CN1993100A - Oral composition - Google Patents
Oral composition Download PDFInfo
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- CN1993100A CN1993100A CN 200580026177 CN200580026177A CN1993100A CN 1993100 A CN1993100 A CN 1993100A CN 200580026177 CN200580026177 CN 200580026177 CN 200580026177 A CN200580026177 A CN 200580026177A CN 1993100 A CN1993100 A CN 1993100A
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- visually
- metal salt
- clear
- divalent metal
- toothpaste composition
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Abstract
A visually clear gel toothpaste composition comprising a sparingly soluble divalent metal salt, characterised in that the sparingly soluble divalent metal salt is fully solubilised by a chelating agent for the metal salt, the chelating agent having a log Ks1 for the divalent metal ion as herein defined of from 3.0 to 7.0.
Description
The present invention relates to contain the gel toothpaste composition of the visually-clear of indissoluble divalent metal salt.The present invention also relates to prepare described method for compositions.
EP-A1-0 740 932 (Unilever) discloses the gel-type dentifrice of visually-clear, described dentifrice contain the zinc salt stronger than zinc citrate water solublity, can be in conjunction with the aminoacid and the low-refraction type abrasive silica of zinc.
In first aspect present invention, provide gel toothpaste composition according to the visually-clear of claim 1.
Divalent metal salt is well-known in this area as anti-dental plaque (plague) and the purposes of antimicrobial in dentifrice composition.Yet, because it makes light dispersion in the mode that only produces opaque compositions, so the divalent metal salt of indissoluble conflicts mutually with the gel dentifrice of visually-clear.
Have surprisingly been found that, the indissoluble divalent metal salt can be changed into the form of the gel dentifrice that is applicable to visually-clear according to dentifrice composition of the present invention.The indissoluble divalent metal salt dissolves fully by the chelating agen of this divalent metal salt, and described chelating agen has 3.0 to 7.0 logK in this definition
S1.
In a preferred embodiment of the invention, the indissoluble divalent metal is be selected from zinc, stannum (II) or copper (II) a kind of, and this divalent metal is more preferably zinc.Suitable zinc salt comprises zinc citrate, zinc lactate, zinc tartrate, zinc pyrophosphate and MALEIC ACID, ZINC SALT.Preferred zinc salt is a zinc citrate, in described preparation type, but described zinc citrate provide the enough biological utilisation zinc ion of preparation and can and the optimum balance of antibacterial between interacting, and do not damage the character of dentifrice composition visually-clear.Preferably, this divalent metal salt is by weight 0.01% to 5.0% of a said composition.
Log K
S1 is the logarithm of first stability constant, and described first stability constant is the ionic binding affinity of specific ligand and special metal.For example, when chelating agen is citrate and bivalent metal ion when being zinc, first stability constant is the binding affinity of a citrate ligand and free zinc ion, and as give a definition: K
S1=[ML]/[M] [L], wherein [ML] is the concentration of metal-ligand complex, [M] is the concentration of free metal ion, and [L] is the concentration of free ligand.Because because the required initial deprotonation effect of part, [L] is the function of pH value of solution, so at the described logK of pH 7.4 records
S1 value is as reference point.
In a preferred embodiment of the invention, the logK of chelating agen part and bivalent metal ion
S1 be equal to or greater than (more preferably greater than) logK of the bivalent metal ion of acidic anionic and indissoluble divalent metal salt
S1.Therefore, the extra ligand that is provided by chelating agen can be identical with the part of encirclement bivalent metal ion in the indissoluble divalent metal salt, and perhaps extra ligand may have than the initial higher affinity that part presented bivalent metal ion., the divalent metal salt with indissoluble is dissolved in the gel dentifrice of visually-clear a preferred back embodiment fully for decomposing also.
Chelating agen is by weight 0.001% to 6% of a said composition, is preferably by weight 0.1% to 4% of said composition.Be applicable to that chelating agen of the present invention comprises the alkali metal salt of citric acid, acetic acid, tartaric acid, maleic acid and pyrophosphoric acid.Citric acid most preferably.
Preferably be admixed in the said composition as alkali-metal citrate (for example potassium citrate or sodium citrate) excessive citrate contained.Potassium citrate most preferably is because it provides zinc citrate deliquescent optimum level when keeping zinc ion to be easy to biological utilisation.
The gel toothpaste composition of visually-clear also preferably comprises abrasive silica.This dentifrice composition preferably comprises by weight 2% to 20%, and more preferably 5% to 12% abrasive silica by weight.Can comprise Sorbosil AC series by the abrasive silica of the present invention that is applicable to that commercial sources obtains, for example provide varying level to grind Sorbosil AC77, Sorbosil AC39 and the Sorbosil AC35 of cleaning properties by the Crosfield supply.More preferably with refractive index 1.430 to 1.460, most preferably the Silicon stone in 1.440 to 1.450 scopes is used for according to toothpaste of the present invention.Sorbosil AC77 most preferably, because it provides outstanding cleaning and abrasive properties, and effective during reduced levels in said composition, thus the interests of consumer improved by reducing cost.
The method that can be used for estimating dentifrice composition visual clarity of the present invention comprises the use standard chart, and described standard chart is made up of the black symbols that varies in size on the white background.This be described in EP 0785169 by Graphic Arts Research Center, the RIT Alphanumeric Resolution TestObject that RochesterInstitute of Technology produces, RT 4-74 (Ineos Silicas Limited).By the ability of apparatus measures by the outturn sample distinguished symbol of standard thickness (1cm).From-12 to+13 with symbol number.Numeral is big more, more just, transparency is high more.For toothpaste according to the present invention, preferably be equal to or greater than 0 value.
Dentifrice composition of the present invention also preferably contains fluoride ion source, the alkali metal salt of fluoride for example, preferred fluorinated sodium.This class fluoride ion source will with provide 100 to 2000ppm, the amount of preferred 900 to 1500ppm free fluoride ion exists.
Dentifrice composition of the present invention preferably contains the preparation that is selected from anti-caries agent, anticalculus agent, anti-malodorant, brightener for tooth, gingivitis agent and composition thereof.
Contain the common constituent of this area in addition according to toothpaste of the present invention, for example:
Antimicrobial, hibitane for example, Sanguinarine extract, metronidazole, quaternary ammonium compound, for example cetylpyridinium chloride; Biguanide (bis-guanide), for example chlorhexidine digluconate, hexedine, Win-41464, Win-21904; And halogenation bisphenol compound, for example 2,2 ' di-2-ethylhexylphosphine oxide-(4-chloro-6-bromophenol);
Antiinflammatory, for example ibuprofen, flurbiprofen, aspirin, indometacin etc.;
Anti-caries agent, for example sodium fluoride and stannous fluoride, amine fluoride, sodium fluorophosphate, sodium trimetaphosphate and casein;
Dental plaque buffer agent, for example carbamide, calcium lactate, calcium glycerophosphate and polyacrylic acid strontium;
Vitamin, for example vitamin A, C and E;
Plant extract;
Desensitizer, for example potassium citrate, potassium chloride, Soluble tartar., potassium bicarbonate, potassium oxalate, potassium nitrate and strontium salt;
Anticalculus agent, for example alkali metal pyrophosphate salts, contain the polymer of hypophosphites (hypophosphite), Organophosphonate and phosphoric acid citrate (phosphocitrates) etc.;
Biomolecule, for example bacteriocin, antibody, enzyme etc.;
Flavorant, for example Oleum menthae and Oleum Menthae Rotundifoliae;
Protein material, for example collagen protein;
Antiseptic;
Opacifying agent;
Coloring agent;
The pH regulator agent;
Sweetener;
Pharmaceutically suitable carrier, for example starch, sucrose, water or water/pure system etc.;
Surfactant, for example anion, nonionic, cation and amphion or amphoteric surfactant;
The microgranule grinding-material, for example Silicon stone, aluminium oxide, calcium carbonate, dicalcium phosphate, calcium pyrophosphate, hydroxyapatite, trimetaphosphate, insoluble hexametaphosphate etc., comprise agglomerant microgranule grinding-material, be generally 3 to 60% the amount by weight of this oral care composition.Most preferred grinding agent is a Silicon stone.
Wetting agent, for example glycerol, Sorbitol, propylene glycol, xylitol, lactose etc.;
Binding agent and thickening agent, for example sodium carboxymethyl cellulose, hydroxyethyl-cellulose (Natrosol
), xanthan gum, Radix Acaciae senegalis etc., and synthetic polymer, for example polyacrylate and carbomer, for example Carbopol
Also can contain and to send the polymerizable compound of passing by enhanced activity composition (for example antimicrobial);
Cushion the pH of this oral care composition and the buffer agent and the salt of ionic strength; And
Other optional members that can comprise are for example bleach (for example per-compound, for example peroxidating diphosphonic acid potassium), effervescent system (for example sodium bicarbonate/citric acid system), color change system etc.
Also can use liposome to pass or stability to improve sending of active component.
Provide the method for visually-clear gel dentifrice of preparation first aspect in second aspect present invention, this method comprises
-divalent metal salt is dissolved in the water;
All the other mouth care compositions of-adding.
Dissolving step is preferably included in the water the indissoluble divalent metal salt and the chelating agen of metal ion that is enough to dissolve the appropriate amount of this divalent metal salt mixes.Complete dissolving appears at solution becomes when limpid.
The silica gel toothpastes of visually-clear generally has the pH in 5.5 to 7.0 scopes.Yet the visually-clear silica gel toothpastes that contains consoluet divalent metal salt if desired has higher pH (for example in 7.0 to 10.0 scopes), can add extra buffer agent.The preferred sodium hydroxide that adopts is increased to desirable value as buffer agent with the pH with said composition.
Preferably after dissolving fully and reach required pH, divalent metal salt adds wetting agent and antiseptic.Suitable wetting agent comprises Sorbitol.
Preferably after wetting agent, add Silicon stone, and mix until preparation even.More preferably abrasive silica is added with foaming agent, described foaming agent is preferably sodium laurylsulfate.More preferably these materials are progressively added to guarantee correct mixing.
Preferably after abrasive silica, add thickening agent, and mix until evenly and do not have an air.
To embodiment of the present invention be described by following non-limiting examples now.
Embodiment
Following example formulation is according to embodiment of the present invention.It prepares according to the following step:
1. Jiang Shui, three hydration zinc citrates, sodium hydroxide and potassium citrate place blender, and stirring is dissolved fully until three hydration zinc citrates.
2. Sorbitol, sweetener, sodium fluoride, colorant and polyalkylene glycol are added blender, and stir until dissolving fully.
3. with the premix drying of thickening Silicon stone and sodium carboxymethyl cellulose, and under vacuum, add blender.Stirring is until evenly.
4. with the premix drying of grinding agent and sodium laurylsulfate, and under vacuum, add blender.Stirring keeps vacuum to remove any air of carrying secretly until evenly simultaneously.
5. flavorant is added blender and stirring to finish this process.
| Composition | ％w/w |
| Abrasive silica | 8.0 |
| The thickening Silicon stone | 8.75 |
| Abrasive silica | 0.5 |
| Sweetener | 0.25 |
| Sodium laurylsulfate | 2.7 |
| Sodium carboxymethyl cellulose | 0.6 |
| (70%aq) Sorbitol | 65.0 |
| Three hydration zinc citrates | 0.5 |
| Potassium citrate | 0.5 |
| Sodium hydroxide | 0.015 |
| Colorant | 0.0165 |
| Colorant | 0.00077 |
| Sodium fluoride | 0.22 |
| Flavorant | 1.2 |
| Purify waste water | 9.74773 |
| Polyalkylene glycol | 2.0 |
Claims (13)
1. the gel toothpaste composition that contains the visually-clear of indissoluble divalent metal salt is characterized in that this indissoluble divalent metal salt dissolves fully by the chelating agen of this slaine, and described chelating agen has 3.0 to 7.0 the logK to bivalent metal ion in this definition
S1.
2. according to the gel toothpaste composition of the visually-clear of claim 1, the logK of wherein said chelating agen and bivalent metal ion
S1 is equal to or greater than the logK of the bivalent metal ion of acidic anionic and indissoluble divalent metal salt
S1.
3. according to the gel toothpaste composition of the visually-clear of claim 1, wherein said indissoluble divalent metal salt is selected from zinc, stannum (II) or copper (II) salt.
4. according to the gel toothpaste composition of the visually-clear of claim 1 or 2, wherein said indissoluble divalent metal salt is a zinc salt.
5. according to the gel toothpaste composition of the visually-clear of aforementioned any claim, wherein said indissoluble divalent metal salt is a zinc citrate.
6. according to the gel toothpaste composition of the visually-clear of aforementioned any claim, wherein said chelating agen is the alkali metal salt of acid, and described acid is selected from citric acid, acetic acid, tartaric acid or pyrophosphoric acid.
7. according to the gel toothpaste composition of the visually-clear of aforementioned any claim, wherein said chelating agen is the alkali metal salt of citric acid.
8. according to the gel toothpaste composition of the visually-clear of aforementioned any claim, wherein said alkali metal is selected from sodium or potassium.
9. according to the gel toothpaste composition of the visually-clear of aforementioned any claim, the alkali metal salt of wherein said citric acid is a potassium citrate.
10. according to the gel toothpaste composition of the visually-clear of aforementioned any claim, wherein said divalent metal salt is by weight 0.01% to 5.0% of a said composition.
11. according to the gel toothpaste composition of the visually-clear of aforementioned any claim, it contains abrasive silica.
12. according to the gel toothpaste composition of the visually-clear of aforementioned any claim, it comprises the preparation that is selected from anti-caries agent, anticalculus agent, anti-malodorant, brightener for tooth, gingivitis agent and composition thereof.
13. preparation is according to the method for the toothpaste of claim 1, it is included in the water indissoluble divalent metal salt is mixed with chelating agen, dissolve fully until this divalent metal salt, add remaining mouth care composition then, described chelating agen has 3.0 to 7.0 logK to this bivalent metal ion
S1.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04254662 | 2004-08-03 | ||
| EP04254661.4 | 2004-08-03 | ||
| EP04254662.2 | 2004-08-03 | ||
| EP04257064.8 | 2004-11-15 | ||
| EP04257063.0 | 2004-11-15 | ||
| EP05250131.9 | 2005-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1993100A true CN1993100A (en) | 2007-07-04 |
Family
ID=34930539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200580026168 Pending CN101027033A (en) | 2004-08-03 | 2005-07-13 | Oral cavity composition |
| CN 200580026177 Pending CN1993100A (en) | 2004-08-03 | 2005-07-13 | Oral composition |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200580026168 Pending CN101027033A (en) | 2004-08-03 | 2005-07-13 | Oral cavity composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN101027033A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103687650A (en) * | 2011-06-17 | 2014-03-26 | 高露洁-棕榄公司 | Oral care compositions |
| CN109890354A (en) * | 2016-10-24 | 2019-06-14 | 高露洁-棕榄公司 | Oral care composition and application method |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3436155B1 (en) * | 2016-03-31 | 2021-10-13 | Unilever Global IP Limited | Toothpaste composition |
-
2005
- 2005-07-13 CN CN 200580026168 patent/CN101027033A/en active Pending
- 2005-07-13 CN CN 200580026177 patent/CN1993100A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103687650A (en) * | 2011-06-17 | 2014-03-26 | 高露洁-棕榄公司 | Oral care compositions |
| CN109890354A (en) * | 2016-10-24 | 2019-06-14 | 高露洁-棕榄公司 | Oral care composition and application method |
| CN109890354B (en) * | 2016-10-24 | 2020-10-02 | 高露洁-棕榄公司 | Oral care compositions and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101027033A (en) | 2007-08-29 |
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Open date: 20070704 |