CN201940273U - Micronizing device for cefmenoxime hydrochloride raw materials - Google Patents
Micronizing device for cefmenoxime hydrochloride raw materials Download PDFInfo
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- CN201940273U CN201940273U CN2011200416771U CN201120041677U CN201940273U CN 201940273 U CN201940273 U CN 201940273U CN 2011200416771 U CN2011200416771 U CN 2011200416771U CN 201120041677 U CN201120041677 U CN 201120041677U CN 201940273 U CN201940273 U CN 201940273U
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- cyclone separator
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- cefmenoxime hydrochloride
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Abstract
The utility model relates to the pharmaceutical field, in particular to a micronizing device for cefmenoxime hydrochloride raw materials. The micronizing device for the cefmenoxime hydrochloride raw materials comprises an airflow crusher, a grading chamber, a cyclone separator, a raw-material-collecting barrel, a dust remover and a draught fan, wherein the grading chamber is arranged above the airflow crusher; an outlet of the grading chamber is connected with the cyclone separator by a pipeline; the raw-material-collecting barrel is connected at the position of an outlet below the cyclone separator; an outlet above the cyclone separator is connected with the dust remover by a pipeline; and the draught fan is connected above the dust remover by a pipeline. When the device is adopted, the particle size of micronized cefmenoxime hydrochloride micropowder is larger than 500 meshes, the dissolving time of the micropowder is within 1.5min, and the dissolving time of cefmenoxime hydrochloride is greatly shortened.
Description
Technical field
The utility model relates to pharmaceutical field, relates in particular to the micronized device of a kind of Cefmenoxime Hcl raw material.
Background technology
Cefmenoxime Hcl, its chemistry is by name: (6R, 7R)-7-[2-(2-amino-4-thiazolyl) (methoxyimino) acetylamino]-3-[[(1-methyl isophthalic acid H-tetrazolium-5-yl)-sulphur] methyl]-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-formates hydrochlorate (2:1).
Its structural formula is as follows:
Molecular formula: (C16H17N9O5S3) 2HCl molecular weight: 1059.58.
Proterties: white or crystallization of Melon yellow look or crystalline powder, no tool or special odor is arranged slightly.Be soluble in methyl-sulfoxide, dimethyl formamide, be not soluble in methyl alcohol, the utmost point is insoluble in water, is dissolved in ethanol and acetone hardly.mp174~175℃(dec)。
Purposes: third generation cephalo all has antibacterial action to Gram-negative and positive aerobic bacteria and anaerobic bacteria.In the Gram-negative bacteria, antibacterial action to Escherichia coli, pneumobacillus is stronger slightly than Cefotiam, obviously be better than the cephazoline of the first generation, the antibacterial action of influenza being bitten blood bacillus, proteus, serratia marcesens, Citrobacter, Enterobacter is also more intense, and Bacteroides is also had very strong antibacterial action.In gram-positive bacteria, also stronger to micrococcus scarlatinae, pneumococcal antibacterial action.Peptococcus, Peptostreptococcus also there is the strong antibiotic effect.Stable to beta lactamase.This product to the effect of staphylococcus not as first and second cynnematin in generation, poor to Pseudomonas aeruginosa, enterobacteria and enterococcus effect.Quiet notes 1g, blood medicine peak value 99.4 mcg/ml, intramuscular injection 0.5g is 10.8 mcg/ml, serum t1/2 is about 1 hour.Metabolism hardly in vivo is mainly through renal excretion.Haemocyanin is in conjunction with rate 85%.This product is good to bile transport, and is higher at body fluid such as sputum, tonsillotome, celiolymph, hydrothorax, peritoneal exudate, kidney, bladder wall, uterus, fallopian tubal, ovary, pelvis diffusate, Cord blood, amniotic fluid and Tissue distribution concentration.But transhipment seldom in milk.Be applicable to responsive microbial septicemia, meningitis, respiratory tract infection, pyothorax, liver and courage infection, peritonitis, urinary tract infection, genital system infection and burn and surgical wound infection etc.
Because the Cefmenoxime Hcl utmost point is insoluble in the character of water, therefore preparing the very big difficulty that run into of parenteral solution.Applicant in May, 2006, the particle diameter of powder was 100 orders by the improvement of synthesis technique, and dissolution time narrowed down to 4 minutes by 8 minutes; Though the improvement of 06 year production technology narrowed down to dissolution time 4 minutes by original 8 minutes, because speed of agitator is too high in the crystallization process, strengthened the operating load of crystallizing tank mechanical sealing member, increase product and be subjected to the risk that visible foreign matters influences.In addition, 4 minutes dissolution time is still longer: because water temperature is lower, and dissolution time is longer, is not easy to medical personnel and uses when preceding about 4 minutes of micro mist, temperature are low; Will not produce muddiness if will there be consoluet product to inject infusion bottle, influence the normal use of product, make in the product use to have hidden danger of quality.
Summary of the invention
In order to solve the dissolution time problem of Cefmenoxime Hcl, the purpose of this utility model provides the micronized device of a kind of Cefmenoxime Hcl raw material, adopt this granularity of installing micronized Cefmenoxime Hcl raw material greater than 500 orders, the dissolution time of micro mist has shortened the Cefmenoxime Hcl dissolution time greatly in 1.5 minutes.
In order to realize above-mentioned purpose, the utility model has adopted following technical scheme:
A kind of micronized device of Cefmenoxime Hcl raw material that is used for, this device comprises airslide disintegrating mill, grading room, cyclone separator, raw material collecting vessel, deduster and air-introduced machine, described grading room is arranged on the airslide disintegrating mill top, the outlet of grading room connects described cyclone separator by pipeline, the exit, below of cyclone separator connects described raw material collecting vessel, the top outlet of cyclone separator connects described deduster by pipeline, and the deduster top connects described air-introduced machine by pipeline.
The granularity that adopts the micronized Cefmenoxime Hcl micro mist of said apparatus is greater than 500 orders, and dissolution time has shortened the Cefmenoxime Hcl dissolution time greatly in 1.5 minutes.
Of the present utility model owing to adopted above-mentioned technical scheme, the introducing of micronization technology has reduced the granularity requirements of synthesis procedure to aseptic raw material, thereby reduced the crystallization rate of raw material, this helps the reduction of product related substance, thereby improves the quality of product.Gas temperature significantly reduces because high pressure air slows down afterwards by jet pipe on the technology, make material be able under low temperature environment, pulverize, this be different from grind or the cutting and grinding process in the phenomenon that raises of temperature, for antibiotic etc. provides the approach of pulverizing preferably to thermo-responsive product.Air-flow is pulverized material to be crushed to and is ground or the inaccessiable granularity of cutting and grinding, and the air-flow grinding mode of the grading wheel that we taked control can carry out granularity accurate classification, this also be in the past the air-flow disintegrating apparatus inaccessible.Compare with common Cefmenoxime Hcl, micronizing Cefmenoxime Hcl raw material has advantages such as fine size, dissolution velocity are fast, easy to use, related substance minimizing.
Description of drawings
Fig. 1 is an apparatus structure schematic diagram of the present utility model.
The specific embodiment
Below the specific embodiment of the present utility model is done a detailed description.
A kind of as shown in Figure 1 micronized device of Cefmenoxime Hcl raw material that is used for, this device comprises airslide disintegrating mill 1, grading room 2, cyclone separator 3, raw material collecting vessel 4, deduster 5 and air-introduced machine 6, described grading room 2 is arranged on 1 side on the airslide disintegrating mill, the outlet of grading room 2 connects described cyclone separator 3 by pipeline, the exit, below of cyclone separator 3 connects described raw material collecting vessel 4, the top outlet of cyclone separator 3 connects described deduster 5 by pipeline, and deduster 5 tops connect described air-introduced machine 6 by pipeline.
The operating procedure of above-mentioned device is:
1, opens compressed air, guarantee that compressed air pressure is at 0.4～0.8Mpa, oil content≤0.1mg/m
3, moisture content≤120mg/m
3, temperature≤40 ℃, treat that pressure stability opens the protection air valve, controlled pressure is at 0.2～0.3Mpa;
2, the classification motor on the startup grading room 2, the frequency of regulating motor is 95HZ;
3, open air-introduced machine 6; Open the air valve of airslide disintegrating mill 1, controlled pressure is about 0.4MPa;
4, by charging hopper the Cefmenoxime Hcl crystalline powder of drying is added to airslide disintegrating mill 1, regulate nozzle group valve pressure about 0.4MPa, pulverize aseptic raw material;
5, the aseptic raw material after above-mentioned steps is pulverized is sent into automatically and is carried out classification in the grading room 2, and at two stage cyclone separator 3 raw material is collected into acceptable material collecting vessel 4, and the gas that has low amounts of dust discharges after deduster 5 dedustings.
This method can obtain granularity greater than 500 purpose Cefmenoxime Hcl micro mists, and dissolution time is brought up in present 1.5 minutes by original clock more than 4 minutes.
Claims (1)
1. micronized device of Cefmenoxime Hcl raw material, it is characterized in that: this device comprises airslide disintegrating mill, grading room, cyclone separator, raw material collecting vessel, deduster and air-introduced machine, described grading room is arranged on the airslide disintegrating mill top, the outlet of grading room connects described cyclone separator by pipeline, the exit, below of cyclone separator connects described raw material collecting vessel, the top outlet of cyclone separator connects described deduster by pipeline, and the deduster top connects described air-introduced machine by pipeline.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011200416771U CN201940273U (en) | 2011-02-18 | 2011-02-18 | Micronizing device for cefmenoxime hydrochloride raw materials |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011200416771U CN201940273U (en) | 2011-02-18 | 2011-02-18 | Micronizing device for cefmenoxime hydrochloride raw materials |
Publications (1)
| Publication Number | Publication Date |
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| CN201940273U true CN201940273U (en) | 2011-08-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011200416771U Expired - Lifetime CN201940273U (en) | 2011-02-18 | 2011-02-18 | Micronizing device for cefmenoxime hydrochloride raw materials |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102659819A (en) * | 2011-02-18 | 2012-09-12 | 浙江尖峰药业有限公司 | Cefmenoxime hydrochloride compound and micronization method thereof |
| CN102872939A (en) * | 2012-09-23 | 2013-01-16 | 浙江杭摩合成材料有限公司 | Totally closed continuous production device for brake pad bonding agent mixed powder |
| CN103480454A (en) * | 2012-06-11 | 2014-01-01 | 四川制药制剂有限公司 | System used for grinding medicine raw materials |
-
2011
- 2011-02-18 CN CN2011200416771U patent/CN201940273U/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102659819A (en) * | 2011-02-18 | 2012-09-12 | 浙江尖峰药业有限公司 | Cefmenoxime hydrochloride compound and micronization method thereof |
| CN103480454A (en) * | 2012-06-11 | 2014-01-01 | 四川制药制剂有限公司 | System used for grinding medicine raw materials |
| CN102872939A (en) * | 2012-09-23 | 2013-01-16 | 浙江杭摩合成材料有限公司 | Totally closed continuous production device for brake pad bonding agent mixed powder |
| CN102872939B (en) * | 2012-09-23 | 2014-06-25 | 浙江杭摩合成材料有限公司 | Totally closed continuous production device for brake pad bonding agent mixed powder |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20110824 |
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| CX01 | Expiry of patent term |