CN203138758U - Combined medical device composed of drug-coated balloon and bracket - Google Patents
Combined medical device composed of drug-coated balloon and bracket Download PDFInfo
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- CN203138758U CN203138758U CN201220490483.4U CN201220490483U CN203138758U CN 203138758 U CN203138758 U CN 203138758U CN 201220490483 U CN201220490483 U CN 201220490483U CN 203138758 U CN203138758 U CN 203138758U
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Abstract
The utility model discloses a combined medical device composed of a drug-coated balloon and a bracket. The combined medical device comprises a balloon and a bracket. A drug-containing coating is coated outside the balloon. The bracket presses and holds the external wall of the balloon. One end of the balloon is provided with a guiding pipe which is communicated with the balloon. The far end of the guiding pipe is connected with a guiding pipe base. Through the mode above, a novel medical device which is obtained through combining the drug-coated balloon balloon (DCB) and a BMS. Furthermore through a series of new design for the balloon and BMS, and low-restenosi-rate treatment effect which is similar with DES is obtained. Simultaneously, the following defects can be prevented: tardive thrombus which may occurs after use of the DES, risk caused by long-term taking of anticoagulant drugs, and economic load caused by taking the anticoagulant drugs. The use of the novel medical device is similar with that of the prior-art DES, and same convenience is obtained.
Description
Technical field
This utility model relates to medical instruments field, particularly relates to the combined medical apparatus and instruments of a kind of medicine carrying sacculus and coronary artery bracket, is used for the treatment of the myocardial ischemia heart disease that causes because of coronary atherosclerosis and the disease that causes because peripheral blood vessel is narrow.
Background technology
Coronary atherosclerotic heart disease (is called for short coronary heart disease, CHD) it is coronarius narrow or stop up the heart disease cause to be that IC atherosclerotic lesion causes, it is a kind of disease comparatively general in the cardiovascular and cerebrovascular disease, statistics shows 2010 has the people above 40% to die from cardiovascular disease among the Chinese dead person, hold pride of place in all causes of death.Show that according to World Health Organization's data in 2011 the coronary heart disease death number of China has been listed as the second place of the world.Treatment means at coronary heart disease comprises Drug therapy, percutaneous coronary artery intervention (Percutaneous Coronary Intervention at present, PCI), the operation of arteria coronaria bypass graft (also is called the cardiovascular Coronary Artery Bypass, Coronary Artery Bypass Grafting, CABG) etc., characteristics such as wherein, PCI is little because of its wound, misery is little, post-operative recovery is fast, evident in efficacy are subjected to extensive concern.
PCI originates from first Application in 1977 in clinical percutaneous tranluminal coronary angioplasty (Percutaneous Transluminal Coronary Angioplasty, PTCA), method with puncture is inserted blood vessel through the conduit that skin will have sacculus, deliver to the coronary artery place of pathological changes always, balloon expandable is opened, utilize the mechanicalness squeezing action of sacculus, with pathological changes speckle compression or cracked, coronary endometrium or part middle level are torn, again make lumen of vessels moulding, thereby the expansion tube chamber is removed narrow.But simple PTCA is because the elastical retraction of blood vessel wall and the hypertrophy of vascular smooth muscle, can occur tube chamber narrow phenomenon again after sacculus is withdrawn from, and is known as restenosis (Restenosis), and its restenosis rate has surpassed 30%.Entered for the 1980's, round the development of PTCA, support (Stent) is introduced gradually, and at present, the PCI of PTCA+Stent has become main means and the main contents of percutaneous coronary intervention.
The support that PCI implants is the 316L stainless steel at first, so-called naked metal rack (the Bare Metal Stent that does not have medicine, BMS), such support can be played a supporting role to blood vessel wall after the sacculus extruding forms official jargon, avoid the elasticity of blood vessels retraction, thereby reach the purpose of rebuilding blood fortune system.In a single day but owing to the elastical retraction of support self, the factors such as vascular smooth muscle hypertrophy that blood vessel causes because of the support implantable stimulation, over time, restenosis rate has still reached 15-30%, and restenosis has taken place, it is very thorny that its successive treatment becomes.
2003, (Drug Eluting Stent DES) obtained the U.S. FDA approval, and the beginning clinical practice is also promoted rapidly, becomes the main flow in present PCI field to utilize the bracket for eluting medicament of polymer load inhibition of cell proliferation medicine at metal support surface.In China, 2007, the application percentage of DES had only 3% PCI still to adopt BMS up to 97%.The pure physical support effect of BMS relatively, DES is when playing the physical support effect, the medicine of load can discharge in several days to the time of some months gradually on the support, thereby suppressed vascular smooth muscle cell curing effectively and reduced restenosis rate in the blood vessel, the restenosis rate of PCI has been reduced to about 3%, has lowered the risk of PCI greatly.
But DES does not solve all problems among the PCI.In DES, because the inflammatory reaction that the introducing of pharmaceutical carrier polymeric material causes, biocompatibility reduce, the problems such as minimal residue of the coating medicine endothelialization process between vascular endothelial cell and the support that makes slows down, thereby need take anticoagulant for a long time to avoid the formation of thrombosis behind PCI.And most of DES adopted the polymeric material of non-degradable type, and these nondegradable polymer retain problems such as also having brought tardy property thrombosis, chronic inflammatory disease, endothelium cancerization in the body for a long time.Had in 2006 and report late period of adopting DES and utmost point advanced thrombus incidence rate and BMS relatively, have slightly but increase on the statistical significance is arranged.
Except coronary heart disease, the PCI technology is also promoted the use of the narrow disease that causes for the treatment of peripheral blood vessel gradually.But similar with the PCI that uses DES in the coronary heart disease, the PCI of the narrow disease of peripheral blood vessel and DES treatment exist restenosis, advanced thrombus, long-term anticoagulant etc. to make the undesirable problem of therapeutic effect too.
Though medicine carrying sacculus interventional procedure can effectively reduce vascellum endometrial hyperplasia, avoid staying in the body for a long time as an alloplasm as metal rack, cause drawbacks such as persistence mechanical stretch, foreign body inflammatory reaction, but owing to there is not the existence of effective support power, the elastical retraction of blood vessel wall and the hypertrophy of vascular smooth muscle, also the restenosis phenomenon can occur late period.
The utility model content
The technical problem that this utility model mainly solves provides a kind of medicine carrying sacculus and a combined medical apparatus and instruments that is configured to, propose to utilize medicine carrying sacculus (the Drug Coated Balloon that carries medicine, DCB) constitute a kind of novel medical apparatus and instruments with BMS, and reach therapeutic effect with the similar low restenosis rate of DES by a series of new design to sacculus and BMS, simultaneously can avoid using the tardy property thrombosis that may occur behind the DES again and take the risk that anticoagulant brings for a long time and avoid taking the financial burden that anticoagulant brings, and the use of the use of this new instruments and existing DES is similar, has same convenience.
For solving the problems of the technologies described above, the technical scheme that this utility model adopts is: a kind of medicine carrying sacculus and a combined medical apparatus and instruments that is configured to are provided, comprise sacculus and support, the sacculus outside is coated with and contains medicine coating, support is pressed and is held on the sacculus outer wall, sacculus one end is provided with the conduit that is communicated with it, and the far-end of conduit is connected with catheter block.
Preferably, described sacculus is single one and expansion pressure homogeneous, and sacculus one end is in series with the conduit that communicates with it, and catheter proximal end and catheter block are fixed, and described sacculus outside is coated with and contains medicine coating, and support is pressed and is held on the sacculus outer wall.
Preferably, described sacculus is single one and the stepped expansion of expansion pressure, the sacculus front portion has higher expansion pressure, the sacculus rear portion has lower expansion pressure, the sacculus front end is in series with the conduit that communicates with it, catheter proximal end and catheter block are fixed, and support is pressed and is held on the outer wall of the sacculus front portion with higher expansion pressure.
Preferably, the sacculus of the stepped expansion of described expansion pressure is coated with in the sacculus front portion with higher expansion pressure at least and contains medicine coating.
Preferably, described sacculus is provided with a plurality of, and by conduit a plurality of sacculus series connection is communicated with between a plurality of sacculus, and the outside of at least one sacculus is coated with and contains medicine coating in described a plurality of sacculus, and described support is pressed and is held on the sacculus outer wall of front end.
Preferably, when described a plurality of sacculus had identical expansion pressure, a plurality of sacculus and support were arranged in the conduit, can send to diseased region respectively by the mode that pushes.
Preferably, comprise the sacculus that a plurality of parallel connections and front and back are arranged, the front end of the described a plurality of sacculus conduit that is communicated with it of connecting respectively is connected with catheter block after the many conduit parallel connections.
Preferably, in the sacculus that described a plurality of parallel connections and front and back are arranged at least the outside of the sacculus of front end be coated with and contain medicine coating, support is pressed and is held on the sacculus outer wall of front end.
Preferably, the sacculus of described front end has higher expansion pressure sacculus, and the sacculus of rear end has the sacculus of low expansion pressure, and the sacculus with higher expansion pressure is not less than 1kgf/cm with the difference of the expansion pressure of the sacculus with low expansion pressure
2
Preferably, described support is the naked metal rack of carrying medicament not, and the material of support is a kind of of rustless steel, cochrome, platinumiridio, platinum evanohm, Nitinol, magnesium alloy, ferrum and alloy thereof, and the length of support is not less than 5mm; Sacculus is positioned at an end of conduit and is communicated with conduit, can inject air, normal saline or similar compressible fluid by conduit and expand, and expansion pressure is 0.1-20kgf/cm
2, the length of sacculus is not less than 5mm.
The beneficial effects of the utility model are: use a kind of medicine carrying sacculus of this utility model and a combined medical apparatus and instruments that is configured to, the implantation of metal rack can be avoided the blood vessel elasticity retraction, obtains long-standing blood fortune tube chamber, rebuilds blood fortune system.In implant frame, utilize the medicine carrying sacculus to the diseased region administration, can suppress blood vessel inner cell hypertrophy, lower the generation of restenosis.And do not have possibility to cause the polymer drug carrier of ill effects such as inflammatory reaction owing to being retained in the naked metal rack of having only of lesion locations, can avoid the formation of endothelialization difficulty and tardy property thrombosis, avoid postoperative to take anticoagulant for a long time, have than existing bracket for eluting medicament and the simple better therapeutic effect of naked metal rack.
Description of drawings
Fig. 1 is the combinative structure sketch map of the naked metal rack of this utility model single medicine carrying sacculus load;
Fig. 2 the utlity model has the series connection sacculus of identical expansion pressure and the combinative structure sketch map of naked metal rack;
Fig. 3 is the structural representation that the utlity model has the another kind of state of combination of the series connection sacculus of identical expansion pressure and naked metal rack;
Fig. 4 the utlity model has the series connection sacculus of different expansion pressures and the combinative structure sketch map of naked metal rack;
Fig. 5 is the combinative structure sketch map of this utility model sacculus in parallel and naked metal rack;
Fig. 6 is the A-A cutaway view of conduit in parallel among this utility model Fig. 5;
Fig. 7 is the A-A cutaway view of the conduit in parallel of another kind of structure among this utility model Fig. 5;
Fig. 8 is that this utility model can stepped dilating sacculus and the combinative structure sketch map of naked metal rack;
Fig. 9 is that this utility model can stepped dilating sacculus and the structural representation of the state that is used in combination of naked metal rack;
Figure 10 is a kind of medicine carrying sacculus of this utility model and a structural representation of the combined medical apparatus and instruments that is configured to.
The specific embodiment
Below in conjunction with accompanying drawing preferred embodiment of the present utility model is described in detail, thereby so that advantage of the present utility model and feature can be easier to be it will be appreciated by those skilled in the art that protection domain of the present utility model is made more explicit defining.
See also Fig. 1-Figure 10, this utility model embodiment comprises:
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, support wherein is the naked metal rack of carrying medicament not, the material of support is a kind of of rustless steel, cochrome, platinumiridio, platinum evanohm, Nitinol, magnesium alloy, ferrum and alloy thereof, and the length of support is not less than 5mm;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the material of sacculus is one or more the combination in polrvinyl chloride, latex, polyethylene, polyethylene terephthalate, nylon, Polyetherimide, polyurethane, the silicone rubber etc.;
A kind of medical apparatus and instruments that is made of sacculus and holder combination, sacculus wherein are positioned at an end of conduit and are communicated with conduit, can inject air, normal saline or similar compressible fluid by conduit and expand, and expansion pressure is 0.1-20kgf/cm
2, the length of sacculus is not less than 5mm;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein on all or part of sacculus load medicine, medicine can be one or more the mixture in rapamycin and derivant, paclitaxel and the derivant thereof, the load capacity of medicine is 1-10 μ g/mm
2
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the medicine of load is to be coated in balloon surface in the mode of coating and to carry out load by mix the back with suitable adhesive on all or part of sacculus, available binding agent includes but not limited to Polyethylene Glycol, macrogol ester, polyglycol ether, polysaccharide and all kinds of surfactants that share etc., and the percentage by weight of its Chinese medicine in coating is between 1-99%;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the medicine coating that contains that the medicine of load and binding agent are formed on all or part of sacculus is that medicine and binding agent are dissolved in water, ethanol, methanol, acetonitrile, acetone, ethyl acetate, chloroform, dichloroethanes, dichloromethane, oxolane, N, in the mixed solvent of one or more in dinethylformamide, the dimethyl sulfoxide equal solvent, be coated to balloon surface through modes such as spraying, dip-coatings then, normal pressure or vacuum drying are removed the medicine coating that contains that obtains behind the solvent;
A kind of medical apparatus and instruments that is made of sacculus and holder combination, the compound mode of its medium-height trestle and sacculus are that support is held in whole medical apparatus and instruments of formation on the sacculus by pressure;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is to press on the single medicine carrying sacculus to hold naked metal rack;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is the sacculus of two arranged in series, connects by one section foley's tube between two sacculus, the sacculus of two arranged in series has identical expansion pressure;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is the sacculus of two arranged in series, connect by one section foley's tube between two sacculus, the sacculus of two arranged in series has different expansion pressures, the sacculus of rear end has lower expansion pressure and the sacculus of front end has higher expansion pressure (left is front end), and the difference of both expansion pressures is not less than 1kgf/cm
2
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is the sacculus of two arranged in series, connect by one section foley's tube between two sacculus, the whole carrying medicaments of the sacculus of two series connection are held naked metal rack in a sacculus pressure of front end;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is the sacculus of two arranged in series, connect by one section foley's tube between two sacculus, the sacculus of rear end carrying medicament on the sacculus of carrying medicament and front end is not wherein pressed at a sacculus of front end and to be held naked metal rack;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is the sacculus of two arranged in series, connect by one section foley's tube between two sacculus, the sacculus of rear end carrying medicament on the sacculus of carrying medicament and front end is not wherein pressed at a sacculus of front end and to be held naked metal rack;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is the sacculus of two arranged in series, two sacculus can be all or on the sacculus of rear end load medicine is arranged, sacculus pressure at front end is possessed naked metal rack, if two sacculus have identical expansion pressure, then two sacculus and support all are placed in the outer catheter, and sacculus and support can break away from outer catheter by the propelling movement of foley's tube; If two sacculus have different expansion pressures, then need not outer catheter;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is that two conduits arranged side by side are operated respectively but two sacculus in parallel of front and back layout, the sacculus of two front and back layouts has identical expansion pressure;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is that two conduits arranged side by side are operated respectively but two sacculus in parallel (left is preceding) of front and back layout, the sacculus of arranging before and after two has different expansion pressures, wherein the rear end sacculus is the low pressure sacculus, has lower expansion pressure, and implanting saccule at front end is the high pressure sacculus, has higher expansion pressure, and the difference of the expansion pressure of two sacculus is not less than 1kgf/cm
2
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is that two conduits arranged side by side are operated respectively but two sacculus in parallel of front and back layout, whole carrying medicaments on two sacculus are held naked metal rack in the implanting saccule at front end pressure;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is that two conduits arranged side by side are operated respectively but two sacculus in parallel of front and back layout, have only carrying medicament on the sacculus of rear end and carrying medicament not on the implanting saccule at front end, press at implanting saccule at front end and hold naked metal rack;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is that two conduits arranged side by side are operated respectively but two sacculus in parallel of front and back layout, have only carrying medicament on the implanting saccule at front end and carrying medicament not on the sacculus of rear end, press at implanting saccule at front end and hold naked metal rack;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme be can stepped expansion sacculus, so-called staged expansion refers under certain expansion pressure, have only the part of sacculus to be opened by expansion, stepped with the other parts formation of the sacculus that does not also expand.The form that constitutes ladder is that the front portion of sacculus has higher expansion pressure and the sacculus rear portion has lower expansion pressure, and the difference of two-part expansion pressure is not less than 1kgf/cm
2
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme be can stepped expansion sacculus, on whole sacculus load medicine, perhaps just on the rear portion of sacculus load medicine;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, wherein the sacculus in a kind of assembled scheme be can stepped expansion sacculus, naked metal rack is held in the front portion of sacculus that can stepped expansion by pressure.
A kind of medical apparatus and instruments that is made of sacculus and holder combination, wherein the sacculus in a kind of assembled scheme is to comprise single sacculus or two sacculus that polyphone is arranged, also can be the sacculus of a plurality of tandem compounds.
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, its using method is to adopt the percutaneous puncture technology, after determining lesion locations, make this apparatus or corresponding assistive device arrive the diseased region of intravascular space, predetermined expansion pressure is expanded and reached to external link by apparatus with normal saline or similar compressible fluid injection sacculus, make the metal rack in the combination be close to blood vessel, discharge the medicine that loads on the sacculus simultaneously, sacculus shrinks after extracting normal saline or compressible fluid then out, the sacculus that will not need to keep somewhere is in vivo withdrawn from external afterwards, and the metal rack in this medical apparatus and instruments is partly stayed predetermined diseased region, reach blood vessel dilating, rebuild the purpose of blood fortune, and the medicine that discharges is attached to the blood vessel endothelium tissue and is absorbed gradually, plays and suppresses the blood vessel endothelium hypertrophy, reduce the effect of restenosis.And according to the difference of compound mode among the present invention program, concrete using method is slightly different;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, to pressing the assembled scheme of holding naked metal rack on the single medicine carrying sacculus, after determining lesion locations, use another one predilation sacculus that the diseased region of angiostenosis is expanded earlier, withdraw from the medical apparatus and instruments of implanting behind this predilation sacculus in this assembled scheme, expand the sacculus in this assembled scheme, withdraw from sacculus after keeping somewhere support and discharging medicine;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, to pressing the assembled scheme of holding naked metal rack on the sacculus of two series connection, after determining lesion locations, if two sacculus of series connection have identical expansion pressure, should make then that the sacculus of rear end is at first pushed to be gone out outer catheter and arrive diseased region and expand and discharges medicine (if load has medicine), the pressure sacculus of possessing naked metal rack of front end was subjected to outer catheter and limited and can not expand this moment.Extraction normal saline or similar compressible fluid after the balloon expandable of rear end is finished continue to push foley's tube and make pressure possess the also expansion of sacculus arrival diseased region of naked metal rack, withdraw from sacculus, outer catheter after keeping somewhere support and discharging medicine;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, to pressing the assembled scheme of holding naked metal rack on the sacculus of two series connection, after determining lesion locations, if two sacculus of series connection have different expansion pressures, then should make the sacculus that is positioned at the rear end at first arrive diseased region and expand and discharge medicine (if load has medicine), this moment, the pressure of front end was possessed the sacculus of naked metal rack because expansion pressure is higher can not expand.After the balloon expandable of rear end is finished, extract normal saline or similar compressible fluid out, continue to push foley's tube and make and press the sacculus of possessing naked metal rack to arrive diseased region to expand and discharges medicine, the indwelling support and discharge medicine after withdraw from sacculus;
A kind of medical apparatus and instruments that is constituted by sacculus and holder combination, to pressing the assembled scheme of holding naked metal rack on the sacculus of stepped expansion, after determining lesion locations, medical apparatus and instruments in this assembled scheme is implanted diseased region, medicine (if load has medicine) is expanded and discharged to a part with the sacculus of rear end under lower expansion pressure, finish the back when the part expansion of the sacculus of rear end and extract normal saline or similar compressible fluid out, continue to push sacculus and make the part arrival diseased region of the sacculus of pressing the front end of possessing naked metal rack expand and discharge medicine, withdraw from sacculus after keeping somewhere support and discharging medicine.
Embodiment 1:
The combination of single sacculus load rapamycin and 316L stainless steel stent.As shown in Figure 1, end connection material at the foley's tube of having made that has catheter block 12 is the sacculus 3 of nylon 12, sacculus is not carried out convolution press hold before, sacculus is immersed in rapamycin-poloxamer alcoholic solution, make the balloon surface deposition of medicament, take out drying, and then immerse this solution, repeated multiple times makes load 5 μ g/mm on the sacculus
2Rapamycin-poloxamer coating 4, behind the vacuum drying sacculus is carried out convolution, afterwards the support 5 of a 316L stainless steel is pressed and be held in the medical apparatus and instruments that obtains single sacculus load rapamycin and the combination of 316L stainless steel stent on the sacculus, can be used for the PTCA operation;
Embodiment 2:
The paclitaxel loaded combination with L605 cochrome support of single sacculus.As shown in Figure 1, end connection material at the foley's tube of having made that has catheter block 12 is the sacculus 3 of polyetheramides, sacculus is not carried out convolution press hold before, to adopt the alcoholic solution of ultrasonic spraying process spraying paclitaxel-poloxamer on the sacculus, repeated multiple times makes load 5 μ g/mm on the sacculus
2Paclitaxel-poloxamer coating 4, behind the vacuum drying sacculus is carried out convolution, afterwards the support 5 of a L605 cochrome material is pressed to be held in to obtain the paclitaxel loaded medical apparatus and instruments with L605 cochrome holder combination of single sacculus on the sacculus, can be used for the PTCA operation;
Embodiment 3:
The combination with platinum evanohm support is not taken charge of in single sacculus load Yiluo.As shown in Figure 1, end connection material at the foley's tube of having made that has catheter block 12 is the sacculus 3 of polyetheramides, sacculus is not carried out convolution press hold before, sacculus is immersed the rapamycin derivative Yiluo not to be taken charge of in the acetonitrile solution with poloxamer, make the balloon surface deposition of medicament, take out drying, and then immerse this solution, repeated multiple times makes load 6 μ g/mm on the sacculus
2Yiluo Mo Si-poloxamer coating 4, behind the vacuum drying sacculus is carried out convolution, afterwards the support 5 of a platinum evanohm material is pressed to be held in to obtain single sacculus load Yiluo on the sacculus and do not take charge of medical apparatus and instruments with platinum evanohm holder combination, can be used for the PTCA operation;
Embodiment 4:
Have identical expansion pressure and two sacculus all the series connection sacculus of load rapamycin and the combination of platinumiridio support.As shown in Figure 2, end connection material at the foley's tube of having made that has catheter block 12 is sacculus 3 and the sacculus 7 of polyetheramides, two sacculus connect with one section conduit 6 and have an identical expansion pressure, sacculus is not carried out convolution press hold before, to adopt the alcoholic solution of ultrasonic spraying process spraying rapamycin-poloxamer on two sacculus, repeated multiple times makes load 3 μ g/mm on the sacculus
2The containing medicine coating 4 and contain medicine coating 8 of rapamycin, behind the vacuum drying sacculus is carried out convolution, afterwards the support 5 of a platinumiridio material is pressed and be held on the sacculus 3 of front end, whole foley's tube is placed an outer catheter 5, thereby obtain the medical apparatus and instruments of series connection sacculus load rapamycin and platinumiridio holder combination, can be used for the PTCA operation.
As shown in Figure 3, in this compositions, medical instrumentation process, at first foley's tube is sent to the lesion locations front end together with outer tube, pushing foley's tube makes sacculus 7 arrive lesion locations, obtain tube chamber and discharge the medicine that contains in the medicine coating 8 with the normal saline expansion, taking out normal saline afterwards shrinks sacculus 7, pushing foley's tube again makes sacculus 3 arrive diseased region together with support 5, again with normal saline injection this sacculus 3 of expansion and support 5, and discharge the medicine that contains in the medicine coating 4, after taking out normal saline, withdraw from sacculus, foley's tube and outer tube are retained in diseased region with support 5;
Embodiment 5:
Have identical expansion pressure and have only the paclitaxel loaded series connection sacculus of the sacculus of front end and the combination of nick-eltitanium alloy stent.Identical with embodiment 4, just the medicine in the combination is paclitaxel, and load capacity is 6 μ g/mm
2, support is the Nitinol material, and does not contain medicine coating 8 on sacculus 7;
Embodiment 6:
Have different expansion pressures and two sacculus all the series connection sacculus of load rapamycin and the combination of L605 cochrome support.Shown in 4, connecting material at an end of the foley's tube of having made that has catheter block 12 is that sacculus 3 and the material of polyetheramides is nylon 12 sacculus 7, two sacculus connect with one section conduit 6 and have different expansion pressures, wherein sacculus 7 is low pressure sacculus, can under lower expansion pressure, open, and sacculus 3 is high pressure sacculus, need open under higher expansion pressure.Sacculus is not carried out convolution press hold before, adopt the alcoholic solution of ultrasonic spraying processes spraying rapamycin-poloxamers at two sacculus, repeated multiple times makes and contains 3 μ g/mm on the sacculus in the load
2The containing medicine coating 4 and contain medicine coating 8 of rapamycin, behind the vacuum drying sacculus is carried out convolution, afterwards the support 5 of a L605 cochrome material is pressed and be held on the sacculus 3 of front end, thereby obtain the medical apparatus and instruments of series connection sacculus load rapamycin and L605 cochrome holder combination, can be used for the PTCA operation.
In this compositions, medical instrumentation process, at first foley's tube is sent to the lesion locations front end, pushing foley's tube makes sacculus 7 arrive lesion locations, obtain tube chamber and discharge the medicine that contains in the medicine coating 8 with the normal saline expansion, taking out normal saline afterwards shrinks sacculus 7, pushing foley's tube again makes sacculus 3 arrive diseased region together with support 5, again with normal saline injection this sacculus 3 of expansion and support 5, and discharge the medicine that contains in the medicine coating 4, after taking out normal saline, withdraw from sacculus, foley's tube, support 5 is retained in diseased region;
Embodiment 7:
Have different expansion pressures and have only the paclitaxel loaded series connection sacculus of the sacculus of front end and the combination of 316L stainless steel stent.As shown in Figure 4, similar to embodiment 6, just the medicine in the combination is paclitaxel, and load capacity is 5 μ g/mm
2, support is the 316L stainless steel, and does not contain medicine coating 8 on sacculus 7;
Embodiment 8:
Have different expansion pressures and have only the paclitaxel loaded series connection sacculus of the sacculus of rear end and the combination of L605 cochrome support.As shown in Figure 4, similar to embodiment 6, just the medicine in the combination is paclitaxel, and load capacity is 5 μ g/mm
2, and on sacculus 3, do not contain medicine coating 4;
Embodiment 9:
Have identical expansion pressure and two sacculus all sacculus in parallel of load rapamycin and the combination of L605 cochrome support.As shown in Figure 5, end connection material at the foley's tube of having made that has catheter block 12 is the sacculus 3 of polyetheramides, connecting 6, two sacculus of sacculus that material is polyetheramides at another end that has the foley's tube 8 of catheter block 9 arranges because the difference of foley's tube length forms front and back.Foley's tube 2 and foley's tube 8 parallel connections also link together, more specifically both connected modes can be any one in the cross-sectional view of Fig. 6 and foley's tube 2 shown in Figure 7 and foley's tube 8, the unitary catheter that can be a diplopore also can be two independently conduit be bonded together.Sacculus 3 has identical expansion pressure with sacculus 6, but can be by two foley's tube seats and foley's tube independent expansion and contraction respectively.Sacculus is not carried out convolution press hold before, adopt the alcoholic solution of ultrasonic spraying processes spraying rapamycin-poloxamers at two sacculus, repeated multiple times makes and contains 3 μ g/mm on the sacculus in the load
2The containing medicine coating 4 and contain medicine coating 7 of rapamycin, behind the vacuum drying sacculus is carried out convolution, afterwards the support 5 of a L605 cochrome material is pressed and be held on the sacculus 3 of front end, thereby obtain the medical apparatus and instruments of sacculus load rapamycin in parallel and L605 cochrome holder combination, can be used for the PTCA operation.
In this compositions, medical instrumentation process, at first foley's tube is sent to the lesion locations front end, pushing foley's tube makes sacculus 6 arrive lesion locations, obtain tube chamber and discharge the medicine that contains in the medicine coating 7 by foley's tube seat 9 and the expansion of foley's tube 8 usefulness normal saline, taking out normal saline afterwards shrinks sacculus 6, pushing foley's tube again makes sacculus 3 arrive diseased region together with support 5, expand this sacculus 3 and support 5 with the normal saline injection again by foley's tube seat 1 and foley's tube 2, and discharge the medicine that contains in the medicine coating 4, after taking out normal saline, withdraw from sacculus, foley's tube is retained in diseased region with support 5;
Embodiment 10:
Have different expansion pressures and two sacculus all paclitaxel loaded sacculus in parallel and the combination of 316L stainless steel stent.As Fig. 5, Fig. 6, shown in Figure 7, similar to embodiment 9, just sacculus 3 and sacculus 6 are to use polyetheramides and polyurethane manufacturing respectively, have different expansion pressures, and the medicine of load is paclitaxel, and the support material is the 316L rustless steel;
Embodiment 11:
Have different expansion pressures and have only the combination of the paclitaxel loaded sacculus in parallel of implanting saccule at front end and L605 cochrome support.As Fig. 5, Fig. 6, shown in Figure 7, similar to embodiment 9, just sacculus 3 and sacculus 6 are to use polyetheramides and polyurethane manufacturing respectively, have different expansion pressures, and the 6 μ g/mm that had only on the sacculus 3 load
2Paclitaxel contain medicine coating, carrying medicament not on the sacculus 6;
Embodiment 12:
Have different expansion pressures and have only the combination of the paclitaxel loaded sacculus in parallel of rear end sacculus and platinum evanohm support.As figure Fig. 5, Fig. 6, shown in Figure 7, similar to embodiment 9, just sacculus 3 and sacculus 6 are to use nylon 12 and silicone rubber manufacturing respectively, have different expansion pressures, and the 6 μ g/mm that had only on the sacculus 6 load
2Paclitaxel contain medicine coating, carrying medicament not on the sacculus 3, and the support material is the platinum evanohm;
Embodiment 13:
Can stepped expansion and whole paclitaxel loaded sacculus and the combination of L605 cochrome support.As shown in Figure 8, end connection material at the foley's tube of having made that has catheter block 12 is the sacculus 3 of nylon 12, wherein sacculus 3 be one can stepped expansion sacculus, the expansion pressure of the sacculus front end 7 of close foley's tube end is lower, and it is higher away from the expansion pressure of the sacculus rear end 4 of catheter tip, sacculus is not carried out convolution press hold before, sacculus is immersed in paclitaxel-poloxamer alcoholic solution, make the balloon surface deposition of medicament, take out dry, and then immersing this solution, repeated multiple times makes load 5 μ g/mm on the sacculus
2Paclitaxel-poloxamer coating 5 and coating 8, behind the vacuum drying sacculus is carried out convolution, afterwards the support 6 of a L605 cochrome material is pressed to be held in to obtain medical apparatus and instruments can stepped dilating sacculus paclitaxel loaded and L605 cochrome holder combination on the sacculus rear end 4, can be used for the PTCA operation;
In this compositions, medical instrumentation process, at first foley's tube is sent to the lesion locations front end, pushing foley's tube makes the sacculus front end 7 of low pressure expansion arrive lesion locations, obtain tube chamber and discharge the medicine that contains in the medicine coating 8 by foley's tube seat 1 and the expansion of foley's tube 2 usefulness normal saline, as shown in Figure 9, taking out normal saline afterwards shrinks sacculus front end 7, pushing foley's tube again makes sacculus rear end 4 arrive diseased region together with support 6, expand this sacculus rear end 4 and support 6 with the normal saline injection again by foley's tube seat 1 and foley's tube 2, and discharge the medicine that contains in the medicine coating 5, after taking out normal saline, withdraw from sacculus, foley's tube is retained in diseased region with support 6;
Embodiment 14:
Can stepped expansion and have only the sacculus of a part of load rapamycin of sacculus of front end and combination such as Fig. 8, shown in Figure 9 of platinumiridio support, similar to embodiment 13, just medicine wherein is rapamycin, load capacity is 8 μ g/mm
2, and only on sacculus rear end 4 load medication coat 5, do not contain medicine coating 8, and the support material is platinumiridio;
Embodiment 15:
Can stepped expansion and have only the paclitaxel loaded sacculus of the part of sacculus of rear end and combination such as Fig. 8, shown in Figure 9 of magnesium alloy bracket, similar to embodiment 13, just the load capacity of drug taxol wherein is 8 μ g/mm
2And only on sacculus front end 7 load medication coat 8, do not contain medicine coating 5, and the support material is magnesium alloy, the purpose that adopts magnesium alloy is that this support can be degraded gradually after implanting diseased region, absorption, metabolism and final the disappearance, in the needs support force, there is implantation instrument to exist thereby reach, and finishes the natural attribute that recovers blood vessel when the blood vessel reparation need not support force fully;
Embodiment 16:
Be used for the peripheral blood vessel pathological changes the long ball capsule can stepped dilating sacculus and the combination of L605 cochrome support.Similar to embodiment 13, just sacculus wherein is the sacculus that is applicable to the peripheral blood vessel pathological changes, has bigger length and diameter, and corresponding support also has bigger diameter.
A kind of medicine carrying sacculus of this utility model can be avoided the blood vessel elasticity retraction with a combined medical apparatus and instruments that is configured to, the implantation of metal rack, obtains long-standing blood fortune tube chamber, rebuilds blood fortune system.In implant frame, utilize the medicine carrying sacculus to the diseased region administration, can suppress blood vessel inner cell hypertrophy, lower the generation of restenosis.And do not have possibility to cause the polymer drug carrier of ill effects such as inflammatory reaction owing to being retained in the naked metal rack of having only of lesion locations, can avoid the formation of endothelialization difficulty and tardy property thrombosis, avoid postoperative to take anticoagulant for a long time, have than existing bracket for eluting medicament and the simple better therapeutic effect of naked metal rack.
The above only is embodiment of the present utility model; be not so limit claim of the present utility model; every equivalent structure or equivalent flow process conversion that utilizes this utility model description and accompanying drawing content to do; or directly or indirectly be used in other relevant technical fields, all in like manner be included in the scope of patent protection of the present utility model.
Claims (10)
1. a medicine carrying sacculus and a combined medical apparatus and instruments that is configured to, it is characterized in that: comprise sacculus and support, the sacculus outside is coated with and contains medicine coating, and support is pressed and is held on the sacculus outer wall, sacculus one end is provided with the conduit that is communicated with it, and the far-end of conduit is connected with catheter block.
2. a kind of medicine carrying sacculus according to claim 1 and a combined medical apparatus and instruments that is configured to, it is characterized in that: described sacculus is single one and expansion pressure homogeneous, sacculus one end is in series with the conduit that communicates with it, catheter proximal end and catheter block are fixed, described sacculus outside is coated with and contains medicine coating, and support is pressed and is held on the sacculus outer wall.
3. a kind of medicine carrying sacculus according to claim 1 and a combined medical apparatus and instruments that is configured to, it is characterized in that: described sacculus is single one and the stepped expansion of expansion pressure, the sacculus front portion has higher expansion pressure, the sacculus rear portion has lower expansion pressure, the sacculus front end is in series with the conduit that communicates with it, catheter proximal end and catheter block are fixed, and support is pressed and is held on the outer wall of the sacculus front portion with higher expansion pressure.
4. a kind of medicine carrying sacculus according to claim 3 and a combined medical apparatus and instruments that is configured to, it is characterized in that: the sacculus of the stepped expansion of described expansion pressure is coated with in the sacculus front portion with higher expansion pressure at least and contains medicine coating.
5. according to claim 1 or 2 or 3 or 4 described a kind of medicine carrying sacculus and a combined medical apparatus and instruments that is configured to, it is characterized in that: described sacculus is provided with a plurality of, and by conduit a plurality of sacculus series connection are communicated with between a plurality of sacculus, the outside of at least one sacculus is coated with and contains medicine coating in described a plurality of sacculus, and described support is pressed and is held on the sacculus outer wall of front end.
6. a kind of medicine carrying sacculus according to claim 5 and a combined medical apparatus and instruments that is configured to, it is characterized in that: when described a plurality of sacculus have identical expansion pressure, a plurality of sacculus and support are arranged in the conduit, can send to diseased region respectively by the mode that pushes.
7. a kind of medicine carrying sacculus according to claim 1 and a combined medical apparatus and instruments that is configured to, it is characterized in that: comprise the sacculus that a plurality of parallel connections and front and back are arranged, the front end of the described a plurality of sacculus conduit that is communicated with it of connecting respectively is connected with catheter block after the many conduit parallel connections.
8. a kind of medicine carrying sacculus according to claim 7 and a combined medical apparatus and instruments that is configured to, it is characterized in that: in the sacculus that described a plurality of parallel connections and front and back are arranged at least the outside of the sacculus of front end be coated with and contain medicine coating, support is pressed and is held on the sacculus outer wall of front end.
9. a kind of medicine carrying sacculus according to claim 8 and a combined medical apparatus and instruments that is configured to, it is characterized in that: the sacculus of described front end has higher expansion pressure sacculus, the sacculus of rear end has the sacculus of low expansion pressure, and the sacculus with higher expansion pressure is not less than 1kgf/cm with the difference of the expansion pressure of the sacculus with low expansion pressure
2
10. a kind of medicine carrying sacculus according to claim 1 and a combined medical apparatus and instruments that is configured to, it is characterized in that: described support is the naked metal rack of carrying medicament not, the material of support is a kind of of rustless steel, cochrome, platinumiridio, platinum evanohm, Nitinol, magnesium alloy, ferrum and alloy thereof, the length of support is not less than 5mm, sacculus is positioned at an end of conduit and is communicated with conduit, can inject air, normal saline or similar compressible fluid by conduit and expand, expansion pressure is 0.1-20kgf/cm
2, the length of sacculus is not less than 5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220490483.4U CN203138758U (en) | 2012-09-25 | 2012-09-25 | Combined medical device composed of drug-coated balloon and bracket |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220490483.4U CN203138758U (en) | 2012-09-25 | 2012-09-25 | Combined medical device composed of drug-coated balloon and bracket |
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| CN203138758U true CN203138758U (en) | 2013-08-21 |
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| CN201220490483.4U Expired - Lifetime CN203138758U (en) | 2012-09-25 | 2012-09-25 | Combined medical device composed of drug-coated balloon and bracket |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940543A (en) * | 2012-09-25 | 2013-02-27 | 苏州爱瑞德医疗科技有限公司 | Combined medical instrument formed by drug coated balloon and stent |
| CN109414528A (en) * | 2017-05-05 | 2019-03-01 | 优敦力公司 | Coated with drug foley's tube for body cavity |
| US11471655B2 (en) | 2012-10-26 | 2022-10-18 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11648337B2 (en) | 2012-10-26 | 2023-05-16 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11730864B2 (en) | 2015-04-24 | 2023-08-22 | Urotronic, Inc. | Drug coated balloon catheters for nonvascular strictures |
| US11826532B2 (en) | 2012-10-26 | 2023-11-28 | Urotronic, Inc. | Balloon catheters for body lumens |
| US11925729B2 (en) | 2012-10-26 | 2024-03-12 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11938287B2 (en) | 2012-10-26 | 2024-03-26 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11957853B2 (en) | 2019-02-22 | 2024-04-16 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
-
2012
- 2012-09-25 CN CN201220490483.4U patent/CN203138758U/en not_active Expired - Lifetime
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102940543A (en) * | 2012-09-25 | 2013-02-27 | 苏州爱瑞德医疗科技有限公司 | Combined medical instrument formed by drug coated balloon and stent |
| US11925729B2 (en) | 2012-10-26 | 2024-03-12 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11938287B2 (en) | 2012-10-26 | 2024-03-26 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11471655B2 (en) | 2012-10-26 | 2022-10-18 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11471656B2 (en) | 2012-10-26 | 2022-10-18 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11648337B2 (en) | 2012-10-26 | 2023-05-16 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11648338B2 (en) | 2012-10-26 | 2023-05-16 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
| US11826532B2 (en) | 2012-10-26 | 2023-11-28 | Urotronic, Inc. | Balloon catheters for body lumens |
| US11826533B2 (en) | 2012-10-26 | 2023-11-28 | Urotronic, Inc. | Balloon catheters for body lumens |
| US11730864B2 (en) | 2015-04-24 | 2023-08-22 | Urotronic, Inc. | Drug coated balloon catheters for nonvascular strictures |
| US11904072B2 (en) | 2015-04-24 | 2024-02-20 | Urotronic, Inc. | Drug coated balloon catheters for nonvascular strictures |
| CN109414528A (en) * | 2017-05-05 | 2019-03-01 | 优敦力公司 | Coated with drug foley's tube for body cavity |
| US11957853B2 (en) | 2019-02-22 | 2024-04-16 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
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Granted publication date: 20130821 |
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