CN201168226Y - Cyclic heat-preserving control appliance for virus inactivation of human blood albumin - Google Patents
Cyclic heat-preserving control appliance for virus inactivation of human blood albumin Download PDFInfo
- Publication number
- CN201168226Y CN201168226Y CNU2008200257171U CN200820025717U CN201168226Y CN 201168226 Y CN201168226 Y CN 201168226Y CN U2008200257171 U CNU2008200257171 U CN U2008200257171U CN 200820025717 U CN200820025717 U CN 200820025717U CN 201168226 Y CN201168226 Y CN 201168226Y
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Abstract
The utility model relates to a human albumin virus inactivation circulation heat preservation control device which includes three layers of inactivation pots; the inner layer is a product pot of 316L material for holding the product; the middle layer is an interlayer for holding the temperature adjusting circulation water; the outer layer is a heat preservation layer; the bottom part of the interlayer of the three layers of inactivation pots is matched and connected with a pipeline circulating pump and a temperature sensor I in turn by pipelines and then is connected with the top end of the interlayer of the inactivation pot by a pipeline provided with a temperature sensor II after being connected in parallel with a heater and a temperature reduction heat exchanger which are all provided with a solenoid pilot actuated valve. The device disclosed by the technical scheme can fast raise temperature and automatically circulate and preserve the temperature as well as can fast reduce temperature after the temperature is preserved to a regulated time; the automatization degree is high; the temperature control precision is high; the bottom part of a stainless steel pot is provided with an electronic scale which can automatically weigh and measure accurately, thus ensuring the safety of blood products, reducing the working intensity and improving the technology level.
Description
Technical field
This utility model relates to a kind of human albumin's inactivation of virus circulation preservation and controlling equipment.
Background technology
The human albumin is a kind of key protein of keeping the normal osmotic pressure of human body colloid, have combination and transport functions such as fatty acid, pigment, dyestuff, cation, vitamin C, hormone, enzyme, bilirubin, medicine, in people's blood plasma, account for about 50% of blood plasma total protein.
Though the human albumin derives from human normal plasma, humanized's normal flora and potential virus are still one of potential danger of blood products medication existence, therefore must be through strict inactivation of virus program.The technological process of present domestic human albumin's inactivation of virus is: water bath → circulating pump → deactivation jar interlayer → water bath, after 60 ℃ of 10 hours heat treated are finished, lay down the tank connected soft pipeline of circulating pump and deactivation, feed tap water and be cooled to below 20 ℃,, be converted into volume with homemade tape measure jar inner height, dispose according to the protein content liquid feeding, labor intensity is big, and automatization level is low, measures inaccurate.
Summary of the invention
This utility model is at the existing in prior technology problem, and a kind of technical scheme of human albumin's inactivation of virus circulation preservation and controlling equipment simple in structure, easy to use is provided.Use the equipment of this scheme can realize being rapidly heated and the Automatic Cycle insulation, again can fast cooling after being incubated the stipulated time, automaticity height, temperature control precision height.In addition, the rustless steel pot bottom is provided with electronic scale, can weigh automatically, and accurate measurement makes things convenient for dosing, has guaranteed the stable of product.Ensure the drug safety of blood products, reduced labor intensity, improved technical merit.
This utility model is realized by following technical measures:
A kind of human albumin's inactivation of virus circulation preservation and controlling equipment, comprise three layers of deactivation jar, its internal layer is the goods jar that holds goods of 316L material, the intermediate layer is the interlayer that holds homoiothermic recirculated water, skin is a heat-insulation layer, the interlayer bottom of three layers of deactivation jar is connected with pipe circle pump and temperature sensor one successively by pipeline, and with heater that is provided with electromagnetic valve and cooling heat exchanger company in parallel after, the pipeline by being provided with temperature sensor two is connected with the top of the interlayer of deactivation jar again.
The cooling heat exchanger also is connected with the coolant circulating pump.-15 ℃ of ethylene glycol coolant enter in the interlayer of three layers of deactivation jar through the coolant circulating pump.
The bottom and the electronic scale of three layers of deactivation jar are connected.Promptly three layers of deactivation jar are placed on the electronic scale.Described electronic scale is 1.5 tons of electronic scales.
Enter interlayer after the recirculated water heater via heating in three layers of deactivation jar interlayer, substituted the water bath of prior art, realized being rapidly heated and the Automatic Cycle insulation; What the cooling heat exchanger substituted prior art enters the operation of stainless cylinder of steel interlayer cooling with tap water, and heat exchanger effectiveness is fast, temperature retention time to after can be in 30 minutes jar in temperature reduce to 10 ℃ by 60 ℃; Electronic scale has substituted former homemade scale metering, and weighing precision is 0.0001Kg (ten thousand/), and machine is handled the volume that calculates the stock solution preparation automatically as calculated.
In the actual production, before starting heating system, three layers of deactivation jar are carried out cleaning-sterilizing, after bacterial endotoxin test meets the requirements, the electronic scale zero clearing, the albumen for the treatment of inactivation of viruses is pumped in the interior laminate jar of deactivation jar, Weighing is according to the protein concentration of measuring, be formulated into the production normal concentration, start heater, in interlayer, send into insulation recirculated water, timing when rising to 59.5 ℃ to a jar interior product temperature, at 60 ± 0.5 ℃, after heat treated was finished in 10 hours, stop heating, the insulation recirculated water in the interlayer is discharged in heater.Restart the coolant circulating pump, and then drive the work of cooling heat exchanger, in interlayer, send into-15 ℃ of ethylene glycol, make products temperature reduce to the regulation requirement rapidly.
The beneficial effects of the utility model can be learnt according to the narration to such scheme; the described human albumin's inactivation of virus of this programme circulation preservation and controlling equipment; can realize being rapidly heated and the Automatic Cycle insulation; again can fast cooling after being incubated the stipulated time; rate of cooling is fast; the automaticity height, the temperature control precision height can have been protected inactivation of virus again the biological activity of goods in required time.In addition, the rustless steel pot bottom is provided with electronic scale, can weigh automatically, and accurate measurement makes things convenient for dosing, has guaranteed the stable of product.Ensure the drug safety of blood products, reduced labor intensity, improved technical merit.
Description of drawings
Fig. 1 is a structural representation of the present utility model.
The specific embodiment
For clearly demonstrating the technical characterstic of this programme,, and, this programme is set forth in conjunction with its accompanying drawing below by a specific embodiment.
As shown in Figure 1, a kind of human albumin's inactivation of virus circulation preservation and controlling equipment comprises three layers of deactivation jar 1, and its internal layer is the goods jar that holds goods of 316L material, is used to hold human blood albumin products.The intermediate layer is the interlayer that holds homoiothermic recirculated water, and skin is a heat-insulation layer.The interlayer bottom of three layers of deactivation jar 1 is connected with pipe circle pump 2 and temperature sensor 1 successively by pipeline, and after in parallel with the heater 5 that is provided with electromagnetic valve 4 and cooling heat exchanger 6, the pipeline by being provided with temperature sensor 27 is connected with the top of the interlayer of deactivation jar 1 again.
Three layers of deactivation jar 1 pier are placed on 1.5 tons of electronic scales 9.
Enter interlayer after recirculated water heater via 5 heating in three layers of deactivation jar 1 interlayer, substituted the water bath of prior art, realized being rapidly heated and the Automatic Cycle insulation; What cooling heat exchanger 6 substituted prior aries enters the operation of stainless cylinder of steel interlayer cooling with tap water, and heat exchanger effectiveness is fast, temperature retention time to after can be in 30 minutes jar in temperature reduce to 10 ℃ by 60 ℃; Electronic scale 9 has substituted former homemade scale metering, and weighing precision is 0.0001Kg (ten thousand/), and machine is handled the volume that calculates the stock solution preparation automatically as calculated.
Work process of the present utility model is, before starting heating system, the deactivation jar is carried out cleaning-sterilizing, after bacterial endotoxin test meets the requirements, the electronic scale zero clearing pumps into deactivation jar, Weighing with the albumen for the treatment of inactivation of viruses, according to the protein concentration of measuring, be formulated into predetermined weight, start heating system, timing when rising to 59.5 ℃ to a jar interior product temperature, at 60 ± 0.5 ℃, after heat treated was finished in 10 hours, stop heating, restart the coolant circulating pump, send into-15 ℃ of ethylene glycol in the interlayer, make products temperature reduce to the regulation requirement rapidly.
Claims (4)
1. human albumin's inactivation of virus circulation preservation and controlling equipment, comprise three layers of deactivation jar (1), its internal layer is the goods jar that holds goods of 316L material, the intermediate layer is the interlayer that holds homoiothermic recirculated water, skin is a heat-insulation layer, it is characterized in that: the interlayer bottom of three layers of deactivation jar (1) is connected with pipe circle pump (2) and temperature sensor one (3) successively by pipeline, and with after heater that is provided with electromagnetic valve (4) (5) and cooling heat exchanger (6) are in parallel, the pipeline by being provided with temperature sensor two (7) is connected with the top of the interlayer of deactivation jar (1) again.
2. human albumin's inactivation of virus circulation preservation and controlling equipment as claimed in claim 1 is characterized in that: cooling heat exchanger (6) also is connected with coolant circulating pump (8).
3. human albumin's inactivation of virus circulation preservation and controlling equipment as claimed in claim 1 is characterized in that: three layers of deactivation jar (1) bottom is connected with electronic scale (9).
4, human albumin's inactivation of virus circulation preservation and controlling equipment as claimed in claim 3, it is characterized in that: described electronic scale (9) is 1.5 tons of electronic scales.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008200257171U CN201168226Y (en) | 2008-07-16 | 2008-07-16 | Cyclic heat-preserving control appliance for virus inactivation of human blood albumin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2008200257171U CN201168226Y (en) | 2008-07-16 | 2008-07-16 | Cyclic heat-preserving control appliance for virus inactivation of human blood albumin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201168226Y true CN201168226Y (en) | 2008-12-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2008200257171U Expired - Lifetime CN201168226Y (en) | 2008-07-16 | 2008-07-16 | Cyclic heat-preserving control appliance for virus inactivation of human blood albumin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201168226Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800875A (en) * | 2015-04-24 | 2015-07-29 | 江南大学 | Biological vaccine inactivation device and control method |
| CN114306659A (en) * | 2022-01-04 | 2022-04-12 | 深圳市卫光生物制品股份有限公司 | Full-automatic temperature control fixed tank type globulin inactivation device and use method |
-
2008
- 2008-07-16 CN CNU2008200257171U patent/CN201168226Y/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800875A (en) * | 2015-04-24 | 2015-07-29 | 江南大学 | Biological vaccine inactivation device and control method |
| CN114306659A (en) * | 2022-01-04 | 2022-04-12 | 深圳市卫光生物制品股份有限公司 | Full-automatic temperature control fixed tank type globulin inactivation device and use method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20081224 |