CN202898421U - Atomized vaccine quantitative collection device - Google Patents

Atomized vaccine quantitative collection device Download PDF

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Publication number
CN202898421U
CN202898421U CN 201220357811 CN201220357811U CN202898421U CN 202898421 U CN202898421 U CN 202898421U CN 201220357811 CN201220357811 CN 201220357811 CN 201220357811 U CN201220357811 U CN 201220357811U CN 202898421 U CN202898421 U CN 202898421U
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China
Prior art keywords
vaccine
atomizing
pressure
air
atomization box
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Expired - Lifetime
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CN 201220357811
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Chinese (zh)
Inventor
冯志新
邵国青
华利忠
韦艳娜
甘源
孔猛
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Jiangsu Academy of Agricultural Sciences
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Jiangsu Academy of Agricultural Sciences
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Abstract

The utility model relates to an atomized vaccine quantitative collection device. The atomized vaccine quantitative collection device is characterized by mainly comprising an atomized vaccine generating device and an atomized vaccine recovering device, wherein the atomized vaccine generating device comprises an atomization generator and a sterile atomization box; and the atomized vaccine recovering device comprises a spiral glass gas-liquid converter, a liquid-phase vaccine collecting device and an adjustable negative pressure maintaining system.

Description

A kind of atomizing vaccine quantitative collection device
Technical field
The utility model is veterinary vaccines immune effect proofing unit, belongs to the animal and veterinary technical field.
Background technology
In the large-scale cultivation field, preventing and curing diseases of animal is the most important, in case communicable disease occurs, not only may cause great financial loss, serious social concern also may will occur and have influence on international trade.Setting up scale raising biovaccine immunity security system, is exactly to get rid of epidemic disease by the method for vaccine immunity to threaten, and the protection Animal Populations is healthy, guarantees the normal production development of plant, performance greatest benefit advantage.
Reach in the past in the present immune system, giving livestock and poultry injecting immune vaccine one by one is the most frequently used method, but this mode efficient is very low, labour intensity is large, labour cost is high, also can have influence on their feed and growth within for some time because scaring produces stress reaction to their faces in seizure livestock and poultry process, serious also a certain amount of death can occur.
At present, aspect vaccine immunity, novel needleless immunization route is progressively substituting conventional intramuscular injection, it is with the mode of vaccine preparation by atomised jet, by the respiration of animal, or directly adopt methods such as being ejected into the animal nasal cavity to enter in the body of animal, thereby make them produce immune effect, this to substitute what bring be a kind of welfare, also is a kind of efficient.Especially in the immunity of animal vaccine, along with the development of large-scale cultivation, the aerosol immunization of animal vaccine not only makes livestock and poultry finish the work under undisturbed feelings, can reach the simultaneously immunity of large quantities of animals simultaneously, and is time saving and energy saving.But vaccine is after atomizing, and its biologic activity and antigenic check are an important job, can understand the effect of animal immune through it, and this just need to have a kind of microbial aerosol collection device for vaccine strain.The utility model is exactly the veterinary vaccines immune effect proofing unit that specialized designs designs and produces in order to carry out this respect experiment.
The microbial aerosol sampling thief of selling in the market also has, be mainly multistage bump sampling thief, it adopts the inertial impaction principle, to be suspended in airborne particle, size by its aerodynamics equivalent diameter, by cascade filtration, the microorganism of different-grain diameter in the air is deposited to respectively in different culture dish or the substratum cultivates detection.But this sampling thief collector can only carry out qualitative detection to the atomizing vaccine, can't satisfy detection by quantitative, also can't detect spray process to atomizing vaccine biologic activity or antigenic damage research.
Summary of the invention
Technical problem to be solved in the utility model is the deficiency that overcomes prior art and equipment, a kind of atomizing vaccine collection device of improved practicality is provided, can realize the quantitative collection of atomizing vaccine is satisfied the atomizing factor to the impact analysis of the vaccine characteristics such as vaccine biologic activity or antigenicity.
Agent structure of the present utility model can be divided into the retrieving arrangement two parts of generating unit and the atomizing vaccine of the vaccine that atomizes, atomizing vaccine generation is connected to form by atomizing vaccine generator 1 and aseptic atomization box 2 two portions, and described atomizing vaccine generator 1 sprays into aseptic atomization box 2 by the shower nozzle vaccine that will atomize; The vaccine atomisation unit that spraying gun simulation is actual, purpose are that the vaccine with liquid state becomes superfine little particulate and floats in air, enter the lung of animal by the respiration of livestock and poultry, thereby reach the effect of animal immune.The shower nozzle of described atomizing vaccine generator 1 can be Special atomizing jet, it can be under non-condition of high voltage, vaccine liquid is passed through the gas-liquid two-phase atomizing type, aqueous vaccine is become the particulate uniformly dispersing of 0.5-10 micron in aseptic atomization box, this shower nozzle proves through the biological activity test of several years, its pressure influence and hydrodynamic force are little to the vigor damage of vaccine, and atomizing effect is uniform and stable.
The recovery system of atomizing vaccine is by air-liquid converter 15, liquid phase vaccine gathering system 12 and adjustable negative-pressure keeping system 16 connect to form successively, one side of described aseptic atomization box 2 is connected with air-liquid converter 15, by will atomize vaccine liquefaction of air-liquid converter 15, the opposite side of air-liquid converter 15 connects liquid phase vaccine gathering system 12, the opposite side connected adjustable negative pressure keeping system 16 of liquid phase vaccine gathering system 12, described air-liquid converter 15 has used the guide-tube structure of elongated spiral type, its inside is provided with a spiral tube 13, described spiral tube 13 is elongated spiral type grass tubes, a large amount of atomizing vaccines is when entering elongated spiral type grass tube 13, because cohesion, the actings in conjunction such as bump form large droplet settling, the spiral type design has strengthened the efficient of droplet settling on the one hand, simultaneously air-flow is formed buffering, reduce gas shock to the vigor injury of atomizing vaccine.The glass spiral tube is easier to processing and fabricating simultaneously, and production cost is lower.In order further to improve the efficient of conversion, and the maintenance efficiency of conversion is stable, in the air-liquid converter 15 outer cover automatic temp Controlling System of having installed, it can arrive another side with the transfer of heat of cooling piece one side under the effect of electric current, be sent in the air by cooler radiator element 3 and go, make air-liquid converter 15 keep below the suitable coagulation temperature of room temperature, can not change because variation of ambient temperature makes the efficient of collection, concrete structure is as follows, described automatic temp Controlling System is by semiconductor chilling plate 14, cooler radiator element 3, temperature sensor 4 and singlechip controller 5 form, described semiconductor chilling plate 14 is fitted in the outside of air-liquid converter 15, cooler radiator element 3 is fitted on the semiconductor chilling plate 14, temperature sensor 4 sends the temperature on radiator element 3 surfaces to singlechip controller 5, the information Control size of current that is sent by temperature sensor 4 by singlechip controller 5, semiconductor chilling plate 14 is adjacent to the transfer of heat of air-liquid converter 15 one sides to other one side by the control to electric current, be sent in the air by radiator element 3 and go, make air-liquid converter 15 keep below the suitable coagulation temperature of room temperature.
In the design of liquid phase vaccine gathering system 12, described liquid phase vaccine gathering system 12 is comprised of full glass drainage casing tube and sample bottle 11, described full glass drainage casing tube is by arcuate bottom glass bushing 17, inlet pipe 10, escape pipe 9 and go out sample osculum 18 and form, wherein inlet pipe 10 need be inserted into the curved bottom of arcuate bottom glass bushing 17, the end band of inlet pipe 10 is crooked, arc at the bottom of the curved mistake of the mouth of pipe goes out sample osculum 18 and aims at the glass bushing pipe, escape pipe 9 enters the mouth of pipe of (generally slightly enter and get final product) arcuate bottom glass bushing 17, one side of air-liquid converter 15 is connected with aseptic atomization box 2, opposite side connects the inlet pipe 10 of glass drainage casing tube, adjustable negative-pressure keeping system 16 connects the escape pipe 9 of full glass drainage casing tube, described adjustable negative-pressure keeping system 16 is by pressure transmitter 6, negative pressure keeps case 7, negative pressure generator 8, singlechip controller 5 forms, described pressure transmitter 6 and aseptic atomization box 2, negative pressure keeps case 7, singlechip controller 5 connects, measure the pressure of aseptic atomization box 2 and negative pressure maintenance case 7 and the result is transferred to singlechip controller 5 by pressure transmitter 6, calculation and control by singlechip controller 5, regulate the rotating speed of negative pressure generator 8, guarantee that pressure is not higher than ambient pressure in the aseptic atomization box 2.Described sample bottle 11 is with scale mark, by going out 18 airtight connections of sample osculum of screw thread and full glass drainage casing tube.
Inlet pipe 10 is equipped with in liquid phase vaccine gathering system 12 inside, escape pipe 9, link to each other by rubber plug, mainly be in order the liquid vaccine of collecting in the air-liquid converter fully to be transported to the bottom of the collector 12 of glass system, for fear of because of inlet mouth and air outlet from too close to, cause air-flow to take away the liquid vaccine that part collects and cause damage.Between inlet pipe and escape pipe certain distance to be arranged, the bottom design camber of collector 12, the tip designs of inlet pipe 10 is bending upwards, and inlet pipe 10 ends will extend through out the sample osculum when installing, the purpose of doing like this be allow the liquid vaccine that flows out from inlet pipe can along with the lower arcuate surface Rapid Flow to escape pipe, reduce gas shock to the vaccine activity injury.The collector bottom design go out the sample osculum, and can be connected with the sample bottle 11 with scale mark, when needs are repeatedly sampled, only need to change a sample bottle 11 and get final product.
In order to guarantee that pressure is not higher than ambient pressure in the aseptic atomization box 2, the process of the reality of complete simulating vaccine atomizing, it is adjustable negative pressure keeping system (16) that the utility model has adopted a cover automatic pressure to keep system, adjustable negative-pressure keeping system (16) is by pressure transmitter (6), negative pressure keeps case (7), negative pressure generator (8), singlechip controller (5) forms, described pressure transmitter (6) and aseptic atomization box (2), negative pressure keeps case (7), singlechip controller (5) connects, measure the pressure of aseptic atomization box (2) and negative pressure maintenance case (7) and the result is transferred to singlechip controller (5) by pressure transmitter (6), calculation and control by singlechip controller (5), regulate the rotating speed of negative pressure generator (8), guarantee that pressure is not higher than ambient pressure in the aseptic atomization box (2).Namely by pressure transmitter 6, measure the pressure of aseptic atomization box and the pressure that negative pressure keeps case 7, by the calculation and control of one-chip computer, regulate the rotating speed of negative pressure generator 8, regulate the negative pressure value that the pressure that keeps sterile cupboard reaches to be needed.
Simultaneously, in order to guarantee to contain in the aseptic atomization box 2 the atomizing vaccine of higher concentration, be convenient to collect rapidly in air-liquid converter 15 liquid vaccine solution, the volume of aseptic atomization box 2 should be controlled within 1/4~1 times that is about atomizing vaccine generator 1 per minute airshed.
Because adopt the enforcement of above technical scheme, the utility model is compared with prior art equipment and is had the following advantages: sampling thief of the present utility model can realize to the atomizing vaccine quantitatively, the collection capacity of atomizing vaccine can be controlled according to the sampling time; The vaccine of collecting is liquid, is convenient to carrying out of follow-up every testing; The utility model is realized operator and separating that the atomizing vaccine occurs and collects, and avoids operator to the interference of testing environment, and the atomizing vaccine is on the impact of HUMAN HEALTH.The utility model device simple, cost of manufacture is low, is convenient to promote the use of.
Description of drawings
Accompanying drawing is the atomize synoptic diagram of vaccine quantitative collection device of the present invention, wherein:
The 1-vaccine generator that atomizes; The aseptic atomization box of 2-; 3-cooler radiator element; The 4-temperature sensor; The 5-singlechip controller; The 6-pressure transmitter; The 7-negative pressure keeps case; The 8-negative pressure generator; The 9-escape pipe; The 10-inlet pipe; The 11-sample bottle; 12-liquid phase vaccine gathering system; The 13-spiral tube; 14-conductor refrigeration sheet; The 15-air-liquid converter; 16-adjustable negative-pressure keeping system; 17-arcuate bottom glass bushing; 18-goes out the sample osculum.
Embodiment
Embodiment 1
As shown in the figure, a kind of atomizing vaccine quantitative collection device, it is characterized in that described atomizing vaccine generation is connected to form by atomizing vaccine generator 1 and aseptic atomization box 2 two portions, the recovery system of described atomizing vaccine is by air-liquid converter 15, and liquid phase vaccine gathering system 12 and adjustable negative-pressure keeping system 16 form.One side of described aseptic atomization box 2 closely is connected with the shower nozzle of atomizing vaccine generator 1, and the volume of aseptic atomization box 2 is 1/4~1 times of atomizing vaccine generator 1 per minute airshed.Described air-liquid converter 15 inside are provided with a spiral tube 13, and spiral tube 13 is elongated spiral type grass tubes; Described liquid phase vaccine gathering system 12 is comprised of full glass drainage casing tube and sample bottle 11, described full glass drainage casing tube is by arcuate bottom glass bushing 17, inlet pipe 10, escape pipe 9 and go out sample osculum 18 and form, wherein inlet pipe 10 is inserted into the curved bottom of arcuate bottom glass bushing 17, the end band of inlet pipe 10 is crooked, arc at the bottom of the curved mistake of the mouth of pipe goes out sample osculum 18 and aims at the glass bushing pipe, escape pipe 9 enters the mouth of pipe of arcuate bottom glass bushing 17, one side of air-liquid converter 15 is connected with aseptic atomization box 2, opposite side connects the inlet pipe 10 of glass drainage casing tube, adjustable negative-pressure keeping system 16 connects the escape pipe 9 of full glass drainage casing tube, described sample bottle 11 is with scale mark, by going out 18 airtight connections of sample osculum of screw thread and full glass drainage casing tube; Described adjustable negative-pressure keeping system 16 keeps case 7, negative pressure generator 8, singlechip controller 5 to form by pressure transmitter 6, negative pressure, calculation and control by singlechip controller 5, regulate the rotating speed of negative pressure generator 8, guarantee that pressure is not higher than ambient pressure in the aseptic atomization box 2.In the described adjustable negative-pressure keeping system 16, pressure transmitter 6 keeps case 7, singlechip controller 5 to be connected with aseptic atomization box 2, negative pressure, measure the pressure of aseptic atomization box 2 and negative pressure maintenance case 7 and the result is transferred to singlechip controller 5 by pressure transmitter 6, calculation and control by singlechip controller 5, regulate the rotating speed of negative pressure generator 8, guarantee pressure in the aseptic atomization box 2 more than or equal to the airshed of atomizing vaccine generator 1 or be not higher than ambient pressure.In the air-liquid converter 15 outer cover automatic temp Controlling System of having installed, described automatic temp Controlling System is by semiconductor chilling plate 14, cooler radiator element 3, temperature sensor 4 and singlechip controller 5 form, described semiconductor chilling plate 14 is fitted in the outside of air-liquid converter 15, cooler radiator element 3 is fitted on the semiconductor chilling plate 14, temperature sensor 4 sends the temperature on radiator element 3 surfaces to singlechip controller 5, the information Control size of current that is sent by temperature sensor 4 by singlechip controller 5, semiconductor chilling plate 14 is adjacent to the transfer of heat of air-liquid converter 15 one sides to other one side by the control to electric current, be sent in the air by radiator element 3 and go, make air-liquid converter 15 keep below the suitable coagulation temperature of room temperature.
Wherein, the airshed of adjustable negative-pressure keeping system 16 is more than or equal to the airshed of atomizing vaccine generator 1.

Claims (7)

1. an atomizing vaccine quantitative collection device is characterized in that its recovery system two portions by atomizing vaccine generation and atomizing vaccine connect to form.
2. a kind of atomizing vaccine quantitative collection device as claimed in claim 1, it is characterized in that described atomizing vaccine generation is connected to form by atomizing vaccine generator (1) and aseptic atomization box (2) two portions, the recovery system of described atomizing vaccine is by air-liquid converter (15), and liquid phase vaccine gathering system (12) and adjustable negative-pressure keeping system (16) form.
3. a kind of atomizing vaccine quantitative collection device as claimed in claim 1, it is characterized in that, atomizing vaccine generation is connected to form by atomizing vaccine generator (1) and aseptic atomization box (2) two portions, one side of described aseptic atomization box (2) closely is connected with the shower nozzle of atomizing vaccine generator (1), and the volume of aseptic atomization box (2) is 1/4~1 times of atomizing vaccine generator (1) per minute airshed.
4. such as the described a kind of atomizing vaccine quantitative collection device of one of claims 1 to 3, it is characterized in that, the recovery system of described atomizing vaccine is by air-liquid converter (15), liquid phase vaccine gathering system (12) and adjustable negative-pressure keeping system (16) connect to form successively, described air-liquid converter (15) inside is provided with a spiral tube (13), and spiral tube (13) is an elongated spiral type grass tube; Described liquid phase vaccine gathering system (12) is comprised of full glass drainage casing tube and sample bottle (11), described full glass drainage casing tube is by arcuate bottom glass bushing (17), inlet pipe (10), escape pipe (9) and go out sample osculum (18) and form, wherein inlet pipe (10) is inserted into the curved bottom of arcuate bottom glass bushing (17), the end band of inlet pipe (10) is crooked, arc at the bottom of the curved mistake of the mouth of pipe goes out sample osculum (18) and aims at the glass bushing pipe, escape pipe (9) enters the mouth of pipe of arcuate bottom glass bushing (17), one side of air-liquid converter (15) is connected with aseptic atomization box (2), opposite side connects the inlet pipe (10) of glass drainage casing tube, adjustable negative-pressure keeping system (16) connects the escape pipe (9) of full glass drainage casing tube, described sample bottle (11) is with scale mark, by going out airtight connection of sample osculum (18) of screw thread and full glass drainage casing tube; Described adjustable negative-pressure keeping system (16) keeps case (7), negative pressure generator (8), singlechip controller (5) to form by pressure transmitter (6), negative pressure, calculation and control by singlechip controller (5), regulate the rotating speed of negative pressure generator (8), guarantee that pressure is not higher than ambient pressure in the aseptic atomization box (2).
5. a kind of atomizing vaccine quantitative collection device as claimed in claim 4, it is characterized in that, in the described adjustable negative-pressure keeping system (16), pressure transmitter (6) and aseptic atomization box (2), negative pressure keeps case (7), singlechip controller (5) connects, measure the pressure of aseptic atomization box (2) and negative pressure maintenance case (7) and the result is transferred to singlechip controller (5) by pressure transmitter (6), calculation and control by singlechip controller (5), regulate the rotating speed of negative pressure generator (8), guarantee that pressure is not higher than ambient pressure in the aseptic atomization box (2).
6. a kind of atomizing vaccine quantitative collection device as claimed in claim 4 is characterized in that the airshed of adjustable negative-pressure keeping system (16) is more than or equal to the airshed of atomizing vaccine generator (1).
7. a kind of atomizing vaccine quantitative collection device as claimed in claim 4, it is characterized in that, one cover automatic temp Controlling System has been installed outside air-liquid converter (15), described automatic temp Controlling System is by semiconductor chilling plate (14), cooler radiator element (3), temperature sensor (4) and singlechip controller (5) form, described semiconductor chilling plate (14) is fitted in the outside of air-liquid converter (15), cooler radiator element (3) is fitted on the semiconductor chilling plate (14), temperature sensor (4) sends the temperature on radiator element (3) surface to singlechip controller (5), the information Control size of current that is sent by temperature sensor (4) by singlechip controller (5), semiconductor chilling plate (14) is adjacent to the transfer of heat of air-liquid converter (15) one side to other one side by the control to electric current, be sent in the air by radiator element (3) and go, make air-liquid converter (15) keep below the suitable coagulation temperature of room temperature.
CN 201220357811 2012-07-23 2012-07-23 Atomized vaccine quantitative collection device Expired - Lifetime CN202898421U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113517062A (en) * 2021-09-14 2021-10-19 青岛未来移动医疗科技有限公司 Intelligent vaccine atomization system and use method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113517062A (en) * 2021-09-14 2021-10-19 青岛未来移动医疗科技有限公司 Intelligent vaccine atomization system and use method
CN113517062B (en) * 2021-09-14 2021-12-10 青岛未来移动医疗科技有限公司 Intelligent vaccine atomization system and use method

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Granted publication date: 20130424

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