices.
description of reference numerals
1,40,70, bags of blood system (leukocyte removal system); 2, filter member; 3, entrance side container; 3a, ingress port (entrance); 4, outlet side container; 4a, outlet port (outlet); 8, the 1st filter course; 8a, the 1st non-woven fabrics; 9, the 2nd filter course; 9a, the 2nd non-woven fabrics; 11, filter (leukocyte removal filter); 16, breather filter (blood introduction part); 19,50, check-valves; 23, blood reclaiming bag (reclaiming bag); 26, son bag; 27d, 42c, shunt stream (loop along separate routes); 32, small diameter part divides (volume control device); 43,44, pricker (blood introduction part); 45, net chamber; 60, external member (leukocyte removal system) for blood transfusion; 63, blood transfusion needle adapter; 64, dropping funnel; 65, roller fixture (volume control device); 73, closed loop (blood introduction part); 74, reservoir bag.
The specific embodiment
Below, withing reference to the accompanying drawings of the leukocyte of embodiment of the present utility model removes system.In addition, in the following description, identical or suitable element is marked to identical Reference numeral, the repetitive description thereof will be omitted.The Blood Preparationses such as the whole blood preparation that in addition, illustrated blood comprises the use of transfusing blood in each embodiment, erythrocyte preparation, platelet transfusion, blood plasma preparation.
the 1st embodiment
The bags of blood system 1(of the 1st embodiment is with reference to Fig. 1) for following situation: for example, in the specialized facilities such as Blood Center, from becoming to grade in blood constituent and remove leukocyte and the blood after filtering is reclaimed by the blood of taking from blood donor being carried out to platelet that centrifugalize obtains.In addition, bags of blood system 1 is characterised in that, this bags of blood system 1 is improved, and makes to remove leukocytic processing in autoblood composition and carries out in closed system.
Bags of blood system 1 has conduit 15,18a, 18b, the 18c, 22,24 passing through for blood.Conduit 15,18a, 18b, 18c, 22,24 form by having flexible blood flexible pipe etc.
Bags of blood system 1 has: blood pathway 27a, and it is formed by conduit 15,18a, 18b, 22; Breather filter (blood introduction part) 16, it is configured in the end of a side of blood pathway 27a; Blood reclaiming bag (reclaiming bag) 23, it is configured in the end of the opposite side of blood pathway 27a; Filter (leukocyte removal filter) 11, it is configured between the breather filter 16 and blood reclaiming bag 23 of blood pathway 27a, for from remove leukocyte the mobile blood of blood pathway 27a; And fixture 20b, it is configured between the breather filter 16 and blood reclaiming bag 23 of blood pathway 27a, for opening and closing blood pathway 27a.
The end side of a side that is provided with breather filter 16 of blood pathway 27a is for receiving the upstream side of blood, and the end side of the opposite side that is provided with blood reclaiming bag 23 of blood pathway 27a is the downstream of having removed the blood after leukocyte for reclaiming.In addition, bags of blood system 1 comprises the branch connector portion 17 of upstream side and the branch connector portion 21 in downstream, and the branch connector portion 17 of upstream side is arranged between breather filter 16 and filter 11, and the branch connector portion 21 in downstream is arranged between filter 11 and blood reclaiming bag 23.
In addition, conduit 15 is connected in conduit 18a via the branch connector portion 17 of upstream side, and conduit 18a is connected in the ingress port 3a that leukocyte is removed the filter 11 of use.By conduit 15,18a and form upstream side stream 27b.
The outlet port 4a of filter 11 is connected in conduit 18b, and conduit 18b is connected in the branch connector portion 21 in downstream.In addition on conduit 18b, be provided with for opening and closing the fixture 20b of stream.Fixture 20b is as lower member: outside it, be loaded on conduit 18b, and flatten conduit 18b by extruded conduit 18b, close closed channel, on the contrary, by discharging, the extruding of conduit 18b is opened to stream.
In addition the small diameter part that, is provided with flow adjustment use between the outlet port 4a of conduit 18b and fixture 20b divides (loop, thin footpath) 32.Small diameter part divides 32 effects of undertaking as volume control device.It is 0.1mm that small diameter part divides 32 net sectional area
2～5.0mm
2, length/net sectional area is 3mm/mm
2～400mm/mm
2.By thering is this small diameter part, divide 32, can carry out rightly flow-control, can suppress leukocytic the spilling causing because forming high flow rate.In addition, as the small diameter part of volume control device, divide 32 to be arranged between outlet port 4a and fixture 20b (downstream of filter 11), thereby can maintain blood, start the flow velocity while annotating, can start equably filling, can effectively utilize filter material.
In addition the end (end of a side) that, bags of blood system 1 has a upstream side is connected in the conduit 24 of blood reclaiming bag 23.In addition on conduit 24, be provided with for opening and closing the fixture 25 of stream.Fixture 25 is as lower component: outside it, be loaded on conduit 24, and flatten conduit 24 by extruded conduit 24, close closed channel, on the contrary, by discharging, the extruding of conduit 24 is opened to stream.In the end (end of opposite side) in the downstream of conduit 24, be provided with son bag 26.In addition, a plurality of son bags 26 also can be set.Son bag 26 can be used in Blood Preparations, the discharge cut apart after filtration and is blended into the air in blood reclaiming bag 23 and samples with blood to checking.
In addition, bags of blood system 1 has shunt stream (loop along separate routes) 27d that walks around filter 11 and be connected in blood pathway 27a.The end (end of a side) of the upstream side of stream 27d is connected between breather filter 16 and filter 11 along separate routes, and the end in downstream (end of opposite side) is connected between filter 11 and blood reclaiming bag 23.That is, stream 27d connects between breather filter 16 and filter 11 and between filter 11 and blood reclaiming bag 23 along separate routes.By thering is stream 27d along separate routes, can utilize stream 27d along separate routes that the air being blended in blood reclaiming bag 23 is extruded to filter 11 upstream sides, can effectively reclaim the blood in filter 11.
Specifically, in the branch connector portion 17 of upstream side and the branch connector portion 21 in downstream, sentence the mode of walking around filter 11 and be connected with and use along separate routes conduit 18c, by forming shunt stream 27d with conduit 18c along separate routes.The branch connector portion 17 of upstream side is the end of the upstream side of shunt stream 27d, and the branch connector portion 21 in downstream is the end in the downstream of shunt stream 27d.
With conduit 18c, be along separate routes that blood flexible pipe etc. has flexible conduit.Along separate routes with being provided with on conduit 18c for opening and closing shunt stream use fixture 20a and the check-valves 19 of stream.Check-valves 19 is as lower member: it has the function that anti-Hemostatic Oral Liquid goes out from upstream side side leakage downstream.Stream is as lower member with fixture 20a along separate routes: its outer being loaded on is used conduit 18c along separate routes, and with conduit 18c, is flattened and use along separate routes conduit 18c along separate routes by extruding, closes closed channel, on the contrary, and by discharging opening stream with the extruding of conduit 18c along separate routes.
Then, explain above-mentioned filter 11.As shown in Figure 2 to 4, filter 11 comprises: the filter member 2 of lamellar, and it is for removing the leukocyte of blood; Entrance side container 3 and outlet side container 4, both configure relatively across filter member 2 for this; The ingress port of blood (entrance) 3a, it is arranged at entrance side container 3; And outlet port (outlet) 4a of blood, it is arranged at outlet side container 4.By entrance side container 3 and outlet side container 4, form container 5, container 5 for example consists of Merlon (PC).The aeration resistance of preferred filters 11 is 20Pa～4900Pa, by being made as this aeration resistance, can carry out rightly the filtration of low viscous Blood Preparations.
The ozzle 3b of ingress port 3a than welding the weld portion 5a that forms each other of the outer rim of entrance side container 3 and the outer rim of outlet side container 4 outstanding laterally.In addition, the ozzle 4b of outlet port 4a than welding the outer rim of entrance side container 3 give prominence to laterally with the weld portion 5a that the outer rim of outlet side container 4 forms each other.Its result, is easy to the conduit passing through for blood to be connected in the ozzle 3b of ingress port 3a and the ozzle 4b of outlet port 4a, thereby makes the connection in loop become easy.In addition, in the present embodiment, the two all gives prominence to the ozzle 4b of the ozzle 3b of ingress port 3a and outlet port 4a laterally than weld portion 5a, but can be also that only wherein any one is given prominence to laterally than weld portion 5a.
In addition, filter 11 comprises: entrance side ledge 3c, and it is along the periphery setting of entrance side container 3, and interior side-prominent to entrance side container 3, and contacts with filter member 2; And outlet side ledge 4c, it is relative with entrance side ledge 3c, and interior side-prominent to outlet side container 4, and by with entrance side ledge 3c between cooperate to compress filter member 2, the spilling of anti-Hemostatic Oral Liquid.In addition, in the present embodiment, because entrance side container 3 and outlet side container 4 are dihedral, therefore entrance side ledge 3c and outlet side ledge 4c are also dihedral, but the in the situation that of entrance side container 3 and other shapes such as outlet side container 4 is rounded, entrance side ledge 3c forms other shapes such as circle corresponding with the shape of this entrance side container 3 and outlet side container 4 with outlet side ledge 4c.
At the inner surface of entrance side container 3, that is, the surface of a side of facing mutually with filter member 2 is formed with: entrance side inner plane 3d, its by entrance side ledge 3c around forming; And entrance side rib 3e, it is given prominence to and connects with filter member 2 from entrance side inner plane 3d, thereby forms the gap 3f for blood flow between entrance side inner plane 3d and filter member 2.In the situation that stipulated mode to comprise the ozzle 3b of entrance side and the ozzle 4b of the outlet side imaginary cross section of disjunction filter 11 (imaginary cross section) 10 symmetrically, entrance side rib 3e configures abreast with respect to imaginary cross section 10, and arranges to clip the mode of imaginary cross section 10 symmetries.
At the inner surface of outlet side container 4, that is, the surface of a side of facing mutually with filter member 2 is formed with: outlet side inner plane 4d, its by outlet side ledge 4c around forming; And outlet side rib 4e, it is given prominence to and connects with filter member 2 from outlet side inner plane 4d, thereby forms the gap 4f for blood flow between outlet side inner plane 4d and filter member 2.As shown in Figure 8, in the situation that stipulated mode to comprise the ozzle 3b of entrance side and the ozzle 4b of the outlet side imaginary cross section 10 of disjunction filter 1 symmetrically, outlet side rib 4e is configured to outlet port 4a direction, inject with the angle of 45 degree with respect to imaginary cross section 10, and arranges to clip the mode of imaginary cross section 10 symmetries.The angle with respect to imaginary cross section 10 of outlet side rib 4e is not limited to 45 degree, so long as the angle in the scope of 10 degree～80 degree.In addition, on the inner surface of outlet side container 4, be correspondingly provided with and with respect to imaginary cross section 10 parallel wire projection 4g outstanding from outlet side inner plane 4d.Specifically, on imaginary cross section 10, be provided with wire projection 4g.In addition, in Fig. 8, in order clearly to export side rib 4e and wire projection 4g, with cross section, schematically show a mouthful inner space for side container 4, and omit the diagram to filter member 2.
In addition, the height of entrance side rib 3e is being made as to Ha, the height of outlet side rib 4e is made as in the situation of Hb, Ha is 0.4mm～1.6mm, and Hb is 0.4mm～0.6mm.In addition, the entrance side rib spacing being equivalent to from the centrage of entrance side rib 3e to the interval till the centrage of adjacent entrance side rib is being made as to Pa, the outlet side rib spacing being equivalent to from the centrage of outlet side rib 4e to the interval till the centrage of adjacent entrance side rib is made as the situation of Pb, Pa is 4.5mm～5.5mm, and Pb is 2.5mm～3.5mm.Adopt this structure, can effectively prevent that filter member 2 from contacting with entrance side inner plane 3d or outlet side inner plane 4d, and by guaranteeing fully the space of gap 3f, 4f, can prevent that the rate of filtration from declining.
Particularly, in the present embodiment, Pa forms greatlyr than Pb.Adopt this structure, due to entrance side rib spacing, Pa is wider, therefore can utilize fully filter area, even in the situation that the blood that comprises aggregation (condensation product) enters into entrance side, also can suppress the generation that mesh stops up.In addition, in the present embodiment, Ha forms highlyer than Hb.Adopt this structure, the gap 3f being formed by entrance side rib 3e is larger than the gap 4f being formed by outlet side rib 4e, even in the situation that the blood that comprises aggregation (condensation product) enters into entrance side, also can suppress the generation that mesh stops up.
Then, explain filter member 2.As mentioned above, filter member 2 in the form of sheets has the 1st filter course 8 and the 2nd filter course 9.The 1st filter course 8 is filter courses that mesh is larger than the mesh of the 2nd filter course 9, is mainly used in catching the coagulums such as condensation product contained in blood (aggregation).On the contrary, the 2nd filter course 9 be mesh than the little filter course of the 1st filter course 8, be mainly used in catching the leukocyte in blood.
The 1st filter course 8 of present embodiment is that the non-woven fabrics 8a by the multilayer chip of stacked identical type forms.For convenience of explanation, the non-woven fabrics 8a that forms the 1st filter course 8 is called to the 1st non-woven fabrics 8a.In addition, the 2nd filter course 9 of present embodiment is that the non-woven fabrics of the multilayer chip by stacked identical type forms.For convenience of explanation, the non-woven fabrics 9a that forms the 2nd filter course 9 is called to the 2nd non-woven fabrics 9a.In addition, can by consideration require the leukocyte removal capacity of filter member 2 and the balance between filtration flow-rate etc. select rightly to form the 1st filter course 8 non-woven fabrics 8a the number of plies or form the number of plies of the non-woven fabrics 9a of the 2nd filter course 9, for example, can respectively form one deck.
The fiber diameter that is used to form the 1st non-woven fabrics 8a of the 1st filter course 8 is 3 μ m～60 μ m, is used to form the fiber diameter of the 2nd non-woven fabrics 9a of the 2nd filter course 9 for being less than 3 μ m.That is the mode, diminishing successively towards outlet port 4a side (downstream) from ingress port 3a side (upstream side) with fiber diameter disposes the 1st filter course 8 and the 2nd filter course 9.Utilize this structure, even if produce in blood in the situation that of having condensation product (aggregation) etc., also can be by utilizing the 1st non-woven fabrics 8a of the upstream side that mesh is larger to catch the condensation product that condensation product reduces the 2nd non-woven fabrics 9a that arrives the downstream that mesh is less.
And, if the fiber diameter of the 1st non-woven fabrics 8a is made as to 4 μ m～40 μ m, can seek more reliably to suppress the mesh obstruction of filter member 2, be therefore preferred.In addition, if the fiber diameter of the 2nd non-woven fabrics 9a of the 2nd filter course 9 is less than 0.3 μ m, filter member 2 is easy to stop up because leukocyte etc. produces mesh, is therefore more preferably fiber diameter and is 0.3 μ m above and be less than 3 μ m.And from aspects such as leukocyte removal capacities, further preferably fiber diameter is 0.5 μ m～2.5 μ m.
In addition, the fiber of the 1st non-woven fabrics 8a and the 2nd non-woven fabrics 9a also can contain polyester, polyamide, polyacrylonitrile, polymethyl methacrylate, polyethylene, polypropylene etc.Like this, by by synthetic fibers as filter member, degeneration that can anti-Hemostatic Oral Liquid.More preferably, the fiber that contains polyester by employing, can obtain fibre diameter stable each non-woven fabrics 8a, 9a.In addition, preferably with hydrophilic macromolecule, be coated with filter member 2.Thus, can improve the response rate of 2 pairs of platelet of filter member or plasma protein.In addition,, by be coated with filter member 2 with hydrophilic macromolecule, can improve wettability.
In the above-described embodiment, illustrated that multi-layer nonwoven fabrics 8a by stacked identical type forms the 1st filter course 8, by the multi-layer nonwoven fabrics 9a of stacked identical type, forms the situation of the 2nd filter course 9.But, also can form the 1st filter course 8 by stacked different types of multi-layer nonwoven fabrics, the in the situation that of this technical scheme, the fiber diameter that forms each non-woven fabrics of the 1st filter course 8 is 3 μ m～60 μ m, is more preferably 4 μ m～40 μ m.And, preferably so that the mode that the fiber diameter of each non-woven fabrics after stacked diminishes successively towards outlet port 4a side (downstream) from ingress port 3a side (upstream side) configures each non-woven fabrics.
In addition, also can form the 2nd filter course 9 by stacked different types of multi-layer nonwoven fabrics, the in the situation that of this embodiment, form the fiber diameter of each non-woven fabrics of the 2nd filter course 9 for being less than 3 μ m and more than 0.3 μ m, being more preferably 0.5 μ m～2.5 μ m.And then, preferably so that the fiber diameter of each non-woven fabrics after stacked configures each non-woven fabrics from its mode diminishing successively towards outlet port 4a side (downstream) of ingress port 3a side (upstream side).
And, also can form the 1st filter course 8 and form the 2nd filter course 9 by stacked multilamellar identical type or different types of non-woven fabrics by layer of non-woven fabric.In addition, also can form the 1st filter course 8 and form the 2nd filter course 9 by layer of non-woven fabric by stacked multilamellar identical type or different types of non-woven fabrics.In addition, also one or more layers non-woven fabrics that can stacked fiber diameter is larger than the fiber diameter of the non-woven fabrics of the 1st filter course 8 by the upstream side at the 1st filter course 8 is separately established other filter course, in addition one or more layers non-woven fabrics that, also can stacked fiber diameter is less than the fiber diameter of the non-woven fabrics of the 2nd filter course 9 by the downstream at the 2nd filter course 9 is separately established other filter course.
Then, use Fig. 1 that the using state (making the state of blood flow) of bags of blood system 1 is described.
The platelet that obtains by the blood of taking from blood donor is carried out to the centrifugalize blood constituent that becomes to grade is temporarily stored in bags of blood 12.On bags of blood 12, be connected with conduit 13, conduit 13 has the sufficiently long coupling part 14b of length to utilize aseptic engagement device (Sterile Connection Device) etc. to be sterilely connected with bags of blood system 1.
At this, all fixture 20a, 20b, 25 in bags of blood system 1 are closed, thereby, blood pathway 27a, shunt stream 27d and the state of conduit 24 in closing.Then, utilize aseptic engagement device (Sterile Connection Device) etc. sterilely to engage the coupling part 14b of conduit 13 and the coupling part 14a of bags of blood system 1.
Then, open fixture 20b after bags of blood 12 is hung over to the coupling part 14a filtering on platform and after having opened aseptic connection, now, blood pathway 27a is opened.Under this state, blood in bags of blood 12 is through conduit 13, via coupling part 14a and through in blood pathway 27a and reclaimed by blood reclaiming bag 23.By the 11 pairs of blood mobile in blood pathway 27a of filter that utilize leukocyte to remove use, filter, thereby remove condensation product and leukocyte.
Then, when bags of blood 12 empties, close fixture 20b.Then, by opening stream along separate routes with fixture 20a and compressing the air that blood reclaiming bag 23 makes to be blended in blood reclaiming bag 23, via shunt stream 27d, turn back in bags of blood 12.Afterwards, by closing stream along separate routes, with fixture 20a, also again open fixture 20b and again open blood pathway 27a.Its result, can effectively reclaim and remain in the blood in blood pathway 27a and filter 11 with blood reclaiming bag 23.
Then, close fixture 20b, closed blood stream 27a.At this, at sealing predetermined portions 28 places in the downstream of branch connector portion 21, carry out the heat-sealing of conduit 22, thereby disconnect the blood pathway by upstream side than conduit 22 completely.As required, utilize stripping (stripping) that the blood remaining in conduit 22 is recycled in blood reclaiming bag 23, and carry out the heat-sealing of conduit 22 at sealing predetermined portions 29 places, thereby disconnect the conduit 22 by upstream side than sealing predetermined portions 29.
Afterwards, in order to sample, to cut apart Blood Preparations and make a part for blood can be extracted into son bag 26 checking with blood.Open fixture 25 and make the stream of conduit 24 open, then compress blood reclaiming bag 23, thereby blood is moved to son bag 26.By closing fixture 25, make the stream of conduit 24 closed.Sealing predetermined portions 30,31 places at conduit 24 seal, thereby blood reclaiming bag 23 and son bag 26 are disconnected.
As mentioned above, adopt bags of blood system 1, can from bags of blood 12, till blood reclaiming bag 23 and son bag 26, form the closed system that antibacterial cannot be sneaked into from outside.Its result can carry out removing leukocytic modulation in the blood after blood sampling in closed system.
the 2nd embodiment
Then, with reference to Fig. 5 explanation, as the leukocyte of the 2nd embodiment, remove the bags of blood system 40 of system.In addition, in the 2nd embodiment, for the structure identical with the 1st embodiment, member, mark the Reference numeral identical with the 1st embodiment, omit detailed explanation.
Bags of blood system 40 has conduit 41a, 41b, 41c, 41d, 41e, 41f, the 41g passing through for blood.Conduit 41a, 41b, 41c, 41d, 41e, 41f, 41g form by having flexible blood flexible pipe.
Bags of blood system 40 comprises: blood pathway 42, and it is formed by conduit 41a, 41b, 41c, 41d, 41e, 41f, 41g; Pricker (blood introduction part) 43,44, it is configured in the end of a side of blood pathway 42; Blood reclaiming bag 23, it is configured in the end of the opposite side of blood pathway 42; Filter 11, it is configured between the pricker 43,44 and blood reclaiming bag 23 of blood pathway 42; And net chamber 45, it is configured between pricker 43,44 and filter 11.
In addition, bags of blood system 40 has the branch connector portion 46 of upstream side and the branch connector portion 47 in downstream, the branch connector portion 46 of upstream side is arranged between net chamber 45 and filter 11, and the branch connector portion 47 in downstream is arranged between filter 11 and blood reclaiming bag 23.
The end of the upstream side of blood pathway 42 is provided with a plurality of stream 42a of branch, 42b to be the mode of a plurality of branches.In addition, in the upper end of the stream 42a of each branch, 42b, be provided with the pricker 43,44 as blood introduction part. Pricker 43,44 can be both plastics, can be also metallic.Bags of blood (not shown) is installed on pricker 43,44.By by pricker 43,44 for blood introduction part, make being connected between bags of blood and blood introduction part become easy.
Also can on pricker 43,44, be provided with blow vent (not shown), this blow vent can close or take off cap by mounting cap and open.Blow vent is as the breather (air vent) of air amount when open and performance function.In addition, the in-built filter cell that prevents that dust, dust etc. from invading that is useful in blow vent.In the present embodiment, example be formed with the countermeasure of the stream 42a of Er Tiao branch, 42b, but, also can be not form the stream 42a of branch, 42b and technical scheme that pricker is installed at the upstream extremity of a primary flow path, can also be that three above branch's streams are set, and the technical scheme of pricker is set at each branch's stream.
On the stream 42a of each branch, 42b, be provided with for opening and closing branch's stream fixture 48 of stream.Branch's stream fixture 48 is as lower member: it is outer is loaded on blood flexible pipe etc. and has flexible conduit 41a, 41b, and flatten conduit 41a, 41b by extruded conduit 41a, 41b, close closed channel, on the contrary, by discharging, the extruding of conduit 41a, 41b is opened to stream.
The end in the downstream of two conduits 41a, 41b is connected in a conduit 41c via adapter portion 49, and conduit 41c is connected in the entrance in net chamber 45.And the outlet in net chamber 45 is connected in conduit 41d.Conduit 41d is connected in conduit 41e via the branch connector portion 46 of upstream side, and conduit 41e is connected in filter 11.In addition, on conduit 41e, be provided with for opening and closing the fixture 68 of stream.
The outlet port of filter 11 is connected with conduit 41f, and conduit 41f is connected in conduit 41g via the branch connector portion 47 in downstream, in the end of downstream side of conduit 41g, is connected with blood reclaiming bag 23.The small diameter part that is provided with flow adjustment use on conduit 41f divides 32.
In the branch connector portion 46 of upstream side and the branch connector portion 47 in downstream, sentence the mode of walking around filter 11 and be connected with and use along separate routes conduit 41h, by forming shunt stream 42c with conduit 41h along separate routes.The branch connector portion 46 of upstream side is the end of the upstream side of shunt stream 42c, and the branch connector portion 47 in downstream is the end in the downstream of shunt stream 42c.In addition, along separate routes with being provided with on conduit 41h: check-valves 50, it is for making blood only mobile to a direction (from downstream upstream side); And fixture 69, it is for opening and closing stream.By thering is check-valves 50, can prevent that unfiltered Blood Preparations is via being blended in blood reclaiming bag 23 with conduit 41h along separate routes.
The using state (making the state of blood flow) of the bags of blood system 40 of present embodiment then, is described.
On the pricker 43,44 of bags of blood system 40, the bags of blood of having put into blood is installed.At first, the blood in bags of blood is through being reclaimed by blood reclaiming bag 23 in blood pathway 42.At the interior mobile blood of blood pathway 42, through net chamber 45, remove aggregation (condensation product), afterwards, by remove the filter 11 of use through leukocyte, remove leukocyte.That is, adopt bags of blood system 40, can, by making the blood importing from the pricker 43,44 as blood introduction part remove the leukocyte in blood through filter 11, can carry out the modulation of blood.
And when bags of blood empties, the air being blended in blood reclaiming bag 23 turns back to pricker 43,44 sides from shunt stream 42c.Afterwards, by making residual blood through filter 11, can effectively reclaim blood.
the 3rd embodiment
Then, with reference to Fig. 6 explanation, as the leukocyte of the 3rd embodiment, remove the external member 60 for blood transfusion of system.In addition, in the 3rd embodiment, for the structure identical with the 1st and the 2nd embodiment, member, mark the Reference numeral identical with the 1st and the 2nd embodiment, omit detailed explanation.
The blood transfusion of the 3rd embodiment is for example used in patient's sick bed side by external member 60.Blood transfusion has conduit 61a, 61b, 61c, 61d, the 61e passing through for blood by external member 60. Conduit 61a, 61b, 61c, 61d, 61e form by having flexible blood flexible pipe.
Blood transfusion comprises by external member 60: blood pathway 62, and it is formed by conduit 61a, 61b, 61c, 61d, 61e; Pricker (blood introduction part) 43,44, it is configured in the end of a side of blood pathway 62; Branch's stream fixture 48, it opens and closes blood pathway 62 for the downstream at pricker 43,44; Blood transfusion needle adapter 63, it is configured in the end of the opposite side of blood pathway 62; Filter 11, it is configured between the pricker 43,44 and blood transfusion needle adapter 63 of blood pathway 62; Net chamber 45, it is configured between pricker 43,44 and filter 11; And dropping funnel 64 and roller fixture 65, both are configured between filter 11 and blood transfusion needle adapter 63 for this.
The end in downstream that is provided with two conduits 61a, the 61b of pricker 43,44 is connected in the conduit 61c of a side via adapter portion 66, conduit 61c is connected in the entrance in net chamber 45.And the outlet in net chamber 45 is connected in conduit 61d.Conduit 61d is connected in filter 11, and is connected with conduit 61e at the outlet port of filter 11.
On conduit 61e, from upstream side, be provided with dropping funnel 64 and roller fixture 65.Dropping funnel 64 refers to drop cylinder, comprise the conduit 61e that is connected with upstream side (filter 11 sides) ingress port, be connected with downstream (roller chuck side 65 sides) conduit 61e outlet port and be adjacent to ingress port the exhaust apparatus arranging.The blood that drips shape dropping funnel 64 discontinuous fall and can be with this interval, whereabouts of visual identity.That is, by holding the length at this interval, whereabouts, the flow velocity that can make to transfuse blood management facilitation.In addition, because dropping funnel 64 is arranged at than the conduit of filter 11 downstreams, be conduit 61e, therefore compare with the situation that to be arranged at than filter 11 be conduit 61d by the conduit of upstream side, can improve the precision of blood transfusion flow velocity management.
In the downstream of the dropping funnel 64 of conduit 61e, be provided with the roller fixture (returning route control device) 65 as volume control device.Roller fixture 65 comprises: roller 65a, and its one side extruded conduit 61e is on one side by manually rotating; And guiding case 65b, it is so that the mode that roller 65a can rotate keeps this roller 65a, and the reciprocating motion undertaken by the rotation of roller 65a of guiding.Conduit 61e is by guiding case 65b.When utilization is manually rotated roller 65a to a direction, roller 65a is at it and guide extruded conduit 61e between case 65b, and by pressing conduit 61e in the mode of flattening conduit 61e, flow path is carried out current limliting.Its result, the flow of blood reduces.On the other hand, when roller 65a is rotated to other direction, the current limliting of the conduit 61e being undertaken by roller 65a is disengaged, and stream expands.Its result, the flow of blood increases, to turn back to initial condition.
By thering is roller fixture 65, can carry out rightly flow-control, can suppress leukocytic the spilling causing because forming high flow rate.Particularly, when directly the blood after being filtered by filter 11 being transfused blood to patient, the dropping speed in the time of can coordinating blood transfusion carries out trickle flow adjustment.
End of downstream side at conduit 61e is provided with blood transfusion needle adapter 63.Blood transfusion needle adapter 63 is to be provided with to thrust the part of pin for patient's blood transfusion.By the downstream at filter 11, blood transfusion needle adapter 63 is set, can directly the blood after being filtered by filter 11 be transfused blood to patient.
In addition, as the variation of above embodiment, also can be further conduit 61e be provided with blood transfusion needle adapter 63 near air capture device is set.Specifically, can form by the structure in this chamber portion chamber portion that volume expanded being set by the part of pin near blood transfusion of blood transfusion needle adapter 63 and by air seizure.By air capture device is set, can prevent that air from entering in patient vessel.
the 4th embodiment
Then, with reference to Fig. 7 explanation, as the leukocyte of the 4th embodiment, remove the bags of blood system 70 of system.In addition, in the 4th embodiment, for the structure identical with the 1st～3rd embodiment, member, mark the Reference numeral identical with the 1st～3rd embodiment, omit detailed explanation.
Bags of blood system 70 has conduit 71a, 71b, 71c, the 71d passing through for blood.Conduit 71a, 71b, 71c, 71d form by having flexible blood flexible pipe.
Bags of blood system 70 comprises: blood pathway 72, and it is formed by conduit 71a, 71b, 71c, 71d; A plurality of airtight loops (closed loop) (blood introduction part) 73, it is configured in the end of a side of blood pathway 72; Blood reclaiming bag 23 and son bag 26, both are configured in the end of the opposite side of blood pathway 72 for this; Filter 11, it is configured between closed loop 73 and blood reclaiming bag 23; And reservoir bag 74, it is configured between closed loop 73 and filter 11.In addition, on a conduit of closed loop 73, be provided with fixture 81, on conduit 71a, be provided with fixture 82, on conduit 71b, be provided with fixture 83, on conduit 71d, be provided with fixture 84.As fixture 81,82,83,84, for example, can use board clamp.
The conduit 71a being connected with a plurality of closed loop 73 at upstream side is connected in the entrance of reservoir bag 74 in downstream.The outlet of reservoir bag 74 is connected in conduit 71b, and this conduit 71b is connected in filter 11, in the outlet port of filter 11, is connected with conduit 71c.Conduit 71c is connected in blood reclaiming bag 23, and in addition, conduit 71d is in blood reclaiming bag 23 and 26 extensions of son bag.
Claims (18)
1. leukocyte is removed a system, and it,, for removing leukocyte from platelet transfusion or blood plasma preparation, is characterized in that,
This leukocyte removal system comprises: the blood introduction part being connected by blood pathway, leukocyte are removed filter and volume control device,
In above-mentioned blood pathway, above-mentioned leukocyte is removed filter deployment in the downstream of above-mentioned blood introduction part.
2. leukocyte according to claim 1 is removed system, it is characterized in that,
Above-mentioned leukocyte is removed filter and is had: the filter member of lamellar, and it is for removing the leukocyte of blood; And entrance side container and outlet side container, both configure relatively across above-mentioned filter member for this,
Above-mentioned filter member is to form by stacked the 1st filter course consisting of one or more layers non-woven fabrics and the 2nd filter course that consists of one or more layers non-woven fabrics,
Above-mentioned the 1st filter course position between the entrance of above-mentioned entrance side container and the outlet of above-mentioned outlet side container, lean on above-mentioned entrance side than above-mentioned the 2nd filter course,
The fiber diameter that forms the non-woven fabrics of above-mentioned the 2nd filter course is less than the fiber diameter of the non-woven fabrics that forms above-mentioned the 1st filter course,
The fiber diameter that forms the non-woven fabrics of above-mentioned the 1st filter course is 3 μ m～60 μ m,
Form the fiber diameter of non-woven fabrics of above-mentioned the 2nd filter course for being less than 3 μ m.
3. leukocyte according to claim 2 is removed system, it is characterized in that,
The end of above-mentioned blood introduction part is more than one pricker.
4. leukocyte according to claim 2 is removed system, it is characterized in that,
The end of above-mentioned blood introduction part is more than one airtight loop.
5. leukocyte according to claim 2 is removed system, it is characterized in that,
The end of above-mentioned blood introduction part is more than one breather filter.
6. according to the leukocyte described in any one in claim 1～5, remove system, it is characterized in that,
The aeration resistance that above-mentioned leukocyte is removed filter is 20Pa～4900Pa.
7. according to the leukocyte described in any one in claim 2～5, remove system, it is characterized in that,
Utilize hydrophilic macromolecule to be coated with the above-mentioned filter member that above-mentioned leukocyte is removed filter.
8. according to the leukocyte described in any one in claim 1～5, remove system, it is characterized in that,
Above-mentioned volume control device is loop diameters control device.
9. according to the leukocyte described in any one in claim 1～5, remove system, it is characterized in that,
Above-mentioned volume control device is loop, thin footpath, and net sectional area is 0.1mm
2～5.0mm
2, length/net sectional area is 3mm/mm
2～400mm/mm
2.
10. according to the leukocyte described in any one in claim 1～5, remove system, it is characterized in that,
Above-mentioned volume control device is arranged at the downstream that leukocyte is removed filter.
11. remove system according to the leukocyte described in any one in claim 1～5, it is characterized in that,
Between above-mentioned blood introduction part and above-mentioned leukocyte removal filter, there is net chamber.
12. remove system according to the leukocyte described in any one in claim 1～5, it is characterized in that,
Between above-mentioned blood introduction part and above-mentioned leukocyte removal filter, have for storing the reservoir bag of the blood before filtration.
13. remove system according to the leukocyte described in any one in claim 1～5, it is characterized in that,
The downstream of removing filter at above-mentioned leukocyte has for reclaiming the reclaiming bag of the blood after filtration.
14. leukocytes according to claim 13 are removed system, it is characterized in that,
This leukocyte removal system has for connecting the shunt loop between above-mentioned blood introduction part and above-mentioned leukocyte removal filter and between above-mentioned leukocyte removal filter and above-mentioned reclaiming bag.
15. leukocytes according to claim 14 are removed system, it is characterized in that,
In above-mentioned shunt loop, have in check-valves and fixture at least any one.
16. leukocytes according to claim 13 are removed system, it is characterized in that,
This leukocyte removal system has at least more than one son bag.
17. remove system according to the leukocyte described in any one in claim 1～5, it is characterized in that,
The downstream of removing filter at above-mentioned leukocyte has blood transfusion needle adapter.
18. leukocytes according to claim 17 are removed system, it is characterized in that,
At above-mentioned leukocyte, remove between filter and above-mentioned blood transfusion needle adapter and there is dropping funnel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320404137.4U CN203469137U (en) | 2013-07-08 | 2013-07-08 | White blood cell removing system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320404137.4U CN203469137U (en) | 2013-07-08 | 2013-07-08 | White blood cell removing system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203469137U true CN203469137U (en) | 2014-03-12 |
Family
ID=50217561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320404137.4U Expired - Lifetime CN203469137U (en) | 2013-07-08 | 2013-07-08 | White blood cell removing system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203469137U (en) |
-
2013
- 2013-07-08 CN CN201320404137.4U patent/CN203469137U/en not_active Expired - Lifetime
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