CN201022992Y - Axial pressure high performance liquid chromatographic column - Google Patents
Axial pressure high performance liquid chromatographic column Download PDFInfo
- Publication number
- CN201022992Y CN201022992Y CNU2007200791107U CN200720079110U CN201022992Y CN 201022992 Y CN201022992 Y CN 201022992Y CN U2007200791107 U CNU2007200791107 U CN U2007200791107U CN 200720079110 U CN200720079110 U CN 200720079110U CN 201022992 Y CN201022992 Y CN 201022992Y
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- China
- Prior art keywords
- column jecket
- pressurization
- push rod
- sector gear
- performance liquid
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- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
A high performance liquid chromatography post with axial pressurization belongs to the chromatography system device of repeatable filling high efficiency absorption material, in particular to the chromatography post with axial pressurization. The utility model comprises an upper cover, a post tube and a lower cover, wherein the upper cover comprises a screw cover and a pressure post tube. A centre shaft of the screw cover is connected with a centre hole on the upper portion of the pressure post tube, and is pin connected with a small segment gear inside the pressure post tube. The small segment gear is engaged with a big segment gear inside the pressure post tube, the rotation direction changes 90 degrees, and the rotating centre shaft of the big segment gear is engaged with a push rod of which the lower portion is connected with a pressure disk, when screwing the screw cover, the high efficiency absorption material is capable of being pressured by a pressure disk continuously.
Description
Technical field
The utility model relates to the hplc chromatography post that can repeat to load efficient adsorption stuffing, relate in particular to loam cake can implement axial pressure the hplc chromatography post.
Background technology
The liquid chromatogram isolation technics is mainly used in the separation of various ingredients material, and will realize efficiently separating purpose, must utilize efficient adsorption stuffing, and adopts the mode of high pressure to make efficient adsorption stuffing give play to best result from efficient.Domestic designed performance liquid chromatographic column at present, basically all be the fixing lower flange mode that goes up, adsorption stuffing self fails to be subjected to continue high pressure, particularly at the efficient adsorption stuffing of particle diameter less than 50um, filler self fails to be subjected to continue high pressure, be difficult to keep continuing closely realizing its efficient separating power, even some utilizes the high-pressure homogenization infusion pump to load efficient sorbing material, but fixing last lower flange can't pressurize, in the use, the filled column bed is easy to subside, and causes post to be imitated reducing rapidly and can't use for a long time.
Summary of the invention
The purpose of this utility model provides a kind of high performance liquid chromatography chromatographic column, can satisfy the purpose of efficient adsorption stuffing continuous compression.
Design of the present utility model is: utilize the low-speed gear transmission to realize axial pressure.Thereby utilize the difference of wheel shaft diameter and the gear drive of the different numbers of teeth to underspeed.
Structure of the present utility model is: axial pressure high performance liquid chromatography chromatographic column, comprise loam cake 1, column jecket 2 and lower cover 3 compositions, it is characterized in that: loam cake 1 is made up of pressurization column jecket 4 and spiral cover 5, the axis 6 of spiral cover 5 is connected with the centre bore rolling bearing on pressurization column jecket 4 tops, little sector gear 7 pin joints in axis 6 and the pressurization column jecket 4, the diameter of little sector gear (7) is greater than the diameter of axis (6); Can rotate freely between spiral cover 5 and the pressurization column jecket 4 like this.
Middle part in the pressurization column jecket 4 is along laterally being provided with a turning cylinder 8, and the two ends of turning cylinder 8 are rotationally connected with the inner tubal wall of pressurization column jecket 4, and the middle part of turning cylinder 8 is provided with tooth, and the tooth on the push rod 9 of turning cylinder 8 and vertical direction is meshing mutually.The bottom of push rod 9 is connected with the center of platen 10, the top of push rod 9 and the fixed disk 11 slip sockets that are fixed on pressurization column jecket 4 inwalls, and the platen 10 that push rod 9 is connected by the bottom and the fixed disk 11 on top are fixed in the pressurization column jecket 4, can only move up and down.Pressurization column jecket 4 is identical with the internal diameter of column jecket 2, and two pipes become the screw thread socket, and platen 10 slip cap closely is connected in column jecket 2 or the pressurization column jecket 4, rotates turning cylinder 8 platen 10 is moved up and down in pressurization column jecket 4 and column jecket 2.Push rod 9 can make half-cylindrical or triangular prism shaped or other can with turning cylinder 8 mutual meshing shapes.
Turning cylinder 8 is connected with the center fixation of big sector gear 12 perpendicular to it, big sector gear 12 is connected with little sector gear 7 teeth at an angle to each other, make big or small sector gear rotation direction orthogonal, little sector gear 7 is 1 with the gear ratio of big sector gear 12: 5-20.
Be provided with through hole 14 from top to down in the axis 6 of described spiral cover 5, push rod 9, the platen 10.Be provided with drainage tube 13 in the through hole 14.
The utility model was in using process, at first lower cover 3 is threaded with column jecket 2, and in solvent pipe of lower cover 3 outlet connections, column jecket 2 is upright, pour the adsorption stuffing homogenate for preparing into column jecket 2 then, with vavuum pump liquid is extracted out from lower cover 3, up to exposing the filler upper epidermis, implant platen 10 then, be connected with solvent pipe 13 on the platen 10, loam cake 1 is screwed on column jecket 2.The turn spiral cover, the little sector 7 of pin joint rotates the big sector gear that will drive vertical direction and rotates 12 on the axis 6 of spiral cover 5, the turning cylinder 8 of big sector gear 12 drives and pressurizes with 9 pairs of platens 10 of its mutually meshing push rod, promote 10 pairs of adsorption stuffings of platen and pressurize, reach predetermined pressure limit and promptly can use.Take in the use liquid from top to bottom pass-through mode separate, if in the use because filled column is loosening to be caused post to be imitated reducing, the turn spiral cover promotes platen filled column is pressurizeed once more, recovers the purpose that post is imitated thereby reach.
Advantage of the present utility model: can guarantee that long its of filler continues efficient separating power, reduce use cost, efficient quick isolate required product.
Description of drawings
Fig. 1 is the structural representation of axial pressure high performance liquid chromatography chromatographic column;
Fig. 2 is the be slidingly connected structural representation of push rod of fixed disk;
Fig. 3 is the be slidingly connected structural representation of push rod of fixed disk;
1 is loam cake, the 2nd among the figure, column jecket, the 3rd, lower cover, the 4th, pressurization column jecket, the 5th, spiral cover, the 6th, axis, the 7th, little sector gear, the 8th, turning cylinder, the 9th, push rod, the 10th, platen, the 11st, fixed disk, the 12nd, big sector gear, the 13rd, drainage tube.
The specific embodiment
Embodiment 1
As depicted in figs. 1 and 2, axial pressure high performance liquid chromatography chromatographic column comprises column jecket 2, loam cake 1 and the lower cover 3 of a both ends open.Lower cover 3 is connected with the lower thread of column jecket 2.Loam cake 1 comprises spiral cover 5 and pressurization column jecket 4, and column jecket 2, pressurization column jecket 4 are identical with the internal diameter of lower cover 3; Pressurization column jecket 4 lower openings, top sealing and center are porose, and the axis 6 of spiral cover 5 is rotationally connected with the centre bore on pressurization column jecket 4 tops, little sector gear 7 pin joints in axis 6 and the pressurization column jecket 4; The sidewall middle part of pressurization column jecket 4 has the hole, turning cylinder 8 passes the center fixation connection that this Kong Bingyu establishes the big sector gear in the compression leg pipe 4, turning cylinder 8 is along pressurization column jecket 4 interior diameter directions, and the inwall of two ends and pressurization column jecket 4 is rotationally connected, to pressurize the then hole at sidewall middle part of column jecket 4 is blocked, and there is tooth at turning cylinder 8 middle parts; The lower end of one half-cylindrical push rod 9 is connected with the center fixation of platen 10, supporting being slidingly connected in hole on the other end and the fixed disk 11 that is located in the pressurization column jecket 4, and push rod 9 diametral planes are provided with tooth and meshing mutually with the tooth at turning cylinder 8 middle parts; Big sector gear 12 is meshing mutually with little sector gear 7, and rotation direction changes 90 degree, and little sector gear 7 is 1: 5 with the gear ratio of big sector gear 12.Be provided with through hole 14 from top to down in the axis 6 of spiral cover 5, push rod 9, the platen 10, drainage tube 13 passes through hole 14 and inserts in the column jecket 2.The lower open end screw thread of the pressurization column jecket 4 of loam cake 1 is spun on the column jecket 2, and turn spiral cover 5 just can be realized purpose of the present invention.
As shown in figures 1 and 3, compare with embodiment 1, difference is that the little sector gear 7 and the gear ratio of big sector gear 12 are 1: 10, and push rod 9 is triangular prism shaped.
As shown in figures 1 and 3, compare with embodiment 1, difference is that the little sector gear 7 and the gear ratio of big sector gear 12 are 1: 20, and push rod 9 is triangular prism shaped.
Claims (4)
1. axial pressure high performance liquid chromatography chromatographic column, comprise loam cake (1), column jecket (2) and lower cover (3), it is characterized in that: loam cake (1) is made up of pressurization column jecket (4) and spiral cover (5), the axis (6) of spiral cover (5) is rotationally connected with the centre bore on pressurization column jecket (4) top, axis (6) and interior little sector gear (7) pin joint of pressurization column jecket (4); Pressurization column jecket (4) is identical with the internal diameter of column jecket (2);
The middle part is along laterally being provided with a turning cylinder (8) in the pressurization column jecket (4), the two ends of turning cylinder (8) are rotationally connected with the inner tubal wall of pressurization column jecket (4), turning cylinder (8) is meshing with the push rod (9) of vertical direction, the bottom of push rod (9) is connected with the center of platen (10), the socket of closely sliding of top and fixed disk (11) the slip socket that is fixed on pressurization column jecket (4) inwall, the inwall of platen (10) and pressurization column jecket (4);
Turning cylinder (8) is connected with the center fixation of big sector gear (12) perpendicular to it, and big sector gear (12) and little sector gear (7) tooth that matches is connected;
Be provided with through hole (14) from top to down in the axis (6) of described spiral cover (5), push rod (9), the platen (10).
2. axial pressure high performance liquid chromatography chromatographic column according to claim 1 is characterized in that: the diameter of little sector gear (7) is greater than the diameter of axis (6).
3. axial pressure high performance liquid chromatography chromatographic column according to claim 1 is characterized in that: push rod (9) is for half-cylindrical.
4. axial pressure high performance liquid chromatography chromatographic column according to claim 1 is characterized in that: push rod (9) is for triangular prism shaped.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200791107U CN201022992Y (en) | 2007-04-13 | 2007-04-13 | Axial pressure high performance liquid chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2007200791107U CN201022992Y (en) | 2007-04-13 | 2007-04-13 | Axial pressure high performance liquid chromatographic column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201022992Y true CN201022992Y (en) | 2008-02-20 |
Family
ID=39096847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2007200791107U Expired - Lifetime CN201022992Y (en) | 2007-04-13 | 2007-04-13 | Axial pressure high performance liquid chromatographic column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201022992Y (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822914A (en) * | 2010-04-23 | 2010-09-08 | 聊城万合工业制造有限公司 | High-efficiency liquid-phase preparation device of axial pressurizing chromatographic column |
| CN102131559A (en) * | 2008-08-27 | 2011-07-20 | 通用电气医疗集团生物科学生物方法公司 | A system and method for manufacturing bed supports for chromatography columns |
| CN102713600A (en) * | 2010-01-28 | 2012-10-03 | 通用电气健康护理生物科学股份公司 | Column for liquid chromatography |
| CN106267901A (en) * | 2016-08-31 | 2017-01-04 | 朱小琼 | Adjustable resin column |
| CN106267900A (en) * | 2016-08-31 | 2017-01-04 | 朱小琼 | Resin column device |
| CN106345144A (en) * | 2016-08-31 | 2017-01-25 | 朱小琼 | Resin column with adjustable resin compactness |
| CN106345143A (en) * | 2016-08-31 | 2017-01-25 | 朱小琼 | Automatic separation device |
| CN106362436A (en) * | 2016-08-31 | 2017-02-01 | 朱小琼 | Separator based on controller |
| CN106390516A (en) * | 2016-08-31 | 2017-02-15 | 朱小琼 | Intelligent separation device |
| CN110393947A (en) * | 2019-09-04 | 2019-11-01 | 广东省生物工程研究所（广州甘蔗糖业研究所） | A kind of preparation method of chromatography column apparatus and chromatographic column |
-
2007
- 2007-04-13 CN CNU2007200791107U patent/CN201022992Y/en not_active Expired - Lifetime
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102131559A (en) * | 2008-08-27 | 2011-07-20 | 通用电气医疗集团生物科学生物方法公司 | A system and method for manufacturing bed supports for chromatography columns |
| US8713783B2 (en) | 2008-08-27 | 2014-05-06 | Ge Healthcare Bio-Sciences Corp. | System and method for manufacturing bed supports for chromatography columns |
| CN102713600A (en) * | 2010-01-28 | 2012-10-03 | 通用电气健康护理生物科学股份公司 | Column for liquid chromatography |
| CN102713600B (en) * | 2010-01-28 | 2014-10-01 | 通用电气健康护理生物科学股份公司 | Column for liquid chromatography |
| CN101822914A (en) * | 2010-04-23 | 2010-09-08 | 聊城万合工业制造有限公司 | High-efficiency liquid-phase preparation device of axial pressurizing chromatographic column |
| CN106345143A (en) * | 2016-08-31 | 2017-01-25 | 朱小琼 | Automatic separation device |
| CN106267900A (en) * | 2016-08-31 | 2017-01-04 | 朱小琼 | Resin column device |
| CN106345144A (en) * | 2016-08-31 | 2017-01-25 | 朱小琼 | Resin column with adjustable resin compactness |
| CN106267901A (en) * | 2016-08-31 | 2017-01-04 | 朱小琼 | Adjustable resin column |
| CN106362436A (en) * | 2016-08-31 | 2017-02-01 | 朱小琼 | Separator based on controller |
| CN106390516A (en) * | 2016-08-31 | 2017-02-15 | 朱小琼 | Intelligent separation device |
| CN106362436B (en) * | 2016-08-31 | 2018-09-18 | 朱小琼 | Separator based on controller |
| CN106345144B (en) * | 2016-08-31 | 2018-12-07 | 朱小琼 | The resin column of adjustable resin compactness |
| CN106345143B (en) * | 2016-08-31 | 2019-01-01 | 靳琦 | The separator of automation |
| CN106267900B (en) * | 2016-08-31 | 2019-04-12 | 靳琦 | Resin column device |
| CN110393947A (en) * | 2019-09-04 | 2019-11-01 | 广东省生物工程研究所（广州甘蔗糖业研究所） | A kind of preparation method of chromatography column apparatus and chromatographic column |
| CN110393947B (en) * | 2019-09-04 | 2024-03-26 | 广东省生物工程研究所（广州甘蔗糖业研究所） | Chromatographic column device and preparation method of chromatographic column |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: 610000 Sichuan city of Chengdu province Wuhou District Wuhou New Town Road No. 8 West two CMC Vuko Patentee after: CHENGDU PUSH BIO-TECHNOLOGY CO., LTD. Address before: 610045 Sichuan city of Chengdu province Wuhou District Vuko East Road 9 No. 2 of three Patentee before: Pusi Biological Science & Technology Co., Ltd., Chengdu |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20080220 |