CN201131740Y

CN201131740Y - Tumor diagnosis instrument

Info

Publication number: CN201131740Y
Application number: CNU2007200328191U
Authority: CN
Inventors: 王怡刚; 李强; 崔建东
Original assignee: SHAANXI CHAOQIANG MEDICAL TECHNOLOGY Co Ltd
Current assignee: SHAANXI CHAOQIANG MEDICAL TECHNOLOGY Co Ltd
Priority date: 2007-09-20
Filing date: 2007-09-20
Publication date: 2008-10-15
Anticipated expiration: 2017-09-20

Abstract

The utility model relates to a tumor diagnostic apparatus. At present, no matter surgical pathology diagnosis or tumor pathology diagnosis, the diagnoses are all made according to the clinical menifetations, operation findings, naked eye change and characteristics under the light microscope synthetically; sometimes the confirmed diagnosis can be made by combining the immunohistochemistry, the flow cytometry, the automatic image analysis and the ultrastructure, even the follow-up results. The tumor diagnostic equipment of the utility model comprises a probe device and a current sampling, filtering, amplifying and processing module, the probe device is a columned electronic chemical battery, the columned and electronic chemical battery is provided with a core conductor, an inner conductor, an inner insulating body, an outer conductor and an outer insulating body along the radial direction from the inner side to the outer side in sequence; the inner conductor and the outer conductor are respectively connected with a conducting wire output; the core conductor adopts electronic battery material with electrons, which can generate potential difference with cations in the tumor cell, and micro-current signals are formed, thus the tumor cell can be detected. The change of the cell division speed in 7 days can be detected by the tumor diagnostic apparatus, the premonitory symptoms of the canceration can be discovered promptly, and the early treatment time can be obtained.

Description

The diagnosing tumor instrument

Technical field

This utility model relates to a kind of for the good pernicious equipment of clinical accurate quick diagnosis tumor, is specifically a kind ofly can discern sodium ions content diagnosing tumor instrument in the tumor molecule.

Background technology

The good pernicious diagnosis of tumor mainly is to rely on pathological diagnosis at present, relies on the pathological analysis to active somatic cell, mainly relies on the experience and the judgement of diagnostician, and pathology are reason, regularity of occurrence and development and the form thereof of study of disease, a science of changes of function.The diagnosis pathology are pathological important branch, and its main purpose is that disease is made correct pathological diagnosis, thereby prevention of disease, treatment and prognosis judgement provide reliable form foundation.

Along with the development of medical science and related discipline, new inspection means are also more and more many, as: B ultrasonic, various endoscope, C T, nuclear magnetic resonance, NMR and various seroimmunity, biochemistry detection etc., to the also corresponding raising of the diagnostic level of various disease.However, in most of the cases, palpation is disconnected really finally to determine disease, also will rely on the diagnosis pathology, and is particularly all the more so to diagnosing tumor.

Diagnosing tumor is the pathological core work of diagnosis, how to accomplish that early diagnosis is the problem that numerous doctors and patient are concerned about most naturally, also is one of difficult point of diagnosing tumor.But still there is not a kind of simple and effective method of early diagnosis at present.No matter be surgical pathology or oncological pathology diagnosis, all make according to characteristic synthetic under clinical manifestation, surgical findings, naked eyes variation and the light microscopic.Sometimes need the binding immunoassay histochemistry, flow cytometry, automatic image analysis, ultrastructure, even Follow-up results just can make a definite diagnosis, thus be a diagnosis subject that relies on experience accumulation, along with continuous practice and summing up experience could progressively improve.Pathology are divided into histopathology and cytopathology two large divisions usually.Pathological diagnosis not only can be judged good, pernicious its prognosis of tumor, and the more important thing is to treatment provides reliable foundation.But pathological diagnosis also has limitation, and because of its biopsy specimen, megasoma are drawn materials and cut sections for microscopic examination all belong to sampling check, what finally see under the light mirror only is the minimum part of pathological changes, can not replace whole pathological changes sometimes; Whether pathological diagnosis is reliable also relevant with choosing of Pathologic specimen in addition; The result that false cloudy natural instincts is also arranged sometimes.To clinical diagnosis and the pathological diagnosis person of not being inconsistent, should in time check pathological diagnosis, if pathological diagnosis is definitely errorless, can consider whether choosing of Pathologic specimen be proper.Again draw materials in case of necessity, do pathological diagnosis once more.If extract specimen in operation, patient also will bear anesthesia, oxygen supply, the blood transfusion expense of waiting in the pathological diagnosis process, and the risk of side effect and life.

The utility model content

The purpose of this utility model be to provide a kind of clinically can be fast, the accurate diagnosing tumor instrument of diagnosing tumour cell.

In order to achieve the above object, the technical solution adopted in the utility model is:

The diagnosing tumor instrument comprises probe apparatus and current sample, filtering, amplification, processing module, it is characterized in that: described probe apparatus comprises probe and is connected lead; Described probe is columned electron chemistry battery, and it radially sets gradually core conductor, inner wire, interior insulator, outer conductor and outer insulator from inside to outside; Inner wire is connected lead output respectively with outer conductor; Described core conductor adopts the battery material of charged son, and it can produce potential difference with the cation in the tumor cell, forms little current signal.

Above-mentioned columned electron chemistry battery is the miniature electro-chemical cell of millicoulomb human relations level.

Above-mentioned columned probe diameter is 2 millimeters, and wherein the diameter of core conductor is 0.4 millimeter, and the thickness of inner wire is 0.3 millimeter, and the thickness of interior insulator is 0.1 millimeter, and the thickness of outer conductor is that the thickness of 0.3 millimeter and outer insulator is 0.1 millimeter.

It is magnesium that above-mentioned core conductor adopts the battery material of charged son, lithium.

Above-mentioned connection lead adopts the constant-resistance lead.

Above-mentioned little current signal is processed into identification signal by current sample, filtering, amplification, processing module.

Utilization tumor electronic diagnosis apparatus, can in seconds detect a Deformation structure is a malignant tumor.Reference value can if there is not reference value, also can be effective to the measured value of Deformation structure detecting in the tissue healthily.By the malignant change of timely, the rapid finder soma of tumor electronic diagnosis apparatus, provide reliable basis to diagnosing tumor, treatment.Its major advantage and function are as follows:

1, earlier detection

Tumor cell transfers the pernicious process that is by quantitative change to qualitative change to by optimum, and in this process, subhealth state cell division speed is constantly accelerated and is converted into malignant cell.The maximum characteristics of tumor electronic diagnosis apparatus are exactly to detect the variation with interior cell division speed in 7 days, find that in time carninomatosis becomes tendency, for the early treatment gains time.

2, auxiliary detection in the operation

The tumor electronic diagnosis apparatus can be in operation process in real time multiple spot detect, can clear and definite tumor-infiltrated scope and lymph metastasis situation, and can obtain testing result fast, help to formulate, revise the operative treatment scheme.

3, therapeutic effect is followed the tracks of

Tumor patient operation back chemicotherapy is an important step of oncotherapy.Traditional detection method judges whether best the need waited for for 6 weeks to therapeutic scheme, the diagnosing tumor instrument can be observed therapeutic effect at chemicotherapy after 4 days, scheme is effectively treated, when sodium ion level can fall back to the peak 15%～20%, near the normal value level, show that the malignant cell split speed reduces, the tumor diffusion is inhibited.Otherwise then should consider to adjust therapeutic scheme.

4, promote clinical basic

It is the standard of formulating according to relevant rationale that tumor electronic diagnosis apparatus pair cell sodium ion detects, for tumor basic research and screening antitumor drug provide new means.

Description of drawings

Fig. 1 is an overall structure principle schematic of the present utility model;

Fig. 2 is a probe transverse cross sectional view of the present utility model;

Fig. 3 is a probe longitudinal profile view of the present utility model.

The specific embodiment

Referring to Fig. 1, Fig. 1 is overall structure principle schematic of the present utility model; This utility model is by probe apparatus 1, and current sample, filtering, amplification, processing module 2 constitute; Probe apparatus 1 is the information collector of check system, and by detecting specimen, the information of collection shows identification signal by display 3 after handling by current sample, filtering, amplification, processing module 2 again.

Referring to Fig. 2, Fig. 3, Fig. 2 are probe transverse cross sectional view of the present utility model; Fig. 3 is a probe longitudinal profile view of the present utility model;

The electron chemistry battery that probe 1 of the present utility model is a columned sealing (the miniature electro-chemical cell of millicoulomb human relations level), it radially sets gradually core conductor 3, inner wire 4, interior insulator 5, outer conductor 6 and outer insulator 7 from inside to outside, its columned probe diameter is 2 millimeters, wherein the diameter of core conductor 3 is 0.4 millimeter, the thickness of inner wire 4 is 0.3 millimeter, the thickness of interior insulator 5 is 0.1 millimeter, and the thickness of outer conductor 6 is that the thickness of 0.3 millimeter and outer insulator 7 is 0.1 millimeter; Inner wire 4 is connected lead 2 outputs respectively with outer conductor 6; Described core conductor 3 adopts the battery material of charged son, and it can produce potential difference with the cation in the tumor cell, forms little current signal.Its core conductor 3 adopts charged sub-magnesium, battery materials such as lithium; For easy to detect, check that probe 1 adopts the constant-resistance leads with the lead 2 that is connected between current sample, filtering, amplification, the processing module 8, its resistance value is constant, check pop one's head in and pick-up between, form good impedance matching.Because it also is constant to the attenuation of electric current for constant resistance, got rid of the distortion in little current information transmission; Checking impedance matching between probe and the pick-up simultaneously, also helping carrying out the digital current signal and amplify.The length of constant-resistance value lead and the resistance value of material are by direct relation, and therefore, constant-resistance value lead and probe correspondence also are disposable.Little current signal is processed into identification signal by current sample, filtering, amplification, processing module 2 and display.

Check that probe 1 comprises tumor tissue surface and tangent plane by probe at the detection position, patient's own control is promptly with organ normal structure and peripheral lymph node.When probe electrode and cells contacting, intracellular cation (positive charge) and interior electronics (negative charge) the generation potential difference of probe minicell form little electric current.Check that probe is the information collector of check system, its effect is to produce little electric current with cells contacting, and requirement is highly sensitive, and the minicell reference potential is accurate.Prove by experiment: probe can be measured slicer or the tissue that removes, even corpse cell tissue is measured.If a stripped organization material is put in the wet container (jar of sealing as a wetted gauze of the non-distilled water of usefulness), even after exsomatizing several hours, still can be obtained typical measured value.Probe is that this probe also can be used for the endoscope of flexibility or rigidity by the blunt nosed cell tissue of checking flexibly.Another kind of type is the pin type electrode that is used for checking deep tissues.It in addition can in operation process, pass skin and cicatrix.Check that probe only measures the cell that directly contacts with detecting head surface, fluid etc., need put in all surfaces of popping one's head in from suitable angle with soft pressure.When just touching tissue surface or pulling out probe, produce a rapid peak point current sometimes, and can reduce rapidly, this is owing to the electrochemistry reason causes.It is just passable that inspection only needs to consider to obtain 3～10 seconds stationary values.Tumor under a cloud is an example, should be with actively it and check.Usually check at its edge or its pedicle of having grown.According to investigation statistics, malignant tumor is measured usually between 30～60 microamperes.To somatoblast, normal cell, inflammatory cells, ulcer cell, undue growth cell and benign tumor measurement at a slow speed, generation is lower than 20 microamperes value usually.If locate to measure 2～3 millimeters of normal structure middle distance borderline tumors, will obtain normal result, exist owing to have tumor cell below the normal cell, so select the position of inspection extremely important.Also have some in particular cases, may influence electric current and raise.As: with laser evaporation or the electrotherapy cutter cut agglomerative tissue surface, in a few days, also can produce very high electric current.The pus flow liquid also produces higher electric current, can solve by absorption, scrub surfaces.During special circumstances, can solve and remedy, improve the accuracy of diagnosis with relative measures.Probe is disposable.The minicell electric weight can run out because work; According to hygienic knowledge, plastics (probe and lead outer package) material reuses after can not being sterilized.

Current sample, filtering, amplification, processing module 8 constitute its pick-up by pick-up, digital current amplifier, computer etc.: be that high fidelity is accepted current signal, and deliver to amplifier and amplify.Its requirement is an impedance matching, sensitivity, fidelity height.The digital current amplifier: by multistage amplification, filtering, little current signal that inspection is obtained is amplified to can be known more and analysis can provide how fractionated basic data.Computer (pathological analysis software): by setting up the pathology mathematical model, lot of data and corresponding inspection data compare computing, make the inspection diagnosis report.

By diagnosing tumor instrument equipment, particularly check the whole independent research productions of probe, reduce diagnosing tumor list example expense, play effect energetically for promoting diagnosing tumor.

The above, it only is preferred embodiment of the present utility model, be not that this utility model is done any pro forma restriction, every foundation technical spirit of the present utility model all still belongs in the scope of technical solutions of the utility model any simple modification, equivalent variations and modification that above embodiment did.

Claims

1, diagnosing tumor instrument comprises probe apparatus and current sample, filtering, amplification, processing module, it is characterized in that: described probe apparatus comprises probe (1) and is connected lead (2); Described probe (1) is columned electron chemistry battery, and it radially sets gradually core conductor (3), inner wire (4), interior insulator (5), outer conductor (6) and outer insulator (7) from inside to outside; Inner wire (4) is connected lead (2) output respectively with outer conductor (6); Described core conductor (3) adopts the battery material of charged son, and it can produce potential difference with the cation in the tumor cell, forms little current signal.

2, diagnosing tumor instrument according to claim 1 is characterized in that: described columned electron chemistry battery is the miniature electro-chemical cell of millicoulomb human relations level.

3, diagnosing tumor instrument according to claim 1 and 2, it is characterized in that: described columned probe diameter is 2 millimeters, wherein the diameter of core conductor (3) is 0.4 millimeter, the thickness of inner wire (4) is 0.3 millimeter, the thickness of interior insulator (5) is 0.1 millimeter, the thickness of outer conductor (6) is 0.3 millimeter, and the thickness of outer insulator (7) is 0.1 millimeter.

4, diagnosing tumor instrument according to claim 1 and 2 is characterized in that: it is magnesium that described core conductor (3) adopts the battery material of charged son, lithium.

5, diagnosing tumor instrument according to claim 1 and 2 is characterized in that: described connection lead (2) adopts the constant-resistance lead.

6, diagnosing tumor instrument according to claim 1 and 2 is characterized in that: described little current signal is processed into identification signal by current sample, filtering, amplification, processing module (8).