CN201312845Y - Antibacterial artificial joint prosthesis - Google Patents
Antibacterial artificial joint prosthesis Download PDFInfo
- Publication number
- CN201312845Y CN201312845Y CN 200820158054 CN200820158054U CN201312845Y CN 201312845 Y CN201312845 Y CN 201312845Y CN 200820158054 CN200820158054 CN 200820158054 CN 200820158054 U CN200820158054 U CN 200820158054U CN 201312845 Y CN201312845 Y CN 201312845Y
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- Prior art keywords
- joint prosthesis
- artificial joint
- prosthesis
- layer
- artificial
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The utility model discloses an antibacterial artificial joint prosthesis which is characterized in that the contact part between an artificial joint prosthesis and the surface of human bone comprises an artificial joint prosthesis substrate layer and a metal silver coating which is covered on the substrate layer and has the thickness of 5mu m to 350mu m. The metal silver or metal silver/hydroxylapatite coating on the surface of the artificial joint prosthesis can not only keep releasing sterilizing silver ion, but also dissociate from the thalli after entering the thalli and the activity losing of the thalli; the sterilization is repeated, so that the novel artificial prosthesis can not only greatly reduce the possibility of infection and loosening complications after being implanted into the human body, but also prevent a series of problems produced by the prior antibiotic-loaded bone cement, and has very good biological compatibility and biological activity.
Description
Technical field
This utility model belongs to technical field of medical instruments, is specifically related to the antibiotic artificial joint prosthesis in a kind of human implantable.
Background technology
Artificial joint prosthesis before more than 100 years, be applied to clinical since, though obtained huge development, but still the solution of still needing of many problems is arranged, as the infection problems that produces behind the implant into body.According to statistics, behind the replacement of total hip, infection rate is 0.1%～1%; Full elbow joint infection rate is 1%～4%; Knee joint then reaches 4%～47%.As everyone knows, the artificial joint prosthesis infection is a kind of catastrophic complication.Trace it to its cause, biofilm (biofilm) is the principal element that causes that artificial joint prosthesis infects.Biofilm is that antibacterial adheres to biomaterial or active mass surface in order to adapt to living environment, and be coated in the mucus proteoglycan substrate that self produces and the bacterial community or the microclone that form, it is a dynamic structure (Costerton JW who constantly changes, StewartPS, Greenberg EP.Bacterialbiofilms:a common cause of persistent infections.Science, 1999; 284 (5418): 1318-1322).After artificial joint prosthesis implants, the surface is covered by blood constituent (albumen, blood plasma macromole, erythrocyte, platelet) immediately, form so-called condition film, antibacterial passes through chemical action, as Van der Waals force, acid group, static, hydrophobicity effect and protein binding etc., stick to condition film and prosthetic surface.Immunity of organisms just often, the majority bacterium that swims is killed, the remaining bacterial adhesion of minority is adjusted gene expression after material surface, in growth and breeding, secrete (the extracellular slime substance of mucilage outside a large amount of born of the same parents, ESS), with a plurality of bacterial adherences to forming biofilm together.At ordinary times, antibacterial is many conceals in biofilm with resting state, changes pathogenic bacterium into from dormancy or resting state when the certain trigger factor.Infect in case take place to make the prosthese generation loosening, the forfeiture normal function, bring great misery to the patient, and infect and also can show effect repeatedly, delay difficult more (Nelson CL, Mclaren AC, Mclarten SG, et al.Is aseptic loosening truly aseptic? Clin Orthop, 2005; 437:25-30), and conventional antibiotherapy is difficult to prove effective, thereby the prevention of artificial joint replacement postoperative infection and treatment are extremely important problems in this field always.Then the someone has studied success added antibiotic in common polymethyl methacrylate (PMMA) bone cement and formed antibiotic-loaded bone cement (antibiotic impregnated bone cement) layer on the artificial joint prosthesis surface and be used as solving infection method one (Espehaug B comparatively commonly used, Engesaerer LB, Voll set SE, et al.Antibioticpro ylaxis in total hip arthroplasty.Review of 10,905 primary cemented totalhip replacements reported to the Norwegian arthroplasty register, 1987 to1995[J] .J Bone Joint surg (Br), 1997,79 (4): 590-595).But after using, find, antibiotic-loaded bone cement discharges the low concentration antibiotic for a long time, make antibacterial produce drug resistance easily, and along with adding antibiotic increasing, the anaphylaxis odds is also very high, and in case difficult treatment takes place, the necessary prosthese that takes out, this not only can bring great misery to patient, but also will bring overweight financial burden.
Summary of the invention
The purpose of this utility model is the problem at prior art, and a kind of antibiotic artificial joint prosthesis is provided, and implants the infection and the loosening incidence rate of back artificial joint prosthesis with great minimizing.
A kind of antibiotic artificial joint prosthesis that this utility model provides is characterized in that be artificial joint prosthesis substrate layer and the metallic silver layer that cover it on to be made of with human body surface of bone contact site at artificial joint prosthesis after the implantation.
Owing to the argent coating is arranged on the artificial joint prosthesis surface of implanting, thereby when its with after oxide isolations such as body fluid contact, argent is incited somebody to action oxidized gradually and is discharged silver ion, when micro silver ion arrives the microbial cell film, because of cell membrane has negative charge, silver ion at first can rely on Coulomb force firmly to be adsorbed on the cell membrane, further the penetration cell wall enters in the pathogenic bacteria then, with the biological intravital protein of pathogenic bacteria, the sulfydryl that exists in the nucleic acid (SH), nitrilo (NH2) waits sulfur-bearing, the functional group of ammonia reacts, make the protein coagulating of pathogenic bacteria, destroy the activity of the cell synzyme of pathogenic bacteria, make cell forfeiture division growth ability and final the extinction, thereby reach antibiotic and reduce or eliminate the purpose that the artificial joint prosthesis infections relating takes place.
For the artificial joint prosthesis that this utility model is provided not only has antibacterial action, also have excellent biological compatibility, the artificial joint prosthesis that this utility model provides is to be to be made of artificial joint prosthesis substrate layer and the argent/hydroxyapatite layer or the metallic silver layer that cover on it in artificial joint prosthesis and human body surface of bone contact site.Above-mentioned prosthese substrate layer can be substrate layer that contains micropore or the substrate layer that does not contain micropore.
The antibiotic artificial joint prosthesis that this utility model provides, it covers argent/hydroxyapatite layer on the artificial joint prosthesis substrate layer or the thickness of metallic silver layer is 5～350 μ m.
Argent/the hydroxyapatite layer or the metallic silver layer that cover on this utility model artificial joint prosthesis substrate layer can adopt methods such as existing conventional vacuum plasma spray coating, electron linear accelerator irradiation, low energy ion beam sputter-deposition, electro-deposition sintering, magnetron sputtering to prepare formation.
At present, to infect topmost pathogenic bacterium be staphylococcus to artificial joint prosthesis.In order to investigate the antibacterial effect of the antibiotic artificial joint prosthesis that this utility model provides, this utility model with rabbit as experimental subject, adopt common not silver plated artificial joint prosthesis to do matched group respectively, with the artificial joint prosthesis that has covered argent/hydroxyapatite layer is experimental group, the row hip replacement surgery, immediate postoperative partly injects 1 * 10 in the medullary substance of femur
7The staphylococcus aureus of CFU carries out radiological examination, bacteriological detection and change of serum C-reactive protein (C-reactiveprotein, mensuration CRP) respectively after 4 weeks.Found that antibiotic articular prosthesis group infection rate is starkly lower than common joint set.
The utlity model has following advantage:
1, because the argent coating that the artificial joint prosthesis surface that this utility model provides has can discharge germ-resistant silver ion constantly, again can enter thalline make its lose activity the back from thalline, dissociate out, repeat sterilization, thereby not only make the probability of the complication that this novel artificial prosthese infects behind implant into body, becomes flexible greatly reduce a series of problems of also having avoided existing antibiotic-loaded bone cement layer to be produced.
2, since the artificial joint prosthesis top layer that provides of this utility model on basis with argent, also contain to biological osseous tissue in the similar hydroxyapatite of calcium phosphate inorganic matter, thereby make this artificial joint prosthesis also have fabulous biocompatibility and biological activity.
3, since the thermal coefficient of expansion of Ag in the argent/hydroxyapatite layer on this utility model artificial joint prosthesis substrate layer than hydroxyapatite (HA) height, make hydroxyapatite process from the sintering temperature cool to room temperature the time can produce compressive stress with the electro-deposition sintering, not only can effectively suppress the expansion of crackle, the bond strength of HA/Ag composite coating is obviously improved, also, the toughness of coating also can be increased because of comprising metal A g with certain ductility.
Description of drawings
Fig. 1 is artificial hip prosthesis's a structural representation;
Fig. 2 is the structural representation of artificial knee joint prosthesis tibial side;
Fig. 3 is the structural representation of artificial knee joint prosthesis femur side;
Fig. 4 is for there being the sectional structure sketch map at metallic silver layer or argent/hydroxyapatite layer position on the artificial joint prosthesis.
The specific embodiment
Provide embodiment so that this utility model is specifically described below in conjunction with accompanying drawing; be necessary to be pointed out that at this following examples only are used for that the utility model is described in further detail; can not be interpreted as restriction to this utility model protection domain; some nonessential improvement and adjustment that the person skilled in the art in this field has done this utility model according to above-mentioned this utility model content still belong to protection domain of the present utility model.
Embodiment 1
At first with the base material for preparing artificial joint prosthesis, be processed into as shown in Figure 1 hip prosthesis 1 as cobalt alloy or titanium alloy, this prosthese can be made the prosthese that contains micropore surface or not contain the common prosthese of micropore surface, and then spray the metallic silver layer 8 that a layer thickness is 6 μ m with magnetron sputtering at the outer surface (being blacking part among Fig. 1) of the latter half of its bulb 2 outer surfaces and its handle 3, making at the position of the latter half of bulb 2 outer surfaces that artificial joint hip prosthesis 1 contacts with the human body surface of bone and its handle 3 is to be made of artificial joint prosthesis substrate layer 7 and the metallic silver layer 8 that covers on it, as shown in Figure 4.
Embodiment 2
At first with the base material for preparing artificial joint prosthesis, be processed into as shown in Figure 1 hip prosthesis 1 as cobalt alloy or titanium alloy, this prosthese can be made the prosthese that contains micropore surface or not contain the common prosthese of micropore surface, and then to deposit sintering one layer thickness at the outer surface (being blacking part among Fig. 1) of the latter half of its bulb 2 outer surfaces and its handle 3 with the electro-deposition sintering process be argent/hydroxyapatite layer 8 of 280 μ m, making at the position of the latter half of bulb 2 outer surfaces that artificial hip prosthesis 1 contacts with the human body surface of bone and its handle 3 is to be made of artificial joint prosthesis substrate layer 7 and argent/hydroxyapatite layer 8 of covering on it, as shown in Figure 4.
Embodiment 3
At first with the base material for preparing artificial joint prosthesis, be processed into as Fig. 2 as cobalt alloy or titanium alloy, knee joint tibial side prosthese 4 shown in 3 or knee joint femur side prosthesis 6, this prosthese can be made the prosthese that contains micropore surface or not contain the common prosthese of micropore surface, then respectively again at the lower surface of tibial side prosthese 4 tibial base, comprise that the outer surface (being blacking part among Fig. 2) of whole implant post 5 and the inner surface (being blacking part among Fig. 3) of knee joint femur side prosthesis 6 are the metallic silver layer 8 of 40 μ m with vacuum plasma spray coating one layer thickness, make the lower surface of knee joint tibial side prosthese 4 pedestals that contact with the human body surface of bone at artificial knee joint prosthesis, comprise that the outer surface of whole implant post 5 or the inner surface position of knee joint femur side prosthesis 6 are to be made of artificial joint prosthesis substrate layer 7 and the metallic silver layer 8 that covers on it, as shown in Figure 4.
Embodiment 4
At first with the base material for preparing artificial joint prosthesis, be processed into as Fig. 2 as cobalt alloy or titanium alloy, knee joint tibial side prosthese 4 shown in 3 or knee joint femur side prosthesis 6, this prosthese can be made the prosthese that contains micropore surface or not contain the common prosthese of micropore surface, then respectively again at the lower surface of tibial side prosthese 4 tibial base, comprise that the outer surface (being blacking part among Fig. 2) of whole implant post 5 and the inner surface (being blacking part among Fig. 3) of knee joint femur side prosthesis 6 are argent/hydroxyapatite layer 8 of 100 μ m with vacuum plasma spray coating one layer thickness, make the lower surface of knee joint tibial side prosthese 4 pedestals that contact with the human body surface of bone at artificial knee joint prosthesis, comprise that the outer surface of whole implant post 5 or the inner surface position of knee joint femur side prosthesis 6 are to be made of artificial joint prosthesis substrate layer 7 and the argent/hydroxyapatite layer 8 that covers on it, as shown in Figure 4.
Claims (3)
1, a kind of antibiotic artificial joint prosthesis is characterized in that in artificial joint prosthesis and human body surface of bone contact site it being to be made of artificial joint prosthesis substrate layer (7) and the containing metal silver coating (8) that covers on it.
2, antibiotic artificial joint prosthesis according to claim 1 is characterized in that in artificial joint prosthesis and human body surface of bone contact site it being to be made of artificial joint prosthesis substrate layer (7) and the argent/hydroxyapatite layer (8) or the metallic silver layer (8) that cover on it.
3, antibiotic artificial joint prosthesis according to claim 1 and 2, it is characterized in that covering the metallic silver layer (8) on the artificial joint prosthesis substrate layer or the thickness of argent/hydroxyapatite layer (8) is 5～350 μ m.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200820158054 CN201312845Y (en) | 2008-12-22 | 2008-12-22 | Antibacterial artificial joint prosthesis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200820158054 CN201312845Y (en) | 2008-12-22 | 2008-12-22 | Antibacterial artificial joint prosthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201312845Y true CN201312845Y (en) | 2009-09-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200820158054 Expired - Fee Related CN201312845Y (en) | 2008-12-22 | 2008-12-22 | Antibacterial artificial joint prosthesis |
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| CN (1) | CN201312845Y (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103298499A (en) * | 2010-10-05 | 2013-09-11 | 德鲁有限责任公司 | Prosthesis component with antimicrobially coated slide surface |
| CN104127914A (en) * | 2014-07-29 | 2014-11-05 | 复旦大学附属华山医院 | Preparation method of HAp blended silver and copper antibacterial composite coating |
| CN104353117A (en) * | 2014-11-18 | 2015-02-18 | 孙钢 | Method for enabling bone cement to generate heat subsequently |
| CN105559948A (en) * | 2015-12-14 | 2016-05-11 | 北京大学第一医院 | Artificial joint prosthesis |
| CN113101414A (en) * | 2021-03-18 | 2021-07-13 | 常熟中科世纪生物科技有限公司 | Artificial joint prosthesis with anti-infection function |
-
2008
- 2008-12-22 CN CN 200820158054 patent/CN201312845Y/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103298499A (en) * | 2010-10-05 | 2013-09-11 | 德鲁有限责任公司 | Prosthesis component with antimicrobially coated slide surface |
| CN104127914A (en) * | 2014-07-29 | 2014-11-05 | 复旦大学附属华山医院 | Preparation method of HAp blended silver and copper antibacterial composite coating |
| CN104353117A (en) * | 2014-11-18 | 2015-02-18 | 孙钢 | Method for enabling bone cement to generate heat subsequently |
| CN104353117B (en) * | 2014-11-18 | 2016-01-20 | 孙钢 | A kind of method making the follow-up generation heat of bone cement |
| CN105559948A (en) * | 2015-12-14 | 2016-05-11 | 北京大学第一医院 | Artificial joint prosthesis |
| CN105559948B (en) * | 2015-12-14 | 2018-12-18 | 北京大学第一医院 | A kind of artificial joint prosthesis |
| CN113101414A (en) * | 2021-03-18 | 2021-07-13 | 常熟中科世纪生物科技有限公司 | Artificial joint prosthesis with anti-infection function |
| CN113101414B (en) * | 2021-03-18 | 2023-03-14 | 常熟中科世纪生物科技有限公司 | Artificial joint prosthesis with anti-infection function |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090923 Termination date: 20131222 |