CN201139762Y - Medicinal partial film coating rubber plug - Google Patents
Medicinal partial film coating rubber plug Download PDFInfo
- Publication number
- CN201139762Y CN201139762Y CNU2007200870344U CN200720087034U CN201139762Y CN 201139762 Y CN201139762 Y CN 201139762Y CN U2007200870344 U CNU2007200870344 U CN U2007200870344U CN 200720087034 U CN200720087034 U CN 200720087034U CN 201139762 Y CN201139762 Y CN 201139762Y
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- rubber plug
- plug
- film
- medicine
- rubber
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- Expired - Lifetime
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Abstract
A theriacal partial film coating rubber plug is structurally characterized in that the surface, on which the rubber plug is contacted with medicine, is deposited and coated with a layer of even paint film of a polychlor chloro paraxylene film, the theriacal film coating rubber plug is made of native rubber, isoprene rubber, and halogenated butyl rubber. Through the paint film of the polychlor chloro paraxylene film, the theriacal local film coating rubber plug separates the rubber plug from the medicine and liquid medicine, thereby avoiding the mutual pervasion and infiltration, lowering the particulate pollution, protecting the stability of the medicine, meeting the compatibility requirement of the rubber plug and the medicine, and having very reliable biological security and stability. The existing medical rubber plug field is widened, and the single butyl rubber plug is widened to be a native rubber, an isoprene rubber plug, and a halogenated butyl rubber plug.
Description
Technical field
This utility model relates to a kind of medicinal coating film plug, is specifically related to a kind of local film capsule of protecting the polychlorostyrene of medicine stability for the xylol film.This plug is applicable to aqueous injection, injectable powder, injection, lyophilized formulations medicine.
Background technology
The practice of butyl rubber plug process more than ten years, its reliable biological property, the good air-tightness energy, stable chemical properties obtains the generally acknowledged of the world of medicine, and butyl rubber plug has obtained swift and violent development in the world, has replaced the plug that natural gum is made in recent years at home.
After using, the butylation plug also found some problems, particularly to the injectable powder example hydrochloric acid cefotiam of some chemistry and biological activity sensitivity; The infusion preparation that number acid alkalescence is stronger is as sodium bicarbonate injection, formula mannitol injection liquid etc.; The infusion preparation of composition complexity such as Chinese medicine injection.Use butyl rubber bung still not satisfy the turbidity and the clarity requirement of medicine, i.e. the compatibility of butyl rubber plug and these medicines requires defective.
Therefore need a kind of novel plug to overcome the shortcoming of above-mentioned butyl rubber plug.For this reason, carried out extensive work both at home and abroad.As sticking one deck dacron membrane on the plug surface, or at capsule forming simultaneously at surface recombination one deck poly tetrafluoroethylene.Paste dacron membrane and need manual operations, loaded down with trivial details, increased the chance of human body to medicine pollution; Ptfe composite film production complex process, plug cost height costs an arm and a leg, and inconvenience is promoted the use of, and is difficult to be implemented in complex-shaped plug (as lyophilizing class plug) surface recombination poly tetrafluoroethylene.
Summary of the invention
The purpose of this utility model is to provide a kind of production technology simple, and cost is low, can keep stability of drug products, safe medicinal coating film plug.
The purpose of this utility model is achieved in that a kind of medicinal coating film plug, comprises plug 1, and the surface deposition coating layer of even polychlorostyrene that contacts with medicine at plug 1 films 2 for the xylol film.Described medicinal coating film plug 1 material is natural rubber or isoprene rubber or halogenated butyl rubber.
The medicinal coating film plug that this utility model provides has the following advantages:
(1) polychlorostyrene is kept apart plug and medicine, medicinal liquid for the xylol membrane coat, avoids phase counterdiffusion and infiltration, reduces particle contamination, and the protection medicine stability satisfies plug and medicine compatibility requirement, has biological safety and biological stability very reliably.
(2) polychlorostyrene is for xylol film cross-linked structure Heat stability is good, coating and plug combined strength bination height.
(3) can be implemented in complex-shaped plug, be coated with application layer as the surface deposition of lyophilizing class plug.
(4) the medicinal coating film plug is cheap relatively than other overlay film plug cost, and moderate cost is convenient to promote the use of.
(5) on the film capsule without any lubricant, can not discharge any lubriation material to liquid medicine as silicone oil, reduce its surperficial particulate matter, stop the generation of " hang pearl " phenomenon.
(6) widened existing medical rubber stopper field, widened by single butyl rubber plug and be natural plug, isoprene plug, halogenated butyl rubber plug.
Description of drawings
The utility model is described in further detail below in conjunction with drawings and Examples.
Fig. 1 is a structural representation of the present utility model.
The specific embodiment
Concrete structure of the present utility model is: a kind of medicinal coating film plug, comprise plug 1, and the surface deposition coating layer of even polychlorostyrene that contacts with medicine at plug 1 films 2 for the xylol film.Described medicinal coating film plug 1 material is natural rubber, isoprene rubber, halogenated butyl rubber.
Production method of the present utility model is as follows: through pretreatment, adopt infusion method with solvent the stain and the lubricating oil on plug surface to be removed in type plug 1, or adopt method for suppersonic cleaning that the stain and the lubricating oil on plug surface are removed.
Plug after the surface preparation 1 is fixed on the coating anchor clamps, is positioned over then in the coating device, through deposition coating one deck local film 2.
This utility model adopts vacuum chemistry vapour deposition (CVD) technology, dichloro two xylol are chloro xylol monomer through distillation, Pintsch process, to plug 1 diffusion into the surface absorption, intermolecular being cross-linked with each other " growth " forms solid-state polychlorostyrene for xylol thin film 2 to chloro xylol monomer under vacuum condition.The position of filming is the surface that plug 1 contacts with medicine, and 2 thickness of filming are 1～10 μ m.
Claims (2)
1, a kind of medical local film capsule comprises plug (1), it is characterized in that, the surface deposition that contacts with medicine at plug (1) applies film (2) of layer of even polychlorostyrene for the xylol film.
2, medical local film capsule according to claim 1 is characterized in that, described medicinal coating film plug (1) material is natural rubber or isoprene rubber or halogenated butyl rubber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200870344U CN201139762Y (en) | 2007-09-19 | 2007-09-19 | Medicinal partial film coating rubber plug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200870344U CN201139762Y (en) | 2007-09-19 | 2007-09-19 | Medicinal partial film coating rubber plug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201139762Y true CN201139762Y (en) | 2008-10-29 |
Family
ID=40067481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007200870344U Expired - Lifetime CN201139762Y (en) | 2007-09-19 | 2007-09-19 | Medicinal partial film coating rubber plug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201139762Y (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670400A (en) * | 2012-04-26 | 2012-09-19 | 深圳致君制药有限公司 | Pharmaceutical packaging composition for injection and preparation method thereof |
| CN103271822A (en) * | 2013-05-22 | 2013-09-04 | 盛州橡塑胶（苏州）有限公司 | Seamless laminated rubber plug and preparation method thereof |
| CN105254945A (en) * | 2015-10-20 | 2016-01-20 | 苏州蔻美新材料有限公司 | Medical antibiotic bottle plug and preparation method thereof |
-
2007
- 2007-09-19 CN CNU2007200870344U patent/CN201139762Y/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670400A (en) * | 2012-04-26 | 2012-09-19 | 深圳致君制药有限公司 | Pharmaceutical packaging composition for injection and preparation method thereof |
| CN103271822A (en) * | 2013-05-22 | 2013-09-04 | 盛州橡塑胶（苏州）有限公司 | Seamless laminated rubber plug and preparation method thereof |
| CN105254945A (en) * | 2015-10-20 | 2016-01-20 | 苏州蔻美新材料有限公司 | Medical antibiotic bottle plug and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20081029 |
|
| CX01 | Expiry of patent term |