CN201997135U - Chromatograph separation chromatographic column - Google Patents
Chromatograph separation chromatographic column Download PDFInfo
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- CN201997135U CN201997135U CN2010206550055U CN201020655005U CN201997135U CN 201997135 U CN201997135 U CN 201997135U CN 2010206550055 U CN2010206550055 U CN 2010206550055U CN 201020655005 U CN201020655005 U CN 201020655005U CN 201997135 U CN201997135 U CN 201997135U
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- chromatographic column
- cylindrical shell
- cylinder
- microwell plate
- column according
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Abstract
The utility model relates to a chromatograph separation chromatographic column, which comprises a cylinder, an upper cover and a lower cover. Microporous plates and guide plates are arranged between the upper cover and the cylinder and between the lower cover and the cylinder. The upper cover and the lower cover are provided with a distributor and a pipeline joint respectively, each distributor is provided with a straight blowing opening and a microporous plate leakage opening, a spraying distribution head capable of moving vertically is arranged in each distributor and provided with a feeding port, and a device for assembling and disassembling the column, a resin tank, a washing liquid tank and a collecting tank are further arranged outside the cylinder and connected with pipelines of the cylinder. The chromatograph separation chromatographic column has the advantages of capability of realizing all steps of ion-exchange chromatography filtration within a closed apace, stable quality and high efficiency.
Description
Technical field
The utility model relates to the equipment of a kind of ion-exchange, chromatography, Separation of Solid and Liquid, the separation of liquid liquid, washing, filtration, regeneration, relates in particular to a kind of chromatographic isolation chromatographic column that uses on medicine and food service industry.
Background technology
At present, ion-exchange, chromatography are under certain pressure, and resin (or other filler) is gone up and stratifiedly under the different flow velocitys to be separated different classes of or different components, and obtain active princlple or the composition planning to obtain.The ion-exchange chromatography filter method of prior art will multiple devices and through multiple working procedure just can finish ion-exchange, chromatography, Separation of Solid and Liquid, liquid liquid separates, wash, filter, regenerate in steps, have quality instability, inefficient shortcoming.In addition, the diameter of the separation equipment that is used for the chromatographic column industry of prior art is less, and the anti-reverse flow of microwell plate is poor, causes the regeneration effect of microwell plate poor.Microwell plate also exists the aperture inhomogeneous, the quality instability, and the easy leakage of material, disposal ability is limited, and maximizing has circumscribed shortcoming.
The utility model content
Technical problem to be solved in the utility model overcomes the deficiencies in the prior art exactly, and a kind of steady quality, chromatographic isolation chromatographic column that efficient is high are provided.
The utility model solves the problems of the technologies described above the technical scheme that is adopted: the chromatographic isolation chromatographic column, comprise that sidewall is provided with the cylindrical shell of visor, loam cake of fixedlying connected and lower cover with cylindrical shell, be provided with microwell plate between loam cake and the cylindrical shell and between lower cover and the cylindrical shell, deflector, loam cake and under cover and be provided with distributor and pipe joint, on distributor, be provided with positive mouthpiece and microwell plate leakage hole, in distributor, be provided with spray dispensing head moving up and down, the spray dispensing head is provided with charging aperture, also is provided with loading and unloading post device outside cylindrical shell, resin container, washing liquid tank is connected with the cylindrical shell pipeline with collecting tank.
The beneficial effects of the utility model are: the chromatographic isolation chromatographic column is provided with cylindrical shell, loam cake and lower cover, be provided with microwell plate, deflector between loam cake and the cylindrical shell and between lower cover and the cylindrical shell, loam cake and under cover and be provided with distributor and pipe joint, on distributor, be provided with positive mouthpiece and microwell plate leakage hole, in distributor, be provided with spray dispensing head moving up and down, the spray dispensing head is provided with charging aperture, also is provided with loading and unloading post device, resin container, washing liquid tank and is connected with the cylindrical shell pipeline with collecting tank outside cylindrical shell.Therefore, has the advantage that in an airtight space, realizes ion-exchange, chromatography, Separation of Solid and Liquid, the separation of liquid liquid, washing, filtration, regeneration step.
Description of drawings
Fig. 1 is the structural representation of the utility model chromatographic isolation chromatographic column;
Fig. 2 is the attached view of Fig. 1;
Fig. 3 is the I portion enlarged drawing of Fig. 1;
Fig. 4 is the II portion enlarged drawing of Fig. 1;
Fig. 5 is the III portion enlarged drawing of Fig. 1;
Fig. 6 is the IV portion enlarged drawing of Fig. 1;
Fig. 7 is the improvement figure of Fig. 4;
Fig. 8 is the improvement figure of Fig. 7;
Fig. 9 is the structural representation of spray dispensing head;
Figure 10 is the longitudinal sectional view of microwell plate;
Figure 11 is the A-A cutaway view of Figure 10;
Figure 12 is the improvement figure of Figure 11;
Figure 13 is the B-B cutaway view of Fig. 7;
Figure 14 is the process chart of the utility model ion-exchange chromatography filter method.
The specific embodiment
The utility model is described in further detail below in conjunction with drawings and Examples:
Shown in Fig. 1 and 14, the chromatographic isolation chromatographic column, comprise that sidewall is provided with the cylindrical shell 9 of visor 11, loam cake 14 of fixedlying connected and lower cover 6 with cylindrical shell 9, be provided with microwell plate 5 between loam cake 14 and the cylindrical shell 9 and between lower cover 6 and the cylindrical shell 9, deflector 7, on loam cake 14 and lower cover 6, be provided with distributor 3 and pipe joint 16, on distributor 3, be provided with positive mouthpiece 13 and microwell plate leakage hole 12, in distributor 3, be provided with spray dispensing head 4 moving up and down, spray dispensing head 4 is provided with charging aperture 8, also is provided with loading and unloading post device outside cylindrical shell 9, resin container, washing liquid tank is connected with cylindrical shell 9 pipelines with collecting tank.Lower cover 6 is installed on the support 2, and support 2 bottoms are provided with adjustable bottom feet dish 1, guarantees chromatographic column installation level.The material of described deflector 7 is a ultra-high molecular weight polyethylene, wall liner plastic layer 10 in the cylindrical shell 9, and visor 11 is arranged in dislocation on upper the depositing of cylindrical shell 9 sidewalls, guarantees that the inner four corner of chromatographic column is all visual; Distributor control box 22 is pneumatic operated valve group or magnetic valve group, by 17 motions of tracheae 18 control cylinders, spray dispensing head 4 is stretched, and makes spray distribute to be in and closes, sprays, loads and unloads three positions of material.Described cylindrical shell 9 outer walls are provided with chuck layer 19, and chuck layer 19 is provided with chuck import and JO, and adjustment liquid flows into from the chuck import, flow out from JO, and the material in the cylindrical shell 9 is carried out adjustment.Realize ion-exchange, chromatography, Separation of Solid and Liquid, the separation of liquid liquid, washing, filtration, regeneration step disposable airtight finishing in a chromatographic isolation chromatographic column.
As shown in Figure 2, lifting bolt 15 is fixed on the loam cake 14, is used to change microwell plate 5 or maintenance or carrying.
As shown in Figure 3, described visor 11 inner surfaces are arc, flush with cylindrical shell 9 inwalls, all around side and 9 seamless cooperations of cylindrical shell.Prevent solid accumulation in its slit, grow bacterium and contaminated material.And also have scale on the visor 11, use as metering.
Shown in Fig. 4 and 6, microwell plate 5 is installed in the deflector 7, and deflector 7 utilizes screw 21 to be fixed in lower cover 6 and the loam cake 14 by sealing ring 20.
As shown in Figure 5, inner seal ring 33 is connected with T type connecting ring 29 by screw thread and compresses, and deflector axle core 30, outer seal ring 32, frustum base 34 and sealing ring 31 utilize bolt 35 to compress sealing; Spray dispensing head 4 is installed in the middle of microwell plate 5.
As shown in Figure 7, withstand voltage deflector 23 is that flow-guiding channel with deflector 7 is by contacting the inside that changes at deflector with the lining plastic cover of lower cover 6; Before not improving, the pressure of 7 abilities of deflector depends on the quantity and the distribution of screw 21, and the pressure of ability is limited, when changing into its inside, only relevant with the type shape and the material of its passage, but superpressure prolongs the pulse cleaning effect in the microwell plate 5 to the above pressure reduction of 0.6MPa.
As shown in Figure 8, described microwell plate 5 is integrative-structures with deflector 23.Monoblock type is withstand voltage, and water conservancy diversion microwell plate 24 is that microwell plate 5 and withstand voltage deflector 23 are made an integral body, and its beneficial effect is that the installation replacing is simpler, convenient, improves maintenance efficiency.
As shown in Figure 9, described spray dispensing head 4 upper surfaces are sphere, make liquid on it flow through sphere more smoothly and enter into filtering area, and anti-ly when underflow pile up material on it; Spray apertures 25 is located on the arcuation face of cylinder 26 and connects with endoporus 27, and the longitudinal section of spray apertures 25 is provided with angle [alpha], makes that liquid or gas spreads in course of injection, speedup, and the impulsive force when strengthening injection makes the quicker dispersion of solid (resin).The sectional area sum of all spray apertures 25 equals the sectional area of 0.1～1 times endoporus 27.
As shown in figure 10, the material of described microwell plate 5 is ultra-high molecular weight polyethylene or stainless steel or Titanium or pottery.Described microwell plate 5 one sides are micropore face 36, and another side is a solid surfaces 37, and border outer cylinder 38 is the micropore face, middle through hole inner cylinder 39 is a solid surfaces, be provided with passage 28 between micropore face 36 and solid surfaces 37, liquid compiles outflow from micropore face 36 admission passages 28 from border outer cylinder 38; Purge gas evenly spreads the back from micropore face 36 quick-fried gas from border outer cylinder 38 admission passages 28 in passage 28.
The cross section of described passage 28 is circular or oval, and the longitudinal section is provided with angle beta near a side of solid surfaces 37.The β angle makes the resistance of passage 28 inner fluid each points identical, and the resistance and the flow velocity of micropore face 36 each points of assurance microwell plate 5 are the same; The each point instantaneous velocity of material turnover microwell plate is controlled within the acceptable range.
As shown in figure 11, the passage 28 of microwell plate 5 is fan-shaped distribution, and making micropore face 36 is 1～5 times of short lines distance to the longest air line distance of passage 28, has guaranteed the flow velocity uniformity of micropore face 36.
As shown in figure 12, passage 28 has the γ angle, by improving behind the computer computer simulation, shortens the range difference of micropore face 36 each points to passage 28, makes the flow velocity of micropore face 36 more even.
As shown in figure 13, just flowing to of liquid is that the micropore face 36 of microwell plate 5 advances, and to the filtration pore channel of microwell plate 5, to passage 28, to outer tunnel 40, to split channel 41, to internal channel 42, to outlet 43, goes out to pipe joint 16 at last; Reverse direction flow is opposite with it.Described microwell plate and deflector can the pressure reduction of anti-0.6MPa gas or liquid; The chromatographic column body can bear 10MPa pressure, diameter at φ more than 1800.
The utility model is specially adapted to pharmaceuticals industry, or industry such as food, agricultural chemicals, chemical industry, metallurgy.
Claims (9)
1. chromatographic isolation chromatographic column, it is characterized in that: comprise that sidewall is provided with the cylindrical shell of visor, the loam cake of fixedlying connected with cylindrical shell and lower cover, be provided with microwell plate, deflector between loam cake and the cylindrical shell and between lower cover and the cylindrical shell, loam cake and under cover and be provided with distributor and pipe joint, on distributor, be provided with positive mouthpiece and microwell plate leakage hole, in distributor, be provided with spray dispensing head moving up and down, the spray dispensing head is provided with charging aperture, also is provided with loading and unloading post device, resin container, washing liquid tank and is connected with the cylindrical shell pipeline with collecting tank outside cylindrical shell.
2. chromatographic isolation chromatographic column according to claim 1 is characterized in that: the material of described microwell plate is ultra-high molecular weight polyethylene or stainless steel or Titanium or pottery.
3. chromatographic isolation chromatographic column according to claim 1, it is characterized in that: described microwell plate simultaneously is the micropore face, another side is a solid surfaces, the border outer cylinder is the micropore face, middle through hole inner cylinder is a solid surfaces, be provided with passage between micropore face and solid surfaces, liquid compiles outflow from micropore face admission passage from the border outer cylinder; Purge gas evenly spreads the back from the quick-fried gas of micropore face from border outer cylinder admission passage in passage.
4. chromatographic isolation chromatographic column according to claim 3 is characterized in that: the cross section of described passage is for circular or oval, and the longitudinal section is provided with angle beta near a side of solid surfaces, and passage is fan-shaped distribution.
5. chromatographic isolation chromatographic column according to claim 1 is characterized in that: described microwell plate and deflector are integrative-structures.
6. chromatographic isolation chromatographic column according to claim 1 is characterized in that: the material of described deflector is a ultra-high molecular weight polyethylene, cylinder inboard wall lining plastic layer.
7. chromatographic isolation chromatographic column according to claim 1 is characterized in that: described visor inner surface is an arc, flushes with cylinder inboard wall, and the side cooperates with cylindrical shell is seamless all around.
8. chromatographic isolation chromatographic column according to claim 1 is characterized in that: described spray dispensing head upper surface is a sphere, and the longitudinal section of spray apertures is provided with angle [alpha].
9. chromatographic isolation chromatographic column according to claim 1, it is characterized in that: described cylinder body outer wall is provided with the chuck layer, and the chuck layer is provided with chuck import and JO, and adjustment liquid flows into from the chuck import, flow out from JO, the material in the cylindrical shell is carried out adjustment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010206550055U CN201997135U (en) | 2010-12-02 | 2010-12-02 | Chromatograph separation chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010206550055U CN201997135U (en) | 2010-12-02 | 2010-12-02 | Chromatograph separation chromatographic column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201997135U true CN201997135U (en) | 2011-10-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010206550055U Expired - Lifetime CN201997135U (en) | 2010-12-02 | 2010-12-02 | Chromatograph separation chromatographic column |
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| Country | Link |
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| CN (1) | CN201997135U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078706A (en) * | 2010-12-02 | 2011-06-01 | 温州市东瓯微孔过滤有限公司 | Ion exchange chromatography filtration method and chromatographic separation column thereof |
-
2010
- 2010-12-02 CN CN2010206550055U patent/CN201997135U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078706A (en) * | 2010-12-02 | 2011-06-01 | 温州市东瓯微孔过滤有限公司 | Ion exchange chromatography filtration method and chromatographic separation column thereof |
| CN102078706B (en) * | 2010-12-02 | 2012-12-12 | 温州市东瓯微孔过滤有限公司 | Ion exchange chromatography filtration method and chromatographic separation column thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| DD01 | Delivery of document by public notice |
Addressee: Rao Xianrui Document name: Notification to Pay the Fees |
|
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI HONGLI PURIFYING TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: DONGOU MICROPOROUS FILTERING CO. LTD., WENZHOU CITY Effective date: 20120817 Owner name: ZHEJIANG DONG'OU FILTERING MACHINERY MANUFACTURING Effective date: 20120817 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Song Xianhong Inventor after: Song Zhiji Inventor after: Song Zhisheng Inventor after: Hu Liangfen Inventor after: Chen Jinfu Inventor after: Zhao Shikai Inventor after: Song Zhili Inventor before: Song Xianhong Inventor before: Song Zhiji Inventor before: Song Zhisheng Inventor before: Hu Liangfen Inventor before: Chen Jinfu Inventor before: Zhao Shikai |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 325003 WENZHOU, ZHEJIANG PROVINCE TO: 201799 QINGPU, SHANGHAI Free format text: CORRECT: INVENTOR; FROM: |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20120817 Address after: 201799, Shanghai District, Qingpu Park Road 99, Shun Pu building, 2 floor, I District, room 286 Patentee after: Shanghai Hongli Purification Technology Co., Ltd. Patentee after: Zhejiang Dongou Filter Manufacturing Co., Ltd. Address before: Yangfushan in Lucheng District of Wenzhou City, Zhejiang province 325003 Tu village industrial zone south Patentee before: Dongou Microporous Filtering Co., Ltd., Wenzhou City |
|
| DD01 | Delivery of document by public notice |
Addressee: Rao Xianrui Document name: Notification of Passing Examination on Formalities |
|
| CX01 | Expiry of patent term |
Granted publication date: 20111005 |
|
| CX01 | Expiry of patent term |