CN203280540U - Cardiac valve prosthesis and support for same - Google Patents
Cardiac valve prosthesis and support for same Download PDFInfo
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- CN203280540U CN203280540U CN2013200925658U CN201320092565U CN203280540U CN 203280540 U CN203280540 U CN 203280540U CN 2013200925658 U CN2013200925658 U CN 2013200925658U CN 201320092565 U CN201320092565 U CN 201320092565U CN 203280540 U CN203280540 U CN 203280540U
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Abstract
The utility model discloses a support used for a cardiac valve prosthesis. The support is used for bearing a cardiac valve film and comprises a flow-in channel, a flow-out channel and a transition region located between the flow-in channel and the flow-out channel which are located along the longitudinal axis. The support is provided with a contraction configuration for conveying and a folding configuration for configuration. In the folding configuration, the flow-in channel is provided with a convex structure which is matched with a cingulum protogenesis structure. Through the convex structure, the support can achieve the automatic positioning function, and after the cardiac valve prosthesis is implanted, the cardiac valve prosthesis is attached tightly and the occurrences of shifting and prosthetic leakage are prevented. The utility model further provides a cardiac valve prosthesis used for displacing the cardiac valve film.
Description
Technical field
This utility model relates in general to a kind of heart valve prosthesis that can carry out cardiac valve replacement of need not operating on.More specifically, thus this utility model relates to a kind of anatomical cardiac structure location of can accurately fitting tightly is difficult for being subjected to displacement and preventing the valve prosthesis support of perivalvular leakage.
Background technology
Along with the arrival of global aging society, aortic valve disease has become one of common cardiovascular disease.The sickness rate domestic in China is 2%-5%, and after American-European countries is positioned at coronary heart disease and hypertension, occupies the 3rd.There is every year thousands of patient to benefit from the surgery aortic valve replacement, even but in developed country, still have the patient of a large amount of severe aortic valve pathological changes because terminal stage of a disease, advanced age and exist multiple complication etc. former thereby can not accept surgical operation therapy, the appearance of percutaneous aortic valve prosthesis product and properties of product constantly perfect,, undoubtedly for this part patient has brought Gospel, provide a kind of effective Therapeutic Method.
Aortic valve disease can be caused by birth defect, natural aging process, infection or forming of cicatrix.As time goes on, calcified material may deposit around aortic valve, cause aortic stenosis and/or valvular insufficiency to cause " aortic regurgitation ".Patient's disease of aortic valve disease is mainly manifested in angina pectoris, faints and heart failure, makes patient's quality of life degradation, and the time-to-live obviously shortens, and must effectively treat.
At first Cribier in 2002 etc. have reported that the first case human body is through conduit aortic valve replacement case, after this, lot of domestic and foreign scholar, doctor have all carried out basis and the clinical research through conduit aortic valve replacement (TAVR), and obtained clinical effectiveness preferably, research shows: surgery changes lobe or there is high risk patient in the surgery heart valve replacement surgery for carrying out, and this new technique is safely and effectively.Compare with surgery hands wood, percutaneous aortic valve film replacement need not out breast and extracorporeal circulation support, is that a kind of wound is little, few intercurrent disease, postoperative rehabilitation is fast, the patient suffering is little, acceptable Therapeutic Method.Although carry out the high-risk patient that mostly is of TAVR operation, postoperative 30 days survival rates are higher than 90%, and the postoperative patient hemodynamic index has obtained obvious improvement.
Percutaneous aortic valve prosthesis product is through constantly upgrading improvement, and being applied at present clinical mainstream product has Edwards valve bracket system and the large class of CoreValve valve bracket system two.The Edwards-SAPIEN bioprosthetic valve, made by bovine pericardium, stitching is assembled on rustless steel (or cochrome) support, use balloon expandable stent to realize the location of valve at lobe ring place, need not delivery sheath, can adopt direct motion, drive in the wrong direction or through the method for apex of the heart approach, insert, can diameter 23mm and two kinds of specifications of 26mm be arranged for the valve of clinical practice.The example of this aortic valve has been described in patent application WO2009/149462A2.Edwards-SAPIEN aortic valve system has been carried out a large amount of clinical experiments, has obtained ideal result of study.The CoreValve valve system is another valve bracket that successfully uses clinically, in first Application in 2005 in human body and succeed.Its artificial valve who mainly by the cloverleaf Cor Sus domestica, is packed is sewn on the Nitinol self-expandable stent, and this support has 26mm, 29mm and three kinds of specifications of 31mm at present.Provided the example of this valve system in US patent application publication US2011/0172765A1.The CoreValve valve bracket is made by Ultimum Ti, and support top is used for being anchored on the ascending aorta of Wa Shi hole top, and its radial support power is lower; Mid-stent is sewed with the lobe leaf, and its geometry indent, do not stopped coronary flow; The support bottom is used for inserting being fixed in the aortic valvular ring place, and its radial support power is strong.Up-to-date clinical research confirmation, implanting the CoreValve valve system not only has good hemodynamic effect, and 30 days mortality rates are 8%, has shown more satisfactory safety.
Yet the aortic valve product that has gone on the market at present still exists some drawbacks and not reasonably local.For percutaneous aortic valve replacement (TAVI) operation, whether accurately the location of valve bracket direct relation the success or failure of performing the operation.The primary structure in human aortic valve zone is complicated, there is the left and right coronary ostium lobe leaf top, there is left ventricle interventricular septum conduction bundle branch below, and Bicuspid valve is adjoined on right side, if locate the fatal complication such as the inaccurate obstruction that probably causes coronary ostium, conductive beam retardance.With regard to two kinds of representational valve system (Edwards and CoreValve), two kinds of products are not recyclable and reorientate.The Edwards valve bracket is discharged by the rapid expanse of sacculus, in case location does not have the leeway of adjusting; Can do adjustment to a certain degree when the CoreValve valve bracket partly discharges, also can't adjust after release.As implant rear discovering and location exist deviation or the support specification improper, cause that easily serious complication occurs in displacement, threatens patients ' lives.In addition, through clinical feedback, the Corevalve valve bracket has the situation about being subjected to displacement after the long destruction conduction bundle branch of ventricle and implantation that stretches into often
Mention above this utility model is intended to solve and prior art in one or more other technologies problems of existing.
The utility model content
A purpose of the present utility model is to provide a kind of heart valve prosthesis, wherein valve bracket can be accurately and the lobe ring fit tightly, thereby prevent perivalvular leakage.
Thereby another purpose of the present utility model is to provide a kind of valve can fixedly positioning the heart valve prosthesis that is not easy to be subjected to displacement.
Another purpose of the present utility model is to provide a kind of heart valve prosthesis, and it can solve valve bracket, and to stretch into left ventricle long thereby the problem that left bundle branch is obstructed easily occurs.
Another purpose of the present utility model is to provide a kind of heart valve prosthesis, and it can solve the valve designs defect or locate the problem that the inaccurate coronary ostium blood flow that causes is obstructed.
The purpose of this utility model also is to provide a kind of heart valve prosthesis, the problems that can not accurately locate etc. due to image error when it can solve and implant.
Correspondingly, this utility model provides a kind of support for heart valve prosthesis, its be used for the supporting cardiac valve and along the longitudinal axis comprise and flow into road, efferent tract and in the transitional region that flows between road and efferent tract, described support has the contracted configuration of conveying and the deployed configuration of deployment, wherein,, in deployed configuration, flow into road and have the concave inward structure that mates with lobe ring primary structure.
According to a kind of embodiment, described support is self-expansion type, and comprises a plurality of construction units of grid configuration.
According to a kind of embodiment, described inflow road adopts at described concave inward structure place with inflow road other parts and compares larger construction unit.
According to a kind of embodiment, in described deployed configuration, described support is tapered to described transitional region from described inflow road, then towards efferent tract, expands.
According to a kind of embodiment, the end of described inflow road and described efferent tract slightly inside contracts and is the design of closing up.
According to a kind of embodiment, described inflow road circumferentially comprises 12 construction units, and described efferent tract circumferentially comprises 6 construction units.
According to a kind of embodiment, described support is taked to have than at efferent tract and the larger wide construction unit of bar of transitional region flowing into the zone, road.
According to a kind of embodiment, the value of the radius at described concave inward structure place is 4-6mm, and the indent degree of depth is 1-2mm, and concave inward structure is positioned at apart from support 1 a near-end 1-2 wave band place.
According to a kind of embodiment, described support adopts Nitinol to make.
This utility model also provides a kind of heart valve prosthesis for cardiac valve replacement, and it comprises cardiac valve and above-mentioned support.
According to a kind of embodiment, described cardiac valve is the cloverleaf valve, and the valve of the unidirectional opening of SANYE that it is comprised of the Cor Sus domestica bag through anti-calcification processing is made and formed.
According to a kind of embodiment, described cardiac valve is by utilizing the suture that polyethylene terephthalate is made to be sewn onto described support.
Realized the automatic location of valve bracket according to valve bracket positioning area of the present utility model by the employing concave inward structure, thus the difficulty that has improved the accuracy that support is located, reduced hands wood.Before support discharges fully, improper recovery and the reorientation operation that realizes support of as improper in discovering and location or support specification; Simultaneously, support flows into road and adopts wedge structure, has effectively prevented the obstruction of coronary ostium, thereby can strictly control support, flows into road and stretches into the length of ventricle, avoids support to stretch into ventricle long and cause the serious complication such as conductive beam retardance.
Description of drawings
By below in conjunction with accompanying drawing to being only the description of exemplary and nonrestrictive embodiment, above-mentioned and further feature of the present utility model and advantage will become clearer:
Fig. 1 is the perspective view according to a kind of exemplary heart valve prosthese of the present utility model;
Fig. 2 is the end-view of heart valve prosthesis shown in Figure 1;
Fig. 3 shows heart valve prosthesis of the present utility model and is in the perspective view of the conveying configuration of part release; And
Fig. 4 describes the side view that is deployed in the heart valve prosthesis of the present utility model in patient body.
The specific embodiment
Stop embodiment below in conjunction with tool, further set forth this utility model.This utility model relates in general to a kind of heart valve prosthesis, and it has the valvular self-expansion type support of supporting.The self-expansion type support has proximal region, zone line and the distal region that distributes in a longitudinal direction.When describing support of the present utility model, proximal region refers to the zone corresponding with the inflow road of valve prosthesis, and correspondingly, distal region refers to the zone corresponding with the efferent tract of valve prosthesis.
Fig. 1 shows the heart valve prosthesis according to a kind of illustrative embodiments of this utility model, is specially a kind of insertion type prosthetic aortic valve prosthese, is used for displacement the aortic valve of pathological changes occurs.This valve prosthesis comprises support 1 and aortic valve 3.Valve 3 is by for example sewing up the inner surface that is fixed to support 1.Support 1 has for the contracted configuration of implanting course of conveying and while implanting and the deployment deployed configuration that meets of heart primary structure, Fig. 1 shows this exemplary deployment deployed configuration.
As shown in the deployment deployed configuration of Fig. 1, support 1 comprises on the whole the fenestral fabric unit and has longitudinal direction.Particularly, support 1 flare network, longitudinally be divided into efferent tract 6, transitional region 7 from top to bottom and flow into road 8.Flow into the prosthese part that 8 correspondences blood when valve operation in road flows into prosthese, stretch into left ventricle after implantation.Efferent tract 6 correspondences blood when valve operation flows out the prosthese part of prosthese, is implanting postadhesion in ascending aorta.
Can see from Fig. 1, according to support 1 of the present utility model, flow into road 8 tapered to transitional region 7, and again towards efferent tract 6 expansions.According to a kind of embodiment, the location diameter that flows into road 8 can in the scope of 21mm～30mm, be for example 30mm; The diameter of efferent tract 6 can be for example 43mm in the scope of 38mm～43mm, to be used for the support of different size, thus the primary anatomical structure of coupling different size.Particularly, the network structure that support efferent tract 6 circumferentially is comprised of 6 cells, the grid cell area is about 0,8～1.6cm
2.For example, it is about 0 that the adjacent mesh cellar area can be respectively, 8cm
2With about 1,3cm
2.Angle between the adjacent wave bar is 60 °～120 °, and more preferably 60 ° of scholars 5 °.The head end of efferent tract 6 is on average arranged two hangers 2, enters carrier sheath pipe or push valve for towing bracket to go out sheath.After valve prosthesis was implanted, efferent tract 6 stretches into ascending aorta and the ascending aorta inwall fits, and can calibrate valve bracket and be parallel to blood flow direction.
Continuation is with reference to Fig. 1, the efferent tract 6 that shown valve bracket transitional region 7 connection diameters are larger and the less inflow road 8 of diameter, circumferentially network is transitioned into by 6 grid cells of efferent tract 6 12 grid cells that flow into road 8, angle between the adjacent wave bar is 5 ° of 50 ° of scholars, the grid area is about 0,7cm
2.
The inflow road 8 of support 1 upwards has the most intensive grid cell in week, and in the illustrated embodiment, support flows into road 8 and circumferentially 12 grid cells, consists of, and the grid area is about 0.5～0.8cm
2, the angle between the adjacent wave bar is 30 °～65 °.After valve prosthesis was implanted, this inflow region 8 was placed in the lobe ring of aortic root.Especially,, according to this utility model, flow into road 8 and be provided with the concave inward structure (position shown in the arrow 9 in figure) of automatically complying with lobe ring primary structure, with primary lobe ring structure, to fit tightly and to realize accurate location.Flow into this concave inward structure in road 8 during by the deployment deployed configuration, with the existing valve prosthesis that does not have this concave inward structure, compare, this profile can realize the self-align of valve bracket, reduces the difficulty of valve location and the accuracy of raising location.And the coupling of shape itself just can provide the footpath strong support force that makes progress circumferentially to fit tightly to guarantee valve bracket and lobe ring, and can provide space for valve work, and the while effectively prevents perivalvular leakage and valve bracket is stressed is subjected to displacement.
According to a kind of preferred implementation, this concave inward structure place can adopt larger grid cell, and the value of radius can be in the scope of 4-6mm, and the indent degree of depth can be 1-2mm, and concave inward structure can be positioned on apart from support 1 a near-end 1-2 wave band place.Be appreciated that this concave inward structure by the form fit with primary lobe ring, make valve prosthesis of the present utility model have self-locating function.In addition, this concave inward structure for support reorientate and reclaim significant.Particularly, due to after deployment, this female parts coordinates with primary lobe ring structure, for example support being flowed into part, while even together with transitional region, from delivery sheath, discharging, inflow road part, particularly its concave inward structure of having discharged namely return near it disposes expansion shape fully, therefore will naturally recline by its profile and aortic valvular ring.Medical personnel can locate situation by for example various Imaging Technology inspections in this process, as find that the position of carrying is undesirable, perhaps the valve specification is improper, can not fit with the lobe ring is perfect, at this moment the tension force of release portion still do not hinder with this discharged partially recycled in delivery sheath, make it possible to reorientate or change after valve and again carry.
Above-mentioned deployment deployment configuration can obtain by using technology known in the art to be applied on metal alloy compositions.For example, the preferred self-expansion type structure of support 1 can form through laser engraving by metal alloy tubing, and through a series of Technologies for Heating Processing (such as typing, grinding, polishing etc.), is shaped to required shape, reaches required super-elasticity and memory function.Described metal alloy tubing can be such as shape-memory materials such as Nitinols.
As mentioned above, preferred memory metal one Nitinol with super-elasticity matter that adopts of support 1 is made, and suture 5 is preferably made with polyethylene terephthalate (PTFE).
As shown in Figure 1, all slightly inside contract and be " closing in " 11 designs according to the inflow road 8 of support 1 of the present utility model and efferent tract 6 two ends, the view angle can be in the scope of 8 °～12 °, more preferably 10 °, to prevent that metal rack is to in-vivo tissue injury (clearer demonstration in Fig. 4) when fitting left ventricle and aorta inwall.
Can realize many advantages according to heart valve prosthesis of the present utility model.Fig. 4 has shown the schematic diagram after implanting according to valve prosthesis of the present utility model, can clearlyer see from this figure, adopt the concave shaped design of complying with primary lobe ring structure by flow into place, location, road at support, valve bracket of the present utility model can be realized fitting tightly with the lobe ring, therefore can accurately locate, and can prevent from implanting simultaneously rear generation displacement and occur to leak in week.Simultaneously, adopt relatively large grid cell at the concave inward structure place owing to flowing into road, overstocked being difficult for causes support adherent not tight with lofty profile distortion again can effectively to avoid the lofty grid cell that has a bulky grain calcified material because of patient's lobe ring place, cause the phenomenon of perivalvular leakage, circumferentially adopt the conventional stent designs of 15 grid cells to compare with flowing into road, the concave inward structure of this macrolattice design has more apparent benefit.
As mentioned above, it is the taper design of major part that support flows into the initiating terminal that adopts in the zone, road, adds that the wide W design of larger bar in inflow zone, road has guaranteed that this section has strong support force, thereby realizes the strong fix of support.This has further strengthened the anti-displacement capacity after the support implantation.
Structurally realize the accurate location of valve due to support of the present utility model, thereby can carry out strict control to the length that valve bracket stretches into left ventricle, for example made the concave inward structure nearside that 1-2 wave band is set just enough again.
Except flowing into the taper design in road, support of the present utility model also, by adopting suitable full shirt rim height H, makes coronary ostium because of the implantation of valve bracket, not hinder the unimpeded of coronary flow.
In addition, valve bracket transition region and efferent tract adopt open (macrolattice) design, can make support comply with primary structure in lobe ring and ascending aorta out-of-alignment situation, guarantee that valve can work.Efferent tract stretches into ascending aorta, and has good adherent property.
Below describe as an example of aortic valve example according to heart valve prosthesis of the present utility model and be implanted to general step in patient body.
1, measure patient's aortic valve ring size according to the inspection of esophagus ultrasonic cardiography or CT, and select accordingly the insertion type prosthetic aortic valve of appropriate size;
2, in frozen water, the prosthetic aortic valve support is loaded in the sheath pipe 10 of valve carrier (not shown) front end;
3, under systemic anesthesia (or local anesthesia) state, the puncture femoral artery, insert carrier sheath pipe 10, through carrier sheath pipe with the seal wire (not shown) through ventral aorta, thoracic aorta, cross aortic valve to left ventricle, set up track;
The delivery sheath 10 that 4, will be mounted with the prosthetic aortic valve support is delivered to the aortic valvular ring place along seal wire, and part discharges valve bracket, and Fig. 3 has shown the support that is in the part release conditions;
5, the location situation of imaging examination valve bracket, as undesirable in finding position, adjustable position, to be adjusted during to ideal position, discharge valve bracket it is expanded, reach the purpose of displacement aortic valve.The aortic root radiography, estimate and have or not arterial valve to backflow;
6, withdraw from sheath pipe 10 along the seal wire track, withdraw from seal wire;
7, reach again according to the esophagus ultrasoundcardiogram position and the effect that the radiography result determines that artificial valve is implanted, then, sew up the vascular puncture mouth, operation is completed.
The above is described this utility model in conjunction with specific embodiments, should be understood that these embodiment only are used for explanation this utility model and are not used in restriction scope of the present utility model.Should be understood that in addition after the content of having read this utility model instruction, those skilled in the art can do to change or revise to this utility model, and these equivalents fall within the application's appended claims limited range equally.
Claims (12)
1. support that is used for heart valve prosthesis, its be used for the supporting cardiac valve and along the longitudinal axis comprise and flow into road, efferent tract and in the transitional region that flows between road and efferent tract, described support has the contracted configuration of conveying and the deployed configuration of deployment,
It is characterized in that,
In described deployed configuration, described inflow road has the concave inward structure with lobe ring primary structure coupling.
2. support according to claim 1, is characterized in that, described support is self-expansion type, and comprise a plurality of construction units of grid configuration.
3. support according to claim 2, is characterized in that, described inflow road adopts at described concave inward structure place with inflow road other parts and compares larger construction unit.
4. the described support of any one according to claim 1-3, is characterized in that, in described deployed configuration, described support is tapered to described transitional region from described inflow road, then towards efferent tract, expands.
5. the described support of any one according to claim 1-3, is characterized in that, the end of described inflow road and described efferent tract slightly inside contracts and being the design of closing up.
6. the described support of any one according to claim 1-2, is characterized in that, described inflow road circumferentially comprises 12 construction units, and described efferent tract circumferentially comprises 6 construction units.
7. the described support of any one according to claim 1-3, is characterized in that, described support is taked to have than at efferent tract and the larger wide construction unit of bar of transitional region flowing into the zone, road.
8. the described support of any one according to claim 1-3, is characterized in that, the value of the radius at described concave inward structure place is 4-6mm, and the indent degree of depth is 1-2mm, and concave inward structure is positioned at apart from support 1 a near-end 1-2 wave band place.
9. the described support of any one according to claim 1-3, is characterized in that, described support adopts Nitinol to make.
10. heart valve prosthesis that is used for cardiac valve replacement comprises:
Cardiac valve; With
According to claim 1-9 described supports of any one.
11. heart valve prosthesis according to claim 10, is characterized in that, described cardiac valve is the cloverleaf valve, and the valve of the unidirectional opening of SANYE that it is comprised of the Cor Sus domestica bag through anti-calcification processing is made and formed.
12. heart valve prosthesis according to claim 10, is characterized in that, described cardiac valve is by utilizing the suture that polyethylene terephthalate is made to be sewn onto described support.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013200925658U CN203280540U (en) | 2013-02-25 | 2013-02-25 | Cardiac valve prosthesis and support for same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013200925658U CN203280540U (en) | 2013-02-25 | 2013-02-25 | Cardiac valve prosthesis and support for same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203280540U true CN203280540U (en) | 2013-11-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013200925658U Expired - Lifetime CN203280540U (en) | 2013-02-25 | 2013-02-25 | Cardiac valve prosthesis and support for same |
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| CN (1) | CN203280540U (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000672A (en) * | 2013-02-25 | 2014-08-27 | 上海微创医疗器械（集团）有限公司 | Cardiac valve prostheses |
| CN104546224A (en) * | 2014-06-17 | 2015-04-29 | 赛诺医疗科学技术有限公司 | Stent type heart valves and stent thereof |
| CN108542554A (en) * | 2018-03-05 | 2018-09-18 | 沛嘉医疗科技(苏州)有限公司 | Through catheter heart valves holder |
| CN109414322A (en) * | 2017-04-07 | 2019-03-01 | 上海甲悦医疗器械有限公司 | A kind of artificial valve |
| CN109567985A (en) * | 2017-09-29 | 2019-04-05 | 上海微创心通医疗科技有限公司 | Heart valve prosthesis |
| CN109984868A (en) * | 2017-12-30 | 2019-07-09 | 上海微创心通医疗科技有限公司 | Heart valve prosthesis and conveyer |
| CN112220594A (en) * | 2020-10-14 | 2021-01-15 | 天津大学 | Anti-regurgitation biliary tract stent of conical spiral valve |
| US10918479B2 (en) | 2013-02-25 | 2021-02-16 | Shanghai Microport Cardioflow Medtech Co., Ltd. | Heart valve prosthesis |
-
2013
- 2013-02-25 CN CN2013200925658U patent/CN203280540U/en not_active Expired - Lifetime
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000672A (en) * | 2013-02-25 | 2014-08-27 | 上海微创医疗器械（集团）有限公司 | Cardiac valve prostheses |
| WO2014127750A1 (en) * | 2013-02-25 | 2014-08-28 | 上海微创医疗器械（集团）有限公司 | Heart valve prosthesis |
| CN104000672B (en) * | 2013-02-25 | 2016-06-15 | 上海微创心通医疗科技有限公司 | Heart valve prosthesis |
| US10918479B2 (en) | 2013-02-25 | 2021-02-16 | Shanghai Microport Cardioflow Medtech Co., Ltd. | Heart valve prosthesis |
| CN104546224A (en) * | 2014-06-17 | 2015-04-29 | 赛诺医疗科学技术有限公司 | Stent type heart valves and stent thereof |
| CN109414322A (en) * | 2017-04-07 | 2019-03-01 | 上海甲悦医疗器械有限公司 | A kind of artificial valve |
| CN109567985A (en) * | 2017-09-29 | 2019-04-05 | 上海微创心通医疗科技有限公司 | Heart valve prosthesis |
| CN109984868A (en) * | 2017-12-30 | 2019-07-09 | 上海微创心通医疗科技有限公司 | Heart valve prosthesis and conveyer |
| CN108542554A (en) * | 2018-03-05 | 2018-09-18 | 沛嘉医疗科技(苏州)有限公司 | Through catheter heart valves holder |
| CN108542554B (en) * | 2018-03-05 | 2021-07-02 | 沛嘉医疗科技(苏州)有限公司 | Transcatheter heart aortic valve stent |
| CN112220594A (en) * | 2020-10-14 | 2021-01-15 | 天津大学 | Anti-regurgitation biliary tract stent of conical spiral valve |
| CN112220594B (en) * | 2020-10-14 | 2024-04-26 | 天津大学 | Cone spiral valve anti-reflux biliary tract stent |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160419 Address after: 201203 Shanghai City Newton Road, Pudong New Area Zhangjiang hi tech Park No. 501 Patentee after: SHANGHAI MICROPORT CARDIOFLOW MEDTECH Co.,Ltd. Address before: 201203, 501, Newton Road, Zhangjiang hi tech park, Shanghai, Pudong Patentee before: SHANGHAI MICROPORT MEDICAL (GROUP) Co.,Ltd. |
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| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20131113 |