CN202151530U - Decarburizing filter device for mycophenolic acid production technology - Google Patents
Decarburizing filter device for mycophenolic acid production technology Download PDFInfo
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- CN202151530U CN202151530U CN2011202086668U CN201120208666U CN202151530U CN 202151530 U CN202151530 U CN 202151530U CN 2011202086668 U CN2011202086668 U CN 2011202086668U CN 201120208666 U CN201120208666 U CN 201120208666U CN 202151530 U CN202151530 U CN 202151530U
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- mycophenolic acid
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Abstract
The utility model discloses a decarburizing filter device for the mycophenolic acid production technology, and belongs to the field of drug substance production equipment. In order to improve the clarity of processed mycophenolic acid feed liquid, reduce activated carbon in the processed mycophenolic acid feed liquid, lower the manual labor consumption and improve the production efficiency, the utility model provides the decarburizing filter device for the mycophenolic acid production technology. The decarburizing filter device comprises a cylinder cone-type filter and a pipeline filter, and compared with the prior art, the utility model has the advantages that mycophenolic acid decarbidizing liquid is roughly filtered through the cylinder cone-type filter firstly and then filtered for the second time through the pipeline filter, so that solid impurities such as active carbon and the like can be effectively removed, impurities in the mycophenolic acid decarbidizing liquid can be reduced remarkably, and meanwhile, washing and slagging operations are carried out in the sealed cylinder cone-type filter, so that the operations are convenient, and the production efficiency is improved.
Description
Technical field
The utility model belongs to the production of raw medicine apparatus field, is specifically related to a kind of Mycophenolic Acid production technology and takes off filter with charcoal.
Background technology
Mycophenolic Acid; Have another name called mycophenolic acid, chemical name is E-4-methyl-6-(1,3-dihydro-7-methyl-4-hydroxyl-6-methoxyl group-3-oxo-5-isobenzofuran-base)-4-hexenoic acid; Be immunodepressant MMF (mycophenolate mofetil, intermediate MMF).MMF (Mycophenolate Mofetil; MMF) be the 2-ethyl ester analog derivative of MPA; Form the metabolite MPA with immunosuppressive activity through taking off ester in vivo, the latter is through suppressing the synthetic of guanine, the propagation of selective exclusion T and bone-marrow-derived lymphocyte; Transplant rejection and autoimmune disease all there are significant curative effect, have been widely used in the treatment of heart, kidney transplant rejection and immunity disease such as LN, vasculitis etc. at present.
Mycophenolic Acid obtains through microbial fermentation production; After fermenting and producing finishes; The zymotic fluid that contains the product Mycophenolic Acid through filtering fermentation liquor, solvent extraction and precipitate and separate, charcoal take off filtration, concentrate, after the operations such as crystallization and vacuum drying; Obtain the Mycophenolic Acid bullion, bullion gets the Mycophenolic Acid finished product through further crystallization.Wherein, charcoal takes off that to filter be earlier with impurity such as the coloring matter in the charcoal absorption product feed liquid and other correlatives, and the active carbon that will adsorb impurity through filter plant is again held back, and reaches the purpose of removing impurity.Yet active carbon also can adsorb few products in absorption impurity, therefore, for improving product yield, needs wash to reclaim product as much as possible active carbon after filtration finishes.Charcoal takes off filter operation and has very significant effects to improving product purity with the control impurity content, can directly have influence on finished product and whether meet quality standard.
Existing charcoal takes off liquid and filters and often to filter with the flat-panel filter that overlays diatomite layer, and flat-panel filter simple structure, mounting or dismounting make things convenient for, good seal performance, but but both also press filtrations of suction filtration are applicable to the filtration treatment of liquid.But; There is following shortcoming when using this equipment: at first; The aperture of flat-panel filter itself is bigger, need be equipped with CN-CA, polypropylene screen, louver film, nylon membrane, polyvinylidene fluoride film or filter aid and use together, is therefore carrying out need overlaying diatomite layer before charcoal takes off the liquid filtration; And in the Mycophenolic Acid feed liquid after handling a spot of active carbon is arranged, relatively more muddy; Secondly, Cake Wash weak effect: the Cake Wash of filter mainly leans on the pressure differential of vacuum filtration or pressure filtration in static washing down, stirs Cake Wash like need and then will open the filter end socket, stirs filter cake by hand by operating personnel.For the product of producing with organic solvent, this both threatened to operating personnel's health, also caused security incident easily; At last, the slag dumping difficulty: the filter cake after the filtration, need after pulling down the end socket of filter, to draw off by hand, inconvenient operation, workload is big, is unfavorable for very much large batch of continuous production operation.
The utility model content
The purpose of the utility model is the deficiency to above-mentioned prior art, provides a kind of Mycophenolic Acid charcoal to take off the device that liquid filters usefulness.Specifically,, reduce manpower and expend, improve the clarity of the Mycophenolic Acid feed liquid after handling in order to enhance productivity; Reduce the activated carbon in the Mycophenolic Acid feed liquid after handling, the utility model provides a kind of Mycophenolic Acid production technology to take off filter with charcoal, and it comprises cone type filter and piping filter; Compared with prior art, the Mycophenolic Acid charcoal takes off liquid at first after cone type filter coarse filtration, passes through the piping filter secondary filter again; Can effectively remove solid impurities such as active carbon, significantly reducing the Mycophenolic Acid charcoal takes off liquid impurity, simultaneously; The operation of washing and deslagging is all carried out in airtight cone type filter, and handled easily has improved production efficiency.
A kind of Mycophenolic Acid production technology for the utility model is taken off filter with charcoal; More particularly; Described cone type filter comprises tank body, agitating device, cylindrical shell filter screen, cylindrical shell chuck, and cone filter screen, cone chuck, cone type filter unload cinder notch, and cylindrical shell filter screen and cylindrical shell chuck are positioned at the top of cone type filter; Cone filter screen and cone chuck are positioned at the bottom of cone type filter, and the cone type filter unloads the least significant end that cinder notch is positioned at the cone type filter.
On the cone type filter, also be provided with feed pipe; Feed pipe is positioned at the top of cone type filter; Also be provided with filtrate pipe, middle filtrate pipe and following filtrate pipe from top to bottom at the cone type filter, and go up filtrate pipe, middle filtrate pipe and following filtrate pipe successively and be provided with upward filtration fluid valve, middle filtrating valve and filtrating valve down; The pipeline fluid strainer is arranged on the discharge nozzle of cone type filter, and the pipeline fluid strainer comprises the piping filter filter core.
Cone type filter tank body adopts stainless steel, the total filter area 3M of filter screen
2, filter screen aperture 20 μ m, the filter material material is 5 layers of 316L stainless steel sintered plate.Piping filter is made for the cartridge type stainless steel material, and piping filter filter core aperture 0.12-0.40 μ m is micropore ceramic filter element.
The utility model is considered; Because the cone type strainer screen divides upper and lower filter two joints; Be cylindrical shell filter screen and cone filter screen; Exist between cylindrical shell filter screen and the cone filter screen, many places must sealed attachment between filter screen and cylindrical shell, cylindrical shell and the cone etc., in use has solid particle such as trace active charcoal through filter screen, filtrating can not reach technological requirement.Yet, when using the filter screen in lower aperture, can influence the filtering rate of cone type filter.Therefore, the utility model is installed a piping filter on cone type filter discharge nozzle, and the piping filter filter core has been carried out preferably; Preferably; Piping filter filter core aperture is 0.22 μ m, and with the solid particle filterings such as trace active charcoal of considering the cone type filter, the filtrating that obtains at last can meet the processing quality requirement fully; Can reach the purpose that improves filtering rate again, significantly be superior to using in the prior art filter type of flat-panel filter.
In a word; The utility model compared with prior art; Have following technical advantage: the Mycophenolic Acid charcoal of the utility model takes off filtration, Cake Wash and the slag dumping process of liquid filter to be accomplished by the equipment operation under airtight situation; Operating process is carried out under airtight situation, has avoided the harm of organic solvent volatilization to operator ' s health, has avoided the pollution to environment; Operating process is accomplished by the equipment operation, and filtering rate is high, has avoided manually-operated, has increased substantially labor productivity; The screen pack aperture that filter itself is equipped with meets the filtration requirement, does not need extra use filter aid and filter membrane, has practiced thrift production cost; This device can effectively filter the Mycophenolic Acid charcoal and take off liquid, and filtrate filtered does not contain solid impurities such as active carbon, has improved the clarity of filtrating, has improved product quality, and steady quality.
Description of drawings
Fig. 1 takes off the structural representation of an embodiment of liquid filter for a kind of Mycophenolic Acid charcoal of the utility model.In Fig. 1,1 is feed pipe, and 2 is the cone type filter, and 21 is the cylindrical shell filter screen, and 22 is the cylindrical shell chuck; 23 is the cone filter screen, and 24 is the cone chuck, and 25 for the cone type filter unloads cinder notch, and 31 is last filtrating pipeline; 32 is middle filtrating pipeline, and 33 are following filtrating pipeline, and 41 is the upward filtration fluid valve, and 42 is middle filtrating valve; 43 are the valve of filtrating down, and 5 is piping filter, and 51 is the piping filter filter core, and 6 is discharge nozzle.
The specific embodiment
Below in conjunction with accompanying drawing, further describe the utility model through specific embodiment, but the utility model is not limited only to following examples.In the scope of the utility model or in the content that does not break away from the utility model, spirit and scope; The described a kind of Mycophenolic Acid charcoal of the utility model is taken off liquid filter and building block thereof be carried out to material and/or the building block that reduced scale or expansion, a kind of Mycophenolic Acid charcoal of replacement take off the liquid filter; Will become apparent to those skilled in the art that they all are regarded as is included within the utility model scope.
Fig. 1 has provided the structural representation that the utility model a kind of Mycophenolic Acid charcoal takes off an embodiment of liquid filter.Can find out that in Fig. 1 a kind of Mycophenolic Acid charcoal of the utility model takes off the liquid filter and comprises cone type filter 2 and piping filter 5, and duct coupling.
For present embodiment a kind of Mycophenolic Acid production technology take off filter with charcoal; More particularly; Described cone type filter comprises tank body, agitating device, cylindrical shell filter screen 21, cylindrical shell chuck 22; Cone filter screen 23, cone chuck 24, cone type filter unload cinder notch 25; Cylindrical shell filter screen 21 and cylindrical shell chuck 22 are positioned at the top of cone type filter, and cone filter screen 23 and cone chuck 24 are positioned at the bottom of cone type filter, and the cone type filter unloads the least significant end that cinder notch 25 is positioned at the cone type filter.
On the cone type filter, also be provided with feed pipe 1; Feed pipe 1 is positioned at the top of cone type filter; Also be provided with filtrate pipe 31, middle filtrate pipe 32 and following filtrate pipe 33 from top to bottom at the cone type filter, and go up filtrate pipe 31, middle filtrate pipe 32 and following filtrate pipe 33 successively and be provided with upward filtration fluid valve 41, middle filtrating valve 42 and filtrating valve 43 down; Pipeline fluid strainer 5 is arranged on the discharge nozzle 6 of cone type filter, and pipeline fluid strainer 5 comprises piping filter filter core 51.
Cone type filter tank body adopts stainless steel, the total filter area 3M of filter screen
2, filter screen aperture 20 μ m, the filter material material is 5 layers of 316L stainless steel sintered plate.Piping filter 5 is made for the cartridge type stainless steel material, and piping filter 5 filter core aperture 0.12-0.40 μ m are micropore ceramic filter element.
Present embodiment the operating process of using charcoal to take off filter of a kind of Mycophenolic Acid production technology be:
Piping filter filter core 51 is packed in the piping filter 5, tighten the screw.Connecting cylinder bevel-type filter 2 takes off filtrate tanks with piping filter 5 and charcoal; Charcoal to be filtered takes off liquid and is compressed air through feed pipe 1 and is pressed in the cone type filter 2; Through material being carried out pressure filtration to cone type filter 2 pressurization, filtrating respectively from last filtrating pipeline 31, filtrating pipeline 32 and 33 outflows of following filtrating pipeline, pass through the piping filter secondary filter again; Filtrating after final the processing enters into charcoal and takes off filtrate tanks, waits for subsequent treatment.
Solid impurities such as the active carbon in the feed liquid then constantly accumulate in and form filter cake in the cone type filter; Filter cake can be through the rotation of the agitating device in the cone type filter; Scrape the filter cake on the filter screen; Material is filtered under thin layer filter cake condition, keep the high rate of filtration, and can constantly upwards promote filter cake.During washing leaching cake; Do the filter of the filter cake in the cone type filter earlier, then cleaning solution is added in the cone type filter, utilize the rotation of parts such as scraper, agitator and extrusion spiral to stir; Filter cake is starched again, at last through becoming filter cake to slurries filtration again to cone type filter compressed gas.As required, can carry out repeatedly Cake Wash operation, carry out filter cake after with Cake Wash to required requirement to draw off.When the filter cake of cone type filter reaches some and accomplishes washing operation as requested, can unload slag operation.During slag dumping, change the rotation direction of cone type filter pushing spiral, the filter cake in the cone type filter outside cone type filter bottom kickoff mechanism.In filtration and Cake Wash process, like need feed liquid is incubated, can in the external jacket of cone type filter, feed heating agent and be incubated.
In a word, take off the filter filtrate filtered through a kind of Mycophenolic Acid production technology of present embodiment with charcoal and do not contain solid impurities such as active carbon, steady quality; Avoided the harm of organic solvent volatilization, avoided pollution environment to operator ' s health; Filtering rate is high, has reduced manually-operated, has increased substantially labor productivity; The screen pack aperture that cone type filter itself is equipped with meets the filtration requirement, does not need extra use filter aid and filter membrane, has practiced thrift production cost.
Claims (2)
1. a Mycophenolic Acid production technology is taken off filter with charcoal; It comprises cone type filter and piping filter; Described cone type filter comprises tank body, agitating device, cylindrical shell filter screen, cylindrical shell chuck, and cone filter screen, cone chuck, cone type filter unload cinder notch, and cylindrical shell filter screen and cylindrical shell chuck are positioned at the top of cone type filter; Cone filter screen and cone chuck are positioned at the bottom of cone type filter, and the cone type filter unloads the least significant end that cinder notch is positioned at the cone type filter;
On the cone type filter, also be provided with feed pipe; Feed pipe is positioned at the top of cone type filter; Also be provided with filtrate pipe, middle filtrate pipe and following filtrate pipe from top to bottom at the cone type filter, and go up filtrate pipe, middle filtrate pipe and following filtrate pipe successively and be provided with upward filtration fluid valve, middle filtrating valve and filtrating valve down; Piping filter is arranged on the discharge nozzle of cone type filter, and piping filter comprises the piping filter filter core, piping filter filter core aperture 0.12-0.40 μ m.
2. a kind of Mycophenolic Acid production technology as claimed in claim 1 is taken off filter with charcoal, it is characterized in that, described piping filter filter core aperture is 0.22 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202086668U CN202151530U (en) | 2011-06-20 | 2011-06-20 | Decarburizing filter device for mycophenolic acid production technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202086668U CN202151530U (en) | 2011-06-20 | 2011-06-20 | Decarburizing filter device for mycophenolic acid production technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202151530U true CN202151530U (en) | 2012-02-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011202086668U Expired - Fee Related CN202151530U (en) | 2011-06-20 | 2011-06-20 | Decarburizing filter device for mycophenolic acid production technology |
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| CN (1) | CN202151530U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105536343A (en) * | 2016-01-25 | 2016-05-04 | 湘潭林海机械制造有限公司 | Squeezing, solid-liquid separating and filtering unit |
-
2011
- 2011-06-20 CN CN2011202086668U patent/CN202151530U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105536343A (en) * | 2016-01-25 | 2016-05-04 | 湘潭林海机械制造有限公司 | Squeezing, solid-liquid separating and filtering unit |
| CN105536343B (en) * | 2016-01-25 | 2017-10-03 | 湘潭林海机械制造有限公司 | Squeeze solid-liquid separation filter group |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120229 Termination date: 20130620 |