CN202314482U - Ibuprofen delayed-release sandwiched tablet - Google Patents
Ibuprofen delayed-release sandwiched tablet Download PDFInfo
- Publication number
- CN202314482U CN202314482U CN2011202789894U CN201120278989U CN202314482U CN 202314482 U CN202314482 U CN 202314482U CN 2011202789894 U CN2011202789894 U CN 2011202789894U CN 201120278989 U CN201120278989 U CN 201120278989U CN 202314482 U CN202314482 U CN 202314482U
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- China
- Prior art keywords
- ibuprofen
- release
- granule
- delayed
- tablet
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Abstract
The utility model discloses an ibuprofen delayed-release sandwiched tablet which comprises particles A and an isolation layer B and is characterized in that in the ibuprofen delayed-release sandwiched tablet, a first quick-release effect layer is composed of the particles A, the isolation layer is composed of particles B subjected to coating, and a second slow-release effect layer is composed of the particles A subjected to coating.
Description
Technical field
This utility model relates to a kind of pharmaceutical formulation technical field of structures, is specifically related to ibuprofen delayed release three-layer tablet.
Background technology
Pain is a kind of complex physical mental activity, is one of modal symptom clinically.It comprises that noxious stimulation acts on the caused pain of body and feels, and body is to the pain reaction of noxious stimulation.The pain sensation can be used as a kind of warning that body comes to harm, and causes the protective reaction of body series of defence property, is the symbol of danger signal, impels people's urgent action, and hedging goes evil.
Heating is because the heating activator acts on body, and then the generation of giving birth to pyrogen (EP) in causing incorporates brain into and act on thermotaxic centre, more so that the release of the maincenter medium that causes generating heat cause then and the change of set point finally cause heating.Mainly show as body temperature and exceed arm's length standard, or the uncomfortable sensation of own fever of the body.
Ibuprofen is to go on the market in Britain nineteen sixty-eight the earliest, because antipyretic-antalgic aspect evident in efficacy, and toxicity is low, be superior to aspirin and acetaminophen, thereby market enlarges rapidly.Since ibuprofen preferably curative effect with have less untoward reaction, the U.S., Britain ratify to transfer it to nonprescription drugs from prescription drugs in succession.To early 1990s, the sales volume of world market Motrin has broken through 1,000,000,000 dollars of high pointes, is to break through 1,000,000,000 dollars antipyretic analgesic product the earliest.
Good antipyretic-antalgic effect has also driven the exploitation listing of numerous dosage forms; Be peroral dosage form and local form of administration; Like tablet, capsule, dry suspension, granule, drop, effervescent tablet, oral cavity disintegration tablet and ointment, gel, liniment, the injection type list marketing is not arranged as yet.And the injection market of U.S.'s treatment pain reached about 6.79 hundred million dollars in 2008, and this explanation ibuprofen kind also has huge market potential.
Ibuprofen is well-known general medicine kind, and crude drug is cheap, and production cost is very low.Domestic pain market capacity is huge, and ibuprofen is that numerous doctor patients know in addition, and marketing is easy, can predict the exploitation listing of ibuprofen injection, considerable economic benefit and social benefit surely.
Common name: ibuprofen
English name: Ibuprofen
Chemical name: 4-isobutyl group-Alpha-Methyl phenylacetic acid
Molecular formula: C
13H
18O
2
Molecular weight: 206.28
Pharmacology type: NSAID.
Mechanism of action: the mechanism of ibuprofen antiinflammatory refrigeration function is synthetic relevant with the inhibition prostaglandin.Prostaglandin is a kind of endogenic pyrogen and inflammatory mediator, and ibuprofen is synthetic through suppressing Cycloxygenase (COX) and then suppressing prostaglandin (PG), and inflammatory reaction, heating and the pain that causes is assembled in alleviation because of prostaglandin.
Summary of the invention
The purpose of this utility model provides a kind of delayed release three-layer tablet; Comprise granule A and sealing coat B; It is characterized in that described ibuprofen delayed release three-layer tablet; The granule A that is respectively ground floor rapid release effect forms, sealing coat is made up of coated granule B, and second layer slow release effect is made up of coated granule A.
The ibuprofen delayed release three-layer tablet that this utility model provided prepares 1000, and compositing formula is following:
The A granule
B granule sealing coat
The ibuprofen delayed release three-layer tablet that this utility model provided prepares 1000 method for preparing, following steps:
1) get ibuprofen, the pregelatinized Starch of recipe quantity, mix homogeneously adopts 2.5% methocel solution, and 20 eye mesh screens are granulated, 50 ± 5 ℃ of dryings, and granulate, subsequent use;
2) with 1) middle pregelatinized Starch, carboxymethyl starch sodium, polyvinylpolypyrrolidone, the magnesium stearate that adds the residue recipe quantity, be mixed and made into granule A;
3) with hydroxypropyl cellulose K15M, hydroxypropyl cellulose K4, mannitol, Pulvis Talci, the blue shallow lake mix homogeneously of recipe quantity, adopt 10% polyvidone alcoholic solution, 20 eye mesh screens are granulated, 50 ± 5 ℃ of dryings, and granulate makes granule B;
4) tabletting: be pressed into cylindric three-layer tablet, granule B is in the centre;
5) coating: carriage rotation (hole) the coating machine with particular design, one of three-layer tablet is inserted in this hole, expose portion (containing the sealing coat and the second medicine layer) with 5% cellulose ether methanol solution spray coating, gets not infiltration layer of thickness 0.2mm water.
6) drying promptly gets ibuprofen delayed release three-layer tablet.
The ibuprofen delayed release three-layer tablet that this utility model provided, ground floor medicine layer is the rapid release effect, second layer medicine layer is a slow release effect, time lag 4.5-5.0 hour in vivo.
Description of drawings
Fig. 1 is this utility model ibuprofen delayed release three-layer tablet structural representation.
The specific embodiment
Specify to help the content of understanding this utility model below in conjunction with accompanying drawing and specific embodiment ibuprofen delayed release three-layer tablet structure this utility model.
As shown in Figure 1, ibuprofen delayed release three-layer tablet prepares 1000, and compositing formula is following:
The A granule
B granule sealing coat
During making:
1) get ibuprofen, the pregelatinized Starch of recipe quantity, mix homogeneously adopts 2.5% methocel solution, and 20 eye mesh screens are granulated, 50 ± 5 ℃ of dryings, and granulate, subsequent use;
2) with 1) middle pregelatinized Starch, carboxymethyl starch sodium, polyvinylpolypyrrolidone, the magnesium stearate that adds the residue recipe quantity, be mixed and made into granule A;
3) with hydroxypropyl cellulose K15M, hydroxypropyl cellulose K4, mannitol, Pulvis Talci, the blue shallow lake mix homogeneously of recipe quantity, adopt 10% polyvidone alcoholic solution, 20 eye mesh screens are granulated, 50 ± 5 ℃ of dryings, and granulate makes granule B;
4) tabletting: be pressed into cylindric three-layer tablet, granule B is in the centre;
5) coating: carriage rotation (hole) the coating machine with particular design, one of three-layer tablet is inserted in this hole, expose portion (containing the sealing coat and the second medicine layer) with 5% cellulose ether methanol solution spray coating, gets not infiltration layer of thickness 0.2mm water.
6) drying promptly gets ibuprofen delayed release three-layer tablet.
Claims (1)
1. ibuprofen delayed release three-layer tablet; Comprise granule A and sealing coat B; It is characterized in that described ibuprofen delayed release three-layer tablet, the granule A that is respectively ground floor rapid release effect forms, sealing coat is made up of coated granule B, and second layer slow release effect is made up of coated granule A.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011202789894U CN202314482U (en) | 2011-08-03 | 2011-08-03 | Ibuprofen delayed-release sandwiched tablet |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011202789894U CN202314482U (en) | 2011-08-03 | 2011-08-03 | Ibuprofen delayed-release sandwiched tablet |
Publications (1)
Publication Number | Publication Date |
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CN202314482U true CN202314482U (en) | 2012-07-11 |
Family
ID=46426488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2011202789894U Expired - Fee Related CN202314482U (en) | 2011-08-03 | 2011-08-03 | Ibuprofen delayed-release sandwiched tablet |
Country Status (1)
Country | Link |
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CN (1) | CN202314482U (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105579033A (en) * | 2013-09-27 | 2016-05-11 | 强生消费者公司 | Compression coated pulsatile release compositions |
WO2022052887A1 (en) * | 2020-09-08 | 2022-03-17 | 越洋医药开发(广州)有限公司 | Ibuprofen controlled-release tablet and preparation method thereof |
-
2011
- 2011-08-03 CN CN2011202789894U patent/CN202314482U/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105579033A (en) * | 2013-09-27 | 2016-05-11 | 强生消费者公司 | Compression coated pulsatile release compositions |
WO2022052887A1 (en) * | 2020-09-08 | 2022-03-17 | 越洋医药开发(广州)有限公司 | Ibuprofen controlled-release tablet and preparation method thereof |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120711 Termination date: 20140803 |
|
EXPY | Termination of patent right or utility model |