CN202676527U - Droplet-droplet micro-extraction device - Google Patents
Droplet-droplet micro-extraction device Download PDFInfo
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- CN202676527U CN202676527U CN 201220318815 CN201220318815U CN202676527U CN 202676527 U CN202676527 U CN 202676527U CN 201220318815 CN201220318815 CN 201220318815 CN 201220318815 U CN201220318815 U CN 201220318815U CN 202676527 U CN202676527 U CN 202676527U
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Abstract
The utility model discloses a droplet-droplet micro-extraction device, which comprises a piezoelectric substrate and a signal generation device, wherein one surface of the piezoelectric substrate is a working surface, two opposite sides of the working surface are provided with a first interdigital transducer and a first reflecting grating, the first interdigital transducer is connected with the signal generation device, the working surface is provided with a hydrophobic film which is provided with a through hole, the through hole and partial working surface corresponding to the through hole constitute a droplet holding cavity for holding extract liquid to be extracted and an organic solvent, and the droplet holding cavity is located on an acoustic propagation path of surface acoustic waves excited by the first interdigital transducer. The droplet-droplet micro-extraction device has the advantages that a micro-extraction process is completed by using the acoustic surface waves excited by the first interdigital transducer and the acoustic surface waves reflected back by the first reflecting grating, so that not only can extraction speed and extraction performance be improved, but also an extra stirring device does not need to be used, so that the droplet-droplet micro-extraction device is simple in structure, reliable in work and easy for integration and can be applied to microflow chips for micro-extraction.
Description
Technical field
The utility model relates to a kind of micro-extraction technique, especially relates to a kind of drop-liquid drop micro-extractor.
Background technology
Liquid-liquid micro-extraction is one of the most frequently used Sample Pretreatment Technique of biochemical analysis, and it is the difference of utilizing the solubleness of material in immiscible solvent, the technology that extracts in the solution that material is formed from it and another kind of solvent with a kind of solvent.There are the weak points such as organic solvent-oil ratio is large, extraction time is long in traditional liquid-liquid micro-extracting method.The shortcoming that exists for solving traditional liquid-liquid micro-extracting method has proposed single drop micro-extracting method.The modal form of single drop micro-extracting method is directly to immerse organic solvent in the sample aqueous solution, organic solvent adopts the microsyringe syringe needle to immerse and deposits in the sample aqueous solution of flask, organic solvent hangs on the syringe needle, continuous stirred sample aqueous solution, accelerate extraction process, after reaching extraction equilibrium, the organic solvent drop is drawn in the microsyringe, carries out the subsequent instrumentation analysis.Single drop micro-extracting method of this form has been applied to environment measuring, biochemical analysis etc.Yet because organic solvent hangs on and directly enters on the syringe needle in the aqueous phase solution, therefore single drop micro-extracting method of this form is only applicable to contain extraction nonpolar or middle polarity analyte liquid sample; On the other hand, for accelerating rate of extraction, reducing extraction time, often need stirring apparatus, increased like this experimental provision volume and Operating Complexity.The instability of extractant on needle point that causes for the stirring rod that overcomes in the stirring apparatus, there is report to adopt rotary flask to replace stirring rod, can accelerate extraction process, can improve again that extractant rocks issuable instability because of stirring on the needle point, the extraction experiments device is simpler in addition, and cross pollution is less.
Head space list drop micro-extraction (HS-SDME) method has obtained fast development after calendar year 2001 proposes, it is that organic drop is positioned in the aqueous sample.Although the method can not affect the stability of organic drop when the rapid stirring sample, it almost is only applicable to effumability or half volatile analyte.
Continuous stream micro-extraction (CFME) method is to grow up on the basis of traditional single drop micro-extracting method, it is to adopt pump to flow in passage with certain flow rate aqueous sample, the organic solvent drop is injected in the passage by traditional introduction valve, Realization analysis thing extraction in the aqueous sample flow process.The method can make the volume consumption of sample larger, can make simultaneously the size of corresponding continuous stream current micro-extraction system larger.
In order further to reduce sample volume, drop-drop current micro-extraction system has been proposed.Utilize that this drop-when the drop current micro-extraction system carried out micro-extraction, extractant hung on the needle point of microsyringe, after finishing extraction, extractant is absorbed in the microsyringe, and inject gas chromatograph is analyzed.This micro-extracting method is so that sample volume reduces to 7 microlitres, and the extractant volume has reduced to 0.5 microlitre.Although its principle of work is similar to single drop micro-extracting method of direct immersion, the method has clear superiority: rate of extraction is fast, sample volume is little, drop good stability and simple operation and other advantages.Thereby, the method be applied in pharmacokinetics, the beer that caffeine detects and foodstuff samples in nicotine detection etc.
With respect to traditional liquid-liquid micro-extracting method, existing drop-drop micro-extracting method can greatly reduce the consumption of organic solvent and shorten extraction time, but often all need mechanical hook-up to stir extract, or adopt rotary flask to improve extraction process, thereby extraction equipment is difficult to miniaturization, can not be applied on the microfluidic device.Such as periodical " analytical chemistry " 1707-1712 page or leaf (Analytical Chemistry in 2006, Vol. 78, No. 5,2006 1707-1712) employing ionization and ion/molecular reaction method are disclosed, in conjunction with drop-drop organic solvent micro-extraction and gas chromatography/mass spectrum determine methoxyacetophenone in the water drop isomers ("
Combining Drop-to-Drop Solvent Microextraction with Gas Chromatography/Mass Spectrometry Using Electronic Ionization and Self-Ion/Molecule Reaction Method To Determine Methoxyacetophenone Isomers in One Drop of Water"), the disclosed drop of this paper-drop micro-extracting method is to be that isomers aqueous solution 7 microlitres of three kinds of methoxyacetophenones of 10ppm are put into the bottle that volume is 100 microlitres with concentration, bottleneck adopts screw-cap and teflon diaphragm seal, microsyringe passes barrier film, and fill 1 microlitre organic solvent at the needle point of microsyringe, wherein 0.5 microlitre organic solvent hangs on needle point and is exposed in the sample liquid to be extracted, after extraction is finished, organic solvent sucks back in the microsyringe, carries out the general detection of follow-up gas chromatography or quality.This extracting process is for improving rate of extraction and extraction degree, and bottle is placed on the stirrer, and fast rotational realizes the improvement of extraction ability.Although the used organic solvent of this extracting process is less, needs the equipment such as stirrer, thereby be not easy to the micro flow chip application; Simultaneously, although with respect to traditional liquid-liquid micro-extracting method, its rate of extraction makes moderate progress, and extraction ability still remains further to be improved.
Summary of the invention
Technical problem to be solved in the utility model provides a kind of simple in structure, reliable operation, and drop-liquid drop micro-extractor that rate of extraction is fast, extraction ability is good.
The utility model solves the problems of the technologies described above the technical scheme that adopts: a kind of drop-liquid drop micro-extractor, it is characterized in that comprising piezoelectric substrate and signal generation apparatus, one surface of described piezoelectric substrate is working surface, one side of described working surface is provided be used to the first interdigital transducer that excites surface acoustic wave, the opposite side of described working surface is provided be used to the first reflecting grating that reflects the surface acoustic wave that described the first interdigital transducer excites, described the first interdigital transducer is connected with described signal generation apparatus, be provided with hydrophobic film on the described working surface, be provided with through hole on the described hydrophobic film, be connected with described working surface at the bottom of the hole of described through hole, described through hole and consist of a drop that is used for putting extract to be extracted and organic solvent with the some work of its correspondence position surface and put the chamber, described drop are put the chamber and are positioned on the acoustic propagation path of the surface acoustic wave that described the first interdigital transducer excites.
Described piezoelectric substrate is LiNbO
3Piezoelectric substrate.
Described signal generation apparatus mainly is comprised of with the power amplifier that is connected with described signal generator the signal generator for generation of the RF electric signal, and described power amplifier is connected with described the first interdigital transducer.
Described the first interdigital transducer comprises two the first bus-bars, and described the first bus-bar is connected with described power amplifier.
Another surface of described piezoelectric substrate is connected with the wire web joint, is provided with the connection pin on the described wire web joint, described connection pin respectively by wire and described the first bus-bar be connected power amplifier and be connected.
Described hydrophobic film is to apply the film that one deck Teflon AF1600 hydrophobic material forms at described working surface.
The thickness of described hydrophobic film is more than or equal to 1 μ m and is less than or equal to 3 μ m.
Be provided with on the described working surface be used to the second reflecting grating that reduces described signal generation apparatus and output to the RF electric signal power on described the first interdigital transducer, described the second reflecting grating and described the first reflecting grating are oppositely arranged, and described the second reflecting grating is positioned at the outside of described the first interdigital transducer.
Be provided with on the described working surface be used to the second interdigital transducer that reflects the surface acoustic wave that described the first interdigital transducer excites, described the second interdigital transducer and described the first interdigital transducer are oppositely arranged, described hydrophobic film is between described the second interdigital transducer and described the first interdigital transducer, and described the second interdigital transducer is positioned at the inboard of described the first reflecting grating.
Described the first interdigital transducer, described the second interdigital transducer, described the first reflecting grating and described the second reflecting grating all adopt microelectronic technique to be made on the described working surface.
Compared with prior art, the utility model has the advantage of:
1) this device is finished the micro-extraction process by the surface acoustic wave that utilizes the first interdigital transducer and excite and the surface acoustic wave of the first reflecting grating reflection, and need not to utilize extra mechanical stirring device, not only so that simple in structure, the reliable operation of this device, and so that this device is easy to integratedly, can be applicable to micro flow chip and carry out micro-extraction.
2) the surface acoustic wave acting in conjunction that is reflected back of the surface acoustic wave that excites by the first interdigital transducer of this device and the first reflecting grating is on extract and organic solvent, can be so that extract and organic solvent rapid movement, thus can improve rate of extraction and extraction ability.
Description of drawings
Fig. 1 is the structural representation of the utility model device.
Embodiment
Embodiment is described in further detail the utility model below in conjunction with accompanying drawing.
As shown in the figure, a kind of drop-liquid drop micro-extractor, comprise piezoelectric substrate 1 and signal generation apparatus 2, signal generation apparatus 2 is mainly by for generation of RF(Radio Frequency, radio frequency) signal generator 21 of electric signal forms with the power amplifier 22 that is connected with signal generator 21, one surface of piezoelectric substrate 1 is working surface 11, one side of working surface 11 is provided be used to the first interdigital transducer 31 that excites surface acoustic wave, the opposite side of working surface 11 is provided with the first reflecting grating 41 of the surface acoustic wave that excites for reflection the first interdigital transducer 31, the position of the first interdigital transducer 31 is relative with the position of the first reflecting grating 41, position between the first interdigital transducer 31 and the first reflecting grating 41 forms an acoustic propagation path, the surface acoustic wave that the first interdigital transducer 31 excites is in working order propagated by the acoustic propagation path, the first interdigital transducer 31 comprises two the first bus-bars 33, the first bus-bar 33 of the first interdigital transducer 31 is connected with the power amplifier 22 in the signal generation apparatus 2, be provided with hydrophobic film 5 on the working surface 11, be provided with through hole 51 on the hydrophobic film 5, be connected with working surface 11 at the bottom of the hole of through hole 51, through hole 51 and the drop storing chamber 6 that is used for putting extract to be extracted and organic solvent with one of the some work surface formation of its correspondence position, drop is put chamber 6 and is positioned on the acoustic propagation path of the surface acoustic wave that the first interdigital transducer 31 excites, and namely drop is put chamber 6 between the first interdigital transducer 31 and the first reflecting grating 41.
In this specific embodiment, a switch can be set between the first interdigital transducer 31 and power amplifier 22 according to actual needs, power amplifier 22 is connected with switch, also can connect a wire web joint 7 on another surface of piezoelectric substrate 1, and arrange at wire web joint 7 and to connect pin 71, connect pin 71 and be connected with the first bus-bar 33 and the switch of the first interdigital transducer 31 by thin wire respectively.At this, wire web joint 7 can adopt PCB(Printed Circuie Board, printed-wiring board (PWB)) plate, also can adopt other arbitrarily existing web joints that can be used for fixing cord; One end of thin wire is fixedly connected on by bond technology or conductive silver glue and connects on the pin 71.
In this specific embodiment, hydrophobic film 5 is to apply the film that one deck Teflon AF1600 hydrophobic material forms at working surface 11, the process of this hydrophobic film 5 of actual fabrication is: the working surface 11 at piezoelectric substrate 1 applies one deck Teflon AF1600 hydrophobic material first, then in the constant temperature oven of 160 degree, dry, drying time is about 1 hour, and the film that forms after the oven dry is hydrophobic film 5.At this, the thickness of hydrophobic film 5 is generally more than or equal to 1 μ m and is less than or equal to 3 μ m, the thickness of hydrophobic film 5 only need satisfy good hydrophobic performance and requires to get final product in actual application, to guarantee when this device is not worked, the extract to be extracted and the organic solvents that are placed in the drop storing chamber 6 do not flow, as: can be 2 μ m with the Thickness Design of hydrophobic film 5.
In this specific embodiment, through hole 51 is by adopting small blades gently to scrape off film at hydrophobic film 5, form till the working surface of hydrophilic piezoelectric substrate until expose, this through hole 51 is be used to placing extract to be extracted and organic solvent, therefore generally be designed to subcircular, all can such as oval, circle; The size of this through hole 51 is that the size of basis extract to be extracted and organic solvent determines, is generally 2mm～4mm.
In this specific embodiment, the RF electric signal power that is loaded on the first interdigital transducer 31 can be regulated according to the size of extract to be extracted and organic solvent, such as extract to be extracted and the organic solvent for 2mm～4mm size, the RF electric signal power that can be loaded on the first interdigital transducer 31 is set to 18dBm～25dBm, if general extract and organic solvent to be extracted are larger, be loaded into then that RF electric signal power on the first interdigital transducer 31 can arrange relatively more greatly.
In this specific embodiment, also can be provided at the working surface 11 of piezoelectric substrate 1 reducing the second interdigital transducer 32 that signal generation apparatus 2 outputs to the second reflecting grating 42 of the RF electric signal power on the first interdigital transducer 31 and is used for the surface acoustic wave that reflection the first interdigital transducer 31 excites, the second reflecting grating 42 and the first reflecting grating 41 are oppositely arranged, the second reflecting grating 42 is positioned at the outside of the first interdigital transducer 31, the second interdigital transducer 32 and the first interdigital transducer 31 are oppositely arranged, hydrophobic film 5 is between the second interdigital transducer 32 and the first interdigital transducer 31, and the second interdigital transducer 32 is positioned at the inboard of the first reflecting grating 41.At this, increased the micro-extraction device behind the second interdigital transducer 32 and the second reflecting grating 42, so that when practical application, the RF electric signal that signal generation apparatus 2 produces can be loaded on any one interdigital transducer, namely be loaded on the first interdigital transducer 31 or the second interdigital transducer 32, use more flexible, as: when the RF electric signal of signal generation apparatus 2 generations is loaded on the second interdigital transducer 32, the surface acoustic wave acting in conjunction that the surface acoustic wave that the second interdigital transducer 32 excites and the second reflecting grating 42 are reflected back is on extract and organic solvent, and 31 of the first interdigital transducers play the effect of the surface acoustic wave that excites of reflection the second interdigital transducer 32.
In this specific embodiment, piezoelectric substrate 1 can adopt existing LiNbO
3Piezoelectric substrate; The first interdigital transducer 31, the second interdigital transducer 32, the first reflecting grating 41 and the second reflecting grating 42 all adopt existing microelectronic technique to be made on the working surface 11, the identical prior art that all adopts of structure of the structure of the second interdigital transducer 32 and the first interdigital transducer 31, the second interdigital transducer 32 comprises two the second bus-bars 34.
The course of work of drop-liquid drop micro-extractor of the present utility model is: extract to be extracted and organic solvent adopt respectively the microsyringe sample introduction to put in the chamber to drop, the start signal generating means, signal generator output RF electric signal, the RF electric signal is through being loaded into after the power amplifier amplification on the first interdigital transducer on the working surface that is arranged at piezoelectric substrate, the first interdigital transducer excites surface acoustic wave, and the surface acoustic wave acting in conjunction that the surface acoustic wave that the first interdigital transducer excites and the first reflecting grating are reflected back is finished extraction process on extract and organic solvent.Because the surface acoustic wave acting in conjunction that the surface acoustic wave that excites of the first interdigital transducer and the first reflecting grating are reflected back is on extract and organic solvent, thereby can be so that extract and organic solvent rapid movement, thereby rate of extraction and extraction degree improved.After finishing extraction, can adopt microsyringe to extract organic solvent after the extraction in order to carry out follow-up quantitative test.
Claims (10)
1. drop-liquid drop micro-extractor, it is characterized in that comprising piezoelectric substrate and signal generation apparatus, one surface of described piezoelectric substrate is working surface, one side of described working surface is provided be used to the first interdigital transducer that excites surface acoustic wave, the opposite side of described working surface is provided be used to the first reflecting grating that reflects the surface acoustic wave that described the first interdigital transducer excites, described the first interdigital transducer is connected with described signal generation apparatus, be provided with hydrophobic film on the described working surface, be provided with through hole on the described hydrophobic film, be connected with described working surface at the bottom of the hole of described through hole, described through hole and consist of a drop that is used for putting extract to be extracted and organic solvent with the some work of its correspondence position surface and put the chamber, described drop are put the chamber and are positioned on the acoustic propagation path of the surface acoustic wave that described the first interdigital transducer excites.
2. a kind of drop-liquid drop micro-extractor according to claim 1 is characterized in that described piezoelectric substrate is LiNbO
3Piezoelectric substrate.
3. a kind of drop-liquid drop micro-extractor according to claim 1 and 2, it is characterized in that described signal generation apparatus mainly is comprised of with the power amplifier that is connected with described signal generator the signal generator for generation of the RF electric signal, described power amplifier is connected with described the first interdigital transducer.
4. a kind of drop-liquid drop micro-extractor according to claim 3 is characterized in that described the first interdigital transducer comprises two the first bus-bars, and described the first bus-bar is connected with described power amplifier.
5. a kind of drop-liquid drop micro-extractor according to claim 4, another surface that it is characterized in that described piezoelectric substrate is connected with the wire web joint, be provided with the connection pin on the described wire web joint, described connection pin respectively by wire and described the first bus-bar be connected power amplifier and be connected.
6. a kind of drop-liquid drop micro-extractor according to claim 4 is characterized in that the film that described hydrophobic film forms for apply one deck Teflon AF1600 hydrophobic material at described working surface.
7. a kind of drop-liquid drop micro-extractor according to claim 6, the thickness that it is characterized in that described hydrophobic film is for more than or equal to 1 μ m and be less than or equal to 3 μ m.
8. a kind of drop-liquid drop micro-extractor according to claim 7, it is characterized in that being provided with on the described working surface be used to the second reflecting grating that reduces described signal generation apparatus and output to the RF electric signal power on described the first interdigital transducer, described the second reflecting grating and described the first reflecting grating are oppositely arranged, and described the second reflecting grating is positioned at the outside of described the first interdigital transducer.
9. a kind of drop-liquid drop micro-extractor according to claim 8, it is characterized in that being provided with on the described working surface be used to the second interdigital transducer that reflects the surface acoustic wave that described the first interdigital transducer excites, described the second interdigital transducer and described the first interdigital transducer are oppositely arranged, described hydrophobic film is between described the second interdigital transducer and described the first interdigital transducer, and described the second interdigital transducer is positioned at the inboard of described the first reflecting grating.
10. a kind of drop-liquid drop micro-extractor according to claim 9 is characterized in that described the first interdigital transducer, described the second interdigital transducer, described the first reflecting grating and described the second reflecting grating all adopt microelectronic technique to be made on the described working surface.
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| CN 201220318815 CN202676527U (en) | 2012-06-29 | 2012-06-29 | Droplet-droplet micro-extraction device |
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| CN 201220318815 CN202676527U (en) | 2012-06-29 | 2012-06-29 | Droplet-droplet micro-extraction device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103120862A (en) * | 2013-01-23 | 2013-05-29 | 宁波大学 | Acoustic surface wave accelerated headspace single-drop microextraction device and acoustic surface wave accelerated headspace single-drop microextraction method |
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2012
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103120862A (en) * | 2013-01-23 | 2013-05-29 | 宁波大学 | Acoustic surface wave accelerated headspace single-drop microextraction device and acoustic surface wave accelerated headspace single-drop microextraction method |
| CN103120862B (en) * | 2013-01-23 | 2015-01-21 | 宁波大学 | Acoustic surface wave accelerated headspace single-drop microextraction device and acoustic surface wave accelerated headspace single-drop microextraction method |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130116 Termination date: 20150629 |
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| EXPY | Termination of patent right or utility model |