CN202105321U - Magnetic nanoparticle magnetic induction thermal focusing system based on compound magnetic field - Google Patents
Magnetic nanoparticle magnetic induction thermal focusing system based on compound magnetic field Download PDFInfo
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- CN202105321U CN202105321U CN2011201792086U CN201120179208U CN202105321U CN 202105321 U CN202105321 U CN 202105321U CN 2011201792086 U CN2011201792086 U CN 2011201792086U CN 201120179208 U CN201120179208 U CN 201120179208U CN 202105321 U CN202105321 U CN 202105321U
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Abstract
The utility model discloses a magnetic nanoparticle magnetic induction thermal focusing system based on a compound magnetic field, which comprises a device for generating an alternating magnetic field, magnetic nanoparticles and at least two permanent magnets, wherein the device for generating an alternating magnetic field generates an alternating magnetic field, the magnetic nanoparticles are dispersed in the alternating magnetic field; the at least two permanent magnets are distributed at two sides of the device for generating an alternating magnetic field, and the same poles of the permanent magnets are opposite to each other; and the distances from the permanent magnets to the center line of the device for generating an alternating magnetic field are basically the same. The magnetic nanoparticle magnetic induction thermal focusing system realizes accurate control on the thermal effect of the magnetic nanoparticles and selective temperature rise on local places in the area dispersed with the magnetic nanoparticles, has lower cost, and can realize selective heating on the tumor area, thus alleviating injury of thermal therapy on normal tissues. The magnetic nanoparticle magnetic induction thermal focusing system can also be used for conducting selective heating on the area of a chemical reaction system simultaneously, thus realizing the aim of controlling the chemical reaction rate.
Description
Technical field
This utility model belongs to biological and medical science technical field of nano material, particularly a kind of magnetic nanoparticle magnetic induction hot focus system based on resultant field.
Background technology
Magnetic nanoparticle can heat up under action of alternating magnetic field.General our heat of in the unit interval, producing with the magnetic material of unit mass that is characterize the size of its heat effect than heat production power (SAR), concrete computing formula does
SAR＝C·ΔT/Δt·1/mFe
Wherein C is the specific heat of sample, and the quality of specific heat and specific heat of water of getting ferrite nanometer particle is average, and Δ T/ Δ t is the initial slope of temperature-time curve, and mFe then is that every gram ferrite nanometer particle is dispersed in GOLD FROM PLATING SOLUTION and belongs to ionic content.
The thermal losses of magnetic nanoparticle mainly is to be caused by magnetic hysteresis and relaxation effect, and its size is relevant with the field intensity and the frequency of the physico-chemical property of material and alternating magnetic field.
Ferromagnetic or the ferrous magnetic nano particle of size big (greater than the single domain size) is in the process of remagnetization; The variation of its magnetic induction always lags behind its magnetic field intensity; This phenomenon presents the hysteresis curve relation magnetic hysteresis between its magnetic flux density B and the magnetic field intensity H.The energy loss that in magnetic history, is caused by hysteresis is called magnetic hystersis loss.Through once magnetization circulation, the magnetic hystersis loss in the per unit volume material equals the area of hysteresis curve, and this part Conversion of energy is a heat energy.If added magnetic field amplitude is little, then magnetizing the hysteresis curve that obtains in a week can represent with analytic expression.This hysteresis curve is called the Rayleigh hysteresis curve.The pairing magnetic field range of Rayleigh hysteresis curve is called Rayleigh region.On-site by the loss power Ph that hysteresis effect causes does a little less than low frequency
Wherein, μ 0 is a permeability of vacuum, and η is a Rayleigh constant, and Hm is a magnetic field amplitude, and f is a field frequency.
This formula clearly illustrates that the loss power that is caused by hysteresis effect is directly proportional with the frequency of externally-applied magnetic field, also is directly proportional with the cube of the amplitude of externally-applied magnetic field, also is directly proportional with Rayleigh constant simultaneously.
Relaxation is divided into Neil relaxation and Blang's relaxation, and wherein Blang's relaxation is a magnetic-particle when receiving action of alternating magnetic field, and the granule that magnetic moment is fixed on direction of easy axis rotates in liquid and the relaxation that produces; The Neil relaxation then be magnetic-particle in alternating magnetic field, intragranular magnetic moment overcomes energy barrier because of thermal agitation---the relaxation that magnetic anisotropy can rotate and produce.
It is generally acknowledged that the loss of superparamagnetic nanomaterial in alternating magnetic field mainly depends on relaxation.For the granule of superparamagnetism, its heat effect is classified as due to Neil relaxation and the Blang's relaxation.
The relaxation time τ B of Blang's relaxation can be expressed as:
τB＝3Vhη/kT
Wherein Vh is particulate hydrodynamic force volume, and η is the dynamic viscosity of carrier fluid, and k is a Boltzmann constant, and T is a temperature.
The relaxation time τ N of Neil relaxation then can be expressed as:
τN＝τ0expKV/kT
τ 0～10-9s wherein, KV is an anisotropy energy, and K is an anisotropy constant, and V is a particle volume.Consider this two kinds of relaxation mechanism, effective relaxation time τ eff of system does
τeff＝τNτB/(τN+τB)
The mechanism that plays a major role is the shortest relaxation time, when τ N＞＞during τ B, τ eff=τ B, when τ N＜＜during τ B, τ eff=τ N.The relaxation loss power of magnetic nanoparticle does
P＝(mHωτeff)2/[2τeffkTρV(1+ω2τeff2)]
Wherein m is a particle moment, and ρ is a grain density.The relation of P and τ eff is a resonance type curve, and when ω τ eff=1, P reaches maximum.
At present, the heat effect of magnetic nanoparticle under action of alternating magnetic field obtained extensive studies and application.Medically, the magnetic induction tumor thermotherapy has become the research focus of treating malignant tumor, and it has advantages such as Wicresoft, targeting effect.Proposed the viewpoint of thermotherapy in magnetic fluid thermotherapy or the cell at Gordon in 1979 etc., promptly adopted the heat medium of magnetic fluid as thermotherapy.The Jordan seminar of Humboldt-Universitaet zu Berlin's medical college of Germany just carried out the research of magnetic fluid thermotherapy from 1993.
Though obtained huge progress in the time of magnetic induction tumor thermotherapy decades in the past; Further develop and use but still have some problems restricting it, as the magnetic induction tumor thermotherapy is carried out thermometric and hot measure control problem, to neoplastic fevers focus issues etc.For realizing hot focus, mainly be to adopt the antibody coupling magnetic nanoparticle at present, combine to realize the targeting of magnetic nanoparticle with specific for tumour antigen at tumor region through antibody to tumor region.But the cost of this method is higher, and the coupling efficiency of antibody and magnetic nanoparticle also remains further to be improved.
The utility model content
The utility model purpose: be directed against the control problem of magnetic nanoparticle intensification behavior under alternating magnetic field of above-mentioned prior art existence, the purpose of this utility model provides a kind of magnetic nanoparticle magnetic induction hot focus system based on resultant field.
Technical scheme: for realizing above-mentioned utility model purpose; The technical scheme that this utility model adopts is a kind of magnetic nanoparticle magnetic induction hot focus system based on resultant field; Comprise the device and the magnetic nanoparticle that produce alternating magnetic field; The device of said generation alternating magnetic field produces alternating magnetic field, and magnetic nanoparticle is arranged in this alternating magnetic field, also comprises at least two both sides and homopolarity permanent magnet opposed that are distributed in the device of said generation alternating magnetic field; Permanent magnetic field is provided, and said permanent magnet apart from the distance of the centrage of the device that produces alternating magnetic field about equally.
Said magnetic nanoparticle can be selected metal and alloy magnetic nanoparticles thereof such as ferrum, cobalt, nickel; Oxide magnetic nano-particle such as ferroso-ferric oxide, iron sesquioxide, Mn ferrite, Conjugate ferrite, Ni ferrite, Zn ferrite and manganese-zinc ferrite; The particle diameter of magnetic nanoparticle can be 1-100nm; Have the function that under alternating magnetic field, heats up, the SAR value can be greater than 50w/g.
The device of said generation alternating magnetic field can be ferrite coil or solenoid coil, and the frequency of said alternating magnetic field can be 50kHz-1MHz, and power can be 10kw-100kw.
Distance between the said homopolarity permanent magnet opposed can be 1-50cm, and the magnetic induction of every said permanent magnet can be 0.1-0.5 tesla, to said permanent magnet available cycles water cooling protection, heats up in alternating magnetic field to avoid permanent magnet.
The quantity of said permanent magnet can be two, and the centrage approximate vertical of the device of its line and generation alternating magnetic field.
The angle that the quantity of said permanent magnet also can be between four and the two groups of homopolarity permanent magnet opposed can be the 30-90 degree.
This utility model is through controlling the intensification behavior of magnetic nanoparticle under alternating magnetic field in compound permanent magnetic field on the alternating magnetic field.The permanent magnetic field that adds is provided by two permanent magnets.Two permanent magnet homopolarities are relative, and mutually exclusive permanent magnetic field is provided, this magnetic field and alternating magnetic field be spatially as shown in Figure 1 carry out compound.So just the center between two permanent magnets provides lack perseverance magnetic field or permanent magnetic field very weak zone, and this zone does not have influence basically to alternating magnetic field.When magnetic nanoparticle is under the resultant field effect when heating up, be in this regional magnetic nanoparticle because can under action of alternating magnetic field, normally heat up by the effect in permanent magnetic field hardly.The magnetic nanoparticle of persevering the action of a magnetic field then has been equivalent to increase magnetic nanoparticle and has carried out the energy barrier that magnetic hysteresis heats up or relaxation heats up; Make granule hysteresis effect loss power reduce; Perhaps make granule Blang rotation or magnetic moment upset difficulty more, reduced the relaxation loss.Magnetic induction heat is suppressed around so having formed; And the inner normal zone of heating up; And magnetic field intensity that can be through changing two distance and permanent magnets between the permanent magnet to the size in this zone and around magnetic induction heat suppress to regulate and control; Thereby selectivity heating in implementation space has promptly realized the magnetic induction hot focus.If more accurate and complicated selection and control are carried out in magnetic induction hot focus zone, then can the permanent magnetic field that need be provided by some permanent magnets of arranging by specific array, shown in Figure 2ly be wherein a kind of arrangement mode.
Beneficial effect: this utility model has been realized heating up to the accurate control of magnetic nanoparticle heat effect with to the selectivity that is dispersed with local location in the magnetic nanoparticle zone; Cost is lower; Can realize selectivity heating, thereby alleviate the damage of thermotherapy normal structure to tumor region.This utility model can also be applied to the regioselectivity heating to chemical reaction system simultaneously, thereby reaches the purpose of control chemical reaction rate.
Description of drawings
Fig. 1 is the sketch map that magnetic nanoparticle heats up under the resultant field effect among the embodiment 1, and 1 refers to alternating magnetic field among the figure, and 2 and 16 refer to first permanent magnet and second permanent magnet, and 3 refer to permanent magnetic field, and 4 refer to magnetic nanoparticle, and 5 refer to solenoid coil;
Fig. 2 is the sketch map that magnetic nanoparticle heats up under the resultant field effect among the embodiment 3, and 6,7,8 and 9 refer to the 3rd to the 6th permanent magnet among the figure, and 10 and 11 refer to the first ferrite coil and the second ferrite coil;
Fig. 3 is the spatial relationship sketch map in alternating magnetic field and permanent magnetic field among the embodiment 2, and 12 refer to ferrites among the figure, and 13 refer to be wrapped in the coil on the ferrite, 14 and 15 finger the 7th permanent magnet and the 8th permanent magnets.
The specific embodiment
Below in conjunction with accompanying drawing and specific embodiment; Further illustrate this utility model; Should understand these embodiment only be used to this utility model is described and be not used in the restriction this utility model scope; After having read this utility model, those skilled in the art all fall within the application's accompanying claims institute restricted portion to the modification of the various equivalent form of values of this utility model.
This utility model has designed the resultant field that is composited by alternating magnetic field and permanent magnetic field.When heating up magnetic nanoparticle under action of alternating magnetic field, resultant field forms magnetic induction hot focus zone, thus the intensification behavior under action of alternating magnetic field of control magnetic nanoparticle.
Specific requirement to magnetic nanoparticle:
Magnetic nanoparticle is selected metal and alloy magnetic nanoparticles thereof such as ferrum, cobalt, nickel; Oxide magnetic nano-particle such as ferroso-ferric oxide, iron sesquioxide, Mn ferrite, Conjugate ferrite, Ni ferrite, Zn ferrite and manganese-zinc ferrite; The particle diameter of nano-particle is 1-100nm; Have the function that under alternating magnetic field, heats up, the SAR value is greater than 50w/g.
Specific requirement to resultant field:
Alternating magnetic field can be provided by ferrite or solenoid coil, and its frequency is 50kHz-1MHz, and power is that 10kw-100kw is adjustable.
Permanent magnetic field can be provided by two homopolarity permanent magnet opposed, the relative same very N utmost point and the N utmost point or the S utmost point and the S utmost point, and the magnetic induction of permanent magnet is that 0.1-0.5 tesla is adjustable, the distance between two permanent magnets is that 1-50cm is adjustable.
Permanent magnetic field also can be provided by some permanent magnets of arranging by specific array, and the magnetic induction of every permanent magnet is that 0.1-0.5 tesla is adjustable.In the permanent magnet array, two blocks of relative Magnet of homopolarity are one group, and angle is that the 30-90 degree is adjustable between two groups.
Heat up in alternating magnetic field for fear of permanent magnet, need permanent magnet is carried out recirculated water cooling protection.
Embodiment 1: solenoid coil produces the magnetic induction hot focus under the alternating magnetic field.
It is the ferroferric oxide nano granules of 12nm that magnetic nanoparticle 4 is selected mean diameter, and for improving particulate stability and biocompatibility, its finishing has dimercaptosuccinic acid, and the concentration of magnetic nanoparticle 4 is 2mg/cm
3Alternating magnetic field 1 is provided by solenoid coil 5, and its rated power is 80kw, and frequency is 100kHz; Permanent magnetic field 3 is provided by two relative first permanent magnet 2 and second permanent magnets 16 of homopolarity, and the magnetic induction of first permanent magnet 2 and second permanent magnet 16 is 0.5T, and the distance between first permanent magnet 2 and the Di Er permanent magnet 16 is 11cm.First permanent magnet 2 and second permanent magnet 16 are cooled off by recirculated water.Alternating magnetic field 1 is as shown in Figure 1 with the spatial relationship in permanent magnetic field 3.The magnetic induction in the permanent magnetic field 3 in magnetic focusing zone approaches 0mT.Can heat up 12 degrees centigrade in 15 minutes in the magnetic focusing zone, and nano-particle 4 dispersive other the regional intensifications that are magnetic have only 6 degrees centigrade or lower.
Embodiment 2: the ferrite coil produces the magnetic induction hot focus under the alternating magnetic field.
It is the iron sesquioxide nano-particle of 12nm that magnetic nanoparticle is selected mean diameter, and its crystal formation is the cubic spinel type, and for improving the stability and the biocompatibility of nano-particle, its finishing has dimercaptosuccinic acid, and the concentration of magnetic nanoparticle is 2mg/cm
3Alternating magnetic field is provided by the ferrite coil, and the ferrite coil is as shown in Figure 3, is made up of ferrite 12 and the coil 13 that is wrapped on the ferrite 12, and the rated power of alternating magnetic field is 100kw, and frequency is 120kHz; Permanent magnetic field is provided by two homopolarity permanent magnet opposed 14 and 15, and the magnetic induction of the 7th permanent magnet 14 and the 8th permanent magnet 15 is 0.5T, and the distance between the 7th permanent magnet 14 and the 8th permanent magnet 15 is 9cm.Permanent magnet 14 and 15 is cooled off by recirculated water.The spatial relationship in alternating magnetic field and permanent magnetic field is as shown in Figure 3.The permanent magnetic field magnetic induction in magnetic focusing zone approaches 0mT.Can heat up 12 degrees centigrade in 15 minutes in the magnetic focusing zone, and other regional intensifications of the nanoparticulate dispersed that is magnetic have only 6 degrees centigrade or lower.
Embodiment 3: the ferrite coil produces alternating magnetic field and permanent magnet array and produces the magnetic focusing under the resultant field effect in permanent magnetic field.
It is the manganese-zinc ferrite nano-particle of 10nm that magnetic nanoparticle is selected mean diameter, and its crystal formation is the cubic spinel type, and for improving the stability and the biocompatibility of nano-particle, its finishing has dimercaptosuccinic acid, and the concentration of magnetic nanoparticle is 2mg/cm
3Alternating magnetic field is provided by the first ferrite coil 10 and the second ferrite coil 11, and its rated power is 100kw, and frequency is 150KHz; Permanent magnetic field is provided by four the 3rd to the 6th relative permanent magnets 6,7,8 and 9 of homopolarity, and the 3rd to the 6th permanent magnet 6,7,8 and 9 magnetic induction are 0.5T.The the 3rd to the 6th permanent magnet 6,7,8 and 9 is cooled off by recirculated water.The spatial relationship of the first ferrite coil 10 and the second ferrite coil 11 and the 3rd to the 6th permanent magnet 6,7,8 and 9 is as shown in Figure 2.The permanent magnetic field magnetic induction in magnetic focusing zone approaches 0mT.Can heat up 12 degrees centigrade in 15 minutes in the magnetic focusing zone, and other regional intensifications of the nanoparticulate dispersed that is magnetic have only 4 degrees centigrade or lower.
Claims (7)
1. magnetic nanoparticle magnetic induction hot focus system based on resultant field; Comprise the device and the magnetic nanoparticle that produce alternating magnetic field; The device of said generation alternating magnetic field produces alternating magnetic field; Magnetic nanoparticle is arranged in this alternating magnetic field, it is characterized in that: also comprise at least two both sides and homopolarity permanent magnet opposed that are distributed in the device of said generation alternating magnetic field, said permanent magnet apart from the distance of the centrage of the device that produces alternating magnetic field about equally.
2. according to the said magnetic nanoparticle magnetic induction hot focus system based on resultant field of claim 1, it is characterized in that: the particle diameter of said magnetic nanoparticle is 1-100nm.
3. according to the said magnetic nanoparticle magnetic induction hot focus system based on resultant field of claim 1, it is characterized in that: the device of said generation alternating magnetic field is ferrite coil or solenoid coil.
4. according to the said magnetic nanoparticle magnetic induction hot focus system based on resultant field of claim 1, it is characterized in that: the distance between the said homopolarity permanent magnet opposed is 1-50cm.
5. according to the said magnetic nanoparticle magnetic induction hot focus system of claim 1, it is characterized in that: said permanent magnet is cooled with circulating water protection based on resultant field.
6. according to the said magnetic nanoparticle magnetic induction hot focus system based on resultant field of claim 1, it is characterized in that: the quantity of said permanent magnet is two, and the centrage approximate vertical of the device of its line and generation alternating magnetic field.
7. according to the said magnetic nanoparticle magnetic induction hot focus system based on resultant field of claim 1, it is characterized in that: the quantity of said permanent magnet is that the angle between four and the two groups of homopolarity permanent magnet opposed is the 30-90 degree.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102179005A (en) * | 2011-05-31 | 2011-09-14 | 东南大学 | Magnetic nano particle magnetic-induction thermal focusing system based on complex magnetic field |
| CN107946018A (en) * | 2017-12-29 | 2018-04-20 | 中国科学院电工研究所 | A kind of focusing magnetic field regulation device |
| CN107929945A (en) * | 2017-12-12 | 2018-04-20 | 山东省肿瘤防治研究院 | A kind of apparats for treating tumor for integrating external high frequency thermotherapy and magnetic induction treatment |
| CN114112098A (en) * | 2021-12-10 | 2022-03-01 | 华中科技大学 | Magnetic nanometer temperature measurement method based on Neille relaxation time |
| CN114367377A (en) * | 2021-12-15 | 2022-04-19 | 中国核工业电机运行技术开发有限公司 | Magnetic field generating assembly for orderly separating and obtaining particles and separating method thereof |
| WO2024016378A1 (en) * | 2022-07-18 | 2024-01-25 | 清华大学 | Automatic temperature control device integrating magnetocaloric and liquid cooling functions, and manufacturing method therefor |
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2011
- 2011-05-31 CN CN2011201792086U patent/CN202105321U/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102179005A (en) * | 2011-05-31 | 2011-09-14 | 东南大学 | Magnetic nano particle magnetic-induction thermal focusing system based on complex magnetic field |
| CN107929945A (en) * | 2017-12-12 | 2018-04-20 | 山东省肿瘤防治研究院 | A kind of apparats for treating tumor for integrating external high frequency thermotherapy and magnetic induction treatment |
| CN107946018A (en) * | 2017-12-29 | 2018-04-20 | 中国科学院电工研究所 | A kind of focusing magnetic field regulation device |
| CN107946018B (en) * | 2017-12-29 | 2020-06-30 | 中国科学院电工研究所 | Focusing magnetic field regulating and controlling device |
| CN114112098A (en) * | 2021-12-10 | 2022-03-01 | 华中科技大学 | Magnetic nanometer temperature measurement method based on Neille relaxation time |
| CN114367377A (en) * | 2021-12-15 | 2022-04-19 | 中国核工业电机运行技术开发有限公司 | Magnetic field generating assembly for orderly separating and obtaining particles and separating method thereof |
| WO2024016378A1 (en) * | 2022-07-18 | 2024-01-25 | 清华大学 | Automatic temperature control device integrating magnetocaloric and liquid cooling functions, and manufacturing method therefor |
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Granted publication date: 20120111 Termination date: 20140531 |