CN201453346U - Circulating type in vivo cell combiner - Google Patents
Circulating type in vivo cell combiner Download PDFInfo
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- CN201453346U CN201453346U CN2009200756333U CN200920075633U CN201453346U CN 201453346 U CN201453346 U CN 201453346U CN 2009200756333 U CN2009200756333 U CN 2009200756333U CN 200920075633 U CN200920075633 U CN 200920075633U CN 201453346 U CN201453346 U CN 201453346U
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Abstract
The utility model relates to a circulating type in vivo cell combiner, which comprises an improved pathfinder, an improved pathfinder inner core, improved pathfinder outer sleeves, connecting caps, a connecting pipe, a micro peristaltic pump, a cell material combining box, a filter screen and an evacuating device. One improved pathfinder outer sleeve is connected with the connecting pipe; the other end of the connecting pipe is connected with the cell material combining box; the other outlet of the cell material combining box is connected with the micro peristaltic pump; the cell material combining box is connected with the other improved pathfinder outer sleeve through the connecting pipe; and joints among every parts of the whole instrument are all connected by the connecting caps. The instrument can integrates the process of combining cell with a material and an autologous blood feedback process, shortens the operation time, and takes full advantage of tissues within operation operating range, in particular takes full advantage of stem cells inside vertebral body during interbody fusion.
Description
[technical field]
This utility model relates to a kind of field of medical appliances, especially relates to a kind ofly being applied in the selective enrichment vertebral body in the bone surgery process stem cell and with the compound and instrument that merge between application and vertebral body of itself and material.
[background technology]
Stem-cell therapy has broad clinical application prospect, and between orthopedic vertebral body in the fusion process, between vertebral body commonly used there being amalgamation mode: takes from body ilium piece bone grafting at present; Get local from body bone (spinous process that excises in the operation, vertebral plate etc.); The homogeneous allogenic bone transplantation bone grafting; Composite recombination human bone shaping protein bone grafting; Utilize stem cell enrichment instrument enrichment ilium marrow blood to treat, and the parallel circulating type cell selective filter recombiner that the inventor once designed is treated.
Self ilium piece bone grafting mode because of bone-grafting material from self, there is not rejection, do not infect the danger of other diseases, become the goldstandard that merges between clinical vertebral body, autologous ilium limited amount, operating time prolong, amount of bleeding increases, postoperative exists for shortcomings such as district's pain but it exists; Get locally when body bone bone grafting, adopt the spinous process of excision in the operation mostly, vertebral plate etc. can shorten operating time as bone-grafting material, reduce the misery that patient gets bone, but have limited the development of this mode because of the limited amount of drawing materials; The fusion efficiencies of homogeneous allogenic bone transplantation bone grafting mode is low, and the probability that has immunoreation and spread disease etc.; The compound recombination human bone shaping proteins of material such as bioactive ceramics granule, high density hydroxyapatite also are applied to clinical, respond well, but the recombination human bone shaping protein costs an arm and a leg, and are not suitable for promoting on a large scale; Utilize stem cell enrichment instrument enrichment ilium marrow blood to carry out merging between the spinal column transverse process, effects such as treatment bone does not connect are good, but because there is the routine clinical remaining blood after the enrichment that do not feed back, increase patient's blood loss, and the stem cell enrichment instrument shortcoming such as costs an arm and a leg and has restricted its development; The parallel circulating type cell selective filter recombiner that the inventor once designed will be by circulating stem cell is compound to material from the marrow blood that ilium extracts, simultaneously all the other blood are fed back, clinical effectiveness is good, and cost is lower, is fit to apply, still, this instrument still needs from patient's ilium multiple spot layer puncture suction marrow blood, the stem cell composite separates with the intraoperative autologous blood transfusion process, has certain pollution risk, has also prolonged operating time simultaneously.
[utility model content]
This utility model is to overcome the deficiencies in the prior art, provide a kind of with cell and material recombination process and the incorporate instrument of intraoperative autologous blood transfusion process, shorten operating time, make full use of the tissue in the operation technique scope, make full use of Intrapyramidal stem cell when especially between vertebral body, merging.
To achieve these goals, the technical scheme taked of this utility model is:
A kind of circulating at the somatic cell recombiner, comprising: improve the device of exploring the way, improve the device inner core of exploring the way, improve explore the way device overcoat, connection tube, miniature peristaltic pump, the compound box of cell material, filter screen, vacuum extractor; This is circulating so to constitute at the somatic cell recombiner, ecto-entad, improvement device overcoat, improvement device and the improvement device inner core socket successively of exploring the way of exploring the way of exploring the way; Improveing the device overcoat of exploring the way links to each other with connection tube, the connection tube other end connects the compound box of cell material, another outlet of the compound box of cell connects miniature peristaltic pump, whole system circulates under the minitype creepage pumping action, the compound box of cell material connects to another improvement device overcoat of exploring the way, a whole set of instrument and patient vertebral body formation loop by connection tube.
Described circulating at the somatic cell recombiner, each parts junction of a whole set of instrument all connects with attachment cap.
Adopt the pedicle of vertebral arch improvement of the device profile device of exploring the way of exploring the way to be, its outer sleeve hollow, perforate respectively on sidewall opposite face close positions, each side opening all is communicated with the needle tubing cavity; Improvement side opening position and the improvement of the device side opening position that device puts outward of exploring the way of exploring the way is identical, and its diameter is slightly less than improves the device overcoat of exploring the way; The improvement device inner core of exploring the way also is the pedicle of vertebral arch device profile of exploring the way, and diameter is slightly less than the improvement device of exploring the way, and is used with improvement device, the improvement device overcoat of exploring the way of exploring the way.
The compound box of described cell material adopts the design of outlet diameter less than inlet diameter.
The compound box of described cell material exit connects filter screen, filters broken bone piece.
The lid of the compound box of described cell material can open placement need with the compound material of stem cell and a certain amount of anticoagulation medicine, close lid after the compound box of cell material promptly be in sealing state.
The external vacuum extractor of the compound box of described cell material, the air in the suction whole circulation system.
During use, at first will insert the improvement improvement of the device inner core device of exploring the way of exploring the way and be inserted in the improvement device overcoat of exploring the way, again the improvement device overcoat of exploring the way is pierced patient tissue, when each improvement is explored the way after device shoots the last hypocentrum of operation technique intervertebral disc respectively, extract the tip inner sleeve, same Intrapyramidal two outer sleeves link to each other with connection tube through attachment cap respectively, connect compound box of cell material and vacuum extractor then, set up whole circulation; Air pumped in vacuum extractor will circulate, and prevented that air embolism from taking place, and opened peristaltic pump, marrow blood circulation beginning; After circulation reaches enough cell material compound quantities for several times, stop circulation, carry out merging between vertebral body.
Good effect of the present utility model is:
1. explore the way and effect that puncture suction kills two birds with one stone by using the device of exploring the way of improvement, reaching, be convenient to obtain Intrapyramidal marrow blood;
2. by setting up whole closed-cycle system, solve synchronously stem cell enrichment, with the compound and intraoperative autologous blood transfusion process of material, reach stem cell and material compound with the autoblood transfusion integrated process, reduce and pollute possibility, all the other compositions are fed back in the body, reduce amount of bleeding, reduce operating time simultaneously;
3. do not need to add somatomedin such as homogeneous allogenic bone or BMP, safe, economical;
4. when between vertebral body, merging, do not need to get bone, reduce complication for the bone district from ilium;
5. by utilizing the adhesion characteristics of stem cell,, reach the purpose of enrichment, compound stem cell through repeatedly circulation;
6. after the centrifugal enrichment, osteoblast precursor concentration can promote to merge between vertebral body than high by 71% in the ilium in the vertebral body.
[description of drawings]
Fig. 1 is a structural representation of improveing explore the way device and inner core and overcoat;
Fig. 2 is that this utility model is applied to the structural representation in the fusion between versus posterior vertebral;
Fig. 3 is that this utility model is applied to the structural representation in the fusion between the vertebral body of preceding road;
Fig. 4 is that this utility model is applied to the structural representation in the fusion between the vertebral body of the preceding road of breast lumbar vertebra;
Fig. 5 is that this utility model is applied to the compound structural representation of ilium inner cell material;
Label in the accompanying drawing is respectively:
1, the improvement device of exploring the way, 2, the improvement device inner core of exploring the way, 3, the improvement device overcoat of exploring the way,
4, attachment cap, 5, connection tube, 6, miniature peristaltic pump,
7, the compound box of cell material, 8, filter screen, 9, vacuum extractor.
[specific embodiment]
Provide the specific embodiment of the present utility model below in conjunction with accompanying drawing, but this utility model is not limited to following embodiment.
Comprise as Fig. 1 and Fig. 2 this utility model main body: several adopt pedicles of vertebral arch explore the way the improvement of device profile explore the way device 1, be all the pedicle of vertebral arch device profile of exploring the way, diameter is slightly less than improvement the explore the way improvement of device 1 explore the way device inner core 2, improvement explore the way device overcoat 3, attachment cap 4, connection tube 6, miniature peristaltic pump 7, the compound box 8 of cell material, filter screen 9.
Improve the device 1 outer sleeve hollow of exploring the way, perforate respectively on its sidewall opposite face close positions, each side opening all is communicated with the needle tubing cavity, the side opening position of improveing the device 1 of exploring the way is identical with the side opening position on improveing the device overcoat 3 of exploring the way, the diameter of device 1 is slightly less than the improvement device overcoat 3 of exploring the way but improvement is explored the way, and improvement device inner core 2 and improvement device 1, the improvement device overcoat 3 of exploring the way of exploring the way of exploring the way is used.
Improveing the device overcoat 3 of exploring the way links to each other with connection tube 5, the other end at connection tube 5 connects the compound box 7 of cell material, the compound box 7 of cell adopts the design of outlet diameter less than inlet diameter, lid can open placement need with the compound material of stem cell and a certain amount of anticoagulation medicine, the compound box of cell material promptly is in sealing state after closing lid, another outlet of the compound box 7 of cell connects miniature peristaltic pump 6, whole system circulation under miniature peristaltic pump 6 effects, the compound box 7 of cell material connects to second improvement device overcoat 3 of exploring the way by another root connection tube 5, in addition, the compound box of cell material 7 exits are mounted with filter screen 9, and external vacuum extractor, the air in the suction whole circulation system (figure does not show).
During use, a whole set of instrument can form the loop with the patient vertebral body; Each parts junction of a whole set of instrument all connects with attachment cap 4.
Before fusion begins between vertebral body, after needing the material of compound cells and an amount of anticoagulation medicine to put into the compound box 7 of cell material, that it is airtight; Air pumped in vacuum extractor 9 will circulate, and prevented that air embolism from taking place; In the operation process, at first will insert the improvement improvement of device inner core 2 device 1 (diameter is 2-4.5mm) of exploring the way of exploring the way, be inserted in and improve the device overcoat 3 of exploring the way, again the improvement device overcoat 3 of exploring the way is pierced patient tissue, explore the way after device 1 shoots the last hypocentrum of operation technique intervertebral disc respectively when four improvement, extract the tip inner sleeve; Same Intrapyramidal two improvement device overcoat 3 of exploring the way links to each other with connection tube 5 through attachment cap 4 respectively, connects compound box 7 of cell material and vacuum extractor 9 then, sets up whole circulation; Open miniature peristaltic pump 6, marrow blood circulation beginning; After marrow blood enters the compound box 7 of cell material, since stem cell have other cell component that do not have with characteristic material adhesion, therefore the stem cell in the compound box 7 of cell material adheres to material surface, reach composite goal, 8 of the filter screens in the compound box of cell material 7 exits stop tiny osseous granules, all the other compositions flow back in the patient vertebral body, and all the other stem cell in the compound box 7 of flushing cell material enter next circulation.After systemic circulation was set up, operator can be extractd the intervertebral disc operation; Crossing after for several times circulation reaches enough cell material compound quantities, stopping circulation, carrying out merging between vertebral body.
This utility model is not limited to above-mentioned embodiment, can also be applied to other operations, as the ilium inner cell material compound operation in fusion, the accompanying drawing 5 between the preceding road of the breast lumbar vertebra vertebral body in the operation of the preceding road vertebral fusion in the accompanying drawing 3, the accompanying drawing 4.
Claims (7)
- One kind circulating at the somatic cell recombiner, comprising: improvement explore the way device, improvement explore the way device inner core, improvement explore the way device overcoat, connection tube, miniature peristaltic pump, the compound box of cell material, filter screen, vacuum extractor; It is characterized in that ecto-entad, improvement device overcoat, improvement device and the improvement device inner core socket successively of exploring the way of exploring the way of exploring the way; The improvement device overcoat of exploring the way links to each other with connection tube, and the connection tube other end connects the compound box of cell material, and another outlet of the compound box of cell connects miniature peristaltic pump, the compound box of cell material by connection tube company to another improvement device overcoat of exploring the way.
- 2. as claimed in claim 1ly it is characterized in that at the somatic cell recombiner each parts junction of a whole set of instrument all connects with attachment cap.
- 3. as claimed in claim 1ly it is characterized in that the improvement device overcoat of exploring the way is the column type cavity at the somatic cell recombiner, perforate respectively on sidewall opposite face close positions, each side opening all is communicated with the needle tubing cavity; The improvement device of exploring the way is the pedicle of vertebral arch device profile of exploring the way, outer sleeve hollow, and its side opening position and the improvement side opening position that device puts outward of exploring the way is identical, and its diameter is slightly less than improves the device overcoat of exploring the way; The improvement device inner core of exploring the way also is the pedicle of vertebral arch device profile of exploring the way, and diameter is slightly less than the improvement device of exploring the way, and is used with improvement device, the improvement device overcoat of exploring the way of exploring the way.
- 4. as claimed in claim 1ly it is characterized in that at the somatic cell recombiner outlet diameter of the compound box of cell material is less than inlet diameter.
- 5. as claimed in claim 1ly it is characterized in that at the somatic cell recombiner the compound box of cell material import department is provided with filter screen.
- 6. as claimed in claim 1ly it is characterized in that at the somatic cell recombiner the compound box of cell material is provided with openable lid, close lid after the compound box of cell material promptly be in sealing state.
- 7. as claimed in claim 1ly it is characterized in that the external vacuum extractor of the compound box of cell material at the somatic cell recombiner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200756333U CN201453346U (en) | 2009-07-31 | 2009-07-31 | Circulating type in vivo cell combiner |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200756333U CN201453346U (en) | 2009-07-31 | 2009-07-31 | Circulating type in vivo cell combiner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201453346U true CN201453346U (en) | 2010-05-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009200756333U Expired - Lifetime CN201453346U (en) | 2009-07-31 | 2009-07-31 | Circulating type in vivo cell combiner |
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| CN (1) | CN201453346U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011150726A1 (en) * | 2010-05-31 | 2011-12-08 | 上海康德莱企业发展集团医疗器械有限公司 | Stem cell filtering screening enrichment and quickly compounding device |
-
2009
- 2009-07-31 CN CN2009200756333U patent/CN201453346U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011150726A1 (en) * | 2010-05-31 | 2011-12-08 | 上海康德莱企业发展集团医疗器械有限公司 | Stem cell filtering screening enrichment and quickly compounding device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20100512 |