CN202761918U - Gyromagnet treatment system based on magnetic nanoparticles - Google Patents
Gyromagnet treatment system based on magnetic nanoparticles Download PDFInfo
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- CN202761918U CN202761918U CN 201220455758 CN201220455758U CN202761918U CN 202761918 U CN202761918 U CN 202761918U CN 201220455758 CN201220455758 CN 201220455758 CN 201220455758 U CN201220455758 U CN 201220455758U CN 202761918 U CN202761918 U CN 202761918U
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Abstract
Disclosed is a gyromagnet treatment system based on magnetic nanoparticles, comprising magnetic nanoparticles, n sets of magnetic field loading systems, a treatment couch, and a rack, wherein the treatment couch is horizontally placed; the magnetic nanoparticles are injected into the to-be-treated body placed upon the treatment couch; the n sets of magnetic field loading systems are installed upon the rack in a manner opposite to or surrounding the treatment couch; and the n is a natural number. According to the utility model, the magnetic nanoparticles are directly injected in the to-be-treated body of the animal or patient requiring treatment as the treatment target. The magnetic nanoparticles are capable of utilizing the modification of the surface singularity to form aggregation at the focus inside the body. Under the alternating magnetic field, the cancer cells can be killed by generating high temperature and force effect upon the cells and organizations, thus to achieve the treatment effect. The treatment system of the utility model features clear target of the magnetic field effect, and explicit mechanism of treatment, and the treatment effect can be quantitatively analyzed.
Description
Technical field
This utility model relates to the gyromagnetic therapy system, is specifically related to a kind of gyromagnetic therapy system based on magnetic nano-particle.
Background technology
The treatment of cancer up to the present, the method that at home and abroad adopts mainly is excision, radiotherapy, chemotherapy and Biotherapeutics.A large amount of scientific researches, meet clinical experiment, clinical experiment and successful case all verified the effectiveness of these therapies aspect some cancer for the treatment of, but, each treatment means or even therapeutic alliance means all can't solve root problem, and corresponding side effect is arranged.Therefore, clinical treatment still extremely needs novel treatment means.
Surgical resection treatment cancer, short term efficacy is remarkable, behind the early-stage cancer excision, can obtain clinical cure, is the effective means of early treatment's tumor.But operation can't be excised the sightless minimal disease of naked eyes and be shifted the cancerous cell of diffusion, and the middle and terminal cancer that shifts in a large number diffusion.
The medicine of chemotherapy all has certain toxicity, and the medicine of chemotherapy does not often have good targeting, it acts on whole body, utilize cancer cell growth, metabolism is more vigorous and preferential kill cancer cell, chemotherapy is all effective in cure to kinds cancer, can treat Senior Minister and Senior Minister's metastasis of general popularity, what have can obviously dwindle tumor, control transfer and recurrence.But the medicine normal tissue damage of chemotherapy is very large, and apparent side effect is arranged.
Radiotherapy utilizes radioactive ray that cancer is treated, and has the effect of killing the local tumor cell, for some Therapeutic Method to radiosensible cancer first-selection.But the penetration capacity of high-energy ray is very strong, is difficult in the treatment focus on, and the radiation injury that therefore produces also is difficult to be confined in the focus scope.The injury of radiation increases with the increase of ray energy and open-assembly time, and radiological medicine commonly used and the ray energy of its use of nuclear medicine diagnosis and treatment means are all very high, can produce the injury that can not reverse by normal tissue.Low dose of radiotherapy does not reach therapeutic effect, and Large Dose Irradiation then may cause such as radiation pneumonia in interior multiple radiation disease.Therefore, common, what the selection of radiotherapy means and dosage should be very is prudent.
Biotherapeutics such as interferon, the element-II etc. that is situated between certainly, part cancer such as renal carcinoma, melanoma etc. are had certain curative effect, but price is expensive, and many tumor efficiencies are imprecise.Gene therapy is still at the experimental stage at present, and clinical efficacy is imprecise, and price is also expensive.
For many years, both at home and abroad the biological action in magnetic field conducted extensive research, it is found that, utilizing magnetic field that disease is treated has certain curative effect really.Multiple magnetotherapy appliance all early oneself be applied to clinical, but its action effect and the mechanism of action all do not obtain the extensive approval of scientific circles at present.Because mechanism is not clear, at present all magnetotherapy appliances all can only be as health-caring equipment but not medical devices sell and use.
Simultaneously existing magnetotherapy has proposed multiple treatment mechanism, as: 1) multiple polymerization body (tumor) is disintegrated; 2) magnetic field enhances metabolism; 3) human body channels and collaterals biological electrical stream is strengthened in magnetic field; 4) tumor is directly carried out thermal therapeutical; 5) nutrition supply to tumor is reduced in magnetic field; 6) magnetic field acts on DNA is synthetic.But above-mentioned mechanism does not all have practical believable experimental result to be confirmed, corresponding mechanism research also fails to carry out, and therefore only is present in hypothesis.
Through the literature search to prior art, patent publication No. CN 101658714A, on open 2010 3.3 date, patent name is " closed dual-magnetic head gyromagnetic therapy apparatus ".In this patent, the gyromagnetic therapy system comprises magnetic head, motor-driven and drive mechanism, controlling organization, patient bed and the frame that magnet arrangements forms.This patent has been mentioned frame and the integral layout of magnetic head, driving mechanism, controlling organization etc. and the specific design and different layouts of magnetic head, but do not use nanoparticle as the necessary component of therapy system, which target generation effect does not describe to area for treatment to instrument yet simultaneously.Conceptual design in this patent is easy, but clinical therapeutic efficacy is bad.Have simultaneously that action target is indefinite, unclear, the therapeutic effect for the treatment of mechanism can't quantitatively wait technology and problem in science.On action target, this patent is claimed and can be acted on blood of human body, human nerve, collaterals of human, human cell DNA even direct effect to cancerous cell or endotrophic material.But do not have so far the science result to prove the action of a magnetic field to which kind of interior tissue site of human body, also not having scientific evidence explanation magnetic field is the impact how to produce on certain tissue of human body.Simultaneously affected by people's subjective feeling very large for its therapeutic effect, and it is qualitative, quantitative that simultaneously Biology Observation and detect and also can't find therapeutic effect, so its therapeutic effect can't carry out science.
" Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery " system summary has been published an article in " Advanced Drug Delivery Reviews " magazine in American Studies personnel Challa S.S.R.Kumar and Faruq Mohammad and 2011 method and the research direction of using magnetic nano-particle and alternating magnetic field that cancer is treated.The Therapeutic Method of the multiple use alternating magnetic field of wherein setting forth all is based on solenoid as for the infected animal body surface, perhaps around the infected animal whole body, then passes into alternating current and produce alternating magnetic field heating magnetically nanoparticle in coil.Use therein high-frequency alternating electromagnetic field is to be produced by electromagnet, its frequency at 50kHz to 10MHz, but field intensity a little less than.The variation magnetic field of using in the method has heat effect extensively to be confirmed to magnetic nano-particle, the power of this kind heat effect increases with frequency and the field intensity rising of alternating magnetic field, can cause that the medicine that the magnetic nano particle sub-surface is carried discharges simultaneously.But because its use is the electromagnetic field of high frequency, wherein magnetic force is very small to the vibrations that nanoparticle causes, this small displacement can't produce impact on the mechanics to biological tissue, and the field intensity of electromagnetic field is also because the restriction of the power of coil and alternative frequency and can not be very large simultaneously.
Relate to the alternating magnetic field that uses magnetic nano-particle and electromagnet to produce in these researchs disease is treated, but the very high (50kHz ~ 10MHz), do not use simultaneously magnet and produce magnetic field of its changes of magnetic field frequency.
There are two kinds of defectives in above-mentioned prior art: first, this utilization electronics circuit produces high-frequency alternating magnetic field, therefore higher to the designing requirement of electronic circuit, overal system design is complicated, the costliness of faking, and for guaranteeing to produce the magnetic field of sufficient intensity, needs a large amount of electric energy of consumption during operation, cause equally cost of use expensive, the expense of the room being carried out electromagnetic shielding is also very high, and owing to the complexity of electronic system, maintenance cost is corresponding raising also simultaneously; Second, this technology is owing to using the electromagnetic field of high frequency, the electromagnetic radiation of its generation is very violent, to the strong jamming of Medical Instruments generation on every side, can cause and damage together or deadlock, owing to needing to use simultaneously with multiple other medical monitoring equipment in the reality, the patient will lie on the patient bed of instrument, therefore treating the space can't seal, and the electromagnetic wave that treatment produces will directly leak into the external world, and there is very serious interference the electromagnetic field of high frequency to various Medical Instruments.
The utility model content
In order to have overcome the defective that action target is indefinite in the gyromagnetic therapy of the prior art, treatment mechanism is indefinite, therapeutic effect can not be quantitative, the utility model proposes a kind of gyromagnetic therapy system based on magnetic nano-particle.Introduce magnetic nano-particle in this system as the direct acting target of rotating excitation field, its treatment target and treatment mechanism are clear and definite, can be desirable be applied in the gyromagnetic therapy therapy of use magnetic nano-particle as the treatment target based on rotary magnet.
The purpose of this utility model is to provide a kind of gyromagnetic therapy system based on magnetic nano-particle.
Gyromagnetic therapy system based on magnetic nano-particle of the present utility model comprises: magnetic nano-particle, n group magnetic field loading system, therapeutic bed and frame; Wherein, therapeutic bed horizontal positioned; Magnetic nano-particle is injected into and is placed on being treated in the body on the therapeutic bed; N group magnetic field loading system is installed on the frame relatively or round therapeutic bed, and wherein, n is natural number.
Magnetic nano-particle is the particle of magnetic material, and the size of at least one direction is less than 100 nanometers.One or more kinds of alloys, chemical compound or mixture in the magnetic material of material employing ferroso-ferric oxide, iron sesquioxide, neodymium iron boron and the ferrocobalt etc. of magnetic nano-particle; Its structure is a kind of in nano-particle, nanometer rods, nano wire and the nanoshell, or a kind of in multilamellar shell structurre and the cagelike structure; Its finishing and functionalization adopt a kind of without in modifications, PEG parcel, Electrostatic Absorption parcel, Silica-coated, dendrimer parcel, antibody modification, bioprotein modification, biological polyoses and glycoprotein modification and the modification of medicine macromole etc.
This utility model adopts n group magnetic field loading system that the magnetic field of the alternation of low frequency is provided for magnetic nano-particle, and wherein, n is natural number.If adopt one group of magnetic field loading system, then loading system relative patient bed in magnetic field is installed on the frame; If adopt two groups of above magnetic field loading systems, then the magnetic field loading system is installed on the frame equably round patient bed.Each group in the loading system of n group magnetic field comprises magnetic head and drive system, the rotation of drive systems magnetic head, thereby the magnetic field that produces alternation.
Magnetic head comprises k piece magnet and magnetic conductive board; K piece magnet is installed on the magnetic conductive board; Magnetic conductive board is made by permeability magnetic material; The direction in the magnetic field of k piece magnet and magnetic conductive board at right angle setting thereon, and the N of half magnet in the k piece magnet is extremely outside, the S of half magnet is extremely outside, wherein, k is positive even numbers.
Magnet can be permanent magnet, also can be electric magnet.
Drive system comprises: swingle, bearing, drive mechanism and motor; Wherein, the magnetic conductive board of magnetic head is installed on the end of swingle; At swingle bearing is set, on the bearing fixed frame; The other end of swingle links to each other with motor by drive mechanism, thereby motor drives the swingle rotation by drive mechanism, and drives the magnetic head rotation.
Drive mechanism is a kind of in conveyer belt, driving belt, driving chain and the travelling gear.
The operation principle of therapy system of the present utility model is: magnetic nano-particle is injected into and is placed on being treated in the body on the therapeutic bed, and magnetic nano-particle is introduced in and is treated body as the target of the action of a magnetic field of alternation.By the magnetic nano-particle arrival affected area that circulates in vivo, because the character of magnetic nano-particle itself and bio-modification etc. produce specific gathering at affected area.Magnetic nano-particle is attached to cancer or disease cell, is attached to cell surface or by cancer cell or disease cell endocytic, forms the labelling to focus.Because its specificity, so magnetic nano-particle can not produce gathering and injury at health tissues.The magnetic field loading system produces the magnetic field of alternation, and magnetic nano-particle is subject to the effect of the magnetic force of different directions, on the mechanics pathological tissues is produced destruction.Simultaneously, frequently polarization and depolarization so that magnetic nano-particle itself with the Conversion of energy in magnetic field be internal energy give birth to hot.Because cancer cell is more responsive to variation of ambient temperature, therefore reaches in the temperature part can produce the disease cell that comprises cancer cell more than 42 degrees centigrade and kill and wound.Because comfortable local generation of use therein magnetic nano-particle assembled, so therapeutic domain can very accurate and not injure normal structure.
Therapy system of the present utility model is large for chemotherapy and radiation means side effect in the treatment of cancer, the operation means can not be finished whole body and the Design of Problems that target is indefinite, treatment mechanism is indefinite, therapeutic effect can not be quantitative is treated in the treatment of smile focus, magnetics treatment.Therapy system of the present utility model is specifically designed to the treatment of various cancers, but native system is theoretical owing to it and the superiority of effect, and the various needs that also can be applied in outside the cancer kill in the treatment for diseases of particular organisms cell, tissue, organ.
Because this utility model uses mechanical rotary magnet, the magnetic field that therefore produces the alternation of low frequency does not need the room is carried out electromagnetic shielding.And this utility model employing permanent magnet, the magnetic field intensity of permanent magnet own is very high, can produce high-intensity magnetic field, reaches good therapeutic effect.
This utility model is injected directly into the animal of needs treatment or being treated in the body of patient with magnetic nano-particle as the treatment target, thereby magnetic nano-particle can be by the in vivo affected area formation gathering of modification of surface specific, under the magnetic field of alternation by produce high heat and to cell, organize the effect of generation power and kill cancer cell reaches therapeutic effect.Therapy system of the present utility model, the action of a magnetic field target is clear and definite, and clear and definite in the therapy apparatus, therapeutic effect can carry out quantitative analysis.
Advantage of the present utility model:
A most outstanding advantage of this utility model is that magnetic nano-particle is incorporated in the system as the treatment target, makes the target of gyromagnetic therapy clearer and more definite, and treatment mechanism is clearer and more definite, therapeutic effect more obviously, can be quantitative.Compare and do not adopt magnetic nano-particle as the gyromagnetic therapy system of target, because magnetic nano-particle can produce corresponding the gathering by the affected area in patient or model animal body, therefore more concentrated to mechanical function and Sheng Re that magnetic nano-particle produces by magnetic field, can better treat the focus part and do not injure human normal biological tissue.Thereby therapy system of the present utility model can reach better therapeutic effect and better safety.
Another advantage has been to reduce the cost of instrument manufacturing.The hardware designs of therapy system of the present utility model is more simple, uses convenient.Do not need complicated electronics circuit that the parameters such as the vibration frequency of electromagnetic field, amplitude are accurately controlled in hardware manufacturing, manufacturing cost can reduce more than 50%, and the hardware maintenance cost is also lower simultaneously.
Another advantage is that the electromagnetic radiation of instrument generation itself is lower.The alternating electric field that do not use of therapy system of the present utility model produces strong alternating magnetic field, simultaneously, because its frequency of alternating magnetic field that the design of use machine driving rotary magnet itself produces is below 2KHz.And using the therapy equipment of alternating electromagnetic field, its electronics circuit is accurately controlled parameters such as the vibration frequency of electromagnetic field, amplitudes, but frequency is all more than 1MHz.Powerful high-frequency alternating electromagnetic field will produce the interference of can not ignore to other armarium, cause fault and the damage of other armarium in the hospital, thereby limit the use of using the therapy system itself of electromagnet and alternating electromagnetic field.
Description of drawings
Fig. 1 is the structural representation of the embodiment one of the gyromagnetic therapy system based on magnetic nano-particle of the present utility model;
Fig. 2 is the structural representation of the embodiment two of the gyromagnetic therapy system based on magnetic nano-particle of the present utility model;
Fig. 3 is the schematic diagram of an embodiment of the magnetic head of the gyromagnetic therapy system based on magnetic nano-particle of the present utility model, (a) is the front view of magnetic head, (b) is the side view of magnetic head.
The specific embodiment
Below in conjunction with accompanying drawing, by specific embodiment, further set forth this utility model.
Embodiment one
In the present embodiment, adopt one group of magnetic field loading system, magnet adopts permanent magnet.
As shown in Figure 1, the gyromagnetic therapy system based on magnetic nano-particle of the present utility model comprises: magnetic nano-particle, magnetic field loading system, therapeutic bed 2 and frame 3; Wherein, therapeutic bed 2 horizontal positioned; Magnetic nano-particle is injected into and is placed on being treated in the body on the therapeutic bed 2; Loading system relative therapeutic bed in magnetic field is installed on the frame 3.The magnetic field loading system comprises magnetic head 11 and drive system.Drive system comprises: swingle 121, bearing 122, drive mechanism 123 and motor 124.The magnetic conductive board of magnetic head 11 is installed on the end of swingle 121; At swingle bearing 122 is set, on bearing 122 fixed frames 3; The other end of swingle 121 links to each other with motor 124 by drive mechanism 123, thereby motor 124 drives swingle 121 rotations by drive mechanism 123, and drives magnetic head 11 rotations.
As shown in Figure 3, magnetic head 11 comprises k piece permanent magnet 111 and magnetic conductive board 112; K piece permanent magnet 111 is installed on the magnetic conductive board 112.Magnetic conductive board 112 is made by permeability magnetic material.The direction in the magnetic field of k piece permanent magnet 111 and magnetic conductive board 112 at right angle settings thereon, and the N of half permanent magnet in the k piece permanent magnet 111 is extremely outside, the S of half permanent magnet is extremely outside, wherein, k is even number.
In the present embodiment, frame is equipped with roller 3 times, and convenient carrying is carried.
The control method of the therapy system in the present embodiment: in being treated body, inject magnetic nano-particle, wait for and lying on the back on therapeutic bed 2 after one hour; Open total power switch, move by therapeutic bed 2, adjust the instrument position, make magnetic head 11 be positioned at the position of the focus that is treated body, rotating speed is adjusted in actuating motor 124 rotations, and the treatment rotating speed is generally at 100 rev/mins to 2000 rev/mins; Select treatment time according to patient's state of an illness, the general treatment time is between 30 minutes to 2 hours; Treatment finishes, and closes all electric switches, treats that the patient leaves therapeutic bed.
Embodiment two
In the present embodiment, adopt 4 groups of magnetic field loading systems, magnet adopts permanent magnet.
As shown in Figure 2, the gyromagnetic therapy system based on magnetic nano-particle of the present utility model comprises: magnetic nano-particle, magnetic field loading system 1, therapeutic bed 2 and frame 3; Wherein, therapeutic bed 2 horizontal positioned; Magnetic nano-particle is injected into and is placed on being treated in the body on the therapeutic bed 2; It is that 1 system is installed on the frame 3 equably round therapeutic bed 2 that magnetic field loads.The magnetic field loading system comprises magnetic head 11 and drive system 12.Drive system 12 comprises: swingle 121, bearing 122, drive mechanism 123 and motor 124.The magnetic conductive board of magnetic head 11 is installed on the end of swingle 121; At swingle bearing 122 is set, on bearing 122 fixed frames 3; The other end of swingle 121 links to each other with motor 124 by drive mechanism 123, thereby motor 124 drives swingle 121 rotations by drive mechanism 123, and drives magnetic head 11 rotations.
In the present embodiment, frame 3 is directly fixing with ground, guarantees stabilization of equipment performance.
The control method of the therapy system in the present embodiment: in being treated body, inject magnetic nano-particle, wait for and lying on the back on therapeutic bed 2 after one hour; Open total power switch, move by therapeutic bed 2, adjust the instrument position, make magnetic head 11 be positioned at the position of the focus that is treated body, rotating speed is adjusted in actuating motor 124 rotations, and the treatment rotating speed is generally at 100 rev/mins to 2000 rev/mins; Select treatment time according to patient's state of an illness, the general treatment time is between 30 minutes to 2 hours; Treatment finishes, and closes all electric switches, treats that the patient leaves therapeutic bed.
In the embodiment that proposes, can substitute the function that permanent magnet is realized system by electric magnet in the above, be mainly reflected in electric current and can produce magnetic field by solenoid.Use electric magnet to replace permanent magnet to be rotated, can be better controlled by magnetic field intensity and the Distribution of Magnetic Field of electronic system to electric magnet, but system energy consumption is higher, manufacturing expense is more expensive.Simultaneously, the electric field that brings out of alternating magnetic field may produce electromagnetic interference to other armarium.
It should be noted that at last, the purpose of publicizing and implementing example is to help further to understand this utility model, but it will be appreciated by those skilled in the art that: in the spirit and scope that do not break away from this utility model and appended claim, various substitutions and modifications all are possible.Therefore, this utility model should not be limited to the disclosed content of embodiment, and the claimed scope of this utility model is as the criterion with the scope that claims define.
Claims (9)
1. a gyromagnetic therapy system is characterized in that, described gyromagnetic therapy system comprises: magnetic nano-particle, n organize magnetic field loading system (1), therapeutic bed (2) and frame (3); Wherein, therapeutic bed (2) horizontal positioned; Magnetic nano-particle is injected into and is placed on being treated in the body on the therapeutic bed (2); N group magnetic field loading system (1) is installed on the frame (3) relatively or round therapeutic bed, and wherein, n is natural number.
2. gyromagnetic therapy as claimed in claim 1 system is characterized in that, described magnetic nano-particle is the particle of magnetic material, and the size of at least one direction is less than 100 nanometers.
3. gyromagnetic therapy as claimed in claim 2 system is characterized in that, the material of described magnetic nano-particle adopts a kind of or two or more in the magnetic material of ferroso-ferric oxide, iron sesquioxide, neodymium iron boron and ferrocobalt.
4. gyromagnetic therapy as claimed in claim 2 system is characterized in that, the structure of described magnetic nano-particle is a kind of in nano-particle, nanometer rods, nano wire and the nanoshell, or a kind of in multilamellar shell structurre and the cagelike structure.
5. gyromagnetic therapy as claimed in claim 2 system, it is characterized in that, the finishing of described magnetic nano-particle and functionalization adopt a kind of without in modifications, PEG parcel, Electrostatic Absorption parcel, Silica-coated, dendrimer parcel, antibody modification, bioprotein modification, biological polyoses and glycoprotein modification and the modification of medicine macromole.
6. gyromagnetic therapy as claimed in claim 1 system is characterized in that, each group in the loading system of described n group magnetic field comprises magnetic head (11) and drive system (12), described drive systems magnetic head rotation, thereby the magnetic field of generation alternation.
7. gyromagnetic therapy as claimed in claim 6 system is characterized in that, described magnetic head (11) comprises k piece magnet (111) and magnetic conductive board (112), and described k piece magnet (111) is installed on the magnetic conductive board (112); Described magnetic conductive board (112) is made by permeability magnetic material; The direction in the magnetic field of described k piece magnet (111) and magnetic conductive board (112) at right angle setting thereon, and the N of half magnet in the described k piece magnet (111) is extremely outside, the S of half magnet is extremely outside, wherein, k is even number.
8. gyromagnetic therapy as claimed in claim 6 system is characterized in that, described drive system comprises: swingle (121), bearing (122), drive mechanism (123) and motor (124); Described magnetic head (11) is installed on the end of described swingle (121); At described swingle (121) bearing (122) is set, on described bearing (122) fixed frame (3); The other end of described swingle (121) links to each other with described motor (124) by described drive mechanism (123), thereby described motor (124) drives swingle (121) rotation by drive mechanism (123), and drives described magnetic head (11) rotation.
9. gyromagnetic therapy as claimed in claim 8 system is characterized in that, described drive mechanism is a kind of in conveyer belt, driving belt, driving chain and the travelling gear.
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| CN 201220455758 CN202761918U (en) | 2012-09-07 | 2012-09-07 | Gyromagnet treatment system based on magnetic nanoparticles |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102814004A (en) * | 2012-09-07 | 2012-12-12 | 北京大学 | Gyromagnet treatment system based on magnetic nanoparticles |
| CN103656861A (en) * | 2013-12-26 | 2014-03-26 | 山东赫希尔医械有限公司 | Magnet high in magnetic flux and gyromagnetic therapeutic machine using the magnet |
| CN112587812A (en) * | 2020-12-14 | 2021-04-02 | 哈尔滨工程大学 | Heat seed containing self-temperature-control magnetic nanowires for magnetic thermal therapy and manufacturing method thereof |
-
2012
- 2012-09-07 CN CN 201220455758 patent/CN202761918U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102814004A (en) * | 2012-09-07 | 2012-12-12 | 北京大学 | Gyromagnet treatment system based on magnetic nanoparticles |
| CN103656861A (en) * | 2013-12-26 | 2014-03-26 | 山东赫希尔医械有限公司 | Magnet high in magnetic flux and gyromagnetic therapeutic machine using the magnet |
| CN103656861B (en) * | 2013-12-26 | 2016-04-27 | 山东赫希尔医械有限公司 | High magnetic flux magnet and use the rotating magnetism therapeutic machine of this magnet |
| CN112587812A (en) * | 2020-12-14 | 2021-04-02 | 哈尔滨工程大学 | Heat seed containing self-temperature-control magnetic nanowires for magnetic thermal therapy and manufacturing method thereof |
| CN112587812B (en) * | 2020-12-14 | 2022-11-25 | 哈尔滨工程大学 | Heat seed containing self-temperature-control magnetic nanowires for magnetic thermal therapy and manufacturing method thereof |
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