CN1965859A - Sodium selenite solution containing clustered water used for animal - Google Patents
Sodium selenite solution containing clustered water used for animal Download PDFInfo
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- CN1965859A CN1965859A CN 200510016146 CN200510016146A CN1965859A CN 1965859 A CN1965859 A CN 1965859A CN 200510016146 CN200510016146 CN 200510016146 CN 200510016146 A CN200510016146 A CN 200510016146A CN 1965859 A CN1965859 A CN 1965859A
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Abstract
The invention relates to a method for using sodium selenate to prepare wide-spectrum antibiosis solution, wherein it uses hexacyclic ring water as carrier that adds frozen hexacyclic ring water into sodium selenate solution, to reduce the volume of hydrone group, the viscosity and surface tension, to reduce the expand resistance and accelerate the drug release. The hexacyclic ring water has strong affinity with cell, to improve the treatment effect on animal bacterial and mycoplasma affection.
Description
Technical field
The invention belongs to the technical field of veterinary drug, relating to the sodium selenite is the Amitin thing that a kind of poultry of feedstock production are used, and is used for the treatment of disease such as poultry trace element deficiency and preparation method thereof.
Background technology
Water is most important composition in all biologies, and the general water content of organism is all more than 60%; Except that dry products, water content is all between 65%-90% in the food; We can say that water plays important effect in our life.Water has many special nature, causes people's attention in recent years.For example: introduced the water with six water clusters structures in magazine " Jiangxi chemical industry " fourth phase in 1997 the 34th page " water of the water mystery of life ", promptly so-called " clustered water " has sanatory function.
University Of Tianjin's journal the 33rd the 1st phase of volume of January in 2000 " six ring structures of water and to the influence of lysozyme thermal denaturation " that record is by theory analysis and experimental results show that six ring structures and the biological function thereof of water.Studies show that, water through low temperature is ultrasonic decide frequency spectrum and shake after, great majority are six rings and the existence of six cage type water clusters, this water plays an important role in bioprotein, nucleic acid, cell and organization activity; When the DSC method experiment showed, with clustered water hydration lysozyme, improved its hot antitypy ability.
" change of water clusters clustering architecture and biological effect thereof " that the chemistry circular fourth phase in 2004 is recorded summarized over nearly 30 years from the rock-steady structure that is found to water cluster of water clusters clustering architecture and the progress of correlation theory calculating; Four kinds of methods that change the water clusters clustering architecture have been summed up, comprise externally-applied magnetic field, extra electric field, laser emission and snead process, the mechanism of action of these four kinds of methods has been discussed respectively, after having introduced the water clusters clustering architecture and diminishing, act on organism, can produce multiple biological effect, aspect much, can improve the physiological function of organism.
Scientific research shows that water clusters is more little, and activity is big more, and this water drinks good more drinking, and vice versa.Many when experiment showed, the structure that changes water the physiological reaction to biology very big influence is arranged; Water with subset structure of five hydrones or six hydrones, promptly five rings water and clustered water have good facilitation to health.In the preparation technology of veterinary oral liquid, pure water is the most frequently used solvent at present, after soon tap water carries out certain water treatment, is used as the solvent of medicine.Yet scientific research shows, uses light water in the process that medicine is made, because the structure of hydrone can not be brought into play bioavailability of medicament to greatest extent.Yet clustered water can keep the stability of long period, for cell very strong affinity is arranged, and can significantly improve the curative effect of medicine, for the recovery of disease facilitation is faster arranged.
Water is a kind of special material, and it has a lot of functions.At first it is a kind of good solvent, and it contains O
2, CO
2Deng material, has different pH values.Therefore, can dissolve a lot of mineral, for human body is carried nutrition; Water body is again one " chemical fields ", wherein can carry out chemical reaction such as acid-base reaction, the redox reaction etc. of various complexity, simultaneously, can also dissolve, chemical action such as precipitation, decomposition, chemical combination, peptization, in the preparation technology of veterinary oral liquid, pure water is the most frequently used solvent.After soon tap water will carry out certain water treatment, as the solvent of medicine.In the process that medicine is made, use light water,, bioavailability of medicament can not be brought into play to greatest extent owing to reasons such as the structure of hydrone and arrangements thereof.
The molecular formula of known sodium selenite is Na
2SeO
3, molecular weight is 172.94.The character of this medicine is a white crystalline powder, and odorless is stable in the air, dissolves in water, and is insoluble in the ethanol again.Press dry product and calculate, contain Na
2SeO
3Must not be less than 97.0%.
Modern scientific research shows: can improve antigen titration degree to sheep red blood cell (SRBC) antigen or tetanus toxoid for the animal selenium supplement.The IgM and the immunoglobulin G that comprise higher level.Otherwise when animal lacked selenium, humoral immune reaction reduced, and comprised that the antigen titration degree reduces and the immunoreation time delay.In addition, selenium can also be offset the immunosuppressant that immunosuppressant causes.
If the drug main sodium selenite solution of at present relevant sodium selenite is with sodium selenite and the solution that the lyase configuration that suits forms, contain sodium selenite (Na
2SeO
3) should be 90.0%～110.0% of labelled amount.
The discrimination method of this medicine is: 1) aqueous solution of this product shows the identification of sodium salt (14 pages of " People's Republic of China's veterinary drug allusion quotation " 2000 editions appendix).
(2) get this product 1ml, add water 100ml, solution is yellow green, shows yellow green and intensive yellow-green fluorescence is arranged under transillumination.
PH value should be 8.0～10.0.(40 pages of " People's Republic of China's veterinary drug allusion quotation " 2000 editions appendix)
Content assaying method is as follows: get this product 10ml (being equivalent to sodium selenite 40mg approximately), the accurate title, decide, and puts in the 100ml measuring bottle, adds water to scale, shake well; Add active carbon 2g again, violent jolting filters, precision is measured filtrate 50ml, puts in the iodine flask, adds potassium iodide test solution 5ml, shake up, add chloroform 10ml again, hydrochloric acid (1-2) 5ml, shake up, close plug, placed 5 minutes the dark place, with sodium thiosulfate volumetric solution (0.05mol/l) titration, during near terminal point, add starch indicator 2ml, strong jolting 30 seconds continues titration and disappears to water layer is blue, and titration results is proofreaied and correct promptly with blank assay.Every 1ml sodium thiosulfate volumetric solution (0.05mol/L) is equivalent to the Na of 2.162mg
2SeO
3
The preparation technology of sodium selenite is:
1, quantitative weighing.
2, get 70 milliliters of purified water sodium selenite, edible blue pigment adding are stirred to whole dissolvings.
3, add purified water to full dose
4, be 8.0～10.0 with dilute sulfuric acid or sodium hydroxide solution adjust pH.
5, filter.
6, semi-finished product censorship is measured
7, certified products fill, loading amount 100 ± 1%.
8, package encapsulation inspection.
9, vanning packing.
Above-described sodium selenite solution existing preparation technology and the detection method of being exists problems such as rate of release is slow, bioavailability difference but have sodium selenite solution now.
Summary of the invention
The object of the present invention is to provide a kind of sodium selenite solution veterinary formulations that rate of release is fast, bioavailability is high that has with the clustered water preparation.
In order to achieve the above object, the invention provides the Amitin thing that a kind of poultry are used, comprise: clustered water is characterized in that with the clustered water be carrier with slightly soluble or the trace element that is dissolved in clustered water being active component, the Amitin thing that the preparation poultry are used.
The molecular formula of described sodium selenite is Na
2SeO
3, molecular weight is 172.94.The character of this medicine is a white crystalline powder, and odorless is stable in the air, dissolves in water, and is insoluble in the ethanol again.
It is characterized in that with the clustered water being the preparing carriers sodium selenite solution:
Described sodium selenite solution is characterized in that:
1, select for use the water (being pure water) of purification as former water, general commercially available qualified pure water, electrical conductivity gets final product less than 20 μ s/cm, leaves standstill after a few hours slowly freezingly, and rate of temperature fall is 2-5 ℃/h, freezing minimum temperature reaches-30～-50 ℃, make the water sufficient crystallising, then thaw again, its course of defrosting is carried out being lower than under 10 ℃, the water that dissolves is in time collected in the temperature environment that is stored in 4-10 ℃, promptly obtains clustered water;
2, quantitative weighing.Get 70 milliliters of clustered waters sodium selenite, edible blue pigment adding are stirred to whole dissolvings.
3, add clustered water to full dose
4, be 8.0～10.0 with dilute sulfuric acid or sodium hydroxide solution adjust pH.
5, filter.
6, semi-finished product censorship is measured
7, certified products fill, loading amount 100 ± 1%.
8, package encapsulation inspection.
9, vanning packing.
It is low that many evidences lack selenium animal body fluid immune level, to the susceptibility increase of disease.Animal serum antibody concentration, immunne response are descended low selenium daily ration and premunition significantly reduces.On the contrary, selenium supplement then can strengthen the humoral immunity of animal.Selenium pair cell immunologic function has potentiation.
The curative effect of medicine of the present invention is described with test below:
1 materials and methods
1.1 test drug
Sodium selenite clustered water solution is recommended agent 0.25ml/L water, drinking-water, main component sodium selenite; Control drug sodium selenite light water solution, composition and dosage are the same.
Experimental animal
200 AA mixing meat young birds, available from Tianjin side's big fowl industry company limited, go out to be transported in this laboratory pouity dwelling place behind the shell and raise in cages, Routine Management is fed to complete feed to 21 age in days, will test with healthy chicken to be divided into 4 groups, wherein 1 group is sodium selenite clustered water solution treatment group, 2 groups is the control drug group, 3 groups of positive matched groups (not treating matched group), 4 groups of negative matched groups (normal healthy controls group).
Except that negative control group, other test group are all to increase the hen house temperature with manual-induced heat stress
Table 1 test grouping
| Group | Test chicken number (only) | Test temperature | Medicine | Usage | Consumption | The beginning administration time | The medication natural law |
| 1 group 2 groups 3 groups 4 groups | 50 50 50 50 | 36℃±1℃ 36℃±1℃ 36℃±1℃ 36℃±1℃ | Sodium selenite clustered water group sodium selenite light water group nothing | Drinking-water drinking-water drinking-water drinking-water | 0.25ml/L 0.25ml/L 0 0 | Experiment beginning medication is the same the same | 5 5 5 5 |
1.3 curative effect determinate standard
1.3.1 the body weight of weightening finish every chicken during according to on-test and off-test is calculated the gain in weight of every chicken, calculates the average weight gain of every group of test chicken then in view of the above.The relative weight gain rate is to calculate by the ratio of each medication treatment group with the weightening finish of normal healthy controls group, and wherein normal healthy controls group chicken rate of body weight gain is made as 100%.
1.3.2 the consumption of feedstuff when expecting anharmonic ratio according to on-test and off-test, the utilization of calculating feedstuff, calculating material anharmonic ratio material anharmonic ratio then is the utilization of feedstuff and the ratio of weight increase amount.
1.3.3 lower limb flesh rate lower limb flesh/body weight * 100%
1.3.4 chest muscle rate chest muscle/body weight * 100%
2.3 result of the test (seeing Table 2)
Table 2 clinical trial
| Group | Food consumption (g) | Weightening finish (g) | The material anharmonic ratio | Lower limb flesh rate (%) | Chest muscle rate (%) |
| Negative control group positive controls clustered water group light water group | 1224.2 1180.6 1202.1 1200.0 | 456.8 415.7 445.2 432.9 | 2.68 2.84 2.68 2.71 | 11.8 9.9 11.6 11.3 | 8.9 8.1 8.8 8.5 |
The table of going up is arranged as can be seen, the lower limb flesh rate of clustered water group and chest muscle rate are apparently higher than the light water group, and the material anharmonic ratio also is lower than negative control group.As seen the curative effect of clustered water group obviously is better than the light water group.
Invention effect: under other condition same case, contain the purified water sodium selenite solution and compare with existing, in the clustered water filling sodium selenite solution with cryopreparation, the smaller volume of water cluster, the viscosity of corresponding water, surface tension etc. descend to some extent, the sodium selenite diffusional resistance is reduced, promote drug release, sodium selenite solution drug release rate and burst size all increase.Clustered water has very strong affinity for cell, and bioavailability is good, for the recovery of disease facilitation is faster arranged.
The specific embodiment
Embodiment 1:a, select for use the water (being pure water) of purification as former water, general commercially available qualified pure water, electrical conductivity gets final product less than 20 μ s/cm, leaves standstill after a few hours slowly freezingly, and rate of temperature fall is 2-5 ℃/h, freezing minimum temperature reaches-30～-50 ℃, make the water sufficient crystallising, then thaw again, its course of defrosting is carried out being lower than under 10 ℃, the water that dissolves is in time collected in the temperature environment that is stored in 4-10 ℃, promptly obtains clustered water;
B, quantitative weighing.Get 70 milliliters of clustered waters sodium selenite, edible blue pigment adding are stirred to whole dissolvings.
C, add clustered water to full dose
D, be 8.0～10.0 with dilute sulfuric acid or sodium hydroxide solution adjust pH.
E, filtration.
F, semi-finished product censorship are measured
G, certified products fill, loading amount 100 ± 1%.
H, package encapsulation inspection.
I, vanning packing.
Implement sharp 2: medicine of the present invention is that selenium replenishes medicine, can be used for preventing and treating diseases such as young stock white muscle disease and chickling exudative diathesis.Using method is for mixing drink, and consumption is a 0.25ml/L water, and logotype 3-5 days is a course of treatment.
Claims (3)
1, a kind of poultry trace element complementary medicine comprises: clustered water is characterized in that with the clustered water be carrier with slightly soluble or the antibacterials that are dissolved in clustered water being that active component prepares poultry trace element complementary medicine.
2, poultry trace element complementary medicine according to claim 1 comprises: clustered water, (molecular formula is Na to sodium selenite
2SeO
3, molecular weight is 172.94.The character of this medicine is a white crystalline powder, and odorless is stable in the air, dissolves in water, and is insoluble in the ethanol again.)
It is characterized in that with the clustered water being the preparing carriers sodium selenite solution.
3, sodium selenite solution according to claim 2 is characterized in that:
A, select the water of purification for use, be pure water as former water, general commercially available qualified pure water, electrical conductivity gets final product less than 20 μ s/cm, leave standstill after a few hours slowly freezing, rate of temperature fall is 2-5 ℃/h, and freezing minimum temperature reaches-30～-50 ℃, makes the water sufficient crystallising, then thaw again, its course of defrosting is carried out being lower than under 10 ℃, and the water that dissolves is in time collected in the temperature environment that is stored in 4-10 ℃, promptly obtains clustered water;
B, quantitative weighing.Get 70 milliliters of clustered waters sodium selenite, edible blue pigment adding are stirred to whole dissolvings.
C, add clustered water to full dose
D, be 8.0～10.0 with dilute sulfuric acid or sodium hydroxide solution adjust pH.
E, filtration.
F, semi-finished product censorship are measured
G, certified products fill, loading amount 100 ± 1%.
H, package encapsulation inspection.
I, vanning packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510016146 CN1965859A (en) | 2005-11-18 | 2005-11-18 | Sodium selenite solution containing clustered water used for animal |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510016146 CN1965859A (en) | 2005-11-18 | 2005-11-18 | Sodium selenite solution containing clustered water used for animal |
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| Publication Number | Publication Date |
|---|---|
| CN1965859A true CN1965859A (en) | 2007-05-23 |
Family
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|---|---|---|---|
| CN 200510016146 Pending CN1965859A (en) | 2005-11-18 | 2005-11-18 | Sodium selenite solution containing clustered water used for animal |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185642B (en) * | 2007-06-22 | 2012-02-29 | 彭秀兰 | Glucosamine lysine selenium salt and production process |
-
2005
- 2005-11-18 CN CN 200510016146 patent/CN1965859A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185642B (en) * | 2007-06-22 | 2012-02-29 | 彭秀兰 | Glucosamine lysine selenium salt and production process |
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