CN201701780U - Valsartan crystallization-dedicated kettle - Google Patents
Valsartan crystallization-dedicated kettle Download PDFInfo
- Publication number
- CN201701780U CN201701780U CN2010202163570U CN201020216357U CN201701780U CN 201701780 U CN201701780 U CN 201701780U CN 2010202163570 U CN2010202163570 U CN 2010202163570U CN 201020216357 U CN201020216357 U CN 201020216357U CN 201701780 U CN201701780 U CN 201701780U
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- kettle
- crystallization
- valsartan
- kettle body
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
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Abstract
The utility model discloses a Valsartan crystallization-dedicated kettle, which comprises a kettle body, a stirring mechanism and a variable-frequency drive mechanism, the upper half part of the kettle body is a cylinder, the lower half part of the kettle body is a cone, the kettle body is provided with an exhaust outlet for exhausting the waste gas produced in the process of crystallization is arranged on the kettle body, the periphery of the kettle body is wrapped by a layer of jacket, and the stirring mechanism is provided with a spiral stainless steel cutting blade and a spiral stainless steel scraper, and thereby can sufficiently stir materials and timely scrape off solid material attached on the wall of the crystallization kettle at the same time in the process of crystallization. The utility model solves the problem that material is hard to take out after Valsartan crystallization, meanwhile, the process has good controllability and stability, and the labor intensity of work is decreased.
Description
Technical field
The utility model relates to a kind of crystallization apparatus, relates in particular to the special-purpose still of a kind of Valsartan crystallization.
Background technology
Valsartan is a kind of white crystalline powder, generally is used in the hypertensive medicine of treatment.
In its crystallization process, because the bulk density of Valsartan is less, after crystallization was finished, whole crystallization reaction liquid presented the solid shape substantially.If adopt common crystallization kettle to prepare Valsartan,, when crystallization is finished, the crystal solution that presents the solid shape substantially can't be transferred to smoothly and be carried out follow-up operation in the centrifuge because common crystallization kettle bottom is level or U word circular arc.
If with Valsartan crystallization in crystallizing tank, the inorganization exhaust gas discharging that then produces in the crystallization process is difficult to control, and it is bigger that crystallization temperature is influenced by outside air temperature, and is difficult to the control of technology, makes the labour intensity of this operation become big.
Summary of the invention
Technical problem to be solved in the utility model is when with traditional crystallization kettle Valsartan being carried out crystallization, and crystal solution is difficult to shift, difficult control etc. of waste gas.
At above problem, the utility model provides a kind of crystal solution transfer of Valsartan, special-purpose still of Valsartan crystallization easy and simple to handle be convenient to.
The special-purpose still of a kind of Valsartan crystallization comprises kettle, agitating device and Frequency Drive device.
Described kettle adopts stainless steel, and its first half is a cylinder, and the latter half is a cone, is provided with kettle cover above the kettle, and a side is provided with material inlet on the kettle cover, and the conical tip place, bottom of kettle is provided with material outlet.The kettle of this shape is convenient in crystallization process the stirring of crystal solution after crystallization process is finished, is utilized the collecting action of cone, and crystal solution is converged to autoclave body bottom, is convenient to take out from material outlet.
Described kettle cover is provided with venthole, the waste gas that produces in the crystallization process in time can be discharged, and prevents that waste gas from kettle internal contamination crystal solution, influencing crystalline quality.
Described kettle periphery is provided with chuck, the chuck bottom is provided with cooling liquid inlet and thermocouple, the chuck top is provided with cooling liquid outlet, by the temperature of thermocouple monitoring kettle intercrystalline liquid,, regulate the kettle temperature inside constantly and distribute according to the requirement of the temperature that records and crystallization process different phase to temperature, realize in the crystallization process good control to temperature, prevent hot-spot, destroy the uniformity of crystallization, avoid changing the variation of the crystallization temperature of bringing as far as possible because of outside air temperature.
Described agitating device comprise be arranged on the kettle center rotating shaft, be fixed with two crosspieces up and down in the rotating shaft, be provided with spiral stainless steel scraping blade between two crosspieces, twine in the rotating shaft and be provided with spiral stainless steel cut sheet, the cutting blade of screw type can make crystal solution fully stir out when the crystal solution viscosity is low, realize the good cold and hot exchange of crystal solution, the temperature of crystal solution each point is consistent substantially, guarantee the homogeneity of crystallization.
Described Frequency Drive device is positioned at kettle cover top, comprises motor and gearratio, wherein motor be positioned at gearratio above, the bottom of gearratio connects the rotating shaft of agitating device, drives crosspiece and cutting blade kettle intercrystalline liquid is stirred.The Frequency Drive device can be regulated the mixing speed of agitating device to crystal solution, and when crystallization began, mixing speed was very fast, is convenient to crystal solution and conducts heat, and makes the material crystallization even.During crystallization later stage discharging, mixing speed is slower, gives the bigger downforce of cutting blade, is convenient to discharging.
The utility model has adopted the kettle of profile particular design, utilize the collecting action of cone, and on kettle cover, set out pore, material is difficult to take out the problem with exhaust-gas treatment when efficiently solving the Valsartan crystallization, improved condition of work, realize good controlled and stable of technical process, guarantee crystalline quality.
Description of drawings
Fig. 1 is the structural representation among the embodiment of the present utility model.
The specific embodiment
As shown in Figure 1, the special-purpose still of a kind of Valsartan crystallization comprises kettle 1, its the first half is a cylinder, and the latter half is a cone, is provided with the kettle cover 7 that is sphere on kettle 1, kettle cover 7 is provided with material inlet 12 and venthole 11, and the place is provided with material outlet 10 on cone summit, the bottom of kettle 1.
Described kettle 1 periphery is provided with chuck 2, and chuck 2 bottoms are provided with cooling liquid inlet 15 and thermocouple 14, and chuck 2 tops are provided with cooling liquid outlet 3, and a side of chuck 2 is provided with support 13, is used to support kettle 1.
Described kettle cover 7 tops are provided with the Frequency Drive device successively, comprise motor 8 and gearratio 9, motor 8 be positioned at gearratio 9 above, the bottom of gearratio 9 connects the rotating shaft 4 of agitating device, be fixed with two crosspieces 6 up and down in the rotating shaft 4, be provided with spiral stainless steel scraping blade 5a between two crosspieces 6, twine in the rotating shaft 4 and be provided with spiral stainless steel cut sheet 5b.
During practical operation, material is poured kettle 1 into from material inlet 12, opens motor 7, and the rotating shaft 4 that drives agitating device by gearratio 9 is rotated, and drive crosspiece 6 and spirality cutting blade 5b stir the crystal solution of kettle 1 inside.
Cooling fluid circulates in chuck 2 from cooling liquid inlet 15 chuck 2 of packing into, flows out chucks 2 from cooling liquid outlet 10 then.Simultaneously, thermocouple 14 begins to monitor the temperature of kettle 1 intercrystalline liquid, the Temperature Distribution of coming crystallization control liquid according to the consumption and the flow velocity of the adjustment cooling fluid that records.
According to the different phase of crystallization process, the Frequency Drive device can also be regulated mixing speed.When crystallization just begins that the mixing speed ratio is very fast, being convenient to the crystal solution internal heat evenly conducts, and makes crystallization have favorable uniformity.Mixing speed is slow during crystallization later stage discharging, can give the bigger downforce of cutting blade, is convenient to discharging.
The solid material that scraping blade 5a can will be attached on crystallization kettle 1 inwall in whipping process is scraped in the crystal solution timely, can not allow the crystalline solid product of separating out adsorb on kettle 1 inwall for a long time, brings certain detection index of product defective.In addition, in the discharging process, it is cleaner that scraping blade 5a can clear up product, can accomplish that substantially discharging finishes, and no visible solid exists in the still, is convenient to the cleaning of kettle 1.After crystallization finishes, because the collecting action of cone, the crystalline solid of generation will converge to the cone bottom automatically, can take out from material outlet 10 very easily.
Claims (6)
1. the special-purpose still of Valsartan crystallization comprises kettle (1), it is characterized in that kettle (1) the first half is a cylinder, and the latter half is a cone.
2. the special-purpose still of Valsartan crystallization as claimed in claim 1, it is characterized in that, kettle (1) inside is provided with agitating device, wherein the rotating shaft of agitating device (4) is positioned at kettle (1) center, be fixed with two crosspieces (6) up and down in the rotating shaft (4), be provided with spiral stainless steel scraping blade (5a) between two crosspieces (6), rotating shaft (4) is gone up to twine and is provided with spiral stainless steel cut sheet (5b).
3. the special-purpose still of Valsartan crystallization as claimed in claim 2 is characterized in that be provided with kettle cover (7) above the kettle (1), kettle cover (7) is provided with material inlet (12), and the place, cone summit, bottom of kettle (1) is provided with material outlet (10).
4. the special-purpose still of Valsartan crystallization as claimed in claim 3 is characterized in that kettle cover (7) is provided with venthole (11).
5. the special-purpose still of Valsartan crystallization as claimed in claim 3 is characterized in that kettle (1) periphery is provided with chuck (2), and chuck (2) bottom is provided with cooling liquid inlet (15) and thermocouple (14), and chuck (2) top is provided with cooling liquid outlet (3).
6. the special-purpose still of Valsartan crystallization as claimed in claim 3 is characterized in that, is provided with gearratio (9) above the kettle cover (7), is provided with motor (8) above the gearratio (9), and the bottom of gearratio (9) connects the rotating shaft (4) of agitating device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010202163570U CN201701780U (en) | 2010-06-03 | 2010-06-03 | Valsartan crystallization-dedicated kettle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010202163570U CN201701780U (en) | 2010-06-03 | 2010-06-03 | Valsartan crystallization-dedicated kettle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201701780U true CN201701780U (en) | 2011-01-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010202163570U Expired - Fee Related CN201701780U (en) | 2010-06-03 | 2010-06-03 | Valsartan crystallization-dedicated kettle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201701780U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108905262A (en) * | 2018-06-12 | 2018-11-30 | 崇义章源钨业股份有限公司 | The system and method for ammonium para-tungstate crystal automation control |
| CN109276907A (en) * | 2018-11-29 | 2019-01-29 | 方文星 | A kind of chemical industry two-stage crystallizing tank |
-
2010
- 2010-06-03 CN CN2010202163570U patent/CN201701780U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108905262A (en) * | 2018-06-12 | 2018-11-30 | 崇义章源钨业股份有限公司 | The system and method for ammonium para-tungstate crystal automation control |
| CN109276907A (en) * | 2018-11-29 | 2019-01-29 | 方文星 | A kind of chemical industry two-stage crystallizing tank |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110112 Termination date: 20160603 |
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| CF01 | Termination of patent right due to non-payment of annual fee |