CN202891869U - Self-stabilization pathfinding capsule for digestive tract - Google Patents
Self-stabilization pathfinding capsule for digestive tract Download PDFInfo
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- CN202891869U CN202891869U CN 201220548430 CN201220548430U CN202891869U CN 202891869 U CN202891869 U CN 202891869U CN 201220548430 CN201220548430 CN 201220548430 CN 201220548430 U CN201220548430 U CN 201220548430U CN 202891869 U CN202891869 U CN 202891869U
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Abstract
The utility model disclosed a self-stabilization pathfinding capsule for digestive tract. The self-stabilization pathfinding capsule for the digestive tract comprises a capsule body and further comprises an intestine dissolving shell and an elastic piece, wherein the intestine dissolving shell and the elastic piece are made of degradable materials. The elastic piece is at least arranged at one end of the capsule body. The intestine dissolving shell wraps the capsule body and the elastic piece so as to enable the elastic piece to be a state of compression. After the intestine dissolving shell reaches the small intestine and dissolves, the elastic piece returns to the original length so as to increase the whole length of the capsule and avoid overturn of the capsule. The elastic piece preferably utilizes a spring. The spring of the self-stabilization pathfinding capsule for the digestive tract is released in the small intestine, so the the whole length of the capsule is increased and stably codirectional movement inside the small intestine can be achieved. A self-stabilization capsule endoscopy also has a spring, wherein the length of the spring can be increased in the inside of the small intestine. The size and weight of the self-stabilization capsule endoscopy are similar to the size and the weight of the self-stabilization pathfinding capsule for the digestive tract. Therefore, the self-stabilization pathfinding capsule for the digestive tract is actually a preview of the self-stabilization capsule endoscopy exam in the motor process of the inner digestive tract, so that feasibility of the self-stabilization capsule endoscopy can be accurately evaluated.
Description
Technical field
This utility model relates to technical field of medical instruments, is specifically related to a kind of digestive tract from the capsule of surely exploring the way.
Background technology
From calendar year 2001 capsule endoscope since FDA Food and Drug Administration approval is used for the inspection of disease of intestine, the characteristics such as capsule endoscope is simple, convenient, painless with it, noinvasive, safety obtain doctor, patient's favor.At present, capsule endoscope is mainly used in the sick diagnosis such as Obscure gastrointestinal bleeding, Crohn disease, intestinal tumor.
Yet, owing to a common complication that becomes capsule endoscope in intestinal tumor or the narrow capsule retention body that causes.Because the capsule endoscope non-degradable in the retention body, must take out, otherwise will cause serious consequence.Small intestinal is different from stomach and colon, because its anatomical position and structure is special, in case capsule endoscope generation retention is taken out relatively difficulty with it, sometimes even need the row laparotomy ventrotomy, this has brought great misery to the patient.
Therefore, whether retention is particularly important in vivo to judge in advance capsule endoscope.At present, how the clinician is at first according to medical history Preliminary screening patients undergoing examination of capsule endoscopy, then further goes the clear and definite bowel narrow that whether exists of contrast examination.But this method accuracy rate is not high, and some patient fails to pinpoint a disease in diagnosis, and some patient's radiography result shows bowel narrow, but still can finish Capsule Endoscopy.This explanation, soon differing is decided to be reality, only has personal practice to know actually.Some bowel narrow is false stricture, capsule endoscope by the time still can produce deformation, capsule is passed through.This part patient accepts Capsule Endoscopy often can have positive findings, for its diagnosis provides important evidence.
The utility models such as PiXiTian in 2006 digestive tract evacuation-detecting slow-release tablet and preparation technology thereof; The utility models such as Elisha Rahinovitz in 2010 a kind of degradable capsule, the assessment intestinal have or not narrow before they can be used for Capsule Endoscopy.Above-mentioned two kinds of capsules all are similar to conventional capsule scope size, but, it moves unpredictable in small intestinal, capsule very easily rolls, because this degradable capsule can't be simulated from steady (being difficult for rolling) capsule endoscope motor process in small intestinal, thus can not accurate evaluation from the feasibility of steady Capsule Endoscopy.
The utility model content
The purpose of this utility model be to provide a kind of can stable motion in digestive tract, can accurate evaluation from the digestive tract of steady Capsule Endoscopy feasibility from the capsule of surely exploring the way.Measurable Capsule Endoscopy feasibility is taken before planning to implement the capsule endoscope patient, and is safe, easy and effective, for the clinician determines whether feasible Capsule Endoscopy provides good foundation for next step.
The purpose of this utility model realizes by following technical measures: a kind of digestive tract is from the capsule of surely exploring the way, comprise the capsule body, it is characterized in that: also comprise enteric shell and the elastic component made by degradable material, described elastic component is arranged on an end of described capsule body at least, described enteric shell wraps the capsule body and elastic component makes described elastic component be in compressive state, after the enteric shell arrived the small intestinal dissolving, elastic component recovered former length and prevents upset with the length that increases whole capsule.
Elastic component of the present utility model discharges in small intestinal, increased the entire length of capsule, can realize in small intestinal stably towards same direction motion, from steady capsule endoscope have too can be in small intestinal the elastic component of the length of growth own, all similar to explore the way size and the weight of capsule of this utility model from steady capsule endoscope size and weight, therefore, the motor process of this utility model in digestive tract is actually the preview from steady Capsule Endoscopy, so, but accurate evaluation is from the feasibility of steady Capsule Endoscopy.
After elastic component described in the utility model recovered former length, the length range of the whole capsule of exploring the way was 5-7cm.The entire length of this utility model behind retracting spring be greater than the maximum gauge of small intestinal, realized preventing the purpose of overturning, and avoided simultaneously retention at small intestinal normal turn position, and make its can not accurate evaluation from the feasibility of steady Capsule Endoscopy.
As preferred implementation of the present utility model, described elastic component adopts spring, and an end of described spring is connected on the described capsule body, and this end is the link of spring, and the other end holds out against on the inwall of described enteric shell.
With spring compression, adopt application of vacuum between enteric shell described in the utility model and capsule body, the elastic component for further.
As a kind of embodiment of the present utility model, described capsule body mainly reaches the time marker of being made by the enteric-coated sustained release material by soluble supporter in Digestive system, contrast media layer, adventitia and forms, it is peripheral that described contrast media layer is coated on described supporter, and described adventitia then is coated on the surface of contrast media layer and supporter coalition; The link of described spring passes adventitia and stretches between adventitia and the contrast media layer fixing.
Contrast media layer described in the utility model is comprised of blanc fixe and the film body that coats blanc fixe, and the link of described spring has fixed disk, and the two sides of described fixed disk is corresponding respectively to be adhesively fixed with film body, adventitia.
Have through hole on the adventitia described in the utility model, described time marker closely is inserted in the through hole with the shutoff through hole.
As a kind of improvement of the present utility model, being coated with in the peripheral monoblock type of described spring can be with the spring adventitia of the common elongation of spring.The spring adventitia both can prevent Spring Card pressure ileocecal valve, also can increase the contact area between spring and the enteric shell, thereby can protect the enteric shell not damaged, when it is normally moved in intestinal, it is stable that this spring adventitia keeps, and guarantees spring and enteric shell overall appearance and performance; This spring adventitia can also reduce the friction between spring and the intestinal wall.
The utlity model has following embodiment:
Described enteric shell adopts the enteric materials such as alginate, Algin to make; Described spring is made by materials such as poly-decanedioic acid witcogum, polylactic acid or gelatin, and this material should have good biocompatibility, suitable elasticity and the characteristic of biodegradability; The spring adventitia is made by the degradation material polylactic acid; Described adventitia can select good biocompatibility, the degradable materials such as polylactic acid, microcrystalline Cellulose, polyvinyl pyrrolidone to make; Described time marker can be selected the making such as enteric-coated sustained release material such as microcrystalline Cellulose, Glyceryl Behenate, polyvinyl pyrrolidone, hydroxypropyl emthylcellulose, lactose, it can keep basicly stable in specifying the 72-96 hours, all dissolvings after the fixed time (96-120 hour); Supporter adopts soluble gelatin, lactose, starch etc. in Digestive system, and its ratio weight is adjustable, and is similar to certainly steady capsule endoscope with the quality that satisfies whole capsule.
Spring described in the utility model is for the maximum pressure (P of intestinal wall
Max) be less than or equal to the critical pressure that makes intestinal wall perforation.Computing formula: P
Net=t/R * σ
T(t is intestinal wall thickness, and R is the intestinal wall radius, σ
TBe the small bowel elastic modelling quantity); P
Max=σ
s* x/S; (σ
sBe the elastic modelling quantity of spring, x is the largest deformation amount, and S is the area of fixed disk).
Compared with prior art, the utlity model has following significant effect:
⑴ this utility model elastic component discharges in small intestinal, increased the entire length of capsule, can realize in small intestinal stably towards same direction motion, from steady capsule endoscope have too can be in small intestinal the elastic component of the length of growth own, all similar to explore the way size and the weight of capsule of this utility model from steady capsule endoscope size and weight, therefore the motor process of this utility model in digestive tract is the preview from steady Capsule Endoscopy in fact, but accurate evaluation is from the feasibility of steady Capsule Endoscopy.
⑵ this utility model is noinvasive, safety not only, and reliable, neither allows the patient stand unnecessary inspection, does not also allow the patient lose a kind of chance of good auxiliary diagnosis disease.
⑶ spring adventitia both can prevent Spring Card pressure ileocecal valve; also can increase the contact area between spring and the enteric shell; thereby can protect the enteric shell not damaged; when it is normally moved in intestinal; it is stable that this adventitia keeps; guarantee spring and enteric shell overall appearance and performance, this spring adventitia can also reduce the friction between spring and the intestinal wall.
⑷ the entire length of this utility model behind retracting spring be greater than the maximum gauge of small intestinal, realized preventing the purpose of overturning, and avoided simultaneously being trapped in small intestinal normal turn position, cause its can not accurate evaluation from the feasibility of steady Capsule Endoscopy.
⑸ enteric shell vacuum packet is rolled in the periphery of capsule body and elastic component, can be further with spring compression.
⑹ this utility model is the preview that true capsule endoscope checks in digestive tract, can find the narrow positions that capsule endoscope can't pass through really, for the inspection of capsule endoscope provides safety guarantee and provides the once chance of feasible Capsule Endoscopy for the patient who has Digestive Tract Stenosis.
Description of drawings
The utility model is described in further detail below in conjunction with the drawings and specific embodiments.
Fig. 1 is the overall structure cross-sectional schematic (only enteric shell cut) of this utility model before spring discharges;
Fig. 2 is the cutaway view of this utility model after spring discharges;
Fig. 3 is the local enlarged diagram of A among Fig. 2;
Fig. 4 is the FB(flow block) that uses this utility model evaluate capsules endoscopy feasibility.
The specific embodiment
Shown in Fig. 1～3, be a kind of digestive tract of this utility model from the capsule 6 of surely exploring the way, all with to have common capsule endoscope now basic identical, it comprises degradable capsule body 1 and enteric shell 2 and the elastic component made by degradable material for its size, quality, outward appearance; Elastic component adopts spring 3, spring 3 is arranged on a wherein end (afterbody of the capsule of namely exploring the way) of capsule body 1, enteric shell 2 vacuum packet wrap capsule body 1 and spring 3 makes spring 3 be in compressive state, one end of spring 3 is connected on the capsule body, this end is the link 31 of spring 3, the other end holds out against on the inwall of enteric shell 2, after the enteric shell arrives the small intestinal dissolving, elastic component recovers former length and prevents upset with the length that increases the whole capsule of exploring the way, and namely the length of whole capsule is greater than human small intestine's maximum gauge.Generally speaking, after elastic component recovered former length, the length range of the whole capsule of exploring the way was 5-7cm.
Capsule body 1 mainly reaches the time marker 14 of being made by the enteric-coated sustained release material by soluble supporter 11 in Digestive system, contrast media layer, adventitia 13 and forms, the contrast media layer is coated on supporter 11 peripheries, and adventitia 13 then is coated on the surface of contrast media layer and supporter 11 coalitions; The link 31 of spring 3 passes adventitia 13 and stretches between adventitia 13 and the contrast media layer fixing; In the present embodiment, the contrast media layer is comprised of blanc fixe 12 and the film body 15 that coats blanc fixe, externally shows the shape of the capsule of exploring the way when the capsule of exploring the way is complete under the x-ray.The link 31 of spring 3 has fixed disk 32, fixed disk 32 is to enter the rear folding circular disk body that forms by the link 31 of spring 3 aperture by the capsule end of exploring the way, the two sides of fixed disk 32 respectively corresponding and film body 15, adventitia 13 connects fixingly so that biogum or UV are gluing, prevents that intestinal juice from entering.Have through hole on adventitia 13 and corresponding to the head of the capsule of exploring the way, time marker 14 closely is inserted in the through hole with the shutoff through hole, does not stay the slit between time marker 14 and the through hole peritreme, prevents that Digestive system from flowing into from the slit.
Being coated with in spring 3 peripheral monoblock types can be with the spring adventitia 4 of spring 3 common elongations.Spring adventitia 4 can prevent Spring Card pressure ileocecal valve, also can increase the contact area between spring and the enteric shell, reduces the friction between spring and the intestinal wall; Spring is for the maximum pressure (P of intestinal wall
Max) be less than or equal to the critical pressure of intestinal wall perforation.Computing formula is as follows: P
Net=t/R * σ
T(t is intestinal wall thickness, and R is the intestinal wall radius, σ
TBe the small bowel elastic modelling quantity); P
Max=σ
s* x/S; (σ
sBe the elastic modelling quantity of spring, x is the largest deformation amount, and S is the area of fixed disk).
In the present embodiment, the enteric shell adopts alginate, Algin or other enteric material to make; Spring is made by materials such as poly-decanedioic acid witcogum, polylactic acid or gelatin, and poly-decanedioic acid witcogum, polylactic acid and gelatin are the degradable biological elastomeric material, and can add disintegrating agent and regulate its biodegradability; The material of spring is selected to need to satisfy: (1) good biocompatibility; (2) degradable (increase safety, such as retention, discharge behind the degradable); (3) suitable to intestinal wall pressure.The fastest approximately 12 hours of normal person's digestive tract evacuation time, average approximately 24 hours.It is stable that the enteric shell keeps under the effect of gastric gastric juice, enter behind the small intestinal because the rapid disintegrate of variation of pH value and intestinal fluid composition, time was less than 10 minutes, discharge compressed spring this moment, spring and capsule body form an integral body and move under the small intestinal peristalsis effect, its increasing that takes up space, whole anteroposterior diameter surpasses the small intestinal maximum gauge, has reached the effect of overturning of preventing; The spring adventitia can be made by degradation material polylactic acid or other enteric-coated sustained release materials, as explores the way capsule not in the retention body, and it can be discharged from anus with capsule; Otherwise this spring adventitia begins degraded after surpassing the given time (approximately 96-120 hour), and Digestive system pours in from the capsule body tail end aperture of exploring the way after the degraded, accelerates to explore the way the capsule disintegrate.
Adventitia can select good biocompatibility, the degradable materials such as polylactic acid, microcrystalline Cellulose, polyvinyl pyrrolidone to make, adventitia keeps the stable of shape and structure at conventional operation in the time, the simulation capsule endoscope is by the human body alimentary canal process, and complete excreting, adventitia is degradable after 96-120 hour, block then incarceration such as bowel narrow, can monitor roughly incarceration position by x-ray, and prolong in time, also can after the above-mentioned fixed time, degrade, finally excrete, can the retention body in; Time marker can be selected enteric-coated sustained release material such as microcrystalline Cellulose, Glyceryl Behenate, polyvinyl pyrrolidone, hydroxypropyl emthylcellulose, the making such as lactose, rate of dissolution is extremely slow at the appointed time for it, only just can dissolve fully exceeding schedule time, namely in the transhipment of normal stool road, this capsule of exploring the way can keep complete, the Reality simulation capsule endoscope is by digestive tract and discharge, be that it can keep basicly stable in specifying the 72-96 hours, all dissolvings after fixed time (96-120 hour), capsule is not discharged yet in case exceed schedule time, then along with the dissolving of time marker, Digestive system enters dissolving supporter in the capsule, and the capsule body subsides thereupon; Supporter adopts soluble gelatin, lactose, starch etc. in Digestive system, and its ratio weight is adjustable, and is similar to certainly steady capsule endoscope with the quality that satisfies whole capsule.
Operation principle of the present utility model is summarized as follows: when the capsule of exploring the way is met narrow in digestive tract or locking and can not pass through the time, the temporary transient incarceration of the capsule of exploring the way therewith, after the process stipulated time, adventitia and time indicator are dissolved fully, the spring of afterbody is also degraded, and Digestive system enters dissolving supporter in the capsule body after the past, and whole capsule subsides, the residue amorphous substance can pass through narrow positions, excretes from anus.
As seen, effect of the present utility model is: whether (1) assess patient is fit to the row Capsule Endoscopy; (2) monitoring capsule position; (3) find the Digestive Tract Stenosis position.
As shown in Figure 4, use this utility model evaluation as follows from the process of steady Capsule Endoscopy feasibility: at first to select the patient that need to carry out this inspection, played the influent stream food the 1st day noon, can take inferior morning from the capsule of surely exploring the way, advise the patient to observe the defecation situation, as finding to discharge then clean sending back to of capsule; Carry out the first time after 13 hours and detect, excrete as capsule is complete, then patient's digestive tract is unobstructed, can then go Capsule Endoscopy.As lose capsule and excrete, then go the X-ray examination inspection, roughly locate the capsule position; Carrying out the second time after 12 hours detects, excrete as capsule is complete, then patient's digestive tract is unobstructed, can then go Capsule Endoscopy, otherwise, again go the X-ray examination inspection, the location capsule, identical with last time such as the position, capsule incarceration then should not be gone Capsule Endoscopy, different such as the position, then might be digestive tract transhipment time lengthening, can go every 12 hours again and observe, this moment be such as the complete discharge of capsule, then patient's digestive tract is still unobstructed, such as imperfect discharge, then might be in digestive tract incarceration (judging it is to prolong or retention the duration of runs according to the time), the row Capsule Endoscopy is risky.
Embodiment of the present utility model is not limited to this, according to foregoing of the present utility model, ordinary skill knowledge and customary means according to this area, do not breaking away under the above-mentioned basic fundamental thought of this utility model prerequisite, this utility model spring can also be arranged on head or the afterbody of the capsule of exploring the way simultaneously; Supporter, contrast media layer, adventitia, time marker, enteric shell and spring, spring adventitia also can select other satisfactory material to make; therefore this utility model can also be made modification, replacement or the change of other various ways, all drops within this utility model rights protection scope.
Claims (10)
1. a digestive tract is from the capsule of surely exploring the way, comprise the capsule body, it is characterized in that: also comprise enteric shell and the elastic component made by degradable material, described elastic component is arranged on an end of described capsule body at least, described enteric shell wraps the capsule body and elastic component makes described elastic component be in compressive state, after the enteric shell arrived the small intestinal dissolving, elastic component recovered former length and prevents upset with the length that increases whole capsule.
2. digestive tract according to claim 1 is from the capsule of surely exploring the way, and it is characterized in that: after described elastic component recovered former length, the length range of the whole capsule of exploring the way was 5～7cm.
3. digestive tract according to claim 1 and 2 is from the capsule of surely exploring the way, it is characterized in that: described elastic component adopts spring, one end of described spring is connected on the described capsule body, and this end is the link of spring, and the other end holds out against on the inwall of described enteric shell.
4. digestive tract according to claim 3 is characterized in that: adopt application of vacuum between described enteric shell and capsule body, the elastic component from the capsule of surely exploring the way.
5. digestive tract according to claim 4 is from the capsule of surely exploring the way, it is characterized in that: described capsule body mainly reaches the time marker of being made by the enteric-coated sustained release material by soluble supporter in Digestive system, contrast media layer, adventitia and forms, it is peripheral that described contrast media layer is coated on described supporter, and described adventitia then is coated on the surface of contrast media layer and supporter coalition; The link of described spring passes adventitia and stretches between adventitia and the contrast media layer fixing.
6. digestive tract according to claim 5 is from the capsule of surely exploring the way, it is characterized in that: described contrast media layer is comprised of blanc fixe and the film body that coats blanc fixe, the link of described spring has fixed disk, and the two sides of described fixed disk is corresponding respectively to be adhesively fixed with film body, adventitia.
7. digestive tract according to claim 6 is from the capsule of surely exploring the way, and it is characterized in that: have through hole on the described adventitia, described time marker closely is inserted in the through hole with the shutoff through hole.
8. digestive tract according to claim 7 is characterized in that from the capsule of surely exploring the way: being coated with in the peripheral monoblock type of described spring can be with the spring adventitia of the common elongation of spring.
9. digestive tract according to claim 8 is characterized in that from the capsule of surely exploring the way: described spring is less than or equal to the critical pressure that makes the intestinal wall perforation for the maximum pressure of intestinal wall.
10. digestive tract according to claim 9 is from the capsule of surely exploring the way, and it is characterized in that: described spring is made by poly-decanedioic acid witcogum, polylactic acid or gelatin; Described spring adventitia is made by polylactic acid, microcrystalline Cellulose or polyvinyl pyrrolidone; Described enteric shell adopts alginate or Algin to make; Described time marker is made by microcrystalline Cellulose, Glyceryl Behenate, polyvinyl pyrrolidone, hydroxypropyl emthylcellulose or lactose; Described supporter adopts gelatin, lactose or starch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220548430 CN202891869U (en) | 2012-10-24 | 2012-10-24 | Self-stabilization pathfinding capsule for digestive tract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220548430 CN202891869U (en) | 2012-10-24 | 2012-10-24 | Self-stabilization pathfinding capsule for digestive tract |
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| Publication Number | Publication Date |
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| CN202891869U true CN202891869U (en) | 2013-04-24 |
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|---|---|---|---|
| CN 201220548430 Expired - Lifetime CN202891869U (en) | 2012-10-24 | 2012-10-24 | Self-stabilization pathfinding capsule for digestive tract |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920418A (en) * | 2012-10-24 | 2013-02-13 | 刘思德 | Self-stable patency capsule of alimentary canal |
| CN103494594A (en) * | 2013-07-08 | 2014-01-08 | 南方医科大学南方医院 | Digestive tract patency capsule |
| CN109528241A (en) * | 2018-11-07 | 2019-03-29 | 西安交通大学医学院第二附属医院 | A kind of tumor in digestive tract cellular collector |
-
2012
- 2012-10-24 CN CN 201220548430 patent/CN202891869U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920418A (en) * | 2012-10-24 | 2013-02-13 | 刘思德 | Self-stable patency capsule of alimentary canal |
| CN102920418B (en) * | 2012-10-24 | 2014-07-30 | 刘思德 | Self-stable patency capsule of alimentary canal |
| CN103494594A (en) * | 2013-07-08 | 2014-01-08 | 南方医科大学南方医院 | Digestive tract patency capsule |
| CN103494594B (en) * | 2013-07-08 | 2015-11-18 | 南方医科大学南方医院 | A kind of digestive tract patency capsule |
| CN109528241A (en) * | 2018-11-07 | 2019-03-29 | 西安交通大学医学院第二附属医院 | A kind of tumor in digestive tract cellular collector |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20130424 Effective date of abandoning: 20140730 |
|
| RGAV | Abandon patent right to avoid regrant |