CN202078559U - Hydrogel type testicular transdermal patch - Google Patents

Abstract

The utility model discloses a hydrogel type testicular transdermal patch, which comprises a backing layer. An adhesive layer which is used for drug delivery by being attached to skin comprises active drugs, molecular gel, hydrogel, penetration enhancer and the like and is attached to the backing layer, a protective film which is used for preventing drugs on the adhesive layer from running off and protecting adhesiveness of the adhesive layer is attached to the adhesive layer and is tearable for use. The novel transdermal patch compared with the traditional patch has the advantages that (1) compatibility with water-soluble and fat-soluble drugs is better, matrix drug loading capacity is high, the characteristics of multiple components and high dose of drug use can be satisfied, (2) the hydrogel patch generally has a water content of 50% and above and is easy for softening stratum corneum and beneficial to transdermal absorption of drugs, and (3) the hydrogel patch is fine in permeability, adhesiveness and thermal insulation. The hydrogel type testicular transdermal patch further has the advantages of low stimulus to skin, reusability for application, avoidance of tearing pain, none of residue and the like.

Description

Aquogel type testis transdermal administration patch

Technical field:

This utility model relates to a kind of patch that contains the medicine for treatment thing, particularly a kind of transdermal test in vitro hydrogel patch that is used for the testis position for the treatment of male sterility, sexual dysfunction.

Background technology:

As everyone knows, testis and epididymis are that mankind spermatozoon takes place and sophisticated tissue, and spermatogenesis or dysmaturity will cause male sterility; With drug-induced spermatogenesis or dysmaturity then is an important measures of male contraception.

The general treatment of male sterility mainly is the oral formulations of various Drug therapys such as various trace elements such as levocarnitine, vitamin E and zinc, selenium, ATP injection etc.Low for gonad function, the unusual situation of hormonal readiness can adopt.As CC, HCG, MCG etc.

In addition, the treatment means etc. that also has various Chinese medicines and auxiliary procreation technology (artificial insemination, gamete transplant).

As the route of administration of medicine, modal is oral and injection, also is the mode of the present main administration of adopting in the treatment of azoospermia.Yet, also do not have at present the product of transdermal medicine for treating azoospermia or male sterility on the domestic market.

The utility model content:

This utility model provides a kind of transdermal test in vitro hydrogel patch that is used for the testis position for the treatment of male sterility, sexual dysfunction.This patch can be used for treating spermatogenesis and the spermioteleosis obstacle that causes because of sex hormones secretion deficiency or peroxide injury, and directly acts on the complex function that the drug transdermal that avoids conception and control birth of spermatid absorbs.Compare with the method for avoiding conception and controling birth with existing treatment means, have the Inherent advantage of hydrogel patch, a kind of means of administration of local organization of active is provided simultaneously.

Concrete technical scheme of the present utility model is as follows:

Aquogel type testis transdermal administration patch; it is characterized in that; comprise a backing layer; be attached with the attaching skin of forming by these existing material components of active medicine, molecular gel, hydrogel and penetrating agent that passes through on the described backing layer and come the adhesive-layer of administration; be attached with one on the described adhesive-layer again and be used for preventing that the adhesive-layer drug component runs off; and protection adhesive-layer viscosity, the protecting film that can throw off during use.

Certainly, the adhesive-layer of above-mentioned patch, wherein, active medicine comprises existing refrigerant cooling agent, hormone medicine, vitamin medicaments, anti-oxidation medicine or compound Chinese medicinal preparation.Molecular gel is by the gel factor, and solvent or their mixture are formed.Hydrogel comprises water-soluble base, water-insoluble substrate or their mixture.Penetrating agent comprises dimethyl sulfoxide, azone class, alcohol compound, volatile oil and/or their mixture.

Aquogel type testis transdermal administration patch described in the utility model is as a kind of novel transdermal administration dosage form, and the advantage of comparing it with traditional patch has:

1) better with the compatibility of water solublity, fat-soluble medicine, the substrate drug loading is big, can satisfy the medication characteristics of multicomponent, heavy dose;

2) hydrogel patch contains the moisture more than 50% usually, is easy to make horny layer softening, is beneficial to the Transdermal absorption of medicine;

3) water-setting agent patch has air permeability and good, cohesiveness and heat insulating ability.And have the zest of skin for a short time, and can stick repeatedly, take off to paste and do not have pain, advantages such as noresidue.Domestic do not have similar products like at present.

Description of drawings:

Further specify this utility model below in conjunction with the drawings and specific embodiments.

Fig. 1 is the structure chart of aquogel type testis transdermal administration patch described in the utility model.

The specific embodiment:

For technological means, creation characteristic that this utility model is realized, reach purpose and effect is easy to understand, below in conjunction with concrete diagram, further set forth this utility model.

As shown in Figure 1; aquogel type testis transdermal administration patch described in the utility model; comprise a backing layer; be attached with the attaching skin of forming by these current material components of active medicine, molecular gel, hydrogel and penetrating agent that passes through on the described backing layer and come the adhesive-layer of administration; be attached with one on the described adhesive-layer again and be used for preventing that the adhesive-layer drug component runs off; and protection adhesive-layer viscosity, the protecting film that can throw off during use.

Below specifically introduce the main component of adhesive-layer:

Active medicine comprises existing refrigerant cooling agent, hormone medicine, vitamin medicaments, anti-oxidation medicine or compound Chinese medicinal preparation.

Molecular gel is by the gel factor, and solvent or their mixture are formed.Wherein, the gel factor comprises the tertiary amine of ad hoc structure and quaternary amines organic compound thereof such as lecithin, N, N, N,-three octadecane amine, gallbladder steroid eicosane amine, the two octadecane amine of methyl, dioctadecyl dimethyl ammonium chloride, organic molecules such as cyclodextrin derivative class such as beta-cyclodextrin, derivative of fatty acid such as 12-hydroxy octadecadienoic acid and associated salts thereof, glyceryl monostearate, glyceryl tristearate, tripalmitin etc.Solvent comprises that alkanes, dimethyl sulfoxide (DMSO), second are fine, cellosolvo, 1-propanol, 1-amylalcohol, 1-capryl alcohol, 1,2-propylene glycol, silicone oil, 14/isopropyl palmitate etc.

Hydrogel comprises water-soluble base, water-insoluble substrate or their mixture.Such as the polyacrylic acid of various models, according to sodium acrylate, carbomer resin, polyvinylpyrrolidone, sodium carboxymethyl cellulose, methylcellulose, polyvinyl alcohol and/or their mixture.

Penetrating agent comprises dimethyl sulfoxide, azone class, alcohol compound, volatile oil and/or their mixture.

In addition, adhesive-layer also can add additive, and this additive component comprises Kaolin, starch, micropowder silica gel, aluminum chloride, Alumen, sodium alginate etc.; Solvent comprises deionized water, propylene glycol, glycerol, ethanol and/or their mixture.

According to this aquogel type testis transdermal administration patch of such scheme preparation, when reality was used, ingredient contained in the patch can enter corium through horny layer and epidermis, diffuses into blood capillary, is transferred to the body circulation.Even directly see through the various recipient cells (comprising testis spermatogenic cell and spermatid) that the scrotum epidermis enters testis tissue.

Clinical practice shows that with respect to modes such as oral and injections, the advantage of transdermal administration patch described in the utility model is:

1) can avoid the degraded of liver first-pass effect and gastrointestinal tract, make the effect of medicine not be subjected to the influence of gastrointestinal factors medicine;

2) can control medicine near constant release, absorb steadily relatively, avoid the repeatedly blood medicine peak valley undulatory property that causes of medication of other preparations;

3) prolong action time, reduce administration number of times;

4) can regulate dosage by changing the administration area, reduce individual variation, and independently medication of patient, also can stop at any time.

More than show and described ultimate principle of the present utility model and principal character and advantage of the present utility model.The technical staff of the industry should understand; this utility model is not restricted to the described embodiments; that describes in the foregoing description and the description just illustrates principle of the present utility model; under the prerequisite that does not break away from this utility model spirit and scope; this utility model also has various changes and modifications, and these changes and improvements all fall in claimed this utility model scope.The claimed scope of this utility model is defined by appending claims and equivalent thereof.

Claims (1)

1. aquogel type testis transdermal administration patch; it is characterized in that; comprise a backing layer; be attached with the attaching skin of forming by these material components of active medicine, molecular gel, hydrogel and penetrating agent that passes through on the described backing layer and come the adhesive-layer of administration; be attached with one on the described adhesive-layer again and be used for preventing that the adhesive-layer drug component runs off; and protection adhesive-layer viscosity, the protecting film that can throw off during use.

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