Summary of the invention
On this basis, we have researched and developed a kind of image-guided equipment of ablation with image two-dimensional process device.This equipment processes by 3-dimensional image and analytical technology is come directly perceived, clear, arbitrarily angled ground display space neighbouring relationship, and carry out surgery planning before qualitative assessment carries out art by calculating, and carry out accurate location in the centesis in conjunction with the intervene operation navigational system, can also by judge tumour ablation whether fully, have or not residual tumor or the edge recurrence assessment of effectively performing the operation.The various difficult problems that the proposition of this equipment has effectively solved before the art, in the art, postoperative runs into have been based upon image-guided tumour heating ablation on more objective, the accurate basis.
The image-guided equipment of ablation with image two-dimensional process device of the present invention comprises processor, display screen, keyboard and mouse.Display screen, keyboard and mouse are connected and are connected with processor, processor is core component of the present invention, its inside comprises image collection device, image processor and Image Management device, and the image collection device is used for gathering image information, and the image information that collects is transferred to image processor; Image processor will be processed, be processed by the image information that the collection of image collection device comes, the image that needs to obtain the user; Image through processing, processing is directly shown by display screen, transfers to simultaneously the Image Management device and stores, and calls at any time in order to the user.Wherein, image processor comprises image two-dimensional process device, image three-dimensional treating apparatus, image measuring device, Image registration device, Image Segmentation device.Described image two-dimensional process device is made of image base conditioning device and image Scissoring device two parts.
Further, image base conditioning device comprises that processing the arithmetical operation that reaches for two width of cloth images for the filtering of single width image processes.
Further, the filtering of single width image is processed and is comprised: squelch, morphological operations, rim detection and other processing mode.
Further, squelch comprises gaussian filtering, medium filtering, total variance filtering.
Further, morphological operations comprises expansion, burn into opening operation, closed operation.
Further, rim detection comprises shade of gray computing, the computing of Laplce's second-order differential, Sobel Operator.
Further, other processing mode comprises Threshold segmentation, image counter-rotating, down-sampling.
Further, the arithmetical operation of two width of cloth images comprises arithmetical operation and Boolean calculation.
Further, arithmetical operation comprises image 2 and image 1 addition, subtracts each other, multiplies each other, is divided by.
Further, Boolean calculation comprise image 2 and image 1 " with ", "or", distance.
The invention solves in the planning of art prescience, the art and accurately locate, the difficult problem of postoperative effect assessment, especially solved the problem of image two-dimensional process, overcome the interference of various human factors, directly improved the curative effect of heating ablation, image-guided tumour heating ablation has been based upon on more objective, the accurate basis.
Embodiment
Below in conjunction with accompanying drawing and specific embodiment the image-guided equipment of ablation with image two-dimensional process device of the present invention is further described, but can not be with this as restriction protection scope of the present invention.
Referring to Fig. 1,2, the image-guided equipment of ablation with image two-dimensional process device of the present invention comprises processor 1, display screen 2, keyboard 3 and mouse 4.Wherein, processor 1 is core component of the present invention, and its inside comprises image collection device 5, image processor 6 and Image Management device 7, and image collection device 5 is used for gathering image information, and the image information that collects is transferred to image processor 6; Image processor 6 will gather the image information that comes by image collection device 5 and process, processes, the image that needs to obtain the user; Image through processing, processing directly shows 2 by display screen, transfers to simultaneously Image Management device 7 and stores, and calls at any time in order to the user.Display screen 2, keyboard 3 are connected with mouse and all are connected with processor 1, and display screen 2 is as the output device of processor 1, and show image is beneficial to the user and browses, judges, analyzes intuitively; Keyboard 3 and mouse 4 be as the input equipment of processor, can manipulation processor 1, and make the user according to oneself demand and judgement, image is processed, processed.
Image processor 6 comprises image two-dimensional process device 8, image three-dimensional treating apparatus 9, image measuring device 10, Image registration device 11, Image Segmentation device 12.
Display screen 2 is comprised of three two dimension view windows and a 3-D view window, and three two dimension view windows are respectively cross-section position window, sagittal plain window, Coronal window.
Image two-dimensional process device 8 is made of image base conditioning device and image Scissoring device two parts.
Image base conditioning device comprises for the filtering of single width image to be processed and processes for the arithmetical operation of two width of cloth images.
The filtering of single width image is processed and is comprised: squelch, morphological operations, rim detection and other processing mode.Wherein, squelch comprises gaussian filtering, medium filtering, total variance filtering; Morphological operations comprises expansion, burn into opening operation, closed operation; Rim detection comprises shade of gray computing, the computing of Laplce's second-order differential, Sobel Operator; Other processing mode comprises Threshold segmentation, image counter-rotating, down-sampling.
The arithmetical operation of two width of cloth images comprises arithmetical operation and Boolean calculation.Arithmetical operation comprises image 2 and image 1 addition, subtracts each other, multiplies each other, is divided by.Boolean calculation comprise image 2 and image 1 " with ", "or", distance.
The image Scissoring device generally can be analyzed all image datas, reaches more flexibly mode of operation for obtaining better contrast, and the user can carry out trimming operation and come selection portion subregion data to carry out the image processing operation.
The trimming operation step is as follows:
(1) in the Image Management device, chooses the image node that needs to carry out trimming operation.
(2) after the cutting, the pixel between former image and the selection image is called boundary voxel.The large I of the gray-scale value of boundary voxel is by after clicking " gray-scale value of selecting the outer voxel in zone is set " check box, adjusting slider or the setting value frame is set sets.
(3) click " creating the cutting frame " button, eject and select clipping boundary type dialog box.Option comprises cube, spheroid, right cylinder and cone.Click in " determining " button rear view and just demonstrate yellow frame and confine scope.
(4) check box of selection " using method " will show user's operation information.
The image three-dimensional treating apparatus reaches " video production " two parts by " volume drawing " and forms.Each point in the middle of the volume data can distribute emission and the absorption parameter of a light.Like this, by the in vivo propagation of section of simulation light, just can realize the demonstration of volume data under the visual angle condition.
The volume render operation step is as follows:
(1) in data management system, choose need the image of executable operations node after, click the check box on " volume drawing " left side.The ample resources of processor can be taken when carrying out volume render operation, therefore the implementation effect that to see volume drawing a moment need be born with.
(2) select " presetting " Shipping Options Page.
(3) except the direct editing transfer function, the image three-dimensional treating apparatus also provides two kinds of figures commonly used that can automatically produce transfer function, i.e. threshold figure and bell figure.This dual mode all comprises two parameters, and up/down and left/right rolling mouse after clicking the cross figure can be used for revising parameter value.
The image processing result can preserve video or view screenshotss by making video record.
Image measuring device can make user and bidimensional image or contain storehouse and individual image dough sheet of the three-dimensional of graphics plane data type carries out interactive operation.It can measuring distance, angle, path and some geometric figures.After carrying out the measurement operation, the identical or different measurement pattern with the selected correction of image can be preserved, in order in the future used.When image has been drawn a plurality of figure, the current application figure is shown in red, and all the other Graphics Applications then are shown as white, and the displayed value on the image is the rreturn value of current application figure.All measurement pattern all can each self-generating the node of an image tree in data management system, show.The single measurement pattern that no longer needs or image can be deleted one by one in data management system or delete as one group of integral body.
If selected the shade image in data management system, then the title of image will be presented at " shade: " back of Information.The statistical information and the grey level histogram that show successively selected image downwards.
The Image registration device reaches " non-rigid registration " three parts by " some registration ", " rigid registration " and forms.The medical image registration refers to one group of medical image behind spatial alternation, makes it and another group keep corresponding point on the motionless medical image to reach consistent on the space.Keep motionless being called with reference to image, conversion is called unsteady image.The result of registration is applied to the image that floats.
The Image Segmentation device can be that anatomical structure and pathologic structure establishment are cut apart at the medical image of human body.Comprise Interactive Segmentation and blood vessel segmentation two parts.Blood vessel segmentation comprises based on the blood vessel segmentation of threshold value with based on two steps of reconstructing blood vessel of model.
Use this image-guided equipment and can be achieved as follows several functions:
1, art preplanning
(1) to tumor size, maximum diameter and tumor surface to the calculating of each piping system distance and visual.Tumor size, shape, maximum diameter and surperficial each point be to vena hepatica, arteria hepatica, portal vein, the bee-line of each piping system of gall-bladder can reflect accurately and measures by this equipment.
The venture analysis of the secure border of (2) tumour ablation being delimited.By the three-dimensional rendering figure after rebuilding, can clearly see melting secure border and whether having risk of delimiting in advance, can according to actual conditions, again delimit secure border.
(3) liver Three-dimension Reconstruction Model generating three-dimensional PDF is reported.After planning is finished, can realize liver Three-dimension Reconstruction Model and every terms of information are exported to PDF software, and generating three-dimensional PDF report.
2, surgical navigational
Intervene operation navigational system under image-guided adopts the medical image of multiple modalities to assist a physician operating theater instruments directly is punctured to inside tumor carries out topical therapeutic, and then improves the operation quality, reduces operation wound, reduces the patient suffering.The function of native system comprises:
(1) native system has been carried out the demarcation between operating theater instruments summit and the trace tool.After magnetic orientator is unified in the coordinate information of the trace tool obtained and the ultrasonoscopy in the art in the same coordinate system, system is mapped to unified information in the coordinate systems in image, realize obtaining the coordinate information of any time operating theater instruments summit in coordinate systems in image, and carry out 3-D display.Finally realized the registration between the front CT image of location instrument, patient/intraoperative ultrasound image, trace tool, operating theater instruments and art.Conversion and the registration of coordinate system have been realized.
(2) native system can carry out registration with the CT image before the art and the ultrasonoscopy in the art, and by the accuracy registration between the medical image in the stereotaxic instrument device realization art, patient, the operating theater instruments.
(3) inserting needle path planning before the art: according to medical image design entry point distance, needle angle and the depth of needle after processing.
(4) inserting needle guiding in the art: the real-time coordinate information of the operating theater instruments that will be obtained by locating device by mapping maps in the coordinate systems in image, calculates simultaneously the deviation between operating theater instruments and the path planning, and accurately guided surgery punctures according to the art preplanning.
(5) merge the three-dimensional artificial device of navigation: operation carry out middle realized intraoperative ultrasound image and art before the real time fusion of CT image, and overlap demonstration with 3-dimensional image.Calculate intraoperative ultrasound image corresponding tangent plane position, space on 3-dimensional image, sample to show corresponding with it multiplanar reconstruction by carry out real-time Three-dimensional Gravity in the CT volume data, be convenient to the doctor from multi-angle, carry out observation and analysis at many levels.
3, postoperative evaluation
This equipment can be judged whether tumour ablation is complete, have or not residual tumor or edge recurrence.
Whether the piping system after (1) clear demonstration is melted has damage.
(2) use the green color-coded scheme of reddish yellow and represent three-dimensional tumor model.Use the green color-coded scheme of reddish yellow and represent assessment result.Be the zone that red expression can not be carried out ablative surgery, the zone that yellow expression is not melted fully, green represents the zone of successful ablation.
(3) three-dimensional tumor model being launched into 2 d plane picture intuitively shows.Tumor model after rebuilding is launched into 2 d plane picture, and the application color-coded scheme is next clear, intuitively displaying is not melted, do not melted fully and the zone of melting fully.
(4) to the assessment of tumour ablation surgical effect.To the assessment of tumour ablation surgical effect, namely analyze whether melt and reached the secure border that melts fully.By this equipment, do not melt, do not melt fully, fully ablation areas accounts for to such an extent that number percent can calculate, the tumour 3 D coordinate of every some correspondence and can calculate and show apart from the distance on surface, ablation area on the planimetric map.