CN201856038U - Continuous laser full-automatic punch for osmotic pump tablets - Google Patents

Continuous laser full-automatic punch for osmotic pump tablets Download PDF

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Publication number
CN201856038U
CN201856038U CN 201020283350 CN201020283350U CN201856038U CN 201856038 U CN201856038 U CN 201856038U CN 201020283350 CN201020283350 CN 201020283350 CN 201020283350 U CN201020283350 U CN 201020283350U CN 201856038 U CN201856038 U CN 201856038U
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CN
China
Prior art keywords
laser generator
camera
laser
rotating disk
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN 201020283350
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Chinese (zh)
Inventor
侯惠民
付民
张惠平
龚忠
钱明英
罗春林
任韵美
王正方
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Modern Pharmaceutical Engineering Research Center Co Ltd
Shanghai Shyndec Pharmaceutical Co Ltd
Original Assignee
Shanghai Modern Pharmaceutical Co Ltd
Shanghai Modern Pharmaceutical Engineering Research Center Co Ltd
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Filing date
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Application filed by Shanghai Modern Pharmaceutical Co Ltd, Shanghai Modern Pharmaceutical Engineering Research Center Co Ltd filed Critical Shanghai Modern Pharmaceutical Co Ltd
Priority to CN 201020283350 priority Critical patent/CN201856038U/en
Application granted granted Critical
Publication of CN201856038U publication Critical patent/CN201856038U/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Abstract

The utility model relates to a punching device, and provides a continuous laser full-automatic punch for osmotic pump tablets, The continuous laser full-automatic punch comprises a rotating disc, a tray, a hopper, a probe, a first laser generator, a first camera head, a second laser generator, a second camera head, an electromagnetic valve and a computer, wherein the rotating disc is connected with a motor, a through hole is formed on the rotating disc, the tray leans on the bottom surface of the tray, a slit or a hole is formed on the tray, a discharge port is formed on one side, an outlet of the hopper abuts against the rotating disc, the probe is arranged on one side of the outlet of the hopper, the first laser generator is arranged above a small hole on one side of the probe, the first camera head is arranged on one side of the first laser generator, the second laser generator is arranged on one side of the first camera head and positioned below the small slit, the second camera head is arranged on one side of the second laser generator, the electromagnetic valve is arranged on one side of the second camera head, and the outlet of the electromagnetic valve is arranged below the small slit. The probe, the first laser generator, the first camera head, the second laser generator, the second camera head and the electromagnetic valve are connected with the computer. The continuous laser full-automatic punch has simple structure and is conductive to industrialized production.

Description

The continuous laser fully automatic perforator of osmotic pump tablet
Technical field
The utility model relates to a kind of device of punching, relates in particular to a kind of perforating device on tablet.
Background technology
Adopt penetration theory to can be made into the Oros sheet of slow release, it can discharge medicine in vivo for a long time equably.
Described Oros sheet with pellicle, is stamped aperture with laser in the label outsourcing again on film, moisture enters label through pellicle in the body of oral back, dissolved substance or osmotic pressure propellant, and produce osmotic pressure, medicine is released continuously, so be called osmotic tablet again.Osmotic tablet has two types, elementary osmotic pump tablet and two-chamber osmotic pump tablet.
The osmotic pressure propellant and the medicine of elementary osmotic pump tablet mix, and do not need tablet is pressed the positive and negative difference, make a call to an aperture in any one side of tablet, and medicine can disengage.(Tsing-Hua University has the laser-beam drilling machine product to be used for all existing report of this purpose laser-beam drilling machine at home and abroad, the existing research laser-beam drilling machine of China Medicine University, the Tianjin laser technology is studied all experimental study reports (Tianjin medicine the 7th the 4th phase of volume of nineteen ninety-five), and U.S. Pat PAT3916899 also has disclosed report.
Two-chamber osmotic pump tablet double-layer structure, one deck are Drug Storage, and another layer produces agent for osmotic pressure.Osmotic pressure generation agent suction is collapsed and is risen, and produces motive force, and medicine is released from aperture, therefore, aperture must be beaten on this one side of coatings of Drug Storage for this class controlled release tablet, otherwise medicine just can not disengage.Therefore, the curative effect that the having or not of hole, size all can ectocrines.
The inventor once had two parts of Chinese patents about the laser boring machine: ZL03270283.3 and ZL03270284.1, these two kinds of devices also use aborning, but speed is slow, does not catch up with the needs of production development, can not carry out the laser boring of diplopore osmotic pump tablet simultaneously in addition.
Retrieval is found, the domestic patent that has many about tablet laser boring.(ZL99103576.3) can be used for single chamber pump tablet high-rate laser punching as " laser borer for high-speed osmotic pump ", is a kind of method that adopts single generating laser, branchs light path, galvanometer, and tablet is through vibrating funnel to guide rail, punches in that tablet is two-sided.Also have " controlled-release pharmaceutical tablet laser drilling system device " (ZL200620074990.4), " high speed laser-beam drilling machine for tablet " (ZL200610096440.7) or the like.
In addition, " controlled-release pharmaceutical tablet laser drilling device " (ZL200820238230.1) (ZL200820032034.9) all adopts two Laser emission, transmission to be with the perforating device of conveying, the identification of color and luster identifier with " controlled-release pharmaceutical tablet laser drilling system device "." tablet self-recognition laser drilling system and control method thereof " (ZL200710052551.2) then discerned the push and pull pump tablet earlier, and then delivers to the rotating disk running, and frame for movement is more complicated.
Obviously, all there are many defectives in present two-chamber osmotic pump controlled-release tablet laser drilling device, as all inspections of not mentioned laser aperture.For osmotic tablet, be invalid if any the tablets of not punching, also may threat to life when serious, so to have or not be very important in the hole, must be differentiated rejecting.Secondly, the size in hole, too big or too little all improper, therefore, above-mentioned patented technology, can not satisfy suitability for industrialized production and needs.
Summary of the invention
The purpose of this utility model is the continuous laser fully automatic perforator of a kind of osmotic pump tablet of design, to overcome the above-mentioned defective that prior art exists, satisfies need of industrial production.
The continuous laser fully automatic perforator of osmotic pump tablet of the present utility model comprises: rotating disk, pallet, hopper, probe, first laser generator, first camera, second laser generator, second camera, magnetic valve and computer;
Described rotating disk is connected with motor, rotating disk is provided with through hole, described pallet abuts against the bottom surface of rotating disk and is fixed on the frame, pallet is provided with and corresponding seam of described aperture or hole, the one side is provided with feed opening, described hopper is arranged on the top of rotating disk, outlet is near rotating disk, described probe is arranged on a side of the outlet of hopper, described first laser generator is arranged on a side of probe, and be positioned at the top of aperture, first camera is arranged on a side of first laser generator, described second laser generator is arranged on the opposite side of first camera, and is positioned at seam or below, hole, and second camera is arranged on the opposite side of second laser generator, described magnetic valve is arranged on the opposite side of second camera, its inlet is connected with compressed air gas source, and outlet is arranged on the below in seam or hole, described probe, first laser generator, first camera, second laser generator, second camera is connected with computer by lead respectively with magnetic valve.
The utility model also is convenient to the punching to single chamber diplopore osmotic pump tablet.This is the another kind of novel osmotic pump of development in recent years, and this diplopore sheet is the front at tablet, and each makes a call to a hole reverse side, thus the utility model just can from up and down two punch.
The utility model adopts horizontal station dial, does not adopt intermittent running, and changes continuous rotation into, and with the laser power size, per minute is brought up to from original 120~180 slices/minute can punch 600~1200.No longer adopt and turn over the chip architecture and the laser tracking structure in multiple generation, and use extremely short millisecond time inner laser irradiation punching.The present invention does not pursue the absolute rounding in hole, and only requiring does not influence drug release rate, the release amount, and the hole slightly is ellipse on the actual proof tablet of the present invention, and drug release rate and release amount are under circular hole hole area similar situation, and be just the same, thereby simplified frame for movement greatly.The utility model adopts two sublasers, because laser power of the present utility model can be 15W~50W, and little, therefore can be directly by the above and below that is placed on tablet, or simple horizontal aspect, add with a speculum.Do not adopt the single transmit device multiple assorted optical means of beam split again, laser power was reduced, can make control again and greatly simplification is installed, in addition low power generating laser price is also inexpensive.
In the utility model, be provided with the testing fixture in aperture, differentiate the back rejecting for atresia, diplopore, the underproof substandard product that all is considered as of inclined to one side hole hole area, and high fidelity factor is arranged, meet industrial GMP requirement.Guaranteed the safety of patient's medication.
Owing to adopted the mode of continuous running and horizontal rotating disc, the mechanical electric aspect is greatly oversimplified, and provides more convenient operation for ordinary maintenance.
The utility model structure is more simple, and all motions are controlled by computer, the time of opening as brightness, the time of Laser emission, the degree of depth of laser boring, laser power, the magnetic valve of light source, qualified and defective counting, rotating speed of motor etc.Therefore, more help industrialized production, be a kind of new high-rate laser punching inspection machine, can be the osmotic pump controlled release tablet of development China, the preparation technique that promotes China is made contributions.
Description of drawings
Fig. 1 is the utility model structural representation.
Fig. 2 is the support holder structure schematic diagram.
The specific embodiment
Referring to Fig. 1 and Fig. 2, the continuous laser fully automatic perforator of osmotic pump tablet of the present utility model comprises: rotating disk 1, pallet 12, hopper 2, probe 3, first laser generator 4, first camera 5, second laser generator 6, second camera 7, magnetic valve 8 and computer 9;
Described rotating disk 1 is connected with motor, rotating disk 1 is provided with through hole 101, adapt with figure of tablet, described pallet 12 abuts against the bottom surface of rotating disk 1 and is fixed on the frame, pallet 12 is provided with and described aperture 101 corresponding seams or hole 121, the one side is provided with feed opening 122, described hopper 2 is arranged on the top of rotating disk 1, its outlet 201 is near rotating disk 1, described probe 3 is arranged on a side of the outlet 201 of hopper 2, described probe 3 can adopt the commercially available universal product, described first laser generator 4 is arranged on a side of probe 3, and be positioned at the top of aperture 101, first camera 5 is arranged on a side of first laser generator 4, described second laser generator 6 is arranged on the opposite side of first camera 5, and be positioned at the seam or the below in hole 121, second camera 7 is arranged on the opposite side of second laser generator 5, described magnetic valve 8 is arranged on the opposite side of second camera 7, its inlet is connected with compressed air gas source, outlet 801 is arranged on the below in seam or hole 121, described probe 3, first laser generator 4, first camera 5, second laser generator 6, second camera 7 is connected with computer 9 by lead respectively with magnetic valve 8;
Further, the utility model also comprises illuminating lamp 14, and described illuminating lamp 14 is separately positioned on first camera 5 and second camera, 7 places, for camera illuminates tablet;
Further, also comprise useless sheet gatherer 10 and qualified gatherer 11;
Described useless sheet gatherer 10 is arranged on the opposite side of magnetic valve 8, is positioned at the top of rotating disk 1 at outlet 801 places of magnetic valve 8, and described qualified gatherer 11 is arranged on the opposite side of useless sheet gatherer 10, is positioned at the below of the aperture 101 of rotating disk 1.
The course of work of the present utility model is such:
No matter tablet is bilayer or single chamber, fall into the emptying aperture 101 of rotating disk 1 by hopper 9, with the rotation of rotating disk 1, differentiate by probe 3, last, then send signal for first laser generator 4 as the double-layer tablet Drug Storage, 4 pairs of tablet punchings of first laser generator by computer; , then give by computer second laser generator 6 and send the signal punching down as Drug Storage, so just reduced the slice turning device in the former patent, and overcome the obstacle that improves punching speed.
The punching result of 5 pairs first laser generators 4 of first camera checks, the punching result of 7 pairs second laser generators 4 of second camera checks, and the result controlled magnetic valve 8 by computer, if any underproof signal, the outlet 801 of magnetic valve 8 is opened, the compressed air sheet that will give up is brought useless sheet gatherer 10 into and is discharged, as qualified, magnetic valve 8 is failure to actuate, have the feed opening 122 that qualified aperture 101 goes to pallet 1 one sides, qualified nationality deadweight in dial rotation drops to the qualified gatherer 11 from 101 automatically.

Claims (3)

1. the continuous laser fully automatic perforator of osmotic pump tablet, comprise rotating disk (1), pallet (12), hopper (2) and probe (3), it is characterized in that, also comprise first laser generator (4), first camera (5), second laser generator (6), second camera (7), magnetic valve (8) and computer (9);
Described rotating disk (1) is connected with motor, rotating disk (1) is provided with through hole (101), described pallet (12) abuts against the bottom surface of rotating disk (1) and is fixed on the frame, pallet (12) is provided with and the corresponding seam of described aperture (101) or hole (121), the one side is provided with feed opening (122), described hopper (2) is arranged on the top of rotating disk (1), its outlet (201) is near rotating disk (1), described probe (3) is arranged on a side of the outlet (201) of hopper (2), described first laser generator (4) is arranged on a side of probe (3), be positioned at the top of aperture (101), first camera (5) is arranged on a side of first laser generator (4), described second laser generator (6) is arranged on the opposite side of first camera (5), and be positioned at the seam or the below of hole (121), second camera (7) is arranged on the opposite side of second laser generator (5), described magnetic valve (8) is arranged on the opposite side of second camera (7), its inlet is connected with compressed air gas source, outlet (801) is arranged on the below of crack (121), described probe (3), first laser generator (4), first camera (5), second laser generator (6), second camera (7) is connected with computer (9) by lead respectively with magnetic valve (8).
2. the continuous laser fully automatic perforator of osmotic pump tablet according to claim 1 is characterized in that, also comprises illuminating lamp (14), and described illuminating lamp (14) is separately positioned on first camera (5) and second camera (7) is located.
3. the continuous laser fully automatic perforator of osmotic pump tablet according to claim 1 and 2, it is characterized in that, also comprise useless sheet gatherer (10) and qualified gatherer (11), described useless sheet gatherer (10) is arranged on the opposite side of magnetic valve (8), be positioned at the top of the rotating disk (1) that the outlet (801) of magnetic valve (8) locates, described qualified gatherer (11) is arranged on the opposite side of useless sheet gatherer (10), is positioned at the below of the aperture (101) of rotating disk (1).
CN 201020283350 2010-08-05 2010-08-05 Continuous laser full-automatic punch for osmotic pump tablets Expired - Lifetime CN201856038U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN 201020283350 CN201856038U (en) 2010-08-05 2010-08-05 Continuous laser full-automatic punch for osmotic pump tablets

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Application Number Priority Date Filing Date Title
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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102950948A (en) * 2011-08-23 2013-03-06 浙江伟星实业发展股份有限公司 Button carving machine and button fixture thereof
CN102950381A (en) * 2011-08-23 2013-03-06 浙江伟星实业发展股份有限公司 Button carving machine
CN103181655A (en) * 2011-12-27 2013-07-03 武汉金运激光股份有限公司 Vamp laser-punching system
CN103202768A (en) * 2012-01-11 2013-07-17 玄文明 Tablet disc-type negative-pressure processing device
CN103551742A (en) * 2013-10-30 2014-02-05 马志敏 High-speed controlled-release tablet perforating machine
CN103802574A (en) * 2012-11-14 2014-05-21 浙江伟星实业发展股份有限公司 Side lettering device
CN104858553A (en) * 2015-06-22 2015-08-26 上海定向材料科技有限公司 Automatic honeycomb ceramic punching apparatus based on visual recognition
CN105945427A (en) * 2016-05-19 2016-09-21 浙江山蒲照明电器有限公司 Fluorescent lamp amalgam welding device and welding method
CN107283077A (en) * 2016-04-13 2017-10-24 激光扫描科技私人有限公司 High speed tablet drilling laser system
CN117141985A (en) * 2023-10-31 2023-12-01 苏州艾隆科技股份有限公司 Drug delivery method and device for drug library

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102950948A (en) * 2011-08-23 2013-03-06 浙江伟星实业发展股份有限公司 Button carving machine and button fixture thereof
CN102950381A (en) * 2011-08-23 2013-03-06 浙江伟星实业发展股份有限公司 Button carving machine
CN102950381B (en) * 2011-08-23 2015-07-15 浙江伟星实业发展股份有限公司 Button carving machine
CN103181655A (en) * 2011-12-27 2013-07-03 武汉金运激光股份有限公司 Vamp laser-punching system
CN103202768A (en) * 2012-01-11 2013-07-17 玄文明 Tablet disc-type negative-pressure processing device
CN103202768B (en) * 2012-01-11 2014-04-09 玄文明 Tablet disc-type negative-pressure processing device
CN103802574B (en) * 2012-11-14 2016-02-03 浙江伟星实业发展股份有限公司 side carving device
CN103802574A (en) * 2012-11-14 2014-05-21 浙江伟星实业发展股份有限公司 Side lettering device
CN103551742B (en) * 2013-10-30 2015-08-05 马志敏 High-speed controlled-release tablet puncher
CN103551742A (en) * 2013-10-30 2014-02-05 马志敏 High-speed controlled-release tablet perforating machine
CN104858553A (en) * 2015-06-22 2015-08-26 上海定向材料科技有限公司 Automatic honeycomb ceramic punching apparatus based on visual recognition
CN107283077A (en) * 2016-04-13 2017-10-24 激光扫描科技私人有限公司 High speed tablet drilling laser system
CN105945427A (en) * 2016-05-19 2016-09-21 浙江山蒲照明电器有限公司 Fluorescent lamp amalgam welding device and welding method
CN105945427B (en) * 2016-05-19 2017-12-29 浙江山蒲照明电器有限公司 Fluorescent lamp amalgam welder and welding method
CN117141985A (en) * 2023-10-31 2023-12-01 苏州艾隆科技股份有限公司 Drug delivery method and device for drug library
CN117141985B (en) * 2023-10-31 2024-01-26 苏州艾隆科技股份有限公司 Drug delivery method and device for drug library

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Granted publication date: 20110608

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