CN202583145U - Chromatographic column device for generator - Google Patents
Chromatographic column device for generator Download PDFInfo
- Publication number
- CN202583145U CN202583145U CN 201220240993 CN201220240993U CN202583145U CN 202583145 U CN202583145 U CN 202583145U CN 201220240993 CN201220240993 CN 201220240993 CN 201220240993 U CN201220240993 U CN 201220240993U CN 202583145 U CN202583145 U CN 202583145U
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- plug
- generator
- glass
- chromatographic column
- silicone tube
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Abstract
The utility model discloses a chromatographic column device for a generator. The chromatographic column device for the generator mainly consists of a glass column, a rubber plug end cap and a silicone tube. The rubber plug end cap and the silicone tube are in an integral structure. The utility model provides the chromatographic column device for the generator which has the advantages of simple structure, reduced air leakage points and dead angles of the device, and improved product quality.
Description
Technical field
The utility model relates to the radiological measuring technical field, particularly a kind of chromatographic column device that is used for generator.
Background technology
Generator is radiopharmaceutic loading attachment, also is the main source of radioactivity imaging medicament, occupies critical role at medical detection range.At present both at home and abroad generator is mainly by the external packing body, and protective device is formed with inner chromatographic column device, the chromatographic column device be its most core also be of paramount importance part.The generator interior arrangement roughly is made up of the cylinder and the various coupling arrangement of adsorbent, carrying adsorbent.The selection of adsorbent is generally according to the type of generator and the adsorptive power of radiopharmaceutical parent is chosen suitable adsorbent; The cylinder that carries adsorbent generally adopts glass column, also has the part generator to select the cylinder of other materials for use, and its shape, size have difference according to separately the mode of production and technological process different; External generator generally selects for use stainless steel as connecting material in the selection of coupling arrangement parts.
The original chromatographic column device of applicant (as shown in Figure 2) by glass column, 2 plug plugs, 2 stainless steel elbows, two silicone tubes totally 7 parts form; Complex structure and in the application in more than 10 years, find to have following major defect: 1 building block is many; Manufacture craft is loaded down with trivial details, the problem that also possibly cause device gas leakage that generator can't normally be used simultaneously; The dead angle is cleaned in the many more easier formation of 2 tie points, brings the probability of bacteria breed hidden danger just big more; 3 are unfavorable for sterilization: what original device used is that model is the medical stainless steel of 0 chromium, 18 nickel, 11 titaniums, and it is disinfected needs in ultrasonic cleaner, to use HNO
3Impurity is removed in washing, carries out oil removal treatment with dish detergent then, and sterilization just can reach sterilization effect in 2 hours under 180 ℃ of high temperature at last.
The external stainless steel that adopts as main coupling arrangement more; Have defective on the apparatus system impermeability, and we tested once and attempt to use stainless steel as main coupling arrangement, but because the stainless steel quality is uneven; The cross section is cast aside the back and is found that the not clear material of dark oil can appear in some stainless steel inside; Be difficult to clean, can not arrive medical standard, and can occur generator elution efficiency abnormal occurrence once in a while after using; And in the chromatographic column manufacture craft, there is nitric acid drip washing step,, has high volence metal ion and get in the adsorbent, influence the elution efficiency of generator if adopt stainless steel for connecting main body.
Summary of the invention
The utility model has overcome deficiency of the prior art, provides a kind of simple in structure, reduces device gas leakage point and dead angle, the chromatographic column device that is used for generator that improves the quality of products.
In order to solve the problems of the technologies described above, the utility model is realized through following technical scheme:
A kind of chromatographic column device that is used for generator mainly is made up of glass column, plug plug, silicone tube, and key is that described plug plug and silicone tube are integral structure.
The utility model is all right:
Said plug plug and silicone tube are pressed into integral structure through press mold technology.
Said press mold technology is carried out under 160 ℃～180 ℃ condition.
Described glass column is cylindrical, the built-in glass core in middle and lower part, and glass core and cylinder sintering form, and arrange adsorbent on the glass core, cover layer of glass on the adsorbent.
Compared with prior art, the beneficial effect of the utility model is:
Plug plug and silicone tube adopt the structure of integral type; The tie point and the dead angle of device are reduced, reduced the hidden danger that bacteria breed brings, make device safer; The product quality of producing is guaranteed; And in the radiopharmaceutical production technology, safety is priority always for the technician, so the utility model has solved those of ordinary skill and thirsts for the high safety reliability problem that solves always.Simultaneously, the utility model has overcome the unusual problem of elution efficiency, guarantees product percent of pass, has reduced unnecessary loss, has also significantly reduced the problem that it can't be used owing to device gas leakage.
Description of drawings
Fig. 1 chromatographic column device synoptic diagram
The original chromatographic column device of Fig. 2 synoptic diagram
Fig. 3 elution efficiency curve map
Silicone tube, 2 top cement plug plugs, 3 glass columns, 4 glass cores, 5 adsorbents, 6 bottom plug plugs, 7 times silicone tubes on 1.
Embodiment
Below in conjunction with accompanying drawing and embodiment the utility model is described in further detail:
A kind of chromatographic column device that is used for generator as shown in Figure 1; Mainly be made up of glass column 3, plug plug, silicone tube, glass column 3 is cylindrical, and glass core 4 places the middle and lower part; Integral body is seamless ring body; Arrange adsorbent 5 on the glass core 4, cover layer of glass on the adsorbent 5, spun glass has prevented that adsorbent 5 from disorderly flying everywhere in lessivation.Wherein the plug plug is divided into upper and lower two, is used for being installed in glass column 3 two ends; Silicone tube also is divided into upper and lower two, and plug plug and silicone tube are integral structure, that is to say, top cement plug plug 2 is an integral structure with last silicone tube 1, and bottom plug plug 6 is an integral structure with following silicone tube 7.The structure of said plug plug and silicone tube integral type can be pressed into one through press mold technology at 160 ℃～180 ℃ by medical silica-gel and medical silica-gel plug and form.
Glass column 3 is cylindrical, and glass core 4 places the middle and lower part, and cylinder design is smaller than the cylinder sizes of conventional device, and glass column 3 thickness do not become, and has improved the firm degree of glass column 3 devices, is that outward appearance is more exquisite, attractive in appearance.Glass column 3 can be made by glass core 4 and glass tube sintering.Silica gel pipe close mouth has certain shrink tension force, it is filled in 3 mouthfuls of glass columns can make it smooth all the time, and seamless combines with glass column 3 inwalls.Top cement plug plug 2 is connected the top (away from glass core 4) of glass column 3, and bottom plug plug 6 is connected the below of glass column 3.
When in production work, using the utility model, radiopharmaceutical
99Mo is got in the glass column 3 through last silicone tube 1 and top cement plug plug 2 by system's negative pressure, is adsorbed in the Al that carries in the glass column 3
2O
3On the adsorbent 5, glass column 3 is selected wall thickness 1.5mm for use, internal diameter 6mm, and glass core 4 is used to intercept the Al of carrying in the glass column 3
2O
3Adsorbent 5 leaked, and the liquid after the absorption flows out through bottom plug plug 6 and following silicone tube 7, gets into refuse and takes up system.
When user (hospital) used the utility model, leacheate got into glass column 3 by last silicone tube 1 and top cement plug plug 2, and the medicine drip washing that generates in the glass column 3 is got off, and flowed out to get in the negative pressure bottle with following silicone tube 7 through bottom plug plug 6 and collected, and patients uses.
Be illustrated in figure 3 as the elution efficiency curve map of generator; Normal elution efficiency curve should be in obvious peak before certain elution volume; Abnormal elution efficiency curve does not then have rule to follow; The leacheate measured value is lower and fluid, can cause reaching medicine video picture concentration, can't the bio-occlusion patient use.Adopt the generator elution efficiency curve of the utility model to be normal elution efficiency curve shown in Figure 3.
Claims (4)
1. a chromatographic column device that is used for generator mainly is made up of glass column, plug plug, silicone tube, it is characterized in that, described plug plug and silicone tube are integral structure.
2. a kind of chromatographic column device that is used for generator according to claim 1 is characterized in that said plug plug and silicone tube are pressed into integral structure through press mold technology.
3. a kind of chromatographic column device that is used for generator according to claim 2 is characterized in that said press mold technology is carried out under 160 ℃～180 ℃ condition.
4. a kind of chromatographic column device that is used for generator according to claim 1 is characterized in that described glass column is cylindrical; The built-in glass core in middle and lower part; Glass core and cylinder sintering form, and arrange adsorbent on the glass core, cover layer of glass on the adsorbent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220240993 CN202583145U (en) | 2012-05-28 | 2012-05-28 | Chromatographic column device for generator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220240993 CN202583145U (en) | 2012-05-28 | 2012-05-28 | Chromatographic column device for generator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202583145U true CN202583145U (en) | 2012-12-05 |
Family
ID=47252546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220240993 Withdrawn - After Issue CN202583145U (en) | 2012-05-28 | 2012-05-28 | Chromatographic column device for generator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202583145U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103454364A (en) * | 2012-05-28 | 2013-12-18 | 原子高科股份有限公司 | Chromatographic column device for generator |
-
2012
- 2012-05-28 CN CN 201220240993 patent/CN202583145U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103454364A (en) * | 2012-05-28 | 2013-12-18 | 原子高科股份有限公司 | Chromatographic column device for generator |
| CN103454364B (en) * | 2012-05-28 | 2015-12-09 | 原子高科股份有限公司 | Chromatographic column device for generator |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20121205 Effective date of abandoning: 20151209 |
|
| C25 | Abandonment of patent right or utility model to avoid double patenting |