CN201207085Y - Standardization and calibration instrument for dose monitoring detector in cancer treatment using heavy ion beam - Google Patents
Standardization and calibration instrument for dose monitoring detector in cancer treatment using heavy ion beam Download PDFInfo
- Publication number
- CN201207085Y CN201207085Y CN 200820029243 CN200820029243U CN201207085Y CN 201207085 Y CN201207085 Y CN 201207085Y CN 200820029243 CN200820029243 CN 200820029243 CN 200820029243 U CN200820029243 U CN 200820029243U CN 201207085 Y CN201207085 Y CN 201207085Y
- Authority
- CN
- China
- Prior art keywords
- monitoring detector
- ion beam
- heavy ion
- dose monitoring
- mini
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Landscapes
- Radiation-Therapy Devices (AREA)
Abstract
The utility model relates to a device for calibrating a dosage monitoring detector used in cancer therapy through heavy ion beams. The device is structurally characterized in that a collimating device, a dosage monitoring detector, a mini ridge filter, a water tank and a standard ionization chamber are arranged on a beam axis sequentially, and the standard ionization chamber is disposed in the water tank. By measuring the absorbed dosages of the standard ionization chamber at different depth in aqueous medium, the depth of the mini expanded Bragg peak(mini-SOBP) of the irridiating beams in water can be measured. At the depth, the dosage monitoring detector is calibrated by the standard ionization chamber, thus obtaining a calibration factor for the dosage monitoring detector to measure cancer-curing beams which have Gauss distributive mini expanded Bragg peak. Through the calibration factor, the whole 3-D conformal radiotherapy process with even physic absorbed dosages or even biological effective dosages in the gross tumor volume can be conveniently controlled, thus satisfying the requirements of thererapies for different clinic cases in aucual clinic thererapy and improving the therapeutic efficacy of the whole curing device.
Description
Technical field
The utility model relates to a kind of device of in the middle of cancer is controlled in the irradiation of enforcement heavy ion beam three-dimensional conformal dose monitoring detector being demarcated and being calibrated.
Background technology
Heavy ion beam is with the relative biological effectiveness (RBE) that depth dose distributes, lateral scattering is little, higher of its reversing and low oxygen enhancement ratio characteristics such as (OER), and making heavy ion beam control cancer becomes advanced in the world now, effective radiotherapy method.At present, have only minority developed country and China carrying out the heavy ion beam clinical treatment experimental study of tumor patient, preliminary clinical treatment experimental study result shows that heavy ion beam controls the curative effect that cancer has highly significant, and does not have obvious toxic and side effects.On present line passive-type beam delivery system extending transversely, all implementing the bidimensional conform irradiation treatment of heavy ion beam to the tumour target area, promptly cooperate the cancer line of controlling extending transversely to form big exposure field with scatterer by swing magnet, transversely intercept this exposure field by multi-diaphragm collimator, the shape that obtains irradiation field is consistent with the maximal projection shape of tumour on beam direction, vertically go up Bragg peak by ridged filtrator broadening heavy ion beam, make spread-out Bragg peak (spread-out Bragg peak, SOBP) width and the tumour target area consistency of thickness on beam direction, the back of spread-out Bragg peak (SOBP) high dose area organized compensator adjustment along shape by what place patient's body surface.
Before implementing the treatment of heavy ion beam bidimensional conform irradiation, accurate monitoring and control to the line exposure dose are key one ring of successful implementation heavy ion beam to the treatment of tumour target area conform irradiation, promptly need the dose monitoring detector in the beam delivery system, demarcate and calibrate as penetrating type ionization chamber, scintillator detector etc., could guarantee that like this dosage of irradiation treatment is consistent with prescribed dose, reach the radiocurable purpose of heavy ion beam.Demarcation and the calibration steps that adopts is at present: under the irradiation of uniform irradiation open country, by moving the standard chamber that places water tank, measurement utilizes the ridged filtrator that the depth dose of the line of Bragg peak broadening after for certain width is distributed, and find the degree of depth of centre position in aqueous medium of this line spread-out Bragg peak in view of the above, then the standard chamber is placed this degree of depth place, utilize the absolute measurement of standard chamber to line absorbed dose in degree of depth place, SOBP centre position water, demarcate and the reading of calibration dose monitoring detector, obtain the relation between the reading of line absorbing agent value and dose monitoring detector in degree of depth place, SOBP centre position water.
Summary of the invention
Be applied to radiocurable advantage for giving full play to heavy ion beam, we utilize heavy ion beam, and (application number: the mini ridged filtrator 200610105306.9) expands to the sharp-pointed Bragg peak of heavy ion beam the small broadening peak (mini-SOBP) of Gaussian dose distribution slightly to the three-dimensional conformal irradiation unit of tumour target area, utilize this small broadening peak to implementing by the successively irradiation treatment of deep layer then, thereby improved the suitable shape degree that heavy ion beam is treated to shallow-layer along certain thickness tumour target area on the beam direction.On this basis, the purpose of this utility model is to provide the demarcation that a kind of heavy ion beam controls dose monitoring detector in the middle of the cancer and the device of calibration.Promptly when the three-dimensional conformal irradiation treatment to beam delivery system in dose monitoring detector demarcate and calibrate, its objective is and when implementing heavy ion beam, accurately control exposure dose tumour target area three-dimensional conformal irradiation treatment, make that the therapeutic dose of tumour target area is consistent with the prescribed dose that the clinician provides, reach the optimum efficiency of heavy ion beam treatment.
The purpose of this utility model is to be achieved through the following technical solutions:
A kind of heavy ion beam is controlled the demarcation and the calibrating installation of the central dose monitoring detector of cancer, is to be made of collimating apparatus, dose monitoring detector, mini ridged filtrator, standard chamber and water tank.Place collimating apparatus, dose monitoring detector, mini ridged filtrator, water tank and standard chamber successively in the beam line downstream, the line irradiation field that adopts collimator intercepts to form by beam delivery system, the irradiation field size is 10cm * 10cm, the standard chamber places water tank, and standard chamber's sensitive volume is 0.1cm
3～0.055cm
3Drive and in water tank, to move by stepper motor, mobile accuracy is 0.1mm, mini ridged filtrator is 65cm～100cm apart from the distance of water tank, and transversely the irradiation field of (being on the perpendicular fasciculus flow path direction) is even at the place, measuring position after to the small spread-out Bragg peak of line by mini ridged filtrator to satisfy.
The energy of above-mentioned line is being controlled within the used energy range of cancer, promptly between 80～430MeV/u.
The beneficial effect of advantage of the present utility model and generation:
(1) peak position of utilizing the standard chamber to seek the small spread-out Bragg peak of gaussian shaped profile of the heavy ion beam that mini ridged filtrator provides accelerator in the water mould can confirm that accelerator provides the energy of line, promptly can confirm to control the energy of cancer line when dose monitoring detector is demarcated and calibrated.The heavy ion beam that is confirmed to be of counterweight ion beam energy is controlled the necessary link of cancer quality certification system, thereby the present invention has the effect of killing two birds with one stone; (2) by demarcation and the calibration of the peak position of the small spread-out Bragg peak of gaussian shaped profile to dose monitoring detector, can control the whole process that Physical Absorption dosage is even or biological effective dose uniform three dimensional conform irradiation is treated in the tumour target area easily, satisfy the needs of the central different clinical cases treatments of actual clinical treatment, improved the therapeutic efficiency of therapeutic system.
Description of drawings
Demarcate and schematic representation of apparatus is adopted in calibration by dose monitoring detector by the utility model carries out for Fig. 1.
Embodiment
Embodiment
Utilize the carbon ion beam of the 100MeV/u that The CAS Institute of Modern Physics's Lanzhou heavy ion research device (HIRFL) provides, we test this device and method and verify in HIRFL shallow-layer oncotherapy terminal.Experimental provision is placed collimating apparatus 2, dose monitoring detector 3, mini ridged filtrator 4, water tank 5 and standard chamber 6 as shown in Figure 1 successively in line 1 downstream, standard chamber 6 places water tank 5.10cm * 10cm uniform irradiation open country that collimating apparatus 2 interceptings are formed by beam delivery system.
The 100MeV/u carbon ion beam arrives the energy of center such as therapeutic system through being measured as 95.1MeV/u through vacuum insulating window and air-gap, mini ridged filtrator is 4mm to the halfwidth of the mini-SOBP that this energy line forms, lift height when therefore, three-dimensional conformal shines is 2mm.The center of water tank 5 place therapeutic system etc. the center, the line irradiation field that adopts collimator intercepts to form by beam delivery system, the irradiation field size is 10cm * 10cm.The dose monitoring detector 3 that adopts during experiment is plastic scintillator detector (BC-418, thickness 50 μ m), and standard chamber 6 is a Markus type parallel-plate chamber (German PTW/Markus-23343, sensitive volume 0.055cm
3), it is 0.1mm that stepper motor drives the precision that moves the standard chamber, mini ridged filtrator 4 is 65cm apart from the distance of water tank 5.Utilize UNIDOS quantimeter (German PTW/UNIDOS) that the measurement count of standard chamber is converted to absorbed dose in the water according to the practical criterion in the IAEA398 technical report.At first, the depth dose with mini-SOBP peak line measures by being distributed, the degree of depth of mini-SOBP peak position in water that obtains line is 21.3mm, the standard chamber is moved to this degree of depth place, plastic scintillator detector is demarcated and calibrated, and the demarcation and the calibration factor f that obtain dose monitoring detector are 8.61 * 10
7Ions/Gy.
Claims (7)
1, a kind of heavy ion beam is controlled the demarcation and the calibrating installation of the central dose monitoring detector of cancer, be to constitute by collimating apparatus (2), dose monitoring detector (3), mini ridged filtrator (4), standard chamber (6) and water tank (5), it is characterized in that placing successively in line (1) downstream collimating apparatus (2), dose monitoring detector (3), mini ridged filtrator (4), water tank (5) and standard chamber (6), standard chamber (6) place water tank (5).
2, a kind of heavy ion beam according to claim 1 is controlled the demarcation and the calibrating installation of the central dose monitoring detector of cancer, and the energy that it is characterized in that line (1) is 80～430MeV/u.
3, a kind of heavy ion beam according to claim 1 is controlled the demarcation and the calibrating installation of the central dose monitoring detector of cancer, it is characterized in that above-mentioned dose monitoring detector (3) is penetrating type ionization chamber or plastic scintillant.
4, a kind of heavy ion beam according to claim 1 is controlled the demarcation and the calibrating installation of the central dose monitoring detector of cancer, it is characterized in that the 10cm * 10cm uniform irradiation open country of adopting collimating apparatus (2) intercepting to be formed by beam delivery system.
5, a kind of heavy ion beam according to claim 1 is controlled the demarcation and the calibrating installation of the central dose monitoring detector of cancer, and the sensitive volume that it is characterized in that standard chamber (6) is 0.1cm
3～0.05cm
3
6, a kind of heavy ion beam according to claim 1 is controlled the demarcation and the calibrating installation of the central dose monitoring detector of cancer, it is characterized in that standard chamber (5) is driven and can be moved in water tank (6) by stepper motor, and mobile accuracy is 0.1mm.
7, a kind of heavy ion beam according to claim 1 is controlled the demarcation and the calibrating installation of the central dose monitoring detector of cancer, it is characterized in that mini ridged filtrator (4) is 65cm～100cm apart from the distance of water tank (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200820029243 CN201207085Y (en) | 2008-05-24 | 2008-05-24 | Standardization and calibration instrument for dose monitoring detector in cancer treatment using heavy ion beam |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200820029243 CN201207085Y (en) | 2008-05-24 | 2008-05-24 | Standardization and calibration instrument for dose monitoring detector in cancer treatment using heavy ion beam |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201207085Y true CN201207085Y (en) | 2009-03-11 |
Family
ID=40466146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200820029243 Expired - Lifetime CN201207085Y (en) | 2008-05-24 | 2008-05-24 | Standardization and calibration instrument for dose monitoring detector in cancer treatment using heavy ion beam |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201207085Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107297024A (en) * | 2016-04-14 | 2017-10-27 | 中国辐射防护研究院 | A kind of betaapplicator surface absorber dose rate calibrating installation and method |
| CN108027445A (en) * | 2015-07-22 | 2018-05-11 | 优瑞技术公司 | Ion chamber for actinometry |
| CN112083467A (en) * | 2020-09-28 | 2020-12-15 | 中国科学院近代物理研究所 | Three-dimensional dose measurement detection system of particle therapy device |
-
2008
- 2008-05-24 CN CN 200820029243 patent/CN201207085Y/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108027445A (en) * | 2015-07-22 | 2018-05-11 | 优瑞技术公司 | Ion chamber for actinometry |
| CN108027445B (en) * | 2015-07-22 | 2022-09-02 | 优瑞技术公司 | Ion chamber for radiometry |
| CN107297024A (en) * | 2016-04-14 | 2017-10-27 | 中国辐射防护研究院 | A kind of betaapplicator surface absorber dose rate calibrating installation and method |
| CN107297024B (en) * | 2016-04-14 | 2019-12-24 | 中国辐射防护研究院 | Beta applicator surface absorption dose rate calibration device and method |
| CN112083467A (en) * | 2020-09-28 | 2020-12-15 | 中国科学院近代物理研究所 | Three-dimensional dose measurement detection system of particle therapy device |
| CN112083467B (en) * | 2020-09-28 | 2022-05-31 | 中国科学院近代物理研究所 | Three-dimensional dose measurement detection system of particle therapy device |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101285887B (en) | Dose monitoring detector calibration device and method in heavy ion beam treating carcinoma | |
| Cashmore | The characterization of unflattened photon beams from a 6 MV linear accelerator | |
| US6207952B1 (en) | Water phantom type dose distribution determining apparatus | |
| Akagi et al. | Ridge filter design for proton therapy at Hyogo Ion Beam Medical Center | |
| Low et al. | Phantoms for IMRT dose distribution measurement and treatment verification | |
| Titt et al. | Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency | |
| US20090224183A1 (en) | Hadron treatment planning with adequate biological weighting | |
| Helmbrecht et al. | Design and implementation of a robust and cost-effective double-scattering system at a horizontal proton beamline | |
| CN201207085Y (en) | Standardization and calibration instrument for dose monitoring detector in cancer treatment using heavy ion beam | |
| Podgorsak | External photon beams: Physical aspects | |
| Lagzda et al. | Relative insensitivity to inhomogeneities on very high energy electron dose distributions | |
| Zani et al. | A synthetic diamond diode in volumetric modulated arc therapy dosimetry | |
| Schuy et al. | Vendor‐agnostic water phantom for 3D dosimetry of complex fields in particle therapy | |
| CN101199425A (en) | Three-dimensional conformal Irradiation unit of heavy ion beam on tumour target area | |
| CN201058045Y (en) | Three-dimensional irradiation device of heavy ion beam to tumour target region | |
| Sahoo et al. | Commissioning of a Modern LINAC for Clinical Treatment and Material Research | |
| Chow et al. | Study on surface dose generated in prostate intensity-modulated radiation therapy treatment | |
| CN115804917A (en) | Double-layer three-dimensional detector array-die body device and method applied to beam measurement | |
| Kim et al. | Investigations of line scanning proton therapy with dynamic multi-leaf collimator | |
| Pavoni et al. | Feasibility on using composite gel-alanine dosimetry on the validation of a multiple brain metastasis radiosurgery VMAT technique | |
| Galal et al. | Dosimetric and mechanical characteristics of a commercial dynamic μMLC used in SRS | |
| CN201226027Y (en) | Detector for strong-regulating dose distribution map | |
| Rouffiac et al. | How to Treat Double Synchronous Abdominal Metastases With Stereotactic MR-Guided Adaptive Radiation Therapy (SMART)? | |
| Li et al. | Progress in heavy ion cancer therapy at IMP | |
| Bhardwaj et al. | Study of 2D ion chamber array for angular response and QA of dynamic MLC and pretreatment IMRT plans |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20090311 |
|
| CX01 | Expiry of patent term |