CN200980675Y - Improved portable percutaneous conductive electrode device - Google Patents
Improved portable percutaneous conductive electrode device Download PDFInfo
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- CN200980675Y CN200980675Y CN 200620118081 CN200620118081U CN200980675Y CN 200980675 Y CN200980675 Y CN 200980675Y CN 200620118081 CN200620118081 CN 200620118081 CN 200620118081 U CN200620118081 U CN 200620118081U CN 200980675 Y CN200980675 Y CN 200980675Y
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Abstract
A modified portable percutaneous-conduct electrode assembly comprises a power, a power connection foot, a cost-type probe, an ionosphere, a semi-permeable membrane, medicine storage and reaction space and an inner covering. The utility model contacts with organism surface, capable of analyzing oil soluble molecules leaded in by ion or water soluble molecules leaded out by ion, and two or more than two utility models, with oil emulsifiable paste or element medicament form and alternate current power, can be used for increasing ion leading-in ratio of the oil soluble molecules. The medicine storage and reaction space is provided with a sensing assembly for measuring which comprises agglutinant molecules, dextran and nanometer noble metal particles or the like and forms a photoelectric biochemical sensor for the purposes of leading-out water soluble glucose molecules via ion and real-time analyzing. The utility model is capable of achieving aims of sending oil soluble medicine with electric property into skin and doing real-time detection of glucose of organism.
Description
Technical field
This utility model relates to a kind of improved Portable percutaneous conductive electrode means, being particularly related to a kind ofly can provide the voltage of different-effect and electric current iontophoresis and let-off gear(stand) to electrode assemblie according to application target, electrode assemblie can combine with medicine oil emulsifiable paste dosage form or photoelectricity biochemical sensor, accurately measures the body fluid glucose to reach oily soluble drug percutaneous transmission or persistence.
Background technology
(ISBN 0721601464 according to Dorland ' s Illustrated Medical Dictionary, Saunders, Published June 2003) is defined as for iontophoresis (iontophoresis): " ion that sees through electric current introducing soluble salts enters bodily tissue to reach the purpose of treatment ", that is utilize the voltage principle, via just, the effect of anion exchange, medicament is advanced in the skin from external guiding, just impose the polarity electrolemma at the organism skin surface, to have identical electrical medicament, as: allow vitamin C, phosphate, A acid Ju acid etc., the principle of utilizing the same sex to repel each other pushes the treatment of skin surface or the method for relief of symptoms.With regard to definition, traditional iontophoresis has two features: the one, and its purpose is " treatment ", and two be that the medicament that imports must be ionizing, water miscible material.
Iontophoresis equipment promptly has been widely studied in early days and discloses from twentieth century.British patent the 410th in 1934 for example, promptly disclose a kind of iontophoresis device for No. 009, as shown in Figure 1, in order to overcome the disadvantage-promptly special low voltage requirements of the equipment known to the skill at that time, mean that sufferer need could accept iontophoresis near this type of power supply, described British patent is with electrode and the combination of materials that contains medicine, import the necessary electric current of medicine then by a battery supplied, this mobile unit allows sufferer to accept medicine leading therapy under the less disturbed situation of daily life.Until the world of medicine recently to considerable interest of having of iontophoresis and relevant research and development, now as lidocaine hydrochloride, acetic acid, hydrocortisone, flouride, penicillin, dexamethasone sodium phosphate and a lot of other medicines mode that all can see through the skin surface introducing reach the effect of treatment.This fact has reflected that also " introducing ionizing, water miscible medicament to reach therapeutic effect " is still the main range of application of iontophoresis technology.
Though iontophoresis is the method that medical treatment is widely used, but be subjected to the restriction of auto levelizer and importing medicine, existing mode effect is limited always, and for example peroxide corpusculum hypertrophy activated receptor (peroxisomeproliferator-activated receptors is pointed out in research recently; PPARs) with its synergist (agonist) but transcriptional factors and controlling gene performance after the effect, further can influence the transcription factor of lipid and lipoprotein metabolism, blood glucose balance, adipose cell differentiation, arteriosclerosis early process and inflammatory response, it is very important medicine target, but the gamete (ligands) that comprises the various peroxide corpusculum hypertrophy activated receptors of its synergist all belongs to non-water-soluble polybasic unsaturated fatty acid form, even medical common steroid (steroids) water solublity is also atomic, all can't use the conventional ion gatherer and import.Promptly at the shortcoming of prior art, sustainability imports oily soluble drug through the skin surface to this utility model.
This utility model is also expanded the range of application of iontophoresis in addition, particularly utilize the homogeneity device to dispose a high sensitive photoelectricity biochemical sensor, to be used to detect the concentration that exports to the skin surface metabolite as high sensitive sampling system and at medicine storage reaction compartment.Though the 6th, 736, No. 777 exposure of United States Patent (USP) in 2004 comprise that an ion guide goes out automatic sampling system and one group of high sensitive electrochemica biological induction apparatus in that this side up, in order to the concentration of analyte in the detection of biological body body fluid.But the service life of this kind electrochemica biological induction apparatus is limited, must often upgrade every day when the patient uses.This utility model is that developing material goes out a kind of new device to contain the measurements such as (lectin) of agglutinin molecule with the long-acting photoelectricity biochemical sensor of sensing component, described device can combine single-mindedly and disengage the photoelectricity signal with glucose molecule, receive the photoelectricity signal by the luminosity induction device in the medicine storage reaction compartment.Add that this utility model is the corpse or other object for laboratory examination and chemical testing acquisition mode of full automatic Noninvasive, more than sustainable one week of use.
Summary of the invention
The purpose of this utility model is to provide a kind of improved Portable percutaneous conductive electrode means, can carry out iontophoresis oil-soluble medicine molecule or ion guide goes out water soluble molecules analysis according to medicine characteristic in the storage reaction compartment.Can be used as that water-insoluble medicine imports and the high sensitive sampling system is used to detect the application of the concentration that exports to the skin surface metabolite.In brief, this utility model is a percutaneous conduction technique Noninvasive, full automatic and device, comprises power supply, power pin, sacrifice type electrode, sheath, semipermeable membrane, a medicine storage reaction compartment and an inner liner.
To achieve these goals, this utility model provides a kind of improved Portable percutaneous conductive electrode means, it is characterized in that, comprise: power supply, it is defined as the portable power of powering in the direct current mode, and its outside links to each other with the inductance of ac-dc conversion filtering, is used to provide the electric current of alter polarity; Power pin joins with microprocessor, and it is defined as the usefulness as regulation and control exchange polar frequency, voltage and calculating; Sacrifice property electrode, it is connected with circuit mode with power supply and power pin, its material oxidation or the required voltage request that reduces should cause water showing electrolysis the time required voltage be low; Sheath, between sacrifice type electrode and semipermeable membrane, it contains the ions binding that can produce through electrochemical action with sacrifice type electrode, generate and can't dissolve or the reverse symmetry ion of electric neutrality end-product; Semipermeable membrane between sheath and medicine storage reaction compartment, is that polarity is selected material, can unidirectional permission in organism and the ion or the ion opposite with pharmaceutical electrode that come enter sheath; Medicine storage reaction compartment, between semipermeable membrane and inner liner, it contains medicine or photoelectricity biochemical sensor; This photoelectricity biochemical sensor comprises to measure uses sensing component; Measurement comprises dextran, nano noble metal particles, agglutinin molecule etc. with sensing component; An inner liner that is close to medicine storage reaction compartment has permeability to target medicine or material.
With conventional ion percutaneous conduction device relatively, this utility model has following several characteristics when carrying out ionic conduction specializing:
The commonly see CURRENT DISTRIBUTION assembly of device (as shown in Figure 1) of tradition mostly is anode and the negative electrode that the passivity material constitutes, but the electrolysis of inevitable water when carrying out ionic conduction, and the hydroxide ion of tart hydrion that it produced and alkalescence has zest to skin, not only user can't be worn for a long time, and the change of pH value can influence the wherein character of medicine in the medicine storage reaction compartment.And this utility model is to belong to the negative electrode or the anode (sacrificial cathodes or anodes) of sacrificing type giving the sufferer water-insoluble medicine or deriving water soluble molecules with the ionic conduction electrode that is adopted during further analyzing, and it respectively can oxidized or reduction.Owing to select material as the CURRENT DISTRIBUTION assembly, its oxidation or reduce required voltage request all than cause water showing electrolysis the time required voltage be low, use such sacrifice type electrode can avoid the electrolysis of water substantially as the CURRENT DISTRIBUTION assembly.For example, anode can use silver and negative electrode can adopt silver/silver chloride to be material.
Use at least one this utility model to contact,, also can use identical materials as CURRENT DISTRIBUTION assembly (for example silver/silver chloride) with when continuing the application of ionic conduction with organism surface.More specifically, this utility model can utilize microprocessor to adjust the flow direction of electric current, earlier with the specific direction power supply, again with polarity inversion (that is anode be transformed into negative electrode and negative electrode changes anode simultaneously into); Changing employed frequency setting is the following low frequency of 0.1Hz (conversion in per 10 seconds once), imports area or derives logistics capacity to increase potential medicine.The redox reaction that standard straight streaming electrode generally can take place as silver and silver chloride, wherein silver chloride becomes silver at cathode oxidation, silver changes silver chloride at anode, owing to the last of CURRENT DISTRIBUTION assembly exhausts therefore planting redox reaction, make and apply electric current for a long time and become problem, this utility model utilizes the method for alter polarity to design the AC type ion conducting electrode and allows reaction circulation back and forth, prolong the time that special electrodes may be used, can lower standard straight streaming short problem electrode life.
This utility model is used to import oil-soluble or water-insoluble medicine divides the period of the day from 11 p.m. to 1 a.m, can dispose oily emulsifiable paste composition dosage form (ointments) in medicine is stored reaction compartment.More specifically, oily emulsifiable paste composition dosage form with bio-compatibility includes but not limited to: (1) oiliness agent base (oleaginous base), as utilize white wax (white wax) and vaseline (petrolatum) heating for dissolving water-insoluble medicine fully to stir into the shape that condenses again; (2) absorbent base (absorption base), as fully stir into the shape that condenses with cholesterol (cholesterol) again after utilizing zinc oxide (zinc oxide), white wax, stearol aliphatic alcohol (stearyl alcohol), vaseline dissolving water-insoluble medicine; (3) water oil-containing emulsifier based (oil in water emulsion bases), as fully stir into emulsion with aqueous solution again after utilizing white wax, sperm oil (spermaceti), stearol aliphatic alcohol, vaseline dissolving water-insoluble medicine; (4) mix water preparation base (water miscible bases), as using glycerol (glycerin), monomethyl ether propylene glycol (propylene glycol) or polyvinyl alcohol (poly ethylene glycol; PEG) fully be mixed with water-insoluble medicine.
It is penetrating with the ion that allows to enter through circuit function in the organism medicine storage reaction compartment that the function of sheath of the present utility model and semipermeable membrane is a reverse symmetry ion (counter ions) that sacrifice type electrode is provided respectively.More specifically, because this utility model uses sacrifice type electrode as the CURRENT DISTRIBUTION assembly, on electrochemistry, must consider and stop the reverse symmetry ion in medicine storage reaction compartment to be not sufficient to stop (as silver electrode from the CURRENT DISTRIBUTION assembly; Ag) via ion that electrochemical action produced (as silver ion; Ag+) move to the unfavorable situation that medicine storage reaction compartment is interior, cause ionic soil, provide the reverse symmetry ion of capacity (as chloride ion so use with the joining sheath of sacrifice type electrode; Cl-) to solve the problem that sacrifice type electrode is faced.As for the semipermeable membrane between sheath and medicine storage reaction compartment then is that one deck polarity is selected material, can unidirectional permission in organism and the ion that comes (as sodium ion; Na+) enter sheath, and unlikely being piled up in the medicine storage reaction compartment increases resistance or with medicine unexpected reaction takes place.
When this utility model is used to measure the organism body fluid glucose,, can increase the acceptance of sufferer owing to belong to the sample mode of non-intrusion type.Particularly patient of diabetes blood glucose monitoring is must every day frequent measures consumption and the number of times that blood glucose could decide the kind of antidiabetic drug and dosage, insulin for several times according to measured data, use blood sugar control, even every day, seven times blood sugar test all was not enough to reflect the sufferer blood glucose value of every day.Use Noninvasive of the present utility model to gather organism body fluid corpse or other object for laboratory examination and chemical testing mode and can sample, increase sufferer detection number of times immediately, even sufferer also can detect in sleep, add that this utility model is that the number of full automatic sample mode and medicine storage reaction compartment can extend because of ac power supply method is unrestricted in theory, so more than one week of sustainable use.More specifically, medicine storage reaction compartment of the present utility model contains aforementioned measurement sensing component, wherein nano noble metal particles can connect with the mode of dextran (dextran) with covalent bond behind the sulphur compound modified, the concentration dependent reaction that cooperates agglutinin molecule and glucose monomer molecule, make the polymerization cluster of nano noble metal particles produce the color of the different depths, just the intensity of extinction can detect the concentration of glucose and changes according to it, further reaches highly sensitive body fluid glucose and measures.
Description of drawings
Fig. 1 is existing iontophoresis device construction sketch map;
Fig. 2 is the parts explosion of ionic conduction electrode assembly of the present utility model;
Fig. 3 is the sketch map that ionic conduction electrode assembly of the present utility model is used to import tool elecrtonegativity oil-soluble or water-insoluble medicine molecule;
Fig. 4 is that ionic conduction electrode assembly of the present utility model is used to derive the sketch map of the interior glucose monomer molecule of body to the photoelectricity biochemical sensor;
Fig. 5: A. is the configuration schematic diagram of photoelectricity biochemical sensor assembly of the present utility model in medicine storage reaction compartment.B. be photoelectricity biochemical sensor assembly of the present utility model and glucose monomer molecular action and carry out the sketch map that concentration amounts is surveyed.
Description of reference numerals: 11 decide the current DC power supply; 12 anodes; 13 negative electrodes; 14 medicine storage areas; 15 buffer storage areas; 16 organism epidermises; D+ water soluble ion chemical medicine thing; The A-anion; 21 upper stratas lid; 22 power pins; 24 sacrifice type electrodes; 25 sheaths; 26 semipermeable membranes; 27 medicines storage reaction compartment; 28 inner liners; 31 electronegative medicines or energising are electronegative medicine (positively charged medicine or energising positively charged medicine); D-elecrtonegativity water-insoluble medicine molecule; 41 photoelectricity biochemical sensors; 42 glucose monomer molecules; 51 agglutinin molecules; 52 nano noble metal particles; 53 sulphur compounds; 54 dextrans; 57 fixed wave length light source assemblies; 58 luminosity induction devices; 59 fixed wave length light beams.
The specific embodiment
Relevant detailed description of the present utility model and technology contents cooperate graphic being described as follows now:
This utility model provides a kind of improved Portable percutaneous conductive electrode means, sees also Fig. 2, is the major part exploded view of ionic conduction electrode assembly of the present utility model, and its particular content is as follows:
The power supply (not shown), it is defined as the portable power of powering in the direct current mode, and its outside must link to each other with the inductance (choking coil) of ac-dc conversion filtering, is used to provide the electric current of alter polarity;
Sacrifice property electrode 24, it is connected with circuit mode with power supply (not shown) and power pin 22, its material oxidation or the required voltage request that reduces should cause water showing electrolysis the time required voltage be low;
Medicine storage reaction compartment 27, between semipermeable membrane 26 and inner liner 28, it contains medicine or photoelectricity biochemical sensor and comprises to measure and use sensing component, and this measurement comprises dextran, nano noble metal particles, agglutinin molecule etc. with sensing component;
An inner liner 28 that is close to medicine storage reaction compartment 27 has permeability (permeable) to target medicine or material.
Assembling of the present utility model
This utility model has proposed a kind of method of assembling improvement type ionic conduction electrode assembly simultaneously, and its concrete steps are as follows:
Choose medicine or the material desired with iontophoresis and derivation;
The sensing component of described medicine or described material is added medicine storage reaction compartment 27, and permeability is arranged with medicine storage reaction compartment 27 next-door neighbours' 28 pairs of described medicines of inner liner or material;
Select suitable sacrifice type electrode 24 and sheath 25;
Choose desiring material with the opposite selective penetrating degree of material of the medicine of iontophoresis and derivation or material electric polarity as semipermeable membrane 26;
Be incorporated into sacrifice type electrode 24 on semipermeable membrane 26 sheath 25 that chooses and be fixed on medicine and store on the reaction compartment 27, make sheath 25 and semipermeable membrane 26 between sacrifice type electrode 24 and medicine storage reaction compartment 27;
(not shown in the figures and power pin 22 is connected with power supply.
This utility model is used to import the water-insoluble medicine molecule
Seeing also Fig. 3, is the sketch map that this utility model imports the water-insoluble medicine molecule.Because oily emulsifiable paste composition dosage form also often contains water (as adopting aforesaid water oil-containing emulsifier based or mixed water preparation base), how to avoid in the medicine water composition when the skin surface imports, to be produced the difficult problem that irritating hydrion of tool and hydroxide ion are the device designs always by electrolysis at ion.In order to overcome the defective of existing apparatus (seeing also Fig. 1), this utility model select its oxidation on the one hand or reduce required voltage request all than cause water showing electrolysis the time required voltage be low sacrifice type electrode; On the other hand, sheath 25 and semipermeable membrane 26 are combined in sacrifice type electrode 24, make the Ionized electrode material and interior and next unlikely being piled up in the medicine storage reaction compartment 27 of ion of organism that produce when continuing to use increase resistance or unexpected reaction take place with medicine.
The pattern that this utility model is specialized in the application of sheath 25 be water sample gel (hydrogel) thin layer include suitable salt or for can with the ion exchange resin or the chelating agen (chelating agent) of sacrifice type electrode 24 ions binding that electrochemical action produces.In addition, if sacrifice type electrode 24 when in device, be anode then the cation in the sheath 25 (or sacrifice type electrode 24 when in device, being negative electrode then the anion in the sheath 25) its mobility should be restricted in semipermeable membrane 26, for reaching this purpose, this utility model is selected the organic macromolecule ion as vitamin B1, B6 or tool bio-compatibilities such as citric acid and acetic acid.
This utility model has the speciality of high selectivity in the application of semipermeable membrane 26, its object lesson comprises: the selectivity permeable membrane of yin, yang ion selectivity permeable membrane and molecular size; The former is as made cation exchange permeable membrane of the made anion exchange permeable membrane of acryl ion transport polymer (acrylic ion-transfer polymer), styrene (styrene) or divinylbenzene (divinyl benzene), sulfonated polystyrene (sulfonated styrene polymer) or sulfonation fluorocarbon polymer (sul-fonated fluorocarbon polymer) etc., and the latter is then as dialyzer (dialysis membrane), Merlon perforated membrane (polycarbonate microporous membranes) etc.
This utility model is used to import the water soluble drug molecule
On the other hand, this utility model also can be applicable to the importing water-soluble substances, its specific step is as follows: if desire imports positively charged medicine [for example importing Dilauid (hydromorphone) anaesthetizes when treating], then the CURRENT DISTRIBUTION assembly of sacrifice type electrode 24 can use the oxidized material that is easy to as silver etc., and sheath 25 should contain can be with the silver ion effect and generate can't dissolve or the reverse symmetry ion of electric neutrality end-product (as chloride ion; Cl-, acetate ion; CH3COO-), sacrifice type electrode 24 (silver) promptly can be emitted silver ion after in a single day being with the power supply connection, but meeting of the chloride ion in the sheath 25 and silver ion effects form the heavy hall of insoluble silver chloride, and then the prevention silver ion enters in the medicine storage reaction compartment 27.
If desire imports electronegative medicine 31[and for example imports acetate ion and carry out muscle inflammation (myositis) when treatment], then the CURRENT DISTRIBUTION assembly of sacrifice type electrode 24 can use the material that is easy to be reduced as silver/silver chloride etc., and sheath 25 should contain can be with the chloride ion effect and generate can't dissolve or the reverse symmetry ion of electric neutrality end-product (as lead ion; Pb2+), sacrifice type electrode 24 (silver/silver chloride) promptly can be emitted chloride ion after in a single day being with the power supply connection, but meeting of the lead ion in the sheath 25 and chloride ion effect form the heavy hall of insoluble lead chloride, and then stop chloride ion to enter in the medicine storage reaction compartment 27.
This utility model is used to measure the organism body fluid glucose
Seeing also Fig. 4, is the sketch map that the mankind of the present utility model are used to measure the organism body fluid glucose.Use at least one improvement Portable percutaneous conductive electrode means of the present utility model to contact with the organism surface, when Alternating Current Power Supply continues to import as cationes such as sodium, hydrogen, cation in moving can be set up an electro-osmosis liquid (electroosmotic fluid) that penetrates epidermis, and the electric neutrality molecular flow that the mobile meeting of electro-osmosis liquid is being carried as glucose etc. goes out health, enters in the inner liner 28 that contacts with the health epidermis and the medicine storage reaction compartment 27.Medicine storage reaction compartment 27 contains conducting medium, with provide and skin between current potential or electric current.
In addition according to this utility model, a kind of device (seeing also Fig. 5) of measuring the concentration of analyte in the organism also is provided, and it comprises with lower member: dextran 54 connects with the nano noble metal particles 52, ionic conduction medium and the agglutinin molecule 51 that through sulphur compound 53 modified diameters are 5nm to 50nm in the mode of covalent bond.54 pairs of agglutinin molecules 51 of dextran that itself and nano noble metal particles 52 blend together one have suitable affinity, add that an agglutinin molecule 51 can combine with a plurality of glucose molecules, this characteristic makes an agglutinin molecule 51 in conjunction with last dextran-nano noble metal particles more than two or two; This can make nano noble metal particles 52 aggregate into the cluster shape, and produces a kind of specific redness.Yet when the existing of glucose monomer molecule 42, will and dextran-nano noble metal particles competition agglutinin molecule 51 on binding site, the two separates catalysis, makes the polymerization cluster of nano noble metal particles to form, and produces a kind of than weak color.And the red light intensity of this kind can detect the concentration of glucose monomer molecule 42 and change according to it, and the light absorption change amount of its generation can be in the 57 times interpretations of fixed wave length light source greater than 600nm, particularly 650nm.This high specificity pick off can be because of occurring influencing testing result as other human body fluid composition such as uric acid, vitamin C, analgesic or haemachrome in the corpse or other object for laboratory examination and chemical testing simultaneously.Especially very person, its sensitivity can reach below " mM (mM) ", is fit to very much the diabetes sufferer and detects concentration of glucose.
Above-mentioned embodiment given example only is for convenience of description, and the interest field that this utility model is advocated should be as the criterion so that claim is described certainly, but not only limits to the foregoing description.
Claims (10)
1. an improved Portable percutaneous conductive electrode means is characterized in that, comprising:
Power supply is the portable power of powering in the direct current mode, and its outside links to each other with the inductance of ac-dc conversion filtering;
Power pin joins with microprocessor, is the electronic building brick of regulation and control exchange polar frequency, voltage and calculating usefulness;
Sacrifice type electrode, it is connected with circuit mode with power supply and power pin, its material oxidation or the required voltage request that reduces should cause water showing electrolysis the time required voltage be low;
Sheath, between sacrifice type electrode and semipermeable membrane, it contains, and the ions binding, the generation that produce through electrochemical action with sacrifice type electrode can't be dissolved or the reverse symmetry ion of electric neutrality end-product;
Semipermeable membrane between sheath and medicine storage reaction compartment, is that polarity is selected material, and unidirectional permission is in organism and the ion or the ion opposite with pharmaceutical electrode that come enter sheath;
Medicine storage reaction compartment is between semipermeable membrane and inner liner;
An inner liner that is close to medicine storage reaction compartment has permeability to target medicine or material.
2. improved Portable percutaneous conductive electrode means as claimed in claim 1 is characterized in that: configuration is used to import the oily emulsifiable paste composition dosage form of oil-soluble or water-insoluble medicine molecule in medicine storage reaction compartment.
3. improved Portable percutaneous conductive electrode means as claimed in claim 1 is characterized in that: configuration is used to import the water-soluble components dosage form of water soluble drug molecule in medicine storage reaction compartment.
4. improved Portable percutaneous conductive electrode means as claimed in claim 1 is characterized in that: be provided with positively charged or energising positively charged medicine in the medicine storage reaction compartment.
5. improved Portable percutaneous conductive electrode means as claimed in claim 1 is characterized in that: be provided with electronegative in the medicine storage reaction compartment or switch on electronegative medicine.
6. improved Portable percutaneous conductive electrode means as claimed in claim 1 is characterized in that: configuration is used to derive the photoelectricity biochemical sensor that the organism substance in vivo is analyzed in medicine storage reaction compartment.
7. improved Portable percutaneous conductive electrode means as claimed in claim 6 is characterized in that: the wavelength of the fixed wave length light source of photoelectricity biochemical sensor wherein surpasses 600nm.
8. improved Portable percutaneous conductive electrode means as claimed in claim 6 is characterized in that: the photoelectricity biochemical sensor comprises the fixed wave length light source assembly that wavelength is surpassed 600nm and is assembled to medicine storage reaction compartment.
9. improved Portable percutaneous conductive electrode means as claimed in claim 6, it is characterized in that: the photoelectricity biochemical sensor comprises to measure uses sensing component, this measurement further comprises dextran, nano noble metal particles, agglutinin molecule with sensing component, is disposed in the medicine storage reaction compartment.
10. improved Portable percutaneous conductive electrode means as claimed in claim 9, it is characterized in that: the diameter of the nano noble metal particles that uses is 5nm to 50nm.
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| CN 200620118081 CN200980675Y (en) | 2006-06-14 | 2006-06-14 | Improved portable percutaneous conductive electrode device |
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| CN 200620118081 CN200980675Y (en) | 2006-06-14 | 2006-06-14 | Improved portable percutaneous conductive electrode device |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040513A (en) * | 2011-10-14 | 2013-04-17 | 巴奥米特制造公司 | Percutaneous plug for delivering power to implantable subcutaneous electrical socket |
| WO2016034291A1 (en) * | 2014-09-05 | 2016-03-10 | miha bodytec GmbH | Ems exercise device, as well as ems electrode, ems garment, ems pulse generating unit, ems signal cable, and ems undergarment for the exercise device, and method for operating an ems exercise device |
| US10300271B2 (en) | 2014-12-16 | 2019-05-28 | miha bodytec GmbH | EMS training device, and method for protecting an EMS training device |
| US10814123B2 (en) | 2014-12-18 | 2020-10-27 | miha bodytec GmbH | EMS stimulation current transmission element and EMS garment equipped with the EMS stimulation current transmission element |
| CN112203715A (en) * | 2018-06-11 | 2021-01-08 | 高露洁-棕榄公司 | Oral care device |
-
2006
- 2006-06-14 CN CN 200620118081 patent/CN200980675Y/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040513A (en) * | 2011-10-14 | 2013-04-17 | 巴奥米特制造公司 | Percutaneous plug for delivering power to implantable subcutaneous electrical socket |
| CN103040513B (en) * | 2011-10-14 | 2017-03-01 | 巴奥米特制造公司 | The subcutaneous electrical socket of implanted and percutaneous plug |
| WO2016034291A1 (en) * | 2014-09-05 | 2016-03-10 | miha bodytec GmbH | Ems exercise device, as well as ems electrode, ems garment, ems pulse generating unit, ems signal cable, and ems undergarment for the exercise device, and method for operating an ems exercise device |
| US10835736B2 (en) | 2014-09-05 | 2020-11-17 | miha bodytec GmbH | EMS exercise device, EMS electrode, EMS garment, EMS stimulus generating unit, EMS signal cable, and EMS undergarment for an EMS exercise device, and method for operating the EMS exercise device |
| US10300271B2 (en) | 2014-12-16 | 2019-05-28 | miha bodytec GmbH | EMS training device, and method for protecting an EMS training device |
| US10814123B2 (en) | 2014-12-18 | 2020-10-27 | miha bodytec GmbH | EMS stimulation current transmission element and EMS garment equipped with the EMS stimulation current transmission element |
| CN112203715A (en) * | 2018-06-11 | 2021-01-08 | 高露洁-棕榄公司 | Oral care device |
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