CN202477899U - Biological material tube - Google Patents
Biological material tube Download PDFInfo
- Publication number
- CN202477899U CN202477899U CN201120540542XU CN201120540542U CN202477899U CN 202477899 U CN202477899 U CN 202477899U CN 201120540542X U CN201120540542X U CN 201120540542XU CN 201120540542 U CN201120540542 U CN 201120540542U CN 202477899 U CN202477899 U CN 202477899U
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- layer
- pipe
- biomaterial
- biological material
- tube
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Abstract
The utility model provides a biological material tube. A tube body of the biological material tube is formed by superimposing multilayer biological materials, and preferably, the multilayer biological materials are small intestinal submucosa. An inner-layer medicament layer is arranged on the inner side of the inner wall of the biological material tube, an outer-layer medicament layer is arranged on the outer side of the outer wall of the biological material tube, and the inner-layer medicament layer and the outer-layer medicament layer are immune modulators and/or slow-release adjuvants. The tube body of the biological material tube can in the shape of a cylindrical tube or a conical tube, and preferably, the number of layers of the multilayer biological materials is 4 to 6, the thickness of the tube wall of the biological material tube is 0.6 to 0.8 mm, and the thicknesses of the inner-layer medicament layer and the outer-layer medicament layer are 120 to 150 m um. The decellularized biological material tube is used for replacing a tubular structure in a human body, can be conveniently applied to the treatment of injuries of a bile duct, a ureter and other parts, and simultaneously has effects of seepage prevention and the like.
Description
Technical field
This utility model relates to a kind of biologic material products, particularly, is a kind of biologic material products that is used for some pipe property structure of alternative human body.
Background technology
The intravital part pipe property of people structure, for example: because the shortage of substitution material in case piping failure can only be got normal structure and repair pipeline, is perhaps guided the tuber drainage thing places such as into external nearby, there are various deficiencies in bile duct, ureter, lymphatic vessel etc.The rise of biomaterial in recent years can partly substitute autologous tissue, has obtained effect preferably.But, be used for substituting the pipe property biomaterial structure of human body, still there is not excellent product at present.Its reason is, the one, and the trial of biomaterial being processed tubular structure still is in the exploratory stage, superior design also do not occur; The 2nd, biomaterial bioprocess in vivo is complicated, and is excessive for the pipe property structure influence of human body, and effect maybe be also unstable.
Therefore, a kind of biomaterial pipe that is applied to substitute human body pipe property structure is provided, can fills up the blank in this field, and significant aspect expansion Application of Biomaterial and simplification part operation plan.
Commercially at present take off the cell biological material and be planar structure, also do not process piped product, be used to prepare tubular-shaped structures like need, make at the scene of need, time and effort consuming, and the appearance of leak source is also unavoidable.In addition, existing commercially take off cell material all have drawn from heterogeneity biological, for example pig.Though this type of material is handled through taking off cell, has removed main immunogenic substance, in heterologous receptor (people) body, still can cause the tangible inflammatory reaction that continues several weeks, inflammation dissipates just now after exogenous biomaterial degraded.Though this process is a self limiting, in the inflammatory process that continues, will cause some untoward reaction.
The utility model content
The main purpose of this utility model is, to above-mentioned variety of issue, provide a kind of be used to replace pipe property structure in the human body take off the cell biological tubes of material.
The another purpose of this utility model is, a kind of biomaterial pipe that has medication coat is provided, and possesses the partial inhibition to inflammation.
For realizing above-mentioned purpose, this utility model adopts following technical scheme:
A kind of biomaterial pipe, its pipe shaft is made up of the stack of multi-layer biological material.
Aforesaid biomaterial pipe, preferably, the inwall of said biomaterial pipe is with the interior internal layer medicament layer that is provided with.
Aforesaid biomaterial pipe preferably, is provided with outer medicament layer beyond the outer wall of said biomaterial pipe.
Aforesaid biomaterial pipe, preferably, the pipe shaft of said biomaterial pipe is cylindrical tube or tapered tube shape.
Aforesaid biomaterial pipe, preferably, described multi-layer biological material is a same material.
Aforesaid biomaterial pipe, preferably, described multi-layer biological material is substrate under the mucous membrane of small intestine (SIS, small intestinal submucosa).
Aforesaid biomaterial pipe, preferably, the number of plies of described multi-layer biological material is the 4-6 layer.
Aforesaid biomaterial pipe, preferably, the pipe thickness of said biomaterial pipe is 0.6-0.8mm.
Aforesaid biomaterial pipe, preferably, said internal layer medicament layer and outer medicament layer are immunomodulator and/or slow release adjuvant.
Aforesaid biomaterial pipe, preferably, the thickness of said internal layer medicament layer is 120-150 μ m.
Aforesaid biomaterial pipe, preferably, the thickness of said outer medicament layer is 120-150 μ m.
The beneficial effect of this utility model is:
This utility model provide a kind of be used to replace pipe property structure in the human body take off the cell biological tubes of material, can be conveniently used in treating the damage at positions such as bile duct, ureter, have effects such as antiseep simultaneously.
And this utility model also provides a kind of technical scheme that has the biomaterial pipe of medication coat, possesses the part regulating action to inflammation, through certain drugs, slow-release time, reach rational adjusting inflammatory effect.Neither block the degraded of biomaterial, the ill effect of the reaction that can effectively reduce inflammation again, being applied to meticulous positions such as bile duct, ureter for biomaterial provides reasonable raw material to handle theory, technology.
Description of drawings
Fig. 1 is the structural representation of a kind of embodiment of this utility model.
Fig. 2 is the profile of a kind of embodiment of this utility model.
Fig. 3 is the structural representation of the another kind of embodiment of this utility model.
The specific embodiment
Shown in the profile of the structural representation of Fig. 1 and Fig. 2; Wherein a kind of embodiment of this utility model, it comprises: the pipe shaft 1 that is formed by stacking biomaterial, at inboard internal layer medicament layer 2 that is provided with of the inwall of pipe shaft 1 and the outer medicament layer 3 that is provided with in the outer exterior wall of pipe shaft 1.
The pipe shaft 1 of this utility model is with the tubulose of processing desired thickness behind the curling many circles of rectangular thin layer biomaterial.As be used for substituting bile duct, this biomaterial can preferably use substrate (SIS) under the commercial mucous membrane of small intestine, for example, and the product Surgisis of COOK company.Specifically, can be with substrate cutting growth 55-70mm under the commodity mucous membrane of small intestine, the lamellar of wide 20mm is soaked in the normal saline, and substrate is the monolayer lamellar under the multiple layer of the fractionation mucous membrane of small intestine.Get substrate under the monolayer mucous membrane of small intestine, be paperwrapped in outside the preferably about 4mm pole of external diameter, twine 4 circles, the about 4mm of internal diameter, wall thickness 0.6-0.8mm, be about the tubular structure of 20mm.With forming stable pipe shaft 1 after its pressurization drying.
After pipe shaft 1 is shaped, to internal and external walls difference dip-coating immunomodulator and slow release adjuvant IL-10 and biological fibrin glue.Particularly, tubular material is infiltrated under pressurized state in the IL-10 solution, the concentration of IL-10 solution is greater than 4 μ g/100mL, and amount of liquid should be greater than 6mL/cm
2, infiltrating time is greater than 75min.Wherein, IL-10 is stored under-20 ℃, be dissolved in normal saline after temperature should be controlled at below 4 ℃, soak to accomplish the back in the low temperature environment drying.After the drying, use 4-6MPa low pressure flush coater to coat biological fibrin glue in the pipe medial wall, form internal layer medicament layer 2, its thickness is preferably 120-150 μ m.The coating of outer medicament layer 3 is the outer walls that are coated with pipe shaft 1 earlier with bioprotein collodion silk spiral brush sifter, and collodion silk diameter 600 μ m have supporting role, in case modification, thickness 120-150 μ m, after brush outer surface repeatedly with IL-10 again, make it reach 0.8-1.2 μ g/cm
2
The biomaterial pipe for preparing through above-mentioned steps uses cobalt
60After the sterilization, encapsulate subsequent use.
The coating type biomaterial pipe of this utility model can be used for substituting tissues such as bile duct, ureter, and oneself proves its effectiveness in zoopery.In the experiment that substitutes the dog bile duct, the bile percent of pass is 100%, and gallbladder leaks and takes place to leak is 0.
In other embodiment of this utility model, to the other end, its diameter can not be identical everywhere by an end of pipe shaft 1.For example shown in the structural representation of Fig. 3, among the embodiment 2 of this utility model, pipe shaft 1 is to be tapered tube shape, promptly by an end to the other end, the diameter of pipe shaft 1 reduces in the extension with pipe shaft.And the raw material of pipe shaft 1 is chosen, winding process, and internal layer 2 is all identical with embodiment 1 with the coating method of skin 3.This conical pipe can be applicable to situation common in the medical treatment: need the two ends bore of connection inconsistent.Preferably, an end opening diameter 16mm of conical pipe, an end opening be less than 1mm, pipe range 30mm.
Claims (10)
1. a biomaterial pipe is characterized in that, its pipe shaft is made up of the stack of multi-layer biological material.
2. biomaterial pipe as claimed in claim 1 is characterized in that, the inwall of said biomaterial pipe is with the interior internal layer medicament layer that is provided with.
3. according to claim 1 or claim 2 biomaterial pipe is characterized in that, is provided with outer medicament layer beyond the outer wall of said biomaterial pipe.
4. according to claim 1 or claim 2 biomaterial pipe is characterized in that the pipe shaft of said biomaterial pipe is cylindrical tube or tapered tube shape.
5. according to claim 1 or claim 2 biomaterial pipe is characterized in that described multi-layer biological material is a same material.
6. according to claim 1 or claim 2 biomaterial pipe is characterized in that described multi-layer biological material is substrate under the mucous membrane of small intestine.
7. according to claim 1 or claim 2 biomaterial pipe is characterized in that the number of plies of described multi-layer biological material is the 4-6 layer.
8. according to claim 1 or claim 2 biomaterial pipe is characterized in that the pipe thickness of said biomaterial pipe is 0.6-0.8mm.
9. according to claim 1 or claim 2 biomaterial pipe is characterized in that said internal layer medicament layer and outer medicament layer are immunomodulator.
10. according to claim 1 or claim 2 biomaterial pipe is characterized in that the thickness of said internal layer medicament layer is 120-150 μ m, and the thickness of said outer medicament layer is 120-150 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120540542XU CN202477899U (en) | 2011-12-21 | 2011-12-21 | Biological material tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120540542XU CN202477899U (en) | 2011-12-21 | 2011-12-21 | Biological material tube |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202477899U true CN202477899U (en) | 2012-10-10 |
Family
ID=46952365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201120540542XU Expired - Fee Related CN202477899U (en) | 2011-12-21 | 2011-12-21 | Biological material tube |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202477899U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895702A (en) * | 2012-11-09 | 2013-01-30 | 四川大学华西医院 | Composite manual bile duct and preparation method thereof |
| CN108310464A (en) * | 2018-03-21 | 2018-07-24 | 吉林大学 | Natural tubulose small intestine acellular matrix film and preparation method thereof |
-
2011
- 2011-12-21 CN CN201120540542XU patent/CN202477899U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895702A (en) * | 2012-11-09 | 2013-01-30 | 四川大学华西医院 | Composite manual bile duct and preparation method thereof |
| CN108310464A (en) * | 2018-03-21 | 2018-07-24 | 吉林大学 | Natural tubulose small intestine acellular matrix film and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121010 Termination date: 20191221 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |