CN202129027U - Ultrafiltration device for removing pyrogen and impurities from Chinese medicine injection - Google Patents
Ultrafiltration device for removing pyrogen and impurities from Chinese medicine injection Download PDFInfo
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- CN202129027U CN202129027U CN201120220654U CN201120220654U CN202129027U CN 202129027 U CN202129027 U CN 202129027U CN 201120220654 U CN201120220654 U CN 201120220654U CN 201120220654 U CN201120220654 U CN 201120220654U CN 202129027 U CN202129027 U CN 202129027U
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Abstract
The utility model relates to an ultrafiltration device for removing pyrogen and impurities from Chinese medicine injection. The device comprises a primary liquid box, an ultrafilter, an ultrafiltration membrane component, a concentrated liquid flowmeter and a permeate liquid flowmeter, wherein one side of the primary liquid box is connected with a liquid inlet I of the ultrafilter; the other side of the primary liquid box is connected with a liquid outlet I of the concentrated liquid flowmeter; a liquid outlet II of the ultrafilter is connected with a liquid inlet II of the ultrafiltration membrane component; a concentrated liquid outlet of the ultrafiltration membrane component is connected with a liquid inlet III of the concentrated liquid flowmeter; a permeate liquid outlet is connected with a liquid inlet IV of the permeate liquid flowmeter; and a liquid outlet III of the permeate liquid flowmeter is externally connected with a liquid outlet pipe. The ultrafiltration device provided by the utility model has the characteristics of low energy consumption, capacities of effectively reducing loss of active ingredients and increasing removal rate of the impurities and bacteria, and light environmental pollution, thereby effectively solving the quality problem of the injection in the preparation process.
Description
Technical field
The utility model relates to biomedicine field, relates in particular to the ultrafiltration apparatus of traditional Chinese medicine depyrogenation and removal of impurities.
Background technology
Chinese medicine has been the medical science marrow of China since several thousand, and in recent years, the magical curative effect of Chinese medicine was approved by countries in the world; The development speed of Chinese medicine is also advanced by leaps and bounds, the raising of Along with people's life water article and the reinforcement of environmental consciousness, and the thought of back to nature is obvious day by day; And Chinese medicine becomes the first-selection that people's medical treatment is cured the disease with its pure natural, advantage such as have no side effect; But the outmoded technology that decocts is adopted in the processing of the Chinese medicine of China always, and not only poor product quality, and pharmacy procedure consumes lot of energy; Make the market of tcm product more and more receive squeezing of external product, let alone go abroad, go to the world.It is reported China's Chinese patent drug proportion only 15% on tcm product market, the world, change the backward situation of Chinese medicine processing technology, must prepare at Chinese medicine and adopt advanced technology in the process.At present, main meagre abstraction technique, supercritical liquid extraction technique, macroporous absorbent resin technology and the membrane separating extractive technique of adopting in the Chinese medicine production and processing.In recent years, the development of membrane separation technique has received people and has paid close attention to greatly, and the application of part has been arranged in the traditional Chinese medicine field.
Mostly the traditional Chinese medicine process for purification is water extraction and alcohol precipitation method at present; Its basic principle be utilize most of compositions such as alkaloid salt in the plants such as medicinal material, glucoside, organic acid, amino acid, polysaccharide etc. soluble in water and pure in characteristic; Water proposes, and its extract is concentrated, and adds the sedimentation for several times repeatedly of suitable ethanol or water; Remove its insoluble matter, obtain clear liquid at last.There are many drawbacks in the method, mainly show defective, the effective ingredient of clarity and bacterium inspection run off serious, the pyrogen clearance is low, complex process, production cycle are long.And ultrafiltration is the difference according to various traditional Chinese medicine ingredients molecular weight sizes, utilizes the membrane module that is fit to membrane aperture, filters through embrane method to make active ingredient be able to separation and purification.Through experimental study, ultrafiltration is compared with water extraction and alcohol precipitation method and can be reduced by 30% left and right sides loss of active ingredients.Replace the alcohol precipitation removal of impurity for reaching, improve the quality of products, guarantee drug safety, save production cost, shorten the purpose of production cycle, hyperfiltration technique will be the development in future direction.
Ultrafiltration has been widely used in field of medicaments at present as a kind of new and high technology.The molecular weight of middle pharmaceutically active ingredient is less relatively; Generally about 1000, and the invalid components molecular weight is big, mostly more than 50000; Can under the prerequisite of not losing effective ingredient, remove macromolecule impurity so use ultrafiltration apparatus; Improve effective ingredient, the hyperfiltration technique with characteristics such as energy consumption is low, non-secondary pollution, normal-temperature operation, separative efficiency height will progressively replace traditional Chinese medicine injection refining and edulcoration method, be the refining new trend of traditional Chinese medicine.
The utility model content
The utility model technical problem to be solved provide a kind of energy consumption low, can effectively reduce the traditional Chinese medicine depyrogenation of loss of active ingredients and the ultrafiltration apparatus of removal of impurities.
For addressing the above problem, the ultrafiltration apparatus of described traditional Chinese medicine depyrogenation of the utility model and removal of impurities is characterized in that: this device comprises stoste case, accurate filter, hyperfiltration membrane assembly, concentrated solution discharge meter and sees through the flow quantity meter; One side of said stoste case and the inlet I of said accurate filter join, and the leakage fluid dram I of its opposite side and said concentrated solution discharge meter joins; The leakage fluid dram II of said accurate filter and the inlet II of said hyperfiltration membrane assembly join; The inlet III of the concentrated solution outlet of said hyperfiltration membrane assembly and said concentrated solution discharge meter joins, and it sees through the liquid outlet and the said inlet IV that sees through the flow quantity meter joins, and should see through the external discharging tube of leakage fluid dram III of flow quantity meter.
One side of said stoste case is joined through the inlet I of raw liquor pump and said accurate filter.
The leakage fluid dram II of said accurate filter joins through the inlet II of high-pressure pump and said hyperfiltration membrane assembly.
The concentrated solution outlet of said hyperfiltration membrane assembly joins through the inlet III of pressure regulator valve and said concentrated solution discharge meter.
Said hyperfiltration membrane assembly is that molecular cut off is the milipore filter of 20KD～50KD.
The utility model compared with prior art has the following advantages:
1, owing to be provided with milipore filter (UF film) assembly in the utility model, material liquid is under the certain pressure effect, through milipore filter; Utilize the selection permeability of film, macromolecular substances, pyrogen and impurity can be trapped, and this technology can replace traditional aqueous extraction-alcohol precipitation technology; Therefore; Can more effectively reduce loss of active ingredients, and improve impurity, pyrogen clearance, thereby effectively prevent the injection problem that quality reduces in the preparation process.
2, because the UF membrane module that is provided with in the utility model has no phase transformation, the characteristics of normal-temperature operation, therefore, the utility model energy consumption is low.
3, because the film separation system in the utility model is compared with original aqueous extraction-alcohol precipitation technology, need not consume the ethanol equal solvent, therefore, the utility model environmental pollution is little.
4, the utility model volume is little, cost is low.
Description of drawings
Below in conjunction with accompanying drawing the specific embodiment of the utility model is done further detailed explanation.
Fig. 1 is the structural representation of the utility model.
---stoste case 2-raw liquor pump 3-accurate filter 4---high-pressure pump 5-hyperfiltration membrane assembly 6-pressure regulator valve 7-concentrated solution discharge meter 8-sees through the flow quantity meter among the figure: 1.
The specific embodiment
As shown in Figure 1, the ultrafiltration apparatus of traditional Chinese medicine depyrogenation and removal of impurities, this device comprise stoste case 1, accurate filter 3, hyperfiltration membrane assembly 5, concentrated solution discharge meter 7 and see through flow quantity meter 8.Hyperfiltration membrane assembly 5 is the milipore filter of 20KD～50KD for molecular cut off.
One side of stoste case 1 is joined through the inlet I of raw liquor pump 2 with accurate filter 3, and the leakage fluid dram I of its opposite side and concentrated solution discharge meter 7 joins; The leakage fluid dram II of accurate filter 3 joins through the inlet II of high-pressure pump 4 with hyperfiltration membrane assembly 5; The concentrated solution outlet of hyperfiltration membrane assembly 5 joins through the inlet III of pressure regulator valve 6 with concentrated solution discharge meter 7, and it joins with the inlet IV that sees through flow quantity meter 8 through the liquid outlet, should be through the external discharging tube of leakage fluid dram III of flow quantity meter 8.
During work; Chinese traditional medicine water extract flows into raw liquor pump 2 by stoste case 1, behind accurate filter 3, is input in the hyperfiltration membrane assembly 5 by high-pressure pump 4; After hyperfiltration membrane assembly 5 separates, see through liquid and flow out for use through seeing through flow quantity meter 8 through the liquid outlet that sees through on the hyperfiltration membrane assembly 5; Concentrate is circulated to stoste case 1 successively through hyperfiltration membrane assembly 5 concentrated solution outlets behind pressure regulator valve 6, concentrated solution discharge meter 7.
Claims (5)
1. the ultrafiltration apparatus of traditional Chinese medicine depyrogenation and removal of impurities is characterized in that: this device comprises stoste case (1), accurate filter (3), hyperfiltration membrane assembly (5), concentrated solution discharge meter (7) and sees through flow quantity meter (8); The inlet I of one side of said stoste case (1) and said accurate filter (3) joins, and the leakage fluid dram I of its opposite side and said concentrated solution discharge meter (7) joins; The inlet II of the leakage fluid dram II of said accurate filter (3) and said hyperfiltration membrane assembly (5) joins; The inlet III of the concentrated solution outlet of said hyperfiltration membrane assembly (5) and said concentrated solution discharge meter (7) joins, and it sees through the liquid outlet and the said inlet IV that sees through flow quantity meter (8) joins, and should see through the external discharging tube of leakage fluid dram III of flow quantity meter (8).
2. the ultrafiltration apparatus of traditional Chinese medicine depyrogenation as claimed in claim 1 and removal of impurities is characterized in that: a side of said stoste case (1) is joined through the inlet I of raw liquor pump (2) with said accurate filter (3).
3. the ultrafiltration apparatus of traditional Chinese medicine depyrogenation as claimed in claim 1 and removal of impurities is characterized in that: the leakage fluid dram II of said accurate filter (3) joins through the inlet II of high-pressure pump (4) with said hyperfiltration membrane assembly (5).
4. the ultrafiltration apparatus of traditional Chinese medicine depyrogenation as claimed in claim 1 and removal of impurities is characterized in that: the concentrated solution outlet of said hyperfiltration membrane assembly (5) joins through the inlet III of pressure regulator valve (6) with said concentrated solution discharge meter (7).
5. the ultrafiltration apparatus of traditional Chinese medicine depyrogenation as claimed in claim 1 and removal of impurities is characterized in that: said hyperfiltration membrane assembly (5) is the milipore filter of 20KD～50KD for molecular cut off.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120220654U CN202129027U (en) | 2011-06-20 | 2011-06-20 | Ultrafiltration device for removing pyrogen and impurities from Chinese medicine injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201120220654U CN202129027U (en) | 2011-06-20 | 2011-06-20 | Ultrafiltration device for removing pyrogen and impurities from Chinese medicine injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202129027U true CN202129027U (en) | 2012-02-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201120220654U Expired - Fee Related CN202129027U (en) | 2011-06-20 | 2011-06-20 | Ultrafiltration device for removing pyrogen and impurities from Chinese medicine injection |
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| CN (1) | CN202129027U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103252166A (en) * | 2013-05-23 | 2013-08-21 | 南京中医药大学 | Absorption and desorption device and desorption method of Chinese medicine volatile oil film |
| CN113101696A (en) * | 2021-03-04 | 2021-07-13 | 贵州省工程复合材料中心 | High-speed centrifugal atomization combined alcohol precipitation device and using method thereof |
-
2011
- 2011-06-20 CN CN201120220654U patent/CN202129027U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103252166A (en) * | 2013-05-23 | 2013-08-21 | 南京中医药大学 | Absorption and desorption device and desorption method of Chinese medicine volatile oil film |
| CN113101696A (en) * | 2021-03-04 | 2021-07-13 | 贵州省工程复合材料中心 | High-speed centrifugal atomization combined alcohol precipitation device and using method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120201 Termination date: 20120620 |