CN201320183Y - Novel human endoscope catheter and system thereof - Google Patents

Abstract

The utility model relates to a novel human endoscope catheter which comprises an ultrasonic component and an optical component. The ultrasonic component is arranged in a sealing sheath and is used to convert an electric signal to an ultrasonic wave, transmit the ultrasonic wave and convert an echo wave responding to the ultrasonic wave from tissues in a human body to an electric signal; the optical component is also arranged in the sealing sheath and is arranged in series with the ultrasonic component and closer to the remote end of the human endoscope catheter; and the optical component sends laser to human body through a transparent section of the sealing sheath and collects the florescent light emitted by the tissues in the human body under the action of the laser through the transparent section of the sealing sheath. The utility model also relates to a system which utilizes the human endoscope catheter. The human endoscope catheter and the system thereof have the following advantages that information of histomorphology and histopathology can be obtained simultaneously, thus saving time, reducing the pain of the patient and greatly improving the accuracy and efficiency of diagnosis.

Description

Peep conduit and system in a kind of novel human body

[technical field]

This utility model relates to medical equipment, more particularly, relates in a kind of novel human body and peeps conduit and system.

[background technology]

Cardiovascular disease especially coronary heart disease has become " the No.1 killer " of serious threat human health at present, acute coronary artery syndrome (acute coronary syndrome, ACS) be to cause the patients with coronary heart disease main causes of death, and the atherosclerosis vulnerable plaque is the greatest factor of bringing out ACS, and therefore qualitative the and detection by quantitative for atheromatous plaque has the important clinical meaning.

For a long time, X line angiographic imaging is taken as " goldstandard " that coronary artery, carotid artery and other cardiovascular pathological changes is carried out anatomic diagnosis, the angiography of fine definition can show blood vessel diameter and tolerance stenosis, and can show atherosclerotic plaque pathological changes in late period, as plaque rupture, intracavity thrombosis and calcification etc.But because lower sensitivity and relatively poor specificity, it is inherent damaging to human body to add this inspection means, and increasing method is used to clinical in to remedy the deficiency of X line angiographic imaging.

(Introvascular Ultrasound, IVUS) imaging technique has just become the important of diagnosis of coronary heart disease and treatment and remedies the image means blood vessel endo-luminal ultrasound since the nineties, even is considered to new " goldstandard " of diagnosis of coronary heart disease.It is realized by the far-end (promptly entering an end of human vas) that the ultrasonic probe with a microminiaturization is integrated in a special conduit that designs for the blood vessel endo-luminal ultrasound, the near-end of conduit (not an end of intravasation, its cross-sectional area is greater than the cross-sectional area of its far-end usually) is connected with ultrasonic device.Ultra sonic imaging can provide the cross sectional image of lumen of vessels, tube wall and surrounding tissue in the lumen of vessels, can carry out qualitative analysis to size, form, composition and the distribution situation of atheromatous plaque, and tectology information accurately can be provided.But this technology can't provide the histopathology information of pathological changes, can not carry out quantitative analysis to the concrete composition and the relative amount of pathological tissues; And the judgement of pathological tissues composition depended on ultrasonic echo intensity, sensitivity and specificity are relatively poor.

In recent years, be used to diagnose the optical biopsy technology of tissue pathological changes to become the general orientation that Modern Optics Technology is used, one of them importance is exactly that tissue spectrum is learned diagnosis.(LaserInduced Fluorescence, LIF) spectral technique becomes a key areas in the optical biopsy technical research with advantages such as its high resolution, sensitivity and degree of accuracy to laser-induced fluorescence (LIF).At present, utilize laser-induced fluorescence (LIF) (LIF) spectral technique to diagnose various lesion tissues to compare deep research, comprise the lesion tissue at digestive tract disease, dermatosis, angiopathy and other positions etc.Fluorescent radiation excites generation down by bio-tissue at the incident illumination of certain wavelength, and the fluorescent radiation band is the information of biochemical composition in a organized way.The fluorescence substrate that produces fluorescence comprises aminoacid, elastin laminin, keratin, vitamin and porphyrin etc.When blood vessel and surrounding tissue generation pathological changes thereof when producing atheromatous plaque, because there is the difference on composition, structure and the metabolism status, so there are one or more difference in its fluorescence spectrum characteristic and normal structure, just can detect the speckle of pathological changes or even different times according to these differences.Time resolution laser-induced fluorescence spectroscopy (Time-resolved Laser-induced Fluorescence Spectroscopy, TR-LIFS) technology employing pulse laser comes the molecule in the excite tissue, measure the time (life-span of fluorescence) that its unique spectral signal and molecule stop then in excited state, spectrum and time information according to these mensuration are determined component of organization, utilize this technology to make diagnosis to the atherosclerosis vulnerable plaque.Laser-induced fluorescence (LIF) (LIF) spectral technique can carry out quantitative analysis to the biochemical component and the relative amount thereof of tissue, but tectology information can't be provided.

Can learn by top description, current single detection means or can only obtain tectology information, can only obtain histopathology information, when not only needing inside of human body tectology information but also needing histopathology information, need carry out endoscope detecting twice to the patient, like this, misery not only consuming time, as to increase the patient, and what need guarantee twice inspection is same position, has increased the difficulty of operation.

[utility model content]

In view of this, be necessary, provide in a kind of efficient, a kind of novel human body that can reduce patient suffering and easy operating and peep conduit at above-mentioned consuming time, the defective that increases the painful of patient and be difficult to operate.

In addition, also be necessary to provide a kind of signal emission, collection and processing system of using this conduit.

Peep conduit in a kind of novel human body, comprise be arranged in the sealing sheath, be ultrasonic emitting with electrical signal conversion and people's in-vivo tissue be converted to the ultrasonic assembly of the signal of telecommunication to described hyperacoustic echo, also comprise be arranged on equally in the described sealing sheath, with described ultrasonic assembly serial arrangement and more close this human body in peep distal end of catheter, the transparent part of laser by described sealing sheath be sent in the human body and gather the optical module of the fluorescence that described people's in-vivo tissue sends under the effect of described laser by described sealing sheath transparent part.

Preferably, described optical module comprise the multimode fibre that is used for transmitting optical signal, the collimating mirror that links to each other with described optical fiber one end, with described collimating mirror relatively and the corner cube prism that changes described Laser Transmission direction and the reception described fluorescence that all directions transmitted with link to each other with described corner cube prism and drive the micro motor that it rotates; Described micro motor, corner cube prism, collimating mirror and multimode fibre are peeped distal end of catheter to proximal direction in described and are set gradually.

Preferably, also comprise be arranged on peep in the described human body catheter proximal end, the described laser of input and export the light input/output interface of described fluorescence, described optical fiber one end links to each other with described smooth input/output interface, the other end links to each other with described collimating mirror.

Preferably, described sealing sheath also comprises the groove on the surface that sets within it, and described optical fiber is arranged in the described groove.

Preferably, also comprise be arranged on the electric input/output interface of peeping catheter proximal end in the described human body, with the electrical signal conversion of outside input be ultrasound wave and the ultrasonic probe that will described hyperacoustic echo be converted to the signal of telecommunication, the lead that transmits the signal of telecommunication between described electric input/output interface and the described ultrasonic probe, in described human body, peep the turning cylinder that the coupled described ultrasonic probe of drive rotates together under the driven by motor of conduit outside and connect described turning cylinder and described human body in peep rotary connector between the motor of conduit outside.

Preferably, the lead of the described transmission signal of telecommunication connects described ultrasonic probe and described electric input/output interface by the through hole that is arranged on the described turning cylinder axis direction.

Preferably, the metal level that also is disposed with theca interna and is used to shield physiology signal between described turning cylinder and the described sealing sheath with smooth inner surface; The transparent part of described sealing sheath is arranged on described ultrasonic transduction assembly and peeps between the catheter tip to described human body.

Preferably, the formed intracavity diameter of described theca interna is the 0.4-0.6 millimeter, and described theca interna thickness is the 20-30 micron, and described sealing sheath external diameter is the 1.0-3.5 millimeter, and its internal diameter is the 0.6-2.5 millimeter.

A kind of system of peeping conduit in the above-mentioned novel human body that uses, the electrical signal conversion that ultrasonic probe forms after comprising the signal of telecommunication that link to each other with described ultrasonic assembly, the described ultrasonic probe of generation excitation and will accepting ultrasonic echo is the supersonic imaging device of B ultrasonic image; Link to each other, produce that laser is input to the intravital laser generator of people and link to each other with described optical module and analyze that the human body interior tissue is subjected to described laser pumping and the fluorescence spectrophotometer of the fluorescence that produces with described optical module; With described supersonic imaging device and fluorescence spectrophotometer links to each other and the computer workstation of processing and analytical data: from ultrasonoscopy, analyze and obtain tectology information, thereby from the fluorescence spectrum signal, analyze spectral distribution and the spectrum time of burying in oblivion obtains histopathology information.

Preferably, also comprise multi-module optical fiber coupler, described multi-module optical fiber coupler comprises three ports, respectively with described human body in peep conduit light input/output interface, laser generator and fluorescence spectrophotometer be connected.

Peep conduit in the above-mentioned novel human body and use the system of this conduit, be provided with the ultrasonic assembly that can obtain inside of human body tectology information owing to peep conduit in this, be provided with the optical module that can obtain inside of human body histopathology information again, so can obtain tectology and pathology information simultaneously, thereby save time, reduce the patient suffering, and improve the accuracy and the efficient of diagnosis.

[description of drawings]

Fig. 1 is a structural representation of peeping conduit among the embodiment in the novel human body;

Fig. 2 be among Fig. 1 A-A to cutaway view;

Fig. 3 be among Fig. 1 B-B to cutaway view;

Fig. 4 is a distal structure sketch map of peeping conduit among the described embodiment in the human body;

Fig. 5 is a system structure sketch map described in the described embodiment.

[specific embodiment]

Be described further below in conjunction with drawings and Examples.

In a preferred embodiment, peep in the human body conduit comprise be arranged in the sealing sheath, be ultrasonic emitting with electrical signal conversion and people's in-vivo tissue be converted to the ultrasonic assembly of the signal of telecommunication to described hyperacoustic echo, and be arranged on equally in the described sealing sheath, with ultrasonic assembly serial arrangement and more close this human body in peep distal end of catheter, the transparent part of laser by described sealing sheath be sent in the human body and gather the optical module of the fluorescence that described people's in-vivo tissue sends under the effect of described laser by described sealing sheath transparent part.Wherein ultrasonic assembly comprises the lead of ultrasonic probe, the transmission signal of telecommunication, the turning cylinder and the rotary connector of drive ultrasonic probe rotation.Optical module comprises multimode fibre and the optic probe that is used for transmitting optical signal.

As shown in Figure 1, the probe segment 24 of peeping distal end of catheter (putting in an end of blood vessel and close detected part) in the human body forms for ultrasonic probe 22 and optic probe 23 serial arrangement, and wherein optic probe 23 is compared more close far-end with ultrasonic probe 22; Catheter proximal end is connected with a handle and stress buffer assembly 18, and external motor (not shown) drives the intermediary turning cylinder 17 of conduit (referring to Fig. 2, Fig. 3) and drives ultrasonic probe 23 carries out 360 ° of scannings.Establish multiple conducting wires in the turning cylinder 17 and be used for the signal transmission of (comprising the signal of telecommunication of the excitation ultrasonic probe that sends from supersonic imaging device and the ultrasonic echo that receives by ultrasonic probe and the signal of telecommunication that converts to).

Fig. 2 be among Fig. 1 A-A to viewgraph of cross-section, peep in the human body conduit also comprise sealing sheath 25, theca interna 27, by the metal level 26 of sealing sheath and inner membrance parcel.The conduit cavity 28 that theca interna 27 forms is used to install turning cylinder 17.In the present embodiment, theca interna 27 is formed by the material politef (being also referred to as Teflon) that has less coefficient of friction, can form a level and smooth and less inner surface of coefficient of friction like this, helps the rotation of turning cylinder 17.Because sealing sheath directly contacts with blood vessel, for fear of injured blood vessel, fabulous elasticity and less hardness must be arranged, especially the distal end of catheter part.The adventitia of conduit can be any material that desirable intensity, elasticity and some other desirable characteristics can be provided, and is thermoplastic polymer in the present embodiment.In other embodiments, also can be polyurethane, elasticity polyamide, silicones and some copolymer.The intracavity diameter that common inner membrance is wrapped to form is 0.5 millimeter, and the thickness of inner membrance is approximately 25 microns; The internal diameter of sealing sheath 25 is 1 millimeter, and external diameter is 2 millimeters.About 0.2 a millimeter groove of diameter is set on the inwall of sealing sheath 25 holds a root multimode fiber 29, multimode fibre 29 is embedded between sealing sheath 25 and the metal level 26.

Fig. 3 is that B-B is turning cylinder 17 to cross section view in the middle of the conduit among Fig. 1.Metal level 26 mainly plays the shielding physiological signals, in the present embodiment, utilizes the elasticity of helical form cutting increase metal level 26, and in other embodiments, metal level also 26 can replace with hypotube.

Fig. 4 is the structural representation of the probe segment 24 of distal end of catheter among Fig. 1, and turning cylinder 17 is connected with ultrasonic probe 22, and does 360 ° of scannings by above-mentioned external motor-driven ultrasonic probe 22.Theca interna 27 and metal level 26 all extend to the length identical with turning cylinder 17, and the transparent part 33 of sealing sheath 25 has been accommodated the optic probe 23 among Fig. 1 at the cavity that distal end of catheter forms.Optic probe 23 comprises collimating mirror 30, corner cube prism 31 and the built-in micro motor 32 relative with collimating mirror 30, multimode fibre 29 links to each other with collimating mirror 30, micro motor 32 drives corner cube prism 31 and realizes 360 degree scannings, transparent sheath 33 guarantees that optical signal passes through smoothly, and the optical signal of being said comprises the laser and the fluorescence that tissue sent that is subjected to above-mentioned laser irradiation that is reflexed to tissue by above-mentioned corner cube prism 31 here.

In the present embodiment, peep conduit in being somebody's turn to do and also comprise light input/output interface, electric input/output interface and rotary connector, above-mentioned three interfaces are accepted the port of the signal that control signal or output receives as the ultrasonic probe 22, optic probe 23 and the turning cylinder 17 that are arranged on catheter interior, all be arranged on the near-end of peeping conduit in this, wherein, the light input/output interface links to each other with light probe by the multimode fibre 29 in the above-mentioned groove that is embedded in described sealing sheath 25 inner surfacies, promptly is connected on the above-mentioned collimating mirror 30 by multimode fibre 29; And above-mentioned electric input/output interface links to each other with above-mentioned ultrasonic probe by the lead that is arranged in the axially extending bore in the described turning cylinder 17, the signal of telecommunication that the outside is produced is sent to ultrasonic probe makes it produce ultrasound wave, and the signal of telecommunication that the ultrasonic echo that ultrasonic probe is accepted converts to is drawn out to external supersonic imaging apparatus; And rotary connector is an actuating device, and it couples together the turning cylinder of external motor and the turning cylinder 17 of catheter interior, makes the turning cylinder 17 of catheter interior rotate with the turning cylinder of above-mentioned external motor.

In the present embodiment, by peeping the design of conduit in the above-mentioned acousto-optic bimodulus, ultra sonic imaging in the lumen of vessels (IVUS) and laser-induced fluorescence spectroscopy (LIF) technology are integrated into a system, make this system that the tectology information and the histopathology information of cardiovascular pathological changes can be provided simultaneously, thereby accuracy and the efficient checked have been improved, save the review time, reduced patient's misery and easy operating.Fig. 5 shows the structural representation of this system, in Fig. 5, supersonic imaging device 11 sends the signal of telecommunication through electric input/output interface 102, be arranged on lead excitation in the turning cylinder 17 and peep ultrasonic probe 22 (referring to Fig. 4) emission ultrasound wave in the conduit 10 in described, external motor 12 drives turning cylinder 17 (referring to Fig. 4) by rotary connector 103 and drives ultrasonic probe 22 realizes 360 ° of scannings, receive and convert the signal of telecommunication to through ultrasonic probe 22 by the ultrasonic echo of tissue reflection, be transferred to supersonic imaging device 11 by described lead and electric input/output interface 102 and carry out analyzing and processing and form the B-mode ultrasonoscopy; Laser generator 14 emission laser arrive multimode fibre 29 through multi-module optical fiber coupler 15, light input/output interface 101, and incide on the corner cube prism 31 after converging by collimating mirror 30, drive corner cube prism 31 by built-in micro motor 32 and realize 360 ° of scannings, this corner cube prism 31 is relative with collimating mirror 30, when this corner cube prism 31 rotates, changed the laser direction that transmits by collimating mirror 30, it is transferred out to all directions perpendicular to this conduit; Simultaneously, because the rotation of corner cube prism 31, make the fluorescence signal that all directions transmitted, that laser pumping tissue produce of its reception perpendicular to this conduit, this signal returns through above-mentioned light path is reverse, be transferred to fluorescence spectrophotometer 16 through multimode fibre 29, light input/output interface 101 and the multi-module optical fiber coupler 15 that embeds sealing sheath 25 inboard wall grooves successively, before entering fluorescence spectrophotometer 16, utilize of the influence of a long wave pass filtering laser generator usually the excited fluorescence signal; Supersonic imaging device 11 and fluorescence spectrophotometer 16 link to each other with a computer workstation 13, handle and analytical data by computer workstation 13, obtain tectology information from the B-mode ultrasonoscopy, obtain histopathology information from laser-induced fluorescence spectroscopy, therefore, peeped the conduit and the system integration in the novel human body of this acousto-optic bimodulus ultra sonic imaging and laser-induced fluorescence spectroscopy technology in the lumen of vessels, can improve the accuracy and the efficient of cardiovascular pathological changes diagnosis greatly, especially in the diagnosis of atheromatous plaque, special advantages be arranged.

Present embodiment has provided signal emission, collection and the processing system of peeping conduit in the human body that is used for vascular test and using this conduit, in other embodiments, change the size of described conduit, also can will peep in described conduit and said system be used for the endoscope detecting of its hetero-organization in the human body or system, digestive tract etc. for example.

The above embodiment has only expressed embodiment of the present utility model, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to this utility model claim.Should be pointed out that for the person of ordinary skill of the art under the prerequisite that does not break away from this utility model design, can also make some distortion and improvement, these all belong to protection domain of the present utility model.Therefore, the protection domain of this utility model patent should be as the criterion with claims.

Claims (10)

1, peep conduit in a kind of novel human body, comprise and being arranged in the sealing sheath, with electrical signal conversion is ultrasonic emitting and the ultrasonic assembly that people's in-vivo tissue is converted to the signal of telecommunication to described hyperacoustic echo, it is characterized in that, also comprise being arranged on equally in the described sealing sheath, with peep distal end of catheter in described ultrasonic assembly serial arrangement and more close this human body, the transparent part of laser by described sealing sheath be sent in the human body and gather the optical module of the fluorescence that described people's in-vivo tissue sends under the effect of described laser by described sealing sheath transparent part.

2, peep conduit in the human body according to claim 1, it is characterized in that, described optical module comprise the multimode fibre that is used for transmitting optical signal, the collimating mirror that links to each other with described optical fiber one end, with described collimating mirror relatively and the corner cube prism that changes described Laser Transmission direction and the reception described fluorescence that all directions transmitted with link to each other with described corner cube prism and drive the micro motor that it rotates; Described micro motor, corner cube prism, collimating mirror and multimode fibre are peeped distal end of catheter to proximal direction in described and are set gradually.

3, peep conduit in the human body according to claim 2, it is characterized in that, also comprise be arranged on peep in the described human body catheter proximal end, the described laser of input and export the light input/output interface of described fluorescence, described optical fiber one end links to each other with described smooth input/output interface, and the other end links to each other with described collimating mirror.

4, peep conduit in the human body according to claim 3, it is characterized in that, described sealing sheath also comprises the groove on the surface that sets within it, and described optical fiber is arranged in the described groove.

5, according to peeping conduit in any described human body of claim 1-4, it is characterized in that, also comprise being arranged on the electric input/output interface of peeping catheter proximal end in the described human body, with the electrical signal conversion of outside input is ultrasound wave and the ultrasonic probe that described hyperacoustic echo is converted to the signal of telecommunication, between described electric input/output interface and described ultrasonic probe, transmit the lead of the signal of telecommunication, in described human body, peep drive the turning cylinder that coupled described ultrasonic probe rotates together under the driven by motor of conduit outside and connect described turning cylinder and described human body in peep rotary connector between the motor of conduit outside.

6, peep conduit in the human body according to claim 5, it is characterized in that, the lead of the described transmission signal of telecommunication connects described ultrasonic probe and described electric input/output interface by the through hole that is arranged on the described turning cylinder axis direction.

7, peep conduit in the human body according to claim 6, it is characterized in that, the metal level that also is disposed with theca interna and is used to shield physiology signal between described turning cylinder and the described sealing sheath with smooth inner surface; The transparent part of described sealing sheath is arranged on described ultrasonic transduction assembly and peeps between the catheter tip to described human body.

8, peep conduit in the human body according to claim 7, it is characterized in that the formed intracavity diameter of described theca interna is the 0.4-0.6 millimeter, described theca interna thickness is the 20-30 micron, described sealing sheath external diameter is the 1.0-3.5 millimeter, and its internal diameter is the 0.6-2.5 millimeter.

9, a kind of system of peeping conduit in the novel human body as claimed in claim 1 that uses, it is characterized in that the electrical signal conversion that ultrasonic probe forms after comprising the signal of telecommunication that link to each other with described ultrasonic assembly, the described ultrasonic probe of generation excitation and will accepting ultrasonic echo is the supersonic imaging device of B ultrasonic image; Link to each other, produce that laser is input to the intravital laser generator of people and link to each other with described optical module and analyze that the human body interior tissue is subjected to described laser pumping and the fluorescence spectrophotometer of the fluorescence that produces with described optical module.

10, system according to claim 9, it is characterized in that, also comprise multi-module optical fiber coupler, described multi-module optical fiber coupler comprises three ports, respectively with described human body in peep conduit light input/output interface, laser generator and fluorescence spectrophotometer be connected.

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