CN202717730U - Production equipment of rebamipide - Google Patents
Production equipment of rebamipide Download PDFInfo
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- CN202717730U CN202717730U CN 201220281737 CN201220281737U CN202717730U CN 202717730 U CN202717730 U CN 202717730U CN 201220281737 CN201220281737 CN 201220281737 CN 201220281737 U CN201220281737 U CN 201220281737U CN 202717730 U CN202717730 U CN 202717730U
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Abstract
The utility model relates to production equipment of rebamipide. The production equipment comprises synthesis equipment, refining equipment and post-treatment equipment, wherein the synthesis equipment comprises a dissolving kettle, an acylation kettle and an acidification kettle; the refining equipment comprises a decolorizing kettle and a crystallization kettle; the post-treatment equipment comprises a vacuum drying box, a crusher and a mixer; the dissolving kettle, the acylation kettle, the acidification kettle, the decolorizing kettle, the crystallization kettle, the vacuum drying box, the crusher and the mixer are arranged in sequence; the dissolving kettle is connected to the acylation kettle via a first filter through a pipeline; the acylation kettle is connected to the acidification kettle via a second filter through a pipeline; the acidification kettle is connected to a third filter; the decolorizing kettle is connected to the crystallization kettle via a fourth filter and a microporous membrane filter through a pipeline; and the crystallization kettle is connected to a fifth filter. The production equipment has the advantages of rational structural design, low energy consumption, low cost, environmental friendliness and the like; and a prepared product has high yield and high quality.
Description
Technical field
The utility model relates to the production unit of a cover medicine, especially relates to the production unit of a cover rebamipide.
Background technology
Rebamipide is a kind of quinolone compounds, and it can improve gastric motility, and the gastric mucosa injury that stomach ulcer, acute gastritis or chronic gastritis acute exacerbation are caused has unusual effect.Its chemical name is 2-(4-chloro-benzoyl amino)-3-(1,2-dihydro-2-oxo--4-quinolyl) propionic acid, and molecular formula is C
19H
15ClN
2O
4, molecular weight is 370.072, molecular structural formula is as follows:
Glass-lined equipment is that the enamel that silicon content is high is applied to the metallic surface, by 950 ℃ of enamel firings, the enamel adherence is made in metallic iron tire surface.Therefore, it has the two-fold advantage of the glazed chemical stability of class and metal strength.Glass-lined equipment mainly comprises retort, storage tank, retort, condenser etc., it is widely used in the reaction, evaporation in the industrial production such as chemical industry, medicine, dyestuff, agricultural chemicals, organic synthesis, oil, food mfg and national defense industry and the scientific research, concentrated, synthetic, extraction, polymerization, saponification, mineralising, chlorination, nitrated etc., to replace expensive stainless steel and non-ferrous metal.
The equipment of traditional mode of production rebamipide is because design is unreasonable, and required equipment relates to more multiple, and the pipeline between the equipment connects loaded down with trivial details, and energy consumption is large, and cost is high, and the product yield of prepared rebamipide is low, and quality is also barely satisfactory.
The utility model content
Technical problem to be solved in the utility model has been to provide a cover to utilize lass lining dissolving vessel, retort etc. to produce the equipment of rebamipide.
The production unit of one cover rebamipide, described production unit comprises synthesis device, purification apparatus and finishing apparatus, described synthesis device comprises dissolution kettle, acidylate still and acidifying still, described purification apparatus comprises decolouring still and crystallization kettle, described finishing apparatus comprises vacuum drying oven, pulverizer and mixing machine, described dissolution kettle, the acidylate still, the acidifying still, the decolouring still, crystallization kettle, vacuum drying oven, pulverizer and mixing machine arrange in turn, described dissolution kettle is connected to the acidylate still by pipeline through the first strainer, the acidylate still is connected to the acidifying still by pipeline through the second strainer, and the acidifying still is connected to the 3rd strainer; The decolouring still is connected to crystallization kettle by pipeline through the 4th strainer and microporous membrane filters, and crystallization kettle is connected to the 5th strainer; The acidylate still is communicated with solvent header tank and raw material header tank by pipeline, and the acidifying still is communicated with sour header tank by pipeline, and crystallization kettle is communicated with the recrystallisation solvent header tank by pipeline.
Preferably, described the first strainer is vacuumfilter, second, third, the 5th strainer is whizzer, the 4th strainer is suction filter.
Preferably, described the 3rd strainer is connected to the waste water geosyncline, and the waste water geosyncline connects water treatment station by pipeline through the waste water transferpump.Avoided the pollution of the waste water and waste liquid in the production process.
Preferably, be provided with microporous membrane filters before the described recrystallisation solvent header tank.The particulate and the bacterium that are used for the filtering recrystallisation solvent.
Preferably, described dissolution kettle, acidylate still, acidifying still, decolouring still and crystallization kettle are glass-lined equipment.
Preferably, be connected with a condenser and a water cooler on the described acidylate still.Has good cooling performance.
Preferably, described acidylate still is connected with the solvent Receiving bin by pipeline.Reacted solvent reclaims through the solvent Receiving bin, has avoided the waste of solvent.
Preferably, described the 5th strainer is connected to the mother liquor geosyncline by pipeline.The filtrate of gained is recycled in the mother liquor geosyncline after filtering.
The utlity model has reasonable in design, the advantages such as energy consumption is little, cost is low, environmental protection, prepared product yield is high, quality is good.
Description of drawings
Fig. 1 is structural representation of the present utility model.
Embodiment
The utility model is described in further detail below in conjunction with the drawings and specific embodiments, but protection domain of the present utility model is not limited to this.
With reference to Fig. 1; one cover is produced the equipment of rebamipide; comprise synthesis device; purification apparatus and finishing apparatus; described synthesis device comprises lass lining dissolution kettle 1; be connected with lass lining acidylate still 2 and the lass lining acidifying still 3 of a condenser 22 and water cooler 23; described purification apparatus comprises lass lining decolouring still 4 and lass lining crystallization kettle 5; described finishing apparatus comprises vacuum drying oven 6; pulverizer 7 and V-type high efficient mixer 8, lass lining dissolution kettle 1; lass lining acidylate still 2; lass lining acidifying still 3; lass lining decolouring still 4; lass lining crystallization kettle 5; vacuum drying oven 6; pulverizer 7 and V-type high efficient mixer 8 arrange in turn.
Lass lining dissolution kettle 1 is connected to lass lining acidylate still 2 by pipeline through vacuumfilter 9, and lass lining acidylate still 2 is connected to lass lining acidifying still 3 by pipeline through whizzer 10, and lass lining acidifying still 3 is connected to whizzer 11; Lass lining decolouring still 4 is connected to lass lining crystallization kettle 5 by pipeline through suction filter 12 and microporous membrane filters 21, and lass lining crystallization kettle 5 is connected to whizzer 13; Lass lining acidylate still 2 is communicated with solvent header tank 14 and raw material header tank 15 by pipeline; lass lining acidifying still 3 is communicated with sour header tank 16 by pipeline; lass lining crystallization kettle 5 is communicated with recrystallisation solvent header tank 17 by pipeline, is provided with microporous membrane filters 25 before the recrystallisation solvent header tank 17.
Whizzer 11 is connected to waste water geosyncline 18, and the waste liquid in the waste water geosyncline 18 is delivered to waste water processing station 20 by waste water transferpump 19.Lass lining acidylate still 2 is connected with solvent Receiving bin 24 by pipeline.Whizzer 13 is connected to mother liquor geosyncline 25 by pipeline.
Equipment use aborning: in lass lining dissolution kettle 1, add a certain amount of solvent; stir the lower raw material that adds; heating makes its dissolving; filter and filtrate is evacuated in the lass lining acidylate still 2 through vacuumfilter 9 while hot; open cold condenser 22 and water cooler 23; make filtrate reach temperature required; stir lower to raw material header tank 15 adding acidylate raw materials; react complete after; through whizzer 10 centrifugings; filtrate is evacuated in the lass lining acidifying still 3; add after a certain amount of acid solution carries out acidifying by sour header tank 16, it is centrifugal that material is put into whizzer 11, and filter cake is washed till neutrality; get rebamipide crude product, filtrate is delivered to waste water processing station 20 by waste water transferpump 19.
Add rebamipide crude product and solvent in the lass lining decolouring still 4, heating makes its dissolving, and add a certain amount of discoloring agent and decolour, through suction filter 12 filtering discoloring agents, filtrate after filtering, microporous membrane filters 21 is evacuated in the lass lining crystallization kettle 5, add required recrystallisation solvent by recrystallisation solvent header tank 17, make rebamipide crystallization in lass lining crystallization kettle 5.After the crystallization, material is centrifugal through whizzer 13, and filtrate is evacuated in the mother liquor geosyncline 25, and filter cake is after washing, and it is dry to put into vacuum drying oven 6, and dry product mixes through the V-type high efficient mixer after pulverizer is pulverized again.
The utility model energy-conserving and environment-protective, reasonable in design, prepared product yield is high, quality is good.
Claims (8)
- One the cover rebamipide production unit, described production unit comprises synthesis device, purification apparatus and finishing apparatus, described synthesis device comprises dissolution kettle, acidylate still and acidifying still, described purification apparatus comprises decolouring still and crystallization kettle, described finishing apparatus comprises vacuum drying oven, pulverizer and mixing machine, it is characterized in that: described dissolution kettle, the acidylate still, the acidifying still, the decolouring still, crystallization kettle, vacuum drying oven, pulverizer and mixing machine arrange in turn, described dissolution kettle is connected to the acidylate still by pipeline through the first strainer, the acidylate still is connected to the acidifying still by pipeline through the second strainer, and the acidifying still is connected to the 3rd strainer; The decolouring still is connected to crystallization kettle by pipeline through the 4th strainer and microporous membrane filters, and crystallization kettle is connected to the 5th strainer; The acidylate still is communicated with solvent header tank and raw material header tank by pipeline, and the acidifying still is communicated with sour header tank by pipeline, and crystallization kettle is communicated with the recrystallisation solvent header tank by pipeline.
- 2. the production unit of rebamipide according to claim 1, it is characterized in that: described the first strainer is vacuumfilter, second, third, the 5th strainer is whizzer, the 4th strainer is suction filter.
- 3. the production unit of rebamipide according to claim 1, it is characterized in that: described the 3rd strainer is connected to the waste water geosyncline, and the waste water geosyncline is connected to waste water processing station by pipeline through the waste water transferpump.
- 4. the production unit of rebamipide according to claim 1 is characterized in that: be provided with microporous membrane filters before the described recrystallisation solvent header tank.
- 5. the production unit of rebamipide according to claim 1 is characterized in that: described dissolution kettle, acidylate still, acidifying still, decolouring still and crystallization kettle are glass-lined equipment.
- 6. the production unit of rebamipide according to claim 1 is characterized in that: be connected with a condenser and a water cooler on the described acidylate still.
- 7. the production unit of rebamipide according to claim 1, it is characterized in that: described acidylate still is connected with the solvent Receiving bin by pipeline.
- 8. the production unit of rebamipide according to claim 1, it is characterized in that: described the 5th strainer is connected to the mother liquor geosyncline by pipeline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220281737 CN202717730U (en) | 2012-06-15 | 2012-06-15 | Production equipment of rebamipide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220281737 CN202717730U (en) | 2012-06-15 | 2012-06-15 | Production equipment of rebamipide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202717730U true CN202717730U (en) | 2013-02-06 |
Family
ID=47619559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220281737 Expired - Lifetime CN202717730U (en) | 2012-06-15 | 2012-06-15 | Production equipment of rebamipide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202717730U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349181A (en) * | 2016-05-09 | 2017-11-17 | 四川科伦药物研究院有限公司 | Ophthalmology water slurry containing Rebamipide and PVP and preparation method thereof |
-
2012
- 2012-06-15 CN CN 201220281737 patent/CN202717730U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349181A (en) * | 2016-05-09 | 2017-11-17 | 四川科伦药物研究院有限公司 | Ophthalmology water slurry containing Rebamipide and PVP and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20130206 |