CN201609360U - Intraocular pressure monitoring device - Google Patents
Intraocular pressure monitoring device Download PDFInfo
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- CN201609360U CN201609360U CN2010201136222U CN201020113622U CN201609360U CN 201609360 U CN201609360 U CN 201609360U CN 2010201136222 U CN2010201136222 U CN 2010201136222U CN 201020113622 U CN201020113622 U CN 201020113622U CN 201609360 U CN201609360 U CN 201609360U
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Abstract
The utility model discloses an intraocular pressure monitoring device, including a wireless pressure sensor implanted to the skin formation of the cornea edge and directly contacted to the sclera organization, and a portable signal receiving processor, wherein the pressure sensor also includes a flexible micro-electrode array sensing the electric impedance variation on the sclera organization surface and a signal processing and transmission unit for converting the electric impedance variation in voltage signal to process and then transmit outside; the signal receiving processor receives the signal, analyzes and fits the signal to obtain intraocular pressure values to store and display. The intraocular pressure monitoring device automatically perform 24 hours successional monitoring to the intraocular pressure of patient without influencing the general physiological activity of the patient, for providing sufficient and exact data for clinical diagnosis and therapy. And the pressure sensor is directly contacted with the sclera organization, to avoid generation of cornea injury, infection and hypoxia, and the like instances resulted probably by long term contact with the cornea organization.
Description
Technical field
This utility model relates to a kind of medical apparatus and instruments, relates in particular to a kind of lasting intraocular pressure monitoring device of implanted.
Background technology
Glaucoma is second largest diseases causing blindness in the world.The report of World Health Organization (WHO) shows, the whole world has 70,000,000 people to suffer from glaucoma, and along with aged tendency of population, expect the year two thousand twenty, this numeral will increase by 50% (Quigley HA, Broman AT.The number of people with glaucoma worldwide in 2010 and 2020.Br JOphthalmol.2006 Mar again; 90 (3): 262-7.).Glaucoma is distinctive optic neuropathy with one group of disease of correspondingly defect of visual field, and the rising of intraocular pressure is one of former factor of this disease, therefore, also be clinically diagnosis of glaucoma and follow up a case by regular visits in one of most important clinical examination index.At present, comparison the recognized standard method of measuring intraocular pressure is for flattening tonometry (applanation tonometer), wherein Goldmann pressing tonometry is considered to the most accurate method, worldwide, also is the method that the glaucoma specialist trusts most.Studies show that more and more it is the one of the main reasons of glaucoma state of an illness progress that the intraocular pressure fluctuation in a day increases, and determine that the intraocular pressure peak value in a day has great important for definite treatment (medication) scheme.But classical tonometry mode (pressing tonometry) needs the doctor to finish in clinic by instrument, and the accuracy of measurement result and patient's mated condition has much relations (Rota-Bartelink AM, PittA, Story I.Influence of diurnal variation on the intraocular pressure measurement of treatedprimary openangle glaucoma during office hours.J Glaucoma.1996; 5:410-415; Konstas AG, Mantziris DA, Stewart WC.Diurnal intraocular pressure in untreated exfoliation and primaryopen-angle glaucoma.Arch Ophthalmol.1997; 115:182-185; Asrani S, Zeimer R, Wilensky J, Gieser D, Vitale S, Lindenmuth K.Large diurnal fluctuations in intraocular pressure are anindependent risk factor in patients with glaucoma.J Glaucoma.2000; 9:134-142.).Therefore, use this kind measuring method, the single intraocular pressure value the when doctor can only obtain patient and goes to a doctor, and measured value due to illness the people when measuring mated condition and deviate from actual physiology actual value.Although the hardworking scheme of taking repeatedly to measure in one day intraocular pressure of doctors, attempt to obtain intraocular pressure day curve, but well imagine, even if we can measure intraocular pressure 4-6 time in one day, can wake patient up the measurement intraocular pressure at night, the result that we obtain remains a rough result, but also may cause measurement result and truth not to be inconsistent because having influenced patient's normal physiological activity (as sleep).Therefore, present tonometry means also are not enough to improve enough foundation accurately to glaucomatous clinical diagnosis and treatment, in other words, we also wait in expectation and can be implemented under the situation that does not influence patient's normal physiological activity, intraocular pressure is carried out successive more accurate measurement, thereby better instruct glaucomatous diagnosis and treatment.
The utility model content
The purpose of this utility model is to provide a kind of tonometry device of implanted, and measuring process need not doctor's operation, under the situation that does not influence patient's normal physiological activity, patient's eyes is compressed into row successional monitoring in 24 hours.
For achieving the above object, this utility model adopts following technical scheme:
A kind of intraocular pressure monitoring device, comprise wireless pressure sensor and portable signal receiving processor, it is characterized in that, described pressure transducer is implanted under the conjunctiva of limbus of corneae, directly contacts with scleral tissue, and it comprises again: be used to experience the flexible micro-electrode array that scleral tissue's surface impedance changes and this impedance variation is converted to the weak voltage signal; With, be used for voltage signal is carried out processing and amplifying and is converted to signal processing and the transmission unit that digital signal is launched; Described flexible micro-electrode array is connected by flexible wire with signal processing and transmission unit.
Comprise a plurality of electrodes in the above-mentioned flexible micro-electrode array, these a plurality of electrodes are experienced the impedance variation on scleral tissue surface after the varieties of intraocular pressure respectively, and this impedance variation is converted to the weak voltage signal passes to signal processing and transmission unit; Signal processing and transmission unit carry out processing and amplifying to signal, and are that digital signal is launched with analog signal conversion; Signal receiving processor receives digital signal, and digital signal is analyzed match, and the numerical value that obtains intraocular pressure is stored and shown.
Further, above-mentioned flexible micro-electrode array preferably comprises and is a plurality of non-closed hoop electrode and point-like electrode that is positioned at the center of circle that the concentric circular mode is arranged, and each electrode is connected with signal processing and transmission unit by flexible wire respectively.The flexible micro-electrode array is a base material with the polyimides preferably, is electrode material with the nickel alloy, and a plurality of nickel alloy electrodes promptly are set in the polyimides substrate.Whole flexible micro-electrode array package is in the biocompatible polymer encapsulated layer, described biocompatible polymer is Parylene (Parylene for example, this material has obtained the U.S. FDA authentication and has been used for human body), the thickness of biocompatible polymer encapsulated layer is advisable with the 8-12 micron, is preferably 10 microns.
Further, above-mentioned signal processing and transmission unit comprise front end analog signal amplifier, central processing unit and outside energy supply reception and signal transmitting antenna three parts again.A plurality of electrodes in the described flexible micro-electrode array are electrically connected with the front end analog signal amplifier by flexible wire, the impedance variation on its scleral tissue surface of experiencing is converted to the weak voltage signal passes to the front end analog signal amplifier, the front end analog signal amplifier passes to central processing unit with signal damping with after amplifying, central processing unit is digital signal with analog signal conversion and is stored, outside energy supply reception and signal transmitting antenna connect central processing unit, and digital signal is launched.The electric energy of whole pressure transducer comes from the electromagnetic oscillation that signal receiving processor takes place, and outside energy supply reception and signal transmitting antenna receive electromagnetic wave and be converted into electric energy.
Above-mentioned signal processing and transmission unit are IC chips, and this IC chip is generally siliceous substrate.The integrated circuit unit chip also wraps up the biocompatible polymer of 8-12 micron uniform thickness, for example Parylene outward.
Above-mentioned signal receiving processor comprises signal receiver and signal reading and recording device again, and the two is electrically connected, and by the signal of signal receiver reception from pressure transducer, signal reading and recording device is handled signal, obtains the numerical value of intraocular pressure.Simultaneously, signal receiver also has an electromagnetic oscillation unit module, and the outside energy supply reception of pressure transducer and signal transmitting antenna receive the electromagnetic oscillation of electromagnetic oscillation unit module generation and are converted into electric energy voltage supply force transducer and use.
The signal that this utility model is experienced pressure transducer by Radio Transmission Technology passes to external signal receiver, for example can use the Radio Transmission Technology of short ranges such as bluetooth, and signal reading and recording device is equipped with more powerful message handler (embedded system, be equivalent to special purpose computer), and data processing software, the plurality of voltages signal that receives is analyzed match, obtain the numerical value of intraocular pressure, and on display, show.
Experiment confirm, the variation of eyeball scleral tissue surface electrology characteristic can reflect the variation of intraocular pressure.Intraocular pressure monitoring device of the present utility model is implanted to pressure transducer under the conjunctiva of limbus of corneae, directly contacts with scleral tissue, and directly gaging pressure changes; Signal receiving processor is of portable form, and carries, and wherein signal receiver can be worn on ear, is convenient to the signal that receiving sensor sends.This intraocular pressure monitoring device is compressed into row successional monitoring in 24 hours to patient's eyes automatically under the situation that does not influence patient's normal physiological activity, be clinical diagnosis and the abundant accurate data of treatment raising.In addition, the device and the scleral tissue that implant in this utility model contact, and these are different with the contacted situation of cornea with existing intraocular pressure detecting instrument, have avoided and the long-term generation that contacts the situations such as corneal injury, infection and anoxia that may cause of cornea tissue.
Description of drawings
Fig. 1 is the scleral surface impedance that records at once behind the priming petock voltage rise height among the embodiment 1 and the graph of a relation of hydraulic pressure.
Fig. 2 is the priming petock pressure drop records after low at once among the embodiment 1 the scleral surface impedance and the graph of a relation of hydraulic pressure.
Fig. 3 is the high scleral surface impedance that recorded in back 1 minute of priming petock voltage rise and the graph of a relation of hydraulic pressure among the embodiment 1.
Fig. 4 is the low scleral surface impedance that recorded in back 1 minute of priming petock pressure drop and the graph of a relation of hydraulic pressure among the embodiment 1.
Fig. 5 is the structural representation of embodiment 2 intraocular pressure monitoring devices, wherein: the 101-pressure transducer; The 102-signal receiver; 103-signal reading and recording device.
Fig. 6 is the structural representation of pressure transducer among the embodiment 2, wherein 1-polyimides flexible substrates; 2-flexible micro-electrode array; The 3-flexible wire; 4-front end analog signal amplifier; The 5-central processing unit; The siliceous substrate of 6-; Outside energy supply reception of 7-and signal transmitting antenna.
The specific embodiment
Below in conjunction with accompanying drawing, this utility model is described in further detail by embodiment.
The correlation detection of embodiment 1 scleral surface electrology characteristic and intraocular pressure
In order to detect the dependency of scleral surface chemical characteristic and intraocular pressure, we utilize Oculus sus domestica to carry out isolated experiment.(annotate: linker is a transfusion device that communicates with atmosphere will to connect device, normal saline is housed, the level height of scalable liquid level) syringe needle inserts in the corpse Oculus sus domestica from optic nerve, recording electrode is a needle electrode, place the sclera place of limbus of corneae, reference electrode is gold-plated plate electrode, places and the be separated by limbus of corneae sclera place at 5mm place of recording electrode.The height that changes the linker perfusion bottle is with the adjusting intraocular pressure, and the variation of writing down the Oculus sus domestica scleral surface electrology characteristic that causes with the intraocular pressure variation with inductance capacitance resistance measuring instrument (Agilent 4284A, Precision LCR meter).Initial water pressure is 20 centimeter water columns, and the measuring instrument output AC voltage is set to 1MHz, 100mV.Measurement result such as following table:
Annotate: R is an impedance real part; X is an imaginary impedance, and is relevant with electric capacity.
Fig. 1～4 have shown after the perfusion variation in water pressure (raise or reduce) immediately or the impedance variation situation of the scleral surface that records 1 minute the time that as can be seen, the surperficial electrology characteristic and the intraocular pressure of scleral tissue are tangible positive correlation.This proved by the impedance variation of measuring the scleral tissue surface obtain intraocular pressure feasibility.
Embodiment 2 intraocular pressure monitoring devices
Referring to Fig. 5, this intraocular pressure monitoring device comprises pressure transducer 101, signal receiver 102 and signal reading and recording device 103, and wherein pressure transducer 101 is implanted under the conjunctiva of limbus of corneae, contacts with scleral tissue, directly experiences eyeball pressure and changes; Pressure transducer 101 is converted to digital electric signal with the pressure signal of experiencing and emits, the signal receiver 102 that is worn on ear by wireless transmission method receives and passes to signal reading and recording device 103 to be handled, obtain the intraocular pressure value, the intraocular pressure value is shown and storage.
The pressure sensor structure of implantation ophthalmic as shown in Figure 6, comprise flexible micro-electrode array 2 and signal processing and transmission unit, flexible micro-electrode array 2 and signal processing and transmission unit all are encapsulated in respectively in the biocompatible polymer Parylene of ten microns uniform thickness.Signal processing and transmission unit comprise front end analog signal amplifier 4, central processing unit 5 and outside energy supply reception and signal transmitting antenna 7 again, are positioned in the siliceous substrate 6.The electrode material of flexible micro-electrode array 2 is a nickel alloy, the shape of electrode and arrangement mode are as shown in Figure 6, comprise a point-like electrode that is positioned at the center of circle and a plurality ofly be the non-closed hoop electrode that the concentric circular mode is arranged, these electrodes are positioned on the polyimides flexible substrates 1.Each electrode all passes through flexible wire 3 and connects front end analog signal amplifier 4.These a plurality of electrodes with its varieties of intraocular pressure of experiencing after the impedance variation on scleral tissue surface be converted to the weak voltage signal and pass to front end analog signal amplifier 4.Front end analog signal amplifier 4 comprises amplifier, A/D converter and buffer again, to the weak voltage signal that receives cushion and amplify after pass to central processing unit 5.Central processing unit 5 comprises RF generator, wave filter and storage element, is that digital signal is also stored with analog signal conversion.Signal after outside energy supply reception and signal transmitting antenna 7 are handled central processing unit 5 is launched.
Above embodiment describes implanted intraocular pressure monitoring device of the present utility model.Those skilled in the art is to be understood that; this embodiment is used to limit this utility model; in the scope that does not break away from this utility model essence, can do various changes and retouching to this intraocular pressure monitoring device, therefore protection domain of the present utility model is looked the claim scope and is defined.
Claims (10)
1. an intraocular pressure monitoring device comprises wireless pressure sensor and portable signal receiving processor, it is characterized in that, described pressure transducer is implanted under the conjunctiva of limbus of corneae, directly contacts with scleral tissue, and it comprises again:
Be used to experience the flexible micro-electrode array that scleral tissue's surface impedance changes and this impedance variation is converted to the weak voltage signal; With
Be used for voltage signal is carried out processing and amplifying and is converted to signal processing and the transmission unit that digital signal is launched;
Described flexible micro-electrode array is connected by flexible wire with signal processing and transmission unit.
2. intraocular pressure monitoring device as claimed in claim 1 is characterized in that, described flexible micro-electrode array comprises and is a plurality of non-closed hoop electrode and point-like electrode that is positioned at the center of circle that the concentric circular mode is arranged.
3. intraocular pressure monitoring device as claimed in claim 1 is characterized in that, described flexible micro-electrode array comprises polyimides substrate and suprabasil a plurality of nickel alloy electrode.
4. intraocular pressure monitoring device as claimed in claim 1 is characterized in that, described signal processing and transmission unit are the IC chips of a siliceous substrate.
5. intraocular pressure monitoring device as claimed in claim 1 is characterized in that, described signal processing and transmission unit comprise again:
Connect the flexible micro-electrode array by flexible wire, be used to cushion and amplify the front end analog signal amplifier of the next signal of flexible micro-electrode array transmission;
Connect the front end analog signal amplifier, being used for the conversion of signals that the transmission of front end analog signal amplifier comes is the central processing unit that digital signal is also stored; With
Connect central processing unit, be used to receive outside electromagnetic wave and be translated into electric energy voltage supply force transducer and use, and outside energy supply reception and signal transmitting antenna that digital signal is launched.
6. intraocular pressure monitoring device as claimed in claim 5 is characterized in that, described signal receiving processor comprises again:
Be used to receive from its signal receiver of wireless signal of pressure sensing; With
Be electrically connected with signal receiver, be used for signal is handled, obtain the signal reading and recording device of intraocular pressure numerical value.
7. intraocular pressure monitoring device as claimed in claim 6 is characterized in that, described signal receiver has an electromagnetic oscillation unit module.
8. intraocular pressure monitoring device as claimed in claim 1 is characterized in that, the flexible micro-electrode array of described pressure transducer and signal processing and transmission unit are encapsulated in respectively in the biocompatible polymer encapsulated layer.
9. intraocular pressure monitoring device as claimed in claim 8 is characterized in that, described encapsulated layer is the Parylene encapsulated layer.
10. intraocular pressure monitoring device as claimed in claim 8 is characterized in that, the thickness of described encapsulated layer is the 8-12 micron.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201136222U CN201609360U (en) | 2010-02-09 | 2010-02-09 | Intraocular pressure monitoring device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010201136222U CN201609360U (en) | 2010-02-09 | 2010-02-09 | Intraocular pressure monitoring device |
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| CN201609360U true CN201609360U (en) | 2010-10-20 |
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| CN2010201136222U Expired - Fee Related CN201609360U (en) | 2010-02-09 | 2010-02-09 | Intraocular pressure monitoring device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983395A (en) * | 2015-05-21 | 2015-10-21 | 华中科技大学同济医学院附属同济医院 | Intraocular pressure real-time measuring device and method based on conjunctival sac pressure detection |
| CN106821305A (en) * | 2017-03-23 | 2017-06-13 | 清华大学 | A kind of intraocular pressure monitoring device |
| CN111407227A (en) * | 2019-01-04 | 2020-07-14 | 中国科学院半导体研究所 | Optical intraocular pressure detection device based on corneal contact lens and preparation and use methods |
-
2010
- 2010-02-09 CN CN2010201136222U patent/CN201609360U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983395A (en) * | 2015-05-21 | 2015-10-21 | 华中科技大学同济医学院附属同济医院 | Intraocular pressure real-time measuring device and method based on conjunctival sac pressure detection |
| CN106821305A (en) * | 2017-03-23 | 2017-06-13 | 清华大学 | A kind of intraocular pressure monitoring device |
| CN111407227A (en) * | 2019-01-04 | 2020-07-14 | 中国科学院半导体研究所 | Optical intraocular pressure detection device based on corneal contact lens and preparation and use methods |
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Legal Events
| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101020 Termination date: 20120209 |