CN201404565Y - Artificial trachea cannula with nano antibiotic material coating - Google Patents
Artificial trachea cannula with nano antibiotic material coating Download PDFInfo
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- CN201404565Y CN201404565Y CN2009200726569U CN200920072656U CN201404565Y CN 201404565 Y CN201404565 Y CN 201404565Y CN 2009200726569 U CN2009200726569 U CN 2009200726569U CN 200920072656 U CN200920072656 U CN 200920072656U CN 201404565 Y CN201404565 Y CN 201404565Y
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- trachea
- trachea cannula
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- artificial trachea
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Abstract
The utility model relates to the technical field of medical treatment apparatuses. The generation of ventilator-associated pneumonia is the result of sucking in secretion with pathogene, and the bacterial contamination of a ventilator gas pipeline is also one important factor causing the ventilator-associated pneumonia. The utility model aims at providing an artificial tracheal cannula which has the board spectrum antimicrobial property and the function of controlling medicine slow release. The artificial trachea cannula of the utility model is characterized in that the inner and the externalsurfaces of a gas supplying pipe (2), an inflating gas-bag (4), an inflating pipe (3) and a liquid discharging pipe (5) are coated with a nano antibiotic material layer (6), the nano antibiotic material layer is mainly formed through mixing high molecular polymer, nano inorganic antibacterial agent and slow release medicine. The artificial trachea cannula not only satisfies the efficacies of a traditional artificial trachea cannula of providing gas paths and keeping airway clear, but also has the excellent efficiencies of the bacteriostasis and controlling the medicine slow release, and provides broad application foreground for clinic application.
Description
Technical field
This utility model relates to technical field of medical instruments, is a kind of artificial trachea cannula made of antibacterial nano material coating.
Background technology
Along with the raising of science and technology development and health of people consciousness, the application of biomaterial on clinical medicine also more and more widely.Still there is some problem in biomaterial bringing to clinical treatment easily simultaneously.No matter it is found that is long-term or short-term is retained in the intravital biomaterial of people, all usually can cause various bacterial infections.
Infectious disease still accounts for 1/3 in the world population cause of the death at present, and ranks first with pneumonia, wherein especially with severe pneumonia.Nosocomial Pneumonia (hospital acquired pneumonia, HAP) be that modal hospital acquired infects, China HAP accounts for the 1st hospital infection, prevalence 1.3%～3.45%, common and the most critical among the HAP is respirator dependency pneumonia (ventilationassociated pneumonia, VAP), it is the pulmonary infection that patients with mechanical ventilation occurs after 48 hours in ventilation, its prevalence 9%～24%, case fatality rate 33%～71% has nearly 30% directly owing to respirator dependency pneumonia in the ICU death.
Respirator dependency pneumonia be to have the result that the secretions of pathogen sucks.When the tracheal intubation that is connected with respirator enters the human body use, since in the environment or the antibacterial among the artificial airway may be attached on the catheter wall, these are colonizated in the interior antibacterial of respirator return and enter trachea along with the aerosol that sprays the formation of suction air-flow or by the condensed water refluence of polluting, damage nasopharynx part mucosa, influence is swallowed and cilium is removed function; And adhere to a large amount of antibacterials around intubate inwall and the air bag, very easily enter lower respiratory tract and cause respirator dependency pneumonia with secretions.For this reason, the germ contamination of respirator gas path pipe is as a key factor of respirator dependency pneumonia and be subjected to people's attention.
At present, the artificial trachea cannula made of clinical use is made by medical plastic catheter material, contains in the tube material or does not contain the plastic cement filler, and zest is big, and antibiotic property is poor, easy infection.
In the face of the particularly dangerous prognosis of serious symptom Nosocomial Pneumonia (comprising respirator dependency pneumonia) of Nosocomial Pneumonia, and the low and temporal hysteresis of clinical nosetiology diagnostic sensitivity and specificity, also have the simultaneous growth of antibiotic resistance, all brought very big difficulty to treatment.On the other hand, although some are efficient, broad ectrum antibiotic constantly comes out, however serious symptom HAP change of illness state complexity, and risk factor is a lot of, and pathogen mostly is height drug resistance or multiple antibiotic resistant strain greatly, and empirical treatment Chang Buneng " hits the mark " or reaches ideal " sitting in the right seat ".
Along with the understanding that formation and respirator dependency pneumonia to the endotracheal tube biofilm concern, people expect to develop a kind of artificial trachea cannula made with antibacterial functions, to reduce the generation of respirator dependency pneumonia.
CN01279719.7 provides a kind of novel tracheal intubation, by the infection-resisting high-molecular material preparation, inorganic or organic anti-infective and macromolecular material is prepared by compound, blend, realizes the anti-infective purpose.Yet animal experiment shows that it is difficult to the antibacterial effect that reaches satisfied in the body.
CN200710113403.7 provides a kind of antibiotic artificial trachea cannula made, the nanometer silver antimicrobial coating is coated in the insertion end surface of trachea body.Owing to only handle, and antimicrobial component is single, thereby can't obtains satisfied antibacterial effect, reach and suppress and minimizing respirator dependency pneumonia incidence rate at the incision position surface.
Summary of the invention
The purpose of this utility model provides a kind of generation that can reduce respirator dependency pneumonia, has the artificial trachea cannula made of broad spectrum antibacterial performance.
Artificial trachea cannula made of the present utility model, raw material and the processing technique of using common medical macromolecular materials to prepare common artificial trachea cannula made are made common medical artificial trachea cannula made, apply the coating of high molecular polymer that one deck contains one or more nano anti-biotic materials at this artificial trachea cannula made surfaces externally and internally again, and in coating, be written into slow releasing pharmaceutical with pharmacological effect, make antibiotic property nano artificial tracheal intubation.
This utility model provides a kind of artificial trachea cannula made of antibacterial nano material coating, comprise that the flexible pipe body with certain-length is promptly to trachea, link and insertion end are arranged for the trachea body, link to each other for the trachea link with respirator, giving the trachea insertion end is wedge; And being enclosed within aerating gasbag to trachea insertion end outer surface, the edge of aerating gasbag is tightly connected with giving the trachea body; Be embedded with gas tube for trachea one side pipe wall, gas tube communicates with aerating gasbag; Be embedded with discharging tube for trachea opposite side tube wall, discharging tube one end has a leakage fluid dram above aerating gasbag, and the other end can link to each other with device such as syringe.
The above-mentioned surfaces externally and internally of trachea, aerating gasbag, gas tube and discharging tube of giving is covered with antibacterial nano material coating, and the thickness of antimicrobial coating is 0.1mm-1mm.
Described antibacterial nano material coating is mainly to be mixed by high molecular polymer, nano inorganic antimicrobial agent and slow releasing pharmaceutical; Described macromolecule polymer material comprises polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetate esters polymer, polyvinyl alcohol, polyurethane, PMAm etc.; Described nano inorganic antimicrobial agent for silver ion be effective antipathogenic composition silver-based inorganic antibacterial agent, be the zine series inorganic germicide of effective antipathogenic composition, be in the anti-biotic materials such as copper based inorganic antibacterial agent of effective antipathogenic composition one or several with copper ion with zinc ion; Described slow releasing pharmaceutical is respirator dependency pneumonia such as quinolones, cephalosporins, penicillins, aminoglycosides, glycopeptide antibacterials commonly used, and two or more mixture in them.
More excellent, macromolecule polymer material is polyvinylpyrrolidone PVP, PVP-vinyl acetate esters polymer; Nano inorganic antimicrobial agent is the nanometer-level silver based inorganic antibacterial agent, comprises the silver that simple substance silver, silver oxide, Silver monobromide, silver nitrate, silver sulfate, silver silicate or zeolite, zirconium phosphate etc. coat.
Slow releasing pharmaceutical is one or more hybrid medicines in the medicines such as piperacillin/Tazobactam Sodium compound formulation, ticarcillin/clavulanic acid compound formulation, cefoperazone/sulbactam compound formulation, imipenum/cilastatin compound formulation, Moxifloxacin, ciprofloxacin, meropenem, amikacin.
Artificial trachea cannula made of the present utility model is by strong but pliable in texture, avirulence, pharynx, larynx, trachea etc. is organized non-stimulated, and plastics that also do not cause allergic reaction or rubber are made the slick conduit of tube wall.These medical grade plastics are medical grade polyvinylchloride, medical grade polyethylene, medical grade silicone rubber or medical grade politef.
This utility model has a leakage fluid dram above aerating gasbag, link to each other with the discharging tube that is embedded in to trachea one side pipe wall, be used for the periodic attraction of deposited liquid on the air bag is come out, prevent that secretions from entering lower respiratory tract, reduce the incidence rate of respirator dependency pneumonia.
This utility model is by applying the coating of high molecular polymer material that one deck contains one or more nano anti-biotic materials at the artificial trachea cannula made surfaces externally and internally, realize the bacteriostasis efficacy of this artificial trachea cannula made, thereby improve the infection conditions of antibacterial in the mechanical ventilation process, reduce the consumption of incidence rate and the saving manpower and the material resources of respirator dependency pneumonia;
This utility model is implemented in the Failure Treated with Mechanical Ventilation process by be written into the pneumonia medicine in the nano-antibacterial coating, at bacteriostatic simultaneously, reaches the effect of controlled slow release medicine, plays the effect of treatment.After the carried medicine sustained-release body implants, can directly act on patient part, reach that dosage is few, local concentration is high, toxic and side effects is little, long action time and eutherapeutic effect;
This utility model adopts at original common artificial trachea cannula made surface-coated nano anti-biotic material, reach antibiotic effect, improve the technical scheme of the infection conditions of antibacterial in the therapeutic process, has excellent anti-microbial property on the one hand, one side manufacturing process simple controllable, with low cost, be fit to produce in batches.
Description of drawings
Fig. 1 is the vertical section structure sketch map of the artificial trachea cannula made of antibacterial nano material coating of the present utility model, and wherein: 1 gives the trachea link, and 2 give trachea, 3 gas tubes, and 4 aerating gasbags, 5 discharging tubes,
6 antibacterial nano material coatings (diagonal line hatches part), 7 give trachea insertion end, 8 leakage fluid drams.
The specific embodiment
Below in conjunction with drawings and Examples this utility model is elaborated, but enforcement of the present utility model is not limited to following embodiment.
Embodiment 1:
A kind of artificial trachea cannula made comprises to trachea 2, gas tube 3 and aerating gasbag 4, link 1 and insertion end 7 is arranged for the trachea body, links to each other for trachea link 1 with respirator, and giving trachea insertion end 7 is wedge, is convenient to insert trachea; Aerating gasbag 4 is enclosed within the outer surface to trachea insertion end 7, and the edge of aerating gasbag is tightly connected with giving the trachea body; Be embedded with gas tube 3 for trachea one side pipe wall, gas tube communicates with aerating gasbag, is used for aerating gasbag 4 inflations; Be embedded with discharging tube 5 for trachea opposite side tube wall, discharging tube one end has a leakage fluid dram 8 above aerating gasbag, and the other end can link to each other with device such as syringe, and the liquid that is used for accumulating on the air bag regularly attracts out.
The extrusion molding processing technique that this tracheal intubation uses the medical grade polyvinylchloride to prepare common tracheal intubation prepares, utilize double screw extruder, extrusion die, after antibiotic property master batch plasticizing extruded, in vacuum cooler, carry out cooling and shaping, pass through traction, cutting and assembling then, prepare the antibacterial artificial endotracheal tube tubing.
Embodiment 2
With macromolecular material polyvinylpyrrolidone (PVP) 5g (Tianjin universal love newly increase income company limited), Moxifloxacin 0.05g (beach, Shenzhen drugmaker), nanoscale zeolite carrying silver antimicrobials 0.15g (Shanghai Bo Nawei comes new material Science and Technology Ltd.), ethanol 100ml, dimethyl formamide 30ml, ethyl acetate 30ml, mix homogeneously, it is stand-by to be made into mixed solution;
The top artificial trachea conduit that makes according to embodiment 1 method was immersed in the mixed solution 0.5 minute, take out, 60-70 ℃ of oven dry about 5-10 minute down makes the artificial trachea cannula made with antibacterial nano material coating, the thickness average out to 0.3mm of its coating.
Embodiment 3
With macromolecular material PVP-vinyl acetate esters polymer 8.5g (Tianjin universal love newly increase income company limited), piperacillin/Tazobactam Sodium compound formulation 0.17g (Dalian Pfizer), nanoscale zirconium phosphate carrying silver antimicrobials 0.4g (Shanghai Bo Nawei comes new material Science and Technology Ltd.), ethanol 100ml, dimethyl formamide 40ml, ethyl acetate 30ml, acetone 10ml, mix homogeneously, wiring solution-forming is stand-by;
The top artificial trachea conduit that makes according to embodiment 1 method was immersed in the mixed solution 1 minute, take out, 60-70 ℃ of oven dry about 5-10 minute down makes the artificial trachea cannula made with antibacterial nano material coating, the thickness average out to 0.5mm of its coating.
Embodiment 4
With macromolecular material polyvinylpyrrolidone PVP 10g, meropenem 0.05g (beach, Shenzhen drugmaker), the nanoscale zirconium phosphate carries zinc antibacterial 0.1g (Shanghai Bo Nawei comes new material Science and Technology Ltd.), ethanol 100ml, dimethyl formamide 40ml, ethyl acetate 30ml, oxolane 20ml, wiring solution-forming is stand-by;
The top artificial trachea conduit that makes according to embodiment 1 method was immersed in the mixed solution 2 minutes, take out, 60-70 ℃ of oven dry about 5-10 minute down makes the artificial trachea cannula made with antibacterial nano material coating, the thickness average out to 1mm of its coating.
Claims (1)
1, a kind of artificial trachea cannula made of antibacterial nano material coating, comprise to trachea (2), gas tube (3) and aerating gasbag (4), link (1) and insertion end (7) are arranged for the trachea body, it is characterized in that, giving the trachea insertion end is wedge, aerating gasbag (4) is enclosed within the outer surface to trachea insertion end (7), and the edge of aerating gasbag is tightly connected with giving the trachea body; Be embedded with gas tube for trachea one side pipe wall, gas tube communicates with aerating gasbag, is embedded with discharging tube (5) for trachea opposite side tube wall, and discharging tube one end has a leakage fluid dram (8) above aerating gasbag; The above-mentioned surfaces externally and internally of trachea, aerating gasbag, gas tube and discharging tube of giving is covered with antibacterial nano material coating (6), and the thickness of coating is 0.1mm-1mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200726569U CN201404565Y (en) | 2009-05-21 | 2009-05-21 | Artificial trachea cannula with nano antibiotic material coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200726569U CN201404565Y (en) | 2009-05-21 | 2009-05-21 | Artificial trachea cannula with nano antibiotic material coating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201404565Y true CN201404565Y (en) | 2010-02-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009200726569U Expired - Fee Related CN201404565Y (en) | 2009-05-21 | 2009-05-21 | Artificial trachea cannula with nano antibiotic material coating |
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| CN (1) | CN201404565Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107837099A (en) * | 2016-09-18 | 2018-03-27 | 成都测迪森生物科技有限公司 | A kind of push type hair planting apparatus |
| WO2018107645A1 (en) * | 2016-12-14 | 2018-06-21 | 天津美迪斯医疗用品有限公司 | Tracheal tube |
-
2009
- 2009-05-21 CN CN2009200726569U patent/CN201404565Y/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107837099A (en) * | 2016-09-18 | 2018-03-27 | 成都测迪森生物科技有限公司 | A kind of push type hair planting apparatus |
| WO2018107645A1 (en) * | 2016-12-14 | 2018-06-21 | 天津美迪斯医疗用品有限公司 | Tracheal tube |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100217 Termination date: 20120521 |