CN203053917U - ICP-MS (inductively coupled plasma mass spectrometry) analysis system - Google Patents
ICP-MS (inductively coupled plasma mass spectrometry) analysis system Download PDFInfo
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- CN203053917U CN203053917U CN201220756835.6U CN201220756835U CN203053917U CN 203053917 U CN203053917 U CN 203053917U CN 201220756835 U CN201220756835 U CN 201220756835U CN 203053917 U CN203053917 U CN 203053917U
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Abstract
The utility model discloses an ICP-MS (inductively coupled plasma mass spectrometry) analysis system which comprises an ICP (inductively coupled plasma) source, a detector and a linear ion trap which is arranged between the ICP source and the detector. The ICP-MS analysis system has the advantages of high collision induced dissociation efficiency, more ion-molecular reaction channels, high-flexibility measurement modes and the like.
Description
Technical field
The utility model relates to the mass spectrophotometry field, relates in particular to the ICP-MS analytic system.
Background technology
Compare with ICP-AES, ICP-MS isotope spectral line much less, natural isotopic has 210 spectral lines, 10 only of the maximum elements of isotope, and the element that has in the emission spectrum such as Ce reach thousands of spectral lines.Disturb less and simple relatively so ICP-MS is considered to spectral line.But As time goes on people deepen constantly the understanding of anything.In fact, the ICP-MS mass spectrum is not that picture is early stage desired so simple, though mass spectral overlapping so general unlike the overlap of spectral lines in the atomic emission spectrum, it also is the serious hindrance of trace analysis that some mass spectrum disturbs.Because ICP-MS detects in the vacuum system of sealing, so in the mensuration process, argon, oxygen, nitrogen, chlorine, hydrogen, carbon plasma that gas and water, acid produce all may enter detection system, thereby at mass number places such as 12,14,16,35,40 very high background are arranged.In addition, though in high-temperature plasma, most molecules are atomization and ionization all, but when interface enters expanding chamber, the unexpected decline because of pressure may form new molecular combinations again, also caused complicated background, the mensuration formation of some element has been disturbed.Special low mass region below 80amu, this situation is even more serious.Therefore, except the single charge ion that will measure, in plasma and in The ion extraction and transmission course, also may form other multiple molions among the ICP-MS.Therefore, mass spectrum interference " isobar " mass spectrum between those known in theory natural stable isotopes disturbs, also exist many from " isobar " the overlapping interference between water, acid, gas and matrix and the concurrent.
Interference among the ICP-MS can be divided into two big classes: " mass spectrum interference " and " non-mass spectrum interference " or title " matrix effect ".The first kind is disturbed can be further divided into four classes: the 1. overlapping interference of isobar; 2. multi-atomic ion disturbs; 3. refractory oxides disturbs; 4. double-charge ion disturbs.1. second type interference can be divided into substantially and to suppress and physical influence that 2. enhancement effect is caused by high content of salt.
Collision/reaction tank technology (collision and reaction-cell) is to solve the important breakthrough that the ICP-MS multi-atomic ion disturbs.The principle of collision/reaction tank technology and application come from the structure analysis of potpourri in the organic mass spectrometry and the fundamental research of ion-molecule reaction.
Collision/reaction tank technology is that a cavity has been installed before the quadrupole rod mass spectrograph, built-in multipole bar (comprising four utmost points, sextupole and ends of the earth bar).Charge into various collision/reacting gas in the cavity, the ion that focuses on by multipole bar is collided and reacts.Monatomic ion can be most by and multi-atomic ion interference etc. can be eliminated in a large number, eliminate the purpose that matrix disturbs thereby reached.
At present, commercial collision/reaction tank system (CRC) has three types: quadrupole rod type (be representative with the DRC technology), and sextupole bar type (be representative with the CCT technology) and ends of the earth bar type (be representative with the ORS technology), different technology all has the characteristics of self.Wherein sextupole bar and ends of the earth bar collision/reaction tank cannot dynamic scans, as just the passage of ion, the ion of different mass-to-charge ratioes passes through indiscriminately, has good ion focus function, losses of ions to be measured is less, and the ion of interference is eliminated by collision/reacting gas.And quadrupole rod type collision/reaction tank possesses the function that the ion of the specific mass charge ratio range of selection passes through, it is selectivity " ion band is logical " function, can select to enter the ion range of reaction tank, and the accessory substance that reaction tank produces be carried out selectivity eliminate, have better dirigibility.
There are three kinds of groundwork principles or mode in collision/reaction tank system (CRC), be interfering ion collision dissociative pattern (collisional induced dissociation, CID), reaction pattern (reaction), interfering ion function discriminate against the elimination pattern (kinetic energy discrimination, KED).The physical principle of collision/reaction tank has determined above three kinds of mode of operations all to exist in all commodity CRC systems, yet different instruments respectively has characteristics on different working modes.
Though it is typically bigger based on differentiation on the crash response pool technology technology path of the ICP-MS of quadrupole rod, but sum up following two common characteristic are arranged: (1) all adopts the ion transfer system based on multipole bar (to comprise quadrupole rod, the sextupole bar, ends of the earth bar).(2) principle of work and mode, basically all be interfering ion collision dissociative pattern (collisional induced dissociation, CID), reaction pattern (reaction), interfering ion function discriminate against the elimination pattern (kinetic energy discrimination, KED).
There is technological deficiency in ion transfer system based on multipole bar as the crash response pond, does brief description below.Because the crash response pond is still transmission system in principle, so the limited time in the crash response pond of ion process and should the time wayward.In order to realize collision dissociative pattern or reaction pattern the action time that guarantees ion and crash response gas, the air pressure in crash response pond need be maintained suitably high level.Under anticyclonic condition, the mean free path of ion is very short, and ion is less by the energy that collision obtains from the RF field, so the efficient that the collision of multi-atomic ion multistep is dissociated is not high.Especially for the monatomic ion of little quality analysis element, the collision solution defection of the relative multi-atomic ion of loss of scattering is more remarkable.In addition, under the reaction pattern, the degree that the interactional time of ionic molecule carries out each reaction has crucial influence, but wayward in based on the system of multipole bar ion transfer system as the crash response pond.
Traditional ICP-MS based on ion trap advantage that possesses skills aspect following two is done briefly bright below.Ion trap is the device of a good ion storage and reaction, and ion trap can realize the loading of ion, and storage such as controls at function.Its crash response pond as ICP-MS is used and can be operated under the relatively low air pressure, and the interaction time can be longer relatively, so the collision dissociation efficiency of multi-atomic ion is higher relatively.In addition, ion trap always is the instrument of a good ion-molecule reaction, its action time is controlled, and by RF amplitude, frequency, the setting of working point q value, and the applying of the AC signal that additionally resonates, can realize non-heat condition, ion-molecule reaction under near-thermal condition and each condition of superthermal condition, the elimination of disturbing for the ICP-MS mass spectrum provides more approach.
The ion trap technology is among development constantly, and ion trap has comprised the 3D-ion trap, column type ion trap, linear ion trap and rectilinear ion trap etc. now.These ion traps all embody and have kept the common feature of ion trap, have ion and load the function of storing and controlling.It is simpler that the release of new ion trap technology is mainly reflected in its processing, easier miniaturization, the ion loading space increases, ion efficiency of loading height, be convenient to advantage such as other mass spectrometries on.
The utility model content
In order to solve deficiency of the prior art, the utility model provides a kind of ICP-MS analytic system that has memory function, the cracked efficient of raising collision, highly sensitive measurement pattern is provided.
The purpose of this utility model is achieved through the following technical solutions:
A kind of ICP-MS analytic system, described analytic system comprises ICP source, detecting device; It is characterized in that: described analytic system further comprises:
Linear ion hydrazine, described linear ion hydrazine is arranged between described ICP source and the detecting device.
According to above-mentioned analytic system, preferably, described detecting device is arranged on the sidepiece of described linear ion hydrazine.
According to above-mentioned analytic system, alternatively, described analytic system further comprises:
Mass analyzer, described mass analyzer is arranged between described linear ion hydrazine and the detecting device.
Compared with prior art, the utlity model has following beneficial effect:
When 1, having all functions in crash response pond of multipole bar, also has the function of ion storage
2, can realize the cracked efficient of higher collision, eliminate and be difficult to collide cracked multi-atomic ion under some normal conditions and disturb;
3, can realize more ion-molecule reaction condition, provide more and eliminate the approach that mass spectrum disturbs by ion-molecule reaction;
4, at the element sample of the low super low concentration of some unit concentration-response values, can carry out ion enrichment earlier, realize the measurement of high sensitivity pattern.
Description of drawings
With reference to accompanying drawing, disclosure of the present utility model will be easier to understand.Those skilled in the art are understood that easily: these accompanying drawings only are used for illustrating the technical solution of the utility model, and are not to be intended to protection domain of the present utility model is construed as limiting.Among the figure:
Fig. 1 is the basic block diagram of the analytic system of the utility model embodiment 1;
Fig. 2 is the basic block diagram of the analytic system of the utility model embodiment 2.
Embodiment:
Fig. 1,2 and following declarative description optional embodiment of the present utility model how to implement with instruction those skilled in the art and reproduce the utility model.In order to instruct technical solutions of the utility model, simplified or omitted some conventional aspects.Those skilled in the art should understand that the modification that is derived from these embodiments or replace will be in scope of the present utility model.Those skilled in the art should understand that following characteristics can make up to form a plurality of modification of the present utility model in every way.Thus, the utility model is not limited to following optional embodiment, and is only limited by claim and their equivalent.
Embodiment 1:
What Fig. 1 had schematically provided the utility model embodiment has ion from the basic block diagram of the ICP-MS analytic system of axle transfer function, and as shown in Figure 1, described analytic system comprises:
The course of work of above-mentioned analytic system is:
Ion produces from the ICP source, enters vacuum system through bipyramid and extraction lens, enters the complex function pond, then enters mass analyzer, arrives detecting device at last.Wherein the linear ion hydrazine based on axial excitation is adopted in compound pond.In this embodiment, after the memory period correlated process was finished in the complex function pond, during quality analysis, quadrupole rod can remain the RF-only pattern or keep synchronous scanning with linear ion hydrazine.The advantage that synchronous scanning has is to allow linear ion hydrazine to load more ion, and linear ion hydrazine is realized thick mass resolution, and quadrupole rod is realized relative high-quality resolution.
Embodiment 2:
What Fig. 2 had schematically provided the utility model embodiment has ion from the basic block diagram of the ICP-MS analytic system of axle transfer function, and as shown in Figure 2, described analytic system comprises:
Linear ion hydrazine, described linear ion hydrazine is arranged between described ICP source and the detecting device.Described linear ion hydrazine adopts the level Four bar.
Described detecting device 62 is in the sidepiece of described linear ion hydrazine 41.
The course of work of above-mentioned analytic system is:
Ion produces from the ICP source, enters vacuum system through bipyramid and extraction lens, enters the complex function pond, then enters mass analyzer (also being above-mentioned linear ion hydrazine), arrives detecting device at last.Wherein the linear ion hydrazine based on shooting is adopted in compound pond, and two detecting devices radially are installed, and after the memory period correlated process was finished in compound pond, during quality analysis, ion signal was by the detecting device collection of ions of both sides.In addition, the introducing mode of crash response gas is with the introducing mode of rectilinear ion trap cold gas.
Claims (3)
1. ICP-MS analytic system, described analytic system comprises ICP source, detecting device; It is characterized in that: described analytic system further comprises:
Linear ion hydrazine, described linear ion hydrazine is arranged between described ICP source and the detecting device.
2. analytic system according to claim 1, it is characterized in that: described detecting device is arranged on the sidepiece of described linear ion hydrazine.
3. analytic system according to claim 1, it is characterized in that: described analytic system further comprises:
Mass analyzer, described mass analyzer is arranged between described linear ion hydrazine and the detecting device.
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| CN201220756835.6U CN203053917U (en) | 2012-12-29 | 2012-12-29 | ICP-MS (inductively coupled plasma mass spectrometry) analysis system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108206125A (en) * | 2016-12-19 | 2018-06-26 | 塞莫费雪科学（不来梅）有限公司 | What isobar interfered in mass spectrograph determines |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108206125A (en) * | 2016-12-19 | 2018-06-26 | 塞莫费雪科学（不来梅）有限公司 | What isobar interfered in mass spectrograph determines |
| CN108206125B (en) * | 2016-12-19 | 2020-06-09 | 塞莫费雪科学（不来梅）有限公司 | Determination of isobaric interferences in mass spectrometers |
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Granted publication date: 20130710 |
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