CN202096205U - Transmission characteristic detection device for neural signals between single neuron and multiple neuron groups - Google Patents
Transmission characteristic detection device for neural signals between single neuron and multiple neuron groups Download PDFInfo
- Publication number
- CN202096205U CN202096205U CN2011201737708U CN201120173770U CN202096205U CN 202096205 U CN202096205 U CN 202096205U CN 2011201737708 U CN2011201737708 U CN 2011201737708U CN 201120173770 U CN201120173770 U CN 201120173770U CN 202096205 U CN202096205 U CN 202096205U
- Authority
- CN
- China
- Prior art keywords
- row
- control end
- electrode
- oxide
- semiconductor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Abstract
A transmission characteristic detection device for neural signals between a single neuron and multiple neuron groups comprises electrode units which are distributed in array and capable of being controlled independently. Each electrode unit includes an exciting electrode and a detecting electrode which are respectively connected with an exciting switch and a detecting switch. Each switch comprises two MOS (metal-oxide-semiconductor) tubes, a source electrode of one MOS tube is connected with a drain electrode of the other MOS tube, and a source electrode of the other MOS tube is then connected to one electrode. Grid electrodes of the MOS tubes in the exciting electrode units of each line and each row are connected respectively and form an exciting switch line control end for each line and an exciting switch row control end for each row, the exciting switch line control end and the exciting switch row control end are respectively connected to different parallel output ends of exciting serial input-parallel output shift registers, grid electrodes of the MOS tubes in the detecting electrode units in each line and each row are connected respectively and form a detecting switch line control end for each line and a detecting switch row control end for each row, and the detecting switch line control end and the detecting switch row control end are connected to different parallel output ends of detecting serial input-parallel output shift registers. Each of exciting signal input ends is connected with a neural signal exciter, and each of detecting signal output ends is connected with a neural signal detector and then output after being connected with a multi-way selection circuit.
Description
Technical field
This utility model relates to a kind of be used to the to comprise human vertebrate neuron and the research device of neuron colony electrical activity signal transmission characteristic, relates in particular to auxiliary MN of a kind of microelectronics system and device for detecting nerve signal transfer characteristic between neuron clusters.
Background technology
Neuroscience constantly develops in the last hundred years, and scientist has developed the MEA of various ways, is used for the cell of cultivating that comprises neuron is carried out signal of telecommunication record and excitation.Yet these MEA are discrete with the microelectronics system of acquisition of signal and excitation mostly.Calendar year 2001; Germany Max Planck Biochemical Research Peter Fromherz and Gunther Zeck the neuron of Limax is placed on the silicon chip that 16 excitation/record two-way function electrode positions are arranged; Each electrode position surrounds with 6 micro plastic posts that prevent that neuron from moving, and is being close between the neuron and is forming interface between neuron and the silicon chip like this.They have designed a voltage stimulator under each neuron; Produce a kind of whole neuronic electric pulse that runs through; And be transferred to another neuron by a neuron; Turn back to silicon chip at last again, thereby can transmit through silicon-neuron-neuron-silicon loop at the clear signal of neuron aspect Shanghai Stock Exchange.But because each contact site of all these MEA needs a lead-out wire, electrode number receives the restriction of array lead-out wire.For example; Extreme electrode number of sites/lead-out wire number of the MEA that Germany MCS company produces is 60; Max Planck Biochemical Research MEA contain 16 excitation/record two-way function electrode site, this is not enough to generate with transmission characteristic and carry out the more research of microcosmic discerning between the neuron colony signal.
2007, this utility model people submitted the utility application (application number 200720131008.7) of an electrod-array to.This utility model in the design of extensive electrod-array, when making the duty of each electrode points controlled, reduces the number of the outer lead-out wire of electrode pair with the structure applications of similar MOS single tube read-write memory significantly.Propose the employing of row and column control voltage subsequently again and apply scheme chronologically, can be with the chip lead-out wire from 4
NBar drops to 2
NArticle+3.Yet this scheme counter electrode array can only realize being accurate to the control of full line or permutation electrode.This utility model proposes digitized ranks control voltage and applies scheme, can realize the accurate control of single electrode.Simultaneously, further the chip lead-out wire is reduced to
N + 5.
The utility model content
This utility model provides high MN of a kind of control accuracy and device for detecting nerve signal transfer characteristic between neuron clusters.
This utility model adopts following technical scheme:
A kind of MN and device for detecting nerve signal transfer characteristic between neuron clusters; Comprise separately controllable electrode unit according to array distribution; This electrode unit comprises: exciting electrode and exploring electrode are connected with energizing switch and search switch respectively on exciting electrode and exploring electrode.
Described energizing switch comprises first metal-oxide-semiconductor and second metal-oxide-semiconductor, and the source of first metal-oxide-semiconductor is connected with the leakage of second metal-oxide-semiconductor, and the source of second metal-oxide-semiconductor is connected with exciting electrode; Described search switch comprises the 3rd metal-oxide-semiconductor and the 4th metal-oxide-semiconductor, and the source of the 3rd metal-oxide-semiconductor is connected with the leakage of the 4th metal-oxide-semiconductor, and the source of the 4th metal-oxide-semiconductor is connected with exploring electrode.
The grid of first metal-oxide-semiconductor in the electrode unit of each row link to each other and form the energizing switch row control end that each is gone, and on energizing switch row control end, are connected with row energization serial input-parallel Output Shift Register and each energizing switch row control end and are connected with each parallel output terminal of row energization serial input-parallel Output Shift Register respectively; Respectively the grid of second metal-oxide-semiconductor in electrode unit of row link to each other and form the energizing switch row control end that each is listed as, and on energizing switch row control end, are connected with row excitation serial input-parallel Output Shift Register and each energizing switch row control end and are connected with each parallel output terminal that is listed as excitation serial input-parallel Output Shift Register respectively; The grid of the 4th metal-oxide-semiconductor in electrode unit of each row link to each other and form the capable control end of search switch of each row, on the capable control end of search switch, are connected with row and survey serial input-parallel Output Shift Register and the capable control end of each search switch and be connected with each parallel output terminal that row is surveyed serial input-parallel Output Shift Register respectively; The grid of the 3rd metal-oxide-semiconductor in electrode unit of each row link to each other and form search switch row control end of each row, on search switch row control end, are connected with row and survey serial input-parallel Output Shift Register and each search switch row control end and be connected with each parallel output terminal that row are surveyed serial input-parallel Output Shift Register respectively.Each pumping signal input all links to each other with the nerve signal activator; Each detectable signal outfan links to each other with the nerve signal detection device, is connected to multiplexer circuit.
Compared with prior art, the utlity model has following advantage:
The said device of this utility model was numbered this utility model people and proposes following the improvement on the basis of 200720131008.7 utility application in 2007: the addressing system of call number word memory; Utilize the string of shift register-and translation function; Select to realize in the circuit " row, column address " addressing at electrode unit; The duty of each electrode points can independently be controlled, has improved the use motility of electrod-array greatly: for array count into
N*
NElectrod-array, the 2n-bits Serial Control level of outside input is shifted depositor and converts the parallel control level to, promptly after " row, column address ", is used to control each electrode.Improved the control accuracy of electrod-array.Outfan adopts MUX, and electrode outlet line reduces to N+5.
Description of drawings
Fig. 1 is this utility model two dimension microelectrode array embodiment circuit diagram.
Fig. 2 is this utility model microelectrode array electrode unit embodiment circuit diagram.
Fig. 3 is that this utility model electrode unit is selected the circuit embodiments circuit diagram.
Fig. 4 is this utility model neuron and neuron colony acquisition of signal and excitation microelectronic chip functional diagram.
The specific embodiment
A kind of MN and device for detecting nerve signal transfer characteristic between neuron clusters; Comprise separately controllable electrode unit according to array distribution; This electrode unit comprises: exciting electrode 5 and exploring electrode 6; On exciting electrode 5 and exploring electrode 6, be connected with energizing switch and search switch respectively
Described energizing switch comprises that the source of first metal-oxide-semiconductor 1 and second metal-oxide-semiconductor, 2, the first metal-oxide-semiconductors 1 and the leakage of second metal-oxide-semiconductor 2 are connected, and the source of second metal-oxide-semiconductor 2 is connected with exciting electrode 5; Described search switch comprises that the source of the 3rd metal-oxide-semiconductor 3 and the 4th metal-oxide-semiconductor 4, the three metal-oxide-semiconductors 3 and the leakage of the 4th metal-oxide-semiconductor 4 are connected, and the source of the 4th metal-oxide-semiconductor 4 is connected with exploring electrode 6.
The grid of first metal-oxide-semiconductor 1 in the electrode unit of each row link to each other and form the energizing switch row control end that each is gone, and on energizing switch row control end, are connected with row energization serial input-parallel Output Shift Register 8 and each energizing switch row control end and are connected with each parallel output terminal of row energization serial input-parallel Output Shift Register 8 respectively; Respectively the grid of second metal-oxide-semiconductor 2 in electrode unit of row link to each other and form the energizing switch row control end that each is listed as, and on energizing switch row control end, are connected with row excitation serial input-parallel Output Shift Register 10 and each energizing switch row control end and are connected with each parallel output terminal that is listed as excitation serial input-parallel Output Shift Register 10 respectively; The grid of the 4th metal-oxide-semiconductor 4 in electrode unit of each row link to each other and form the capable control end of search switch of each row, on the capable control end of search switch, are connected with row and survey serial input-parallel Output Shift Register 7 and the capable control end of each search switch and be connected with each parallel output terminal that row is surveyed serial input-parallel Output Shift Register 7 respectively; The grid of the 3rd metal-oxide-semiconductor 3 in electrode unit of each row link to each other and form search switch row control end of each row, on search switch row control end, are connected with row and survey serial input-parallel Output Shift Register 9 and each search switch row control end and be connected with each parallel output terminal that row are surveyed serial input-parallel Output Shift Register 9 respectively.Each pumping signal input all links to each other with the nerve signal activator, and each detectable signal outfan links to each other with the nerve signal detection device, is connected to multiplexer circuit.
With reference to Fig. 4, embodiment 1.
Present embodiment is the sniffer that is used to realize nerve signal transmission characteristic between MN and the multi-neuron cluster.Comprise and adopt the bioelectrical signals detection that has of standard CMOS process design realization to select circuit, nerve signal detection amplifier array and nerve signal exciter array with extensive micron order (adapting) electrod-array district, MOS switching network, the electrode unit of incentive characteristic with neuronic dendron and axon diameter.Wherein the structure of similar computer MOS single tube read-write memory is adopted in the microelectrode array design, and the electrod-array element circuit is designed to
NOK
NThe form of row.Independently electrode points and four MOS switches constitute each electrode unit circuit by two.Two electrode points are respectively as exciting electrode point and detecting electrode point, and four MOS switches are divided into two groups, control the duty of exciting electrode and detecting electrode respectively.In any moment, single excitation or single detecting function not only can be realized, and original position excitation and the function of surveying can be realized, realized the controlled purpose of array point duty.The row of MOS switching network, row on-off control end select the also line output of circuit to link to each other with electrode unit; Electrode unit selects the circuit employing to have the serial input of data latch function and the shift register of line output; The MOS switching network that is attached thereto is exported and sent into to the signal of serial input with parallel mode after through shift register, as row, the row switch controlling signal of MOS switching network.The nerve signal activator adopts the form of row electrod-array units shared, is used for that nerve signal is carried out in the microstructures such as pericaryon, dendron and aixs cylinder that contacts with exciting electrode and encourages, and synchronization can satisfy choosing simultaneously
NIndividual electrode points is carried out signal excitation.With reference to Fig. 4, electrode unit is selected the V of circuit
Ci2And V
Ci (n+1)Gauge tap is chosen the exciting electrode of the 2nd row the 1st row, by V
I1The pumping signal of input only encourages the A neuron.The nerve signal detection amplifier adopts the form of array of row electrodes units shared; The nerve signal amplifier is used to amplify the nerve signal that is detected from the microstructures such as neuronic cell space, dendron and aixs cylinder of contact with it by exploring electrode, and synchronization can satisfy choosing simultaneously
NIndividual electrode points is carried out acquisition of signal.With reference to Fig. 4, electrode unit is selected the V of circuit
Co (n-1)And V
Co (n+2)Gauge tap is chosen the exploring electrode of capable the 2nd row of n-1, surveys neuron B gained signal by V
O (n-1)Send into multiplexer circuit.
Claims (1)
1. MN and device for detecting nerve signal transfer characteristic between neuron clusters; It is characterized in that; Comprise separately controllable electrode unit according to array distribution; This electrode unit comprises: exciting electrode (5) and exploring electrode (6) are connected with energizing switch and search switch respectively on exciting electrode (5) and exploring electrode (6)
Described energizing switch comprises first metal-oxide-semiconductor (1) and second metal-oxide-semiconductor (2), and the source of first metal-oxide-semiconductor (1) is connected with the leakage of second metal-oxide-semiconductor (2), and the source of second metal-oxide-semiconductor (2) is connected with exciting electrode (5); Described search switch comprises the 3rd metal-oxide-semiconductor (3) and the 4th metal-oxide-semiconductor (4), and the source of the 3rd metal-oxide-semiconductor (3) is connected with the leakage of the 4th metal-oxide-semiconductor (4), and the source of the 4th metal-oxide-semiconductor (4) is connected with exploring electrode (6),
The grid of first metal-oxide-semiconductor (1) in the electrode unit of each row link to each other and form the energizing switch row control end that each is gone, and on energizing switch row control end, are connected with row energization serial input-parallel Output Shift Register (8) and each energizing switch row control end and are connected with each parallel output terminal of row energization serial input-parallel Output Shift Register (8) respectively; Respectively the grid of second metal-oxide-semiconductor (2) in electrode unit of row link to each other and form the energizing switch row control end that each is listed as, and on energizing switch row control end, are connected with row excitation serial input-parallel Output Shift Register (10) and each energizing switch row control end and are connected with each parallel output terminal that is listed as excitation serial input-parallel Output Shift Register (10) respectively; The grid of the 4th metal-oxide-semiconductor (4) in electrode unit of each row link to each other and form the capable control end of search switch of each row, on the capable control end of search switch, are connected with row and survey serial input-parallel Output Shift Register (7) and the capable control end of each search switch and be connected with each parallel output terminal that row is surveyed serial input-parallel Output Shift Register (7) respectively; The grid of the 3rd metal-oxide-semiconductor (3) in electrode unit of each row link to each other and form search switch row control end of each row, on search switch row control end, are connected with row and survey serial input-parallel Output Shift Register (9) and each search switch row control end and be connected with each parallel output terminal that row are surveyed serial input-parallel Output Shift Register (9) respectively; Each pumping signal input all links to each other with the nerve signal activator; Each detectable signal outfan links to each other with the nerve signal detection device, is connected to multiplexer circuit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201737708U CN202096205U (en) | 2011-05-27 | 2011-05-27 | Transmission characteristic detection device for neural signals between single neuron and multiple neuron groups |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201737708U CN202096205U (en) | 2011-05-27 | 2011-05-27 | Transmission characteristic detection device for neural signals between single neuron and multiple neuron groups |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202096205U true CN202096205U (en) | 2012-01-04 |
Family
ID=45382245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011201737708U Expired - Fee Related CN202096205U (en) | 2011-05-27 | 2011-05-27 | Transmission characteristic detection device for neural signals between single neuron and multiple neuron groups |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202096205U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102279217A (en) * | 2011-05-27 | 2011-12-14 | 东南大学 | Detecting device for nerve signal transfer characteristic of single neuron and multiple neuron colonies |
-
2011
- 2011-05-27 CN CN2011201737708U patent/CN202096205U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102279217A (en) * | 2011-05-27 | 2011-12-14 | 东南大学 | Detecting device for nerve signal transfer characteristic of single neuron and multiple neuron colonies |
| CN102279217B (en) * | 2011-05-27 | 2014-04-16 | 东南大学 | Detecting device for nerve signal transfer characteristic of single neuron and multiple neuron colonies |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106845634B (en) | A kind of neuron circuit based on memory resistor | |
| TW200501038A (en) | Active matrix array device, electronic device and operating method for an active matrix array device | |
| CN110688030B (en) | Touch display panel and display device | |
| EP1460638A3 (en) | Semiconductor memory device with shift register-based refresh address generation circuit | |
| CN105869594A (en) | Drive method, liquid crystal display panel and electronic device | |
| CN108291887B (en) | Electric potential measuring device | |
| CN104090697A (en) | Capacitance type embedded touch screen and touch location method and display device of capacitance type embedded touch screen | |
| CN108257542B (en) | Pixel circuit and display device | |
| CN102566817A (en) | Sensing methods for touch sensing devices | |
| EP1326162A3 (en) | An integrated digitizing tablet and display apparatus and method of operation | |
| CN103713787A (en) | Signal processing circuit, signal processing method, position detecting device, and electronic apparatus | |
| CN109637453A (en) | Display panel and its driving method, display device | |
| CN107578740B (en) | Display device, source electrode drive circuit and display system | |
| CN202096205U (en) | Transmission characteristic detection device for neural signals between single neuron and multiple neuron groups | |
| CN107393505A (en) | Photosensitive circuit and photosensitive circuit driving method, display device | |
| CN102279217B (en) | Detecting device for nerve signal transfer characteristic of single neuron and multiple neuron colonies | |
| CN108814769A (en) | Sensor, system, pressure detection circuit, method and electronic skin | |
| CN107329622A (en) | A kind of contact panel, array base palte and display device | |
| CN110459179A (en) | A kind of display device | |
| CN104365023A (en) | Apparatus and system for switching equalization | |
| CN101181158B (en) | Detecting element for transferring characteristics of neuron signal between single neuron and multiple neuron cluster | |
| CN101349691B (en) | Neuron and device for detecting nerve signal transfer characteristic between neuron clusters | |
| CN201269873Y (en) | Characteristic detection apparatus for neutral signal transmission between neutral cells and multiple neutral cell clusters | |
| CN108256503A (en) | Fingerprint sensing device | |
| CN205487263U (en) | Array substrate , display device and be used for detecting array substrate's circuit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120104 Termination date: 20120527 |