CN202257125U - Automatic detection controller for sample visible component analytical instrument - Google Patents
Automatic detection controller for sample visible component analytical instrument Download PDFInfo
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- CN202257125U CN202257125U CN2011203967738U CN201120396773U CN202257125U CN 202257125 U CN202257125 U CN 202257125U CN 2011203967738 U CN2011203967738 U CN 2011203967738U CN 201120396773 U CN201120396773 U CN 201120396773U CN 202257125 U CN202257125 U CN 202257125U
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Abstract
An automatic detection controller for sample visible component analytical instrument comprises at least one multi-channel processing module, each multi-channel processing module is connected with a master computer via a communication interface respectively; each multi-channel processing module comprises a flow counting chamber including multiple channels; each channel of the flow counting chamber comprises an independent input end and an independent output end; the input end is connected with a sampling probe via a first input control valve; the output end is connected with a sample input pump via a second input control valve; the first input control valve, the second input control valve and the sample input pump are connected with an output end of a pump valve control unit respectively; and the input end of the pump valve control unit is connected with a counting chamber control module. The control of the device mainly starts each multi-channel processing module via the master computer, for making each multi-channel processing module work independently and in parallel; each multi-channel processing module starts each channel of the flow counting chamber via the counting chamber control module, for making each channel work in divided times and in parallel.
Description
Technical field
The utility model relates to a kind of sample visible component analyser, particularly a kind of sample visible component analyser automatic detection and control device.
Background technology
Existing sample visible component analytical approach mainly contains Flow Cytometry and the inspection of microscope form.
Flow Cytometry has performance preferably when the constant relatively visible component of testing environment and composition, to this type sample, classify and count with Flow Cytometry, can realize objective, detection fast, and its typical application is a cellanalyzer.But concerning urine, ight soil and other humoral specimens; Situation will be complicated many, not following 40 kinds like the visible component in the urine specimen, if the segmentation also can classify more; And in different patient specimens, also there are various variations with a kind of cell; This has greatly increased the complicacy of analyzing, and also has a large amount of impurity in the sample that has in addition, and this has more increased the difficulty of streaming methods analyst.The employing streaming technology is analyzed, in case impurity is many in the sample, or cell category is many, and deviation will appear in its testing result, has very high false negative and false positive.
The inspection of microscope form is technological technological based on artificial sediment microscopic inspection, and it replaces the judgement of human brain to carry out the identification and the counting of the cellular morphology under the similar conventional microscope with computer, and the characteristics of microscope form inspection technology are: locate standard, can follow the tracks of; The result is objective stable; Store convenience, can reappear, detect the various characteristics of target and can extract, but its defective is also arranged; As; Want to photograph distinct image and to accurate identification of various visible components and counting, just must precipitate sample at least 100 seconds, the greatest drawback that is to say this method is that detection speed is slow.
Summary of the invention
The utility model technical matters to be solved is that conventional microscope form inspection is wasted time and energy to above-mentioned clinical urine, ight soil and other body fluid present situation and problem provide a kind of sample visible component analyser automatic detection and control device; It is based on morphological examination " goldstandard "---the inspection of microscope form, and these apparatus and method can alleviate the workload of simple microscope microscopy, the false positive and the false negative rate of reduction employing Flow Cytometry instrument greatly; Reduce manual reinspection rate; Reduce personal error, and by robotization, the high precision of instrument, the reliability, the standardization that have also improved testing result; In clinical examination, has higher using value; And improved work efficiency greatly, improved detection speed, be the clinical check result fast and accurately that provides.
For solving the slow-footed problem of automatic microscopy; The utility model provides a kind of sample visible component analyser automatic detection and control device; Comprise at least one hyperchannel processing module, these hyperchannel processing modules are connected with main control computer through communication interface respectively; Each hyperchannel processing module comprises that contains a multichannel flowing counting pool; Each passage of this flowing counting pool has independently input end and output terminal; This input end is connected with sampling probe through first input control valve; This output terminal is connected with the sample front pump through second input control valve; Those first input control valves, second input control valve and sample front pump are connected with an output terminal of pump valve control assembly respectively, and the input end of this pump valve control assembly is connected with the counting chamber control module.
Each hyperchannel processing module comprises that also one cleans branch road; This cleans a route purge control valve, scavenging pump, cleaning liquid pool and service sink and forms; This purge control valve contains a normally open valve and a normally close valve at least; The normally close valve of this purge control valve connects the output terminal of each passage second input control valve; The input end of this purge control valve connects scavenging pump, and the input end of this scavenging pump is imported solenoid valve through cleaning fluid and connected the cleaning liquid pool, and this cleans the normally open valve connection service sink of delivery side of pump through purge control valve.
The counting chamber control module of each hyperchannel processing module also connects microscope control assembly and CCD control assembly.This microscope control assembly connects microscope, and this CCD control assembly connects the CCD camera.
This main control computer and counting chamber control module are respectively multi-purpose computer or embedded system.
The utility model also provides the control method of above-mentioned sample visible component analyser automatic detection and control device, and it is mainly, and main control computer starts each hyperchannel processing module respectively, makes each hyperchannel processing module independent parallel work; Each hyperchannel processing module makes each passage pipelined-flash work through each passage of counting chamber control module startup flowing counting pool.
Each passage pipelined-flash method of work of this flowing counting pool comprises the following steps:
A, counting chamber control module judge whether flowing counting pool has idle channel, if not then continue step D; If have, just notify the pump valve control assembly to open this idle channel, sampling probe is inserted in the service sink, start scavenging pump, this idle channel is cleaned;
B, clean to accomplish after, sampling probe inserted in the sample sample is drawn into this idle channel through sampling probe and accomplishes sample introduction operation;
In case the C sample is inhaled in the above-mentioned idle channel, the counting chamber control module makes the sample of this suction begin the timing that primary dcreening operation staticly settles the time;
D, counting chamber control module judge whether the sample that the primary dcreening operation time of staticly settling arrives, if having, then continue step e; If no, the sample that the time of staticly settling fully of then judging whether arrives if having, then continues step F; If the sample that arrives of the time of staticly settling does not fully then continue step G;
E, arrive when the sample primary dcreening operation time of staticly settling; The counting chamber control module starts microscope control assembly and CCD control assembly; Carry out microscopical low power lens primary dcreening operation scanning with driving microscope and CCD camera and adopt figure and identification; If primary dcreening operation scanning identification finds that suspicious object is arranged, then start the timing that this sample gets into the time that staticly settles fully, and continue step G; If suspicious object is not found in primary dcreening operation scanning identification, then preserve and jump to step G as negative findings;
F, the time of staticly settling arrives fully when sample; The counting chamber control module starts microscope control assembly and CCD control assembly; Carry out microscopical low power lens primary dcreening operation and scan and adopt figure and identification to drive microscope and CCD camera, and the result of statistical computation general objective, confirm the morphological parameters of general objective cell; Judge whether to exist little target simultaneously, if there is not little target then to jump to step G; Then confirm its physical location if there is little target; Through microscopical high power objective the little target of location under low power lens is carried out magnified sweep and adopt figure and identification; Cell to wherein carries out statistic of classification calculating, and extracts its cellular morphology parameter and carry out the morphology statistical study;
G, judged whether exit instruction, if not then change steps A over to, if having then quit a program.
Compared with prior art; The beneficial effect that the utility model had is: each hyperchannel processing module comprises that one contains multichannel flowing counting pool in the utility model; And each passage to flowing counting pool carries out timesharing control, has improved the detection speed of single hyperchannel processing module; Communication interface through main control computer connects a plurality of hyperchannel processing modules simultaneously, makes each hyperchannel processing modules implement cascade, reaches the purpose that significantly improves detection speed.
Specifically, the utility model is designed with primary dcreening operation and staticly settles time and complete settling time in testing process; And detection is divided into primary dcreening operation and detects and detect fully, when confirmatory sample when primary dcreening operation detects is a negatives, can not do deposition and subsequent detection fully; Improve detection speed; Only when primary dcreening operation detect to be found tangible suspicious object, just this sample is done deposition fully, and do when precipitating fully at this passage and can handle other passages, so; Through hyperchannel time-division processing method, overcome because of sample and need precipitate the slow shortcoming of analysis speed that the long period causes.
On the other hand; To the single channel counting chamber; The microscopy flow process from each step that the deposition-low power scanning-high power of sample introduction-primary dcreening operation deposition-primary dcreening operation scanning-fully scans the whole process of cleaning can only the serial execution; Not only deposition has taken the time, and its pump valve control cycle and microscope scan period are not all utilized fully.Handle through pipelined-flash after adopting the hyperchannel counting chamber; Not only the time can handle other passage in deposition when a passage; And when a passage in when scanning; Other passage can carry out sample introduction and cleaning, is perhaps carrying out sample introduction when cleaning when a passage, and other passage then can carry out microscope scanning.Through this parallel processing, further improved the speed that microscopy is analyzed again.
In addition, also through main control computer a plurality of hyperchannel processing modules are carried out cascade, each hyperchannel processing module can independently be accomplished sample analysis, thereby the detection speed of sample can be increased exponentially.
Description of drawings
Fig. 1 is the pump valve system pipeline structural representation of the utility model sample visible component analyser automatic gauging control device one embodiment.
Fig. 2 is the structural representation of the utility model sample visible component analyser automatic gauging control device one embodiment.
Fig. 3 is a kind of connected mode synoptic diagram of the utility model hyperchannel counting chamber.
Fig. 4 is the another kind of connected mode synoptic diagram of the utility model hyperchannel counting chamber.
Fig. 5 is the control method synoptic diagram of the utility model sample visible component analyser automatic gauging control device.
Fig. 6 is a plurality of hyperchannel processing module of a utility model cascade synoptic diagram.
Embodiment
Like Fig. 1, shown in Figure 2, the hyperchannel processing module comprises a mobile counting chamber 3 in the utility model sample visible component analyser automatic gauging control device, and this flowing counting pool 3 comprises at least two passages that are set up in parallel.Be example with triple channel (30,40,50) in this example.Those passages (30,40,50) all are to be processed by optical glass material, and all have identical standard volume and standard cavity thickness.Those passages (30,40,50) are respectively equipped with independently input end and output terminal; This input end is connected with sampling probe (34,44,54) through first input control valve (DZ31, DZ41, DZ51) respectively; This output terminal is connected with sample front pump 2 through second input control valve (DZ32, DZ42, DZ52), and the output terminal of this sample front pump 2 connects waste liquid pool 1.Those first input control valves (DZ31, DZ41, DZ51), second input control valve (DZ32, DZ42, DZ52) and sample front pump 2 are connected with an output terminal of pump valve control assembly 4 respectively, and the input end of this pump valve control assembly 4 is connected with counting chamber control module 5.This counting chamber control module 5 can be an intelligent control card or an embedded system, can also be a multi-purpose computer.
The output terminal of this second input control valve (DZ32, DZ42, DZ52) connects one and cleans branch road 8, and this cleans branch road 8 and is made up of purge control valve DZ10, scavenging pump 81, cleaning liquid pool 82 and service sink 83.This purge control valve DZ10 is the combination valves that join more, and it contains a normally open valve and a normally close valve at least.The normally close valve of this purge control valve DZ10 connects the output terminal of each passage second input control valve; The input end of this purge control valve DZ10 connects scavenging pump 81; The input end of this scavenging pump 81 connects cleaning liquid pool 82 through cleaning fluid input solenoid valve DZ9, and the output terminal of this scavenging pump 81 connects service sink 83 through the normally open valve of purge control valve DZ10.This scavenging pump 81, purge control valve DZ10, cleaning fluid input solenoid valve DZ9 also are connected with an output terminal of pump valve control assembly 4 respectively.
This counting chamber control module 5 also connects microscope control assembly 6 and CCD control assembly 7, and this microscope control assembly 6 connects microscope 61, and this CCD control assembly 7 connects CCD camera 71.This microscope 61 can scan detecting sample, and location needs the position of photographic images, and these CCD camera 71 shooting sample images also convert thereof into bitmap sheet file and are kept on the storer as source document.
Like Fig. 3, the sampling probe in the utility model can be an independent sampling probe, and each passage (30,40,50) is connected with sampling probe through many reduction of fractions to a common denominators prop; Also can be as shown in Figure 4, three sampling probes that the sampling probe in the utility model is formed as one, each passage (30,40,50) connect with corresponding sampling probe respectively.
As shown in Figure 5, when the utility model sample visible component analyser automatic detection device used, the control method of each hyperchannel processing module comprised the following steps:
A, counting chamber control module 5 judge whether flowing counting pool 3 has idle channel, if not then continue step D; If have, just notify pump valve control assembly 4 to open this idle channel, sampling probe is inserted in the service sink 83, start scavenging pump 81, this idle channel is cleaned;
B, clean to accomplish after, sampling probe inserted in the sample sample is drawn into this idle channel through sampling probe and accomplishes sample introduction operation;
In case the C sample is inhaled in the above-mentioned idle channel, counting chamber control module 5 makes the sample of this suction begin the timing that primary dcreening operation staticly settles the time;
D, counting chamber control module 5 judge whether the sample that the primary dcreening operation time of staticly settling arrives, if having, then continue step e; If no, the sample that the time of staticly settling fully of then judging whether arrives if having, then continues step F; If the sample that arrives of the time of staticly settling does not fully then continue step G;
E, arrive when the sample primary dcreening operation time of staticly settling; Counting chamber control module 5 starts microscope control assembly 6 and CCD control assembly 7; Carry out the scanning of low power lens primary dcreening operation with driving microscope 61 and CCD camera 71 and adopt figure and identification; If primary dcreening operation scanning identification finds that suspicious object is arranged, then start the timing that this sample gets into the time that staticly settles fully, and continue step G; If suspicious object is not found in primary dcreening operation scanning identification, then preserve and jump to step G as negative findings;
F, the time of staticly settling arrives fully when sample; Counting chamber control module 5 starts microscope control assembly 6 and CCD control assembly 7; Carry out the scanning of low power lens primary dcreening operation with CCD camera 71 and adopt figure and identification to drive microscope 61, and the result of statistical computation general objective, confirm the morphological parameters of general objective cell; Judge whether to exist little target simultaneously, if there is not little target then to jump to step G; Then confirm its physical location if there is little target; High power objective through microscope 6 carries out magnified sweep to the little target of location under low power lens and adopts figure and identification; Cell to wherein carries out statistic of classification calculating, and extracts its cellular morphology parameter and carry out the morphology statistical study;
G, judged whether exit instruction, if not then change steps A over to, if having then quit a program.
This primary dcreening operation staticly settles time and staticly settling the time fully, can decide that (detect with the urine specimen visible component, primary dcreening operation staticly settles time T 1=10～15s, staticly settles time T 2=100～120s fully according to institute's this character of test sample.）。
In the utility model, adopt and contain multichannel flowing counting pool, fundamental purpose is in order to improve pattern detection speed.Below, be example just with the urine specimen, through data this is elaborated: in the utility model testing process, generally have:
A) inhale appearance time: 10～15s;
B) primary dcreening operation staticly settles the time: 10～15s;
C) primary dcreening operation scanning photo opporunity: 10～15s (to find that the visible component target is a purpose in the sample, promptly as long as find that target just stops scanning and takes pictures, if when visible component content is high in the sample, take pictures and find target easily, and the used time is just few by scanning; Visible component content after a little while, the time of scanning is just long; Generally confirm to scan the amount of taking pictures according to detecting the sensitivity that requires, such as, the sensitivity of sample examination requirements is < 1 target/>1 μ l; Scanning amount should be greater than 1 μ l so; If sensitivity require for 1 target/10 μ l, scanning amount should be greater than 10 μ l, if also do not find target greater than the scanning amount that is provided with so; Then be regarded as negatives, no longer continue scanning.Can guarantee not omission, and determine sweep time.）；
D) staticly settle the time fully: 100～120s;
E) (with the destination number that collects enough requirements is purpose, promptly collects the minimum sensitivity that needs and requires the highest that type visible component target just to stop scanning taking pictures to scan photo opporunity: 20～30s fully.And maximum collection capacity is limited to the corresponding minimum collection capacity of sensitivity requirement mxm..）；
F) flushing channel time: 10～15s.
That is to say that independent detection finishes a positive urine fluid samples, cleaned passage and made passage be in idle condition, need the 160s time at least; Only 22.5/hour of detection speeds; If do not adopt counting chamber hyperchannel time-division processing, its detection speed is just too slow, and efficient is too low.
Contain multichannel flowing counting pool if adopt, and to after its implementation time-division processing, be example with 3 channel counts ponds, positive detection is fastest brings up to original 3 times, promptly 67/hour.
Through above-mentioned pipelined-flash disposal route; Made the single pump valve control cycle and the microscope scan period of hyperchannel processing module obtain utilizing more fully; To further improve detection speed, can increase passage simultaneously and implement through shortening single pump valve control cycle and the time of microscope scan period; But this method is owing to receive the restriction of separate unit microscope and pump valve control cycle, and it is impossible to want to continue to significantly improve analysis speed.
The foregoing description is that example describes with a hyperchannel processing module, but the utility model is not limited to a hyperchannel processing module, and it can also be two, three, four or passage processing module more the more.
Continue significantly to improve analysis speed like need, then can adopt the cascade of a plurality of hyperchannel processing module.As shown in Figure 6, be a plurality of hyperchannel processing module of the utility model cascade synoptic diagram.These hyperchannel processing modules are carried out Coordination Treatment through main control computer; This main control computer can be a multi-purpose computer; It also can be an embedded system; Each hyperchannel processing module can independently be accomplished sample analysis, and main control computer carries out the exchange of order and data through communication interface and each hyperchannel processing module.The analysis of each hyperchannel processing module can be independent fully like this, can not produce mutual restriction, thereby can reach the purpose that significantly improves analysis speed.As adopt the cascade of two hyperchannel processing modules, and each microscope disposes 3 channel counts ponds, and then the maximum analysis speed of positive sample can reach 134/hour.
Why adopt flowing counting pool hyperchannel time-division processing method can improve detection speed?
At first, the utility model is designed with primary dcreening operation and detects scanning in testing process; When confirmatory sample when primary dcreening operation detects is a negatives; Can not do deposition and subsequent detection fully, can improve the detection speed of negative sample so greatly, just this sample done deposition fully when only when primary dcreening operation detects, finding tangible suspicious object; And do when precipitating fully at this passage and can handle other passages simultaneously again; So, through hyperchannel time-division processing method, overcome because of sample and need precipitate the slow shortcoming of analysis speed that the long period causes.
In addition; To the single channel counting chamber; The microscopy flow process from each step that the deposition-low power scanning-high power of sample introduction-primary dcreening operation deposition-primary dcreening operation scanning-fully scans the whole process of cleaning can only the serial execution; Not only deposition has taken the time, and its pump valve control cycle and microscope scan period are not all utilized fully.Handle through pipelined-flash after adopting the hyperchannel counting chamber; Not only the time can handle other passage in deposition when a passage; And when a passage in when scanning; Other passage can carry out sample introduction and cleaning, is perhaps carrying out sample introduction when cleaning when a passage, and other passage then can carry out microscope scanning.Through this parallel processing, further improved the speed that microscopy is analyzed again.
Secondly, adopt the cascade of a plurality of hyperchannel processing module, the analysis of each hyperchannel processing module can be independent fully, can not produce mutual restriction, thereby make the microscopy analysis speed on the basis of single hyperchannel processing module, obtain significantly improving again.
Claims (4)
1. a sample visible component analyser automatic detection and control device is characterized in that comprising at least one hyperchannel processing module, and these hyperchannel processing modules are connected with main control computer through communication interface respectively; Each hyperchannel processing module comprises that contains a multichannel flowing counting pool; Each passage of this flowing counting pool has independently input end and output terminal; This input end is connected with sampling probe through first input control valve; This output terminal is connected with the sample front pump through second input control valve; Those first input control valves, second input control valve and sample front pump are connected with an output terminal of pump valve control assembly respectively, and the input end of this pump valve control assembly is connected with the counting chamber control module.
2. sample visible component analyser automatic detection and control device according to claim 1; It is characterized in that each hyperchannel processing module comprises that also one cleans branch road; This cleans a route purge control valve, scavenging pump, cleaning liquid pool and service sink and forms; This purge control valve contains a normally open valve and a normally close valve at least, and the normally close valve of this purge control valve connects the output terminal of each passage second input control valve, and the input end of this purge control valve connects scavenging pump; The input end of this scavenging pump connects the cleaning liquid pool through cleaning fluid input solenoid valve, and this cleaning delivery side of pump connects service sink through the normally open valve of purge control valve.
3. sample visible component analyser automatic detection and control device according to claim 1; It is characterized in that; This counting chamber control module connects microscope control assembly and CCD control assembly, and this microscope control assembly connects microscope, and this CCD control assembly connects the CCD camera.
4. sample visible component analyser automatic detection and control device according to claim 1 is characterized in that this main control computer and counting chamber control module are respectively multi-purpose computer or embedded system.
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| CN2011203967738U CN202257125U (en) | 2011-10-18 | 2011-10-18 | Automatic detection controller for sample visible component analytical instrument |
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| CN2011203967738U CN202257125U (en) | 2011-10-18 | 2011-10-18 | Automatic detection controller for sample visible component analytical instrument |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102768271A (en) * | 2012-08-10 | 2012-11-07 | 长沙高新技术产业开发区爱威科技实业有限公司 | Sample analyzing method and comprehensive sample analyzer |
| CN106199034A (en) * | 2016-08-26 | 2016-12-07 | 山东宝威生物科技有限公司 | A kind of urine sediments analyzer four-way combined test system |
| CN106574934A (en) * | 2014-07-07 | 2017-04-19 | 株式会社日立高新技术 | Analysis device and analysis method |
-
2011
- 2011-10-18 CN CN2011203967738U patent/CN202257125U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102768271A (en) * | 2012-08-10 | 2012-11-07 | 长沙高新技术产业开发区爱威科技实业有限公司 | Sample analyzing method and comprehensive sample analyzer |
| CN102768271B (en) * | 2012-08-10 | 2014-06-04 | 爱威科技股份有限公司 | Sample analyzing method and comprehensive sample analyzer |
| CN106574934A (en) * | 2014-07-07 | 2017-04-19 | 株式会社日立高新技术 | Analysis device and analysis method |
| CN106199034A (en) * | 2016-08-26 | 2016-12-07 | 山东宝威生物科技有限公司 | A kind of urine sediments analyzer four-way combined test system |
| CN106199034B (en) * | 2016-08-26 | 2018-05-01 | 山东宝威生物科技有限公司 | A kind of urine sediments analyzer four-way combined test system |
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Owner name: AVE SCIENCE + TECHNOLOGY CO., LTD. Free format text: FORMER NAME: AVE SCIENCE + TECHNOLOGY INDUSTRY CO., LTD. CHANGSHA HIGH NEW TECHNOLOGY INDUSTRY DEVELOPMENT ZONE |
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Address after: 410205 Hunan province Changsha Wenxuan High-tech Development Zone, Road No. 27 building B6 Yuyuan mountain valley Patentee after: AVE Science & Technology Co., Ltd. Address before: 410013, M1 building, Torch Group, torch City, Changsha hi tech Development Zone, Hunan, Changsha, 4 Patentee before: AVE Science & Technology Industry Co., Ltd. Changsha High New Technology Industry Development Zone |
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