CN1957900B - Edible and medicinal anti-crinkle cosmetic of Chinese traditional medicine containing composite collagen, amino acid, and vitamin, and preparation method - Google Patents

Abstract

A product used as food or cosmetic for synthesizing collagen protein and supplying rich amino acids is prepared from hydrolytic collagen protein, amino acid composition, vitamin composition and Chinese-medicinal material composition. Its preparing process is also disclosed.

Description

Composition collagen, amino acid, vitamine Chinese medicine eatable resistant to crushing cosmetic and manufacture method

Technical field: the invention belongs to the foods and cosmetics field.

Background technology: the function of collagen protein is as mattress; can allow the tissue performance connect; buffering; functions such as protection; human body skin; skeleton; tooth; even collagen protein arranged all in the eyes; as seen it is all very broad to bodily fuctions's importance and influence surface; but the collagen content in the skin is more comparatively speaking; and and people generally pay attention to most; the most directly perceived; the also skin wrinkle that takes place at first; old and feeble (change) and aesthetic etc. in close relations; so being subjected to social each side shows great attention to and tool huge commercial opportunities and social benefit; all spare no effort to research and develop all kinds of Related products of production and marketing; especially increasing male adds the very huge women battle array of improving looks also as to without hesitationly; its market; economic benefit and repayment are all very surprising and flourishing long time; and constantly increase progressively with dramatic increase amplitude and speed, prospect is very tempting really.But take a broad view of all numerous Related products of market, conclude all similar, promptly mainly contain as collagen beverage, tablet, make up, products such as skin protection, not only it is theoretical and actual functional capability is all very limited, and the more tempting effect of being declared as " collagen protein that replenish to run off; recover skin elasticity " with its alluring advertisement speech as " be full of brilliance to you; the skin of elastic force; the collagen protein that excitation fiber blast cell hypertrophy is new and station youthful vigor " wait and differ extremely greatly different especially, reason is also very simple in fact: for for oral administration as above-mentioned market main product collagen beverage, tablet etc., its contained collagen protein has all resolved into the micromolecule product of having lost collagen protein and complete molecular structure and function through the digestion overwhelming majority, be again that general distributes after the absorption, transform and degraded, the collagen protein that can arrive skin at last is quite limited; The cosmetic that external is as above stated, products such as skin protection, because of collagen protein from the foreign body kind and be macromole, external not only is difficult to enter in a large number skin, especially deep skin such as skin corium, and be only here major decision collagen protein amount and the beauty treatment as water holding, water conservation and the key position of effect such as crease-resistant and performance, also easily cause allergy, and the collagen protein that can not enter skin in a large number and be deposited in skin surface is the excellent culture medium of microorganism, extremely sharp its swift and violent breeding also produces toxin, endanger skin on the contrary with physically and mentally healthy, and whether collagen protein can stimulate the new collagen protein of fibroblast hypertrophy " still have a question and deficiency is accepted and believed; even so nonetheless; the amount of its generation and hold time also inevitable extremely limited; because cell ageing and deterioration are inevitable; significantly descend as 30 years old later on synthetic proteic ability of collagen of human body; 20-30% approximately descends during than the peak, up to 60%, and the not anti-reflection of metabolic degradation speed of collagen protein increases content is further reduced in the time of 60 years old.

Goal of the invention: the present invention designs a kind of composition collagen, amino acid, vitamine Chinese medicine eatable resistant to crushing cosmetic and manufacture method for addressing the above problem exactly, and its cardinal principle and innovation are that advantage is as described below.

The synthesis capability of collagen protein with the age increase significantly descend, " unable to make ends meet " phenomenon that degraded but increases with the age and problem definition in the body the synthetic proteic prerequisite of collagen and prerequisite be will synthesize voluntarily earlier or the additional enough various amino acid starting materials of external source, could resist and have collagen protein and quicken the decrement problem with the age increase.So, though the micromolecule aminoacid that collagen protein digestion or hydrolysis produce has been lost the 26S Proteasome Structure and Function of collagen protein, but all be that composition requisite raw material of collagen protein and proportioning are also flawless, thereby realized the above-mentioned goal of the invention that remedies synthetic voluntarily insufficient collagen protein decrement and increase collagen protein synthesis and reserves with exogenous amino acid, the more important thing is and to prevent effectively that skin from quickening the problem that skin aging etc. is lost more than gain because of direct a large amount of and long-term external collagen protein may make self synthesizing amino acid and collagen protein ability further degenerate and form dependency, what this " eats what is mended " saying with the traditional Chinese medical science Sihe scientific basis part mutually, short because of being in one step of acid in the simple cycle of edman degradation Edman technology in addition, not only degraded is that the fast cost of speed of production is low, and is the micromolecule aminoacid that easily absorbs the nothing rejection because of product, thereby having solved external collagen molecules disaster in the lump absorbs and viral hidden danger, raw material sources and affinity and rejection allergy, resource guarantee and price, the enzyme hydrolysis cycle grows up to this high serial problem.Vitamin A directly promotes epithelium (skin) cell metabolism vigor, vitamin C activates the synthetic proteic hydroxylase of collagen and promotes collagen protein synthesis, its acidity still is good antibacterial and anti-corrosion additive, vitamin E is strengthened VC, the anti-oxidation efficacy of VA, Ministry of Public Health is ratified bright of legal dietotherapeutic Chinese medicine Radix Polygoni Multiflori, send out is the extension and the direct and indirect health status that indicates skin of skin, Chinese angelica blood supplementing, blood is capable to be root synthetic and metabolism, the Radix Rehmanniae Preparata the kidney invigorating, kidney is basis of marrow, Radix Glycyrrhizae Preparata warming middle-JIAO and harmonizing the spleen and stomach, taste are that vigour is material and energy source, these make essence, gas, blood is prosperous and powerful so skin-nourishing is supplied with and the metabolism abundance tonifying both YIN and YANG, replenishing essence marrow replenishing QI and blood.Multi-pronged formation benign cycle like this and effective aging resistance and having no side effect and contraindication, mouthfeel and color and luster are good, so no crowd's branch, adaptation is wide makes more crowds benefited.

Specific embodiments: product of the present invention is by hydrolytic collagen aminoacids complex 10-30 part; Compound vitamin 0.5-1 part, wherein VA0.1-0.3 part, VC10-15 part, VE0.5-1 part, other kind that above raw material adopts GB2760 or GB14880 approval to use should be converted by active substance; Compound Chinese medicine 1-3 part, wherein Radix Polygoni Multiflori 3-5 part, Radix Angelicae Sinensis 1.5-3 part, Radix Rehmanniae Preparata 3-5 part, Radix Glycyrrhizae Preparata 0.5-2 part are formed.

The manufacture method of product of the present invention:

The hydrochloric acid hydrolysis collagen protein will be directly adopted in the manufacturing of hydrolytic collagen aminoacids complex, (product Sal is harmless and concentration is very low need not specially dispel in the sodium hydroxide neutralization, and good and the dissolubility height is very easy removes in following process for separating and purifying because of dissolubility) amino acid hydrolyticsolution that is prepared from of the conventional processes well known method of hydrolyzed solution, also can further conventionally separate, the every kind of single amino acid of purifying, because of various, the collagen protein that comprises different plant species, its main amino acid residue kind (all only has seldom 5 kinds, see below and state) and all highly advolutions of relative amount, as all being mainly glycine, proline, hydroxyproline, lysine, hydroxylysine and typical 337 regular textures and content (see below and state the 4th of additional benefits), be easy to separate and purify so purity and yield are all very high, can control synthetic method match in excellence or beauty (see below and state the 4th of additional benefits) with the people fully, but resource is wide, technology is simple, cost is low, so easily satisfy public demand; Be concentrated in vacuo to dry matter content 35-45%, be spray dried into water content below 5%, airtight standby;

Being manufactured in the sterilizing room of compound vitamin, get VA0.1-0.3 part, VC10-15 part, VE0.5-1 part, other kind that above raw material adopts GB2760 or GB14880 approval to use should be converted by active substance, joins in the nonmetal mortar evenly porphyrize 1-2 minute, and is airtight standby;

Being manufactured in the sterilizing room of compound Chinese medicine got Radix Polygoni Multiflori 3-5 part, Radix Angelicae Sinensis 1.5-3 part, Radix Rehmanniae Preparata 3-5 part, Radix Glycyrrhizae Preparata 0.5-2 part, pulverizes jointly, crosses the 200-300 mesh sieve, and be airtight standby;

Being manufactured in the sterilizing room of product of the present invention got hydrolytic collagen aminoacids complex 10-30 part; Compound vitamin 0-1 part; Compound Chinese medicine 0-3 part, join jointly in the stainless steel equipment of belt stirrer, 20-60 rev/min mixed thoroughly 3-5 minute powder product or be packaged into capsule or adding eats or medicinal bonding plasticizer such as lactose etc. are pressed into the tablet of 0.3-0.5 gram/sheet by 0.3-0.5 gram/grain.

The purposes of product of the present invention and usage, consumption: as the host or the additive of food, medicine, cosmetic skin care product, usage and consumption need to use by production; As food, medicine, cosmetic skin care product, usage and consumption are advised facial external (smearing) every day three times, each 0.3-0.5 gram, every day for oral administration three times, each 1-3 gram, the suggestion oral administration and externally uses simultaneously, same fool proof and be the benefited property of whole body, better effects if, especially over 30 women, not only need the face outside to smear, and only depend on that face has smeared inadequately, essential inside and outside dual-purpose to be to strengthen compensation dosage and to increase compensation approach and channel; The suggestion of child's teenager is for oral administration to get final product, but this does not also mean that product of the present invention is not suitable for their external, but because they are in various materials at this moment and comprise collagen protein synthesis ability peak period, need not especially the outside smears additional, but need raw material and requirement bigger equally, though this is because their raw material synthesis capability is powerful equally, but its cell proliferation rate is faster, so proteinogen material aminoacid especially the various amino acid whose consumptions of collagen protein and depletion rate far beyond synthesizing height, tend to neonate birth back early stage (promptly be born back 28 days in baby) as traditional view and should not use aminoacid, think that now this is not right, as finishing by the research of the Cai Wei of hospital of attached Xinhua of Shanghai Communications University professor seminar, " the neonate nutritional support clinical practice guide " that is about to publicize and implement in year points out that add aminoacid (renal insufficiency person exception) to neonate as early as possible could guarantee its nutritional sufficiency, reduce mortality rate and increase brain development and nootropics and health status, not only aminoacid is like this in fact, many other materials are so same as constituting nuclear core substance nucleotide etc., so nucleotide is all ratified and used to Ministry of Public Health and a lot of famous brand milk products, especially the resource scarcity great Deoxydization nucleotide of function that costs an arm and a leg.

Embodiment:

1, in sterilizing room, get 10 parts of hydrolytic collagen aminoacids complexs, 0.5 part of compound vitamin, 1 part of compound Chinese medicine, join jointly in the stainless steel equipment of belt stirrer, 20-60 rev/min mixed thoroughly 3-5 minute powder product or be packaged into capsule or adding eats or medicinal bonding plasticizer such as lactose etc. are pressed into 0.3-0.5 gram/tablet by 0.3-0.5 gram/grain.

2, in sterilizing room, get 20 parts of hydrolytic collagen aminoacids complexs; 1 part of compound vitamin, 2 parts of compound Chinese medicines, join jointly in the stainless steel equipment of belt stirrer, 20-60 rev/min mixed thoroughly 3-5 minute powder product or be packaged into capsule or adding eats or medicinal bonding plasticizer such as lactose etc. are pressed into the tablet of 0.3-0.5 gram/sheet by 0.3-0.5 gram/grain.

3, in sterilizing room, get 30 parts of hydrolytic collagen aminoacids complexs; 1 part of compound vitamin, 3 parts of compound Chinese medicines, join jointly in the stainless steel equipment of belt stirrer, 20-60 rev/min mixed thoroughly 3-5 minute powder product or be packaged into capsule or adding eats or medicinal bonding plasticizer such as lactose etc. are pressed into the tablet of 0.3-0.5 gram/sheet by 0.3-0.5 gram/grain.

Additional benefits:

1, the present invention uses human body easily to lack and the of the utmost importance and comprehensive VC replacement of function antiseptic, making product need not to add separately antiseptic is tool excellent antibacterial and anti-rotten function and effect, not only harmless and effectively prevent and treat its serial deficiency disease such as common frequently-occurring disease gingival hemorrhage etc. because of having compensated VC simultaneously.

2; the present invention protects and has transferred synthetic collagen protein of human body self and raw material and rationally uses raw-material intrinsic factor with machine-processed; many tissues; organ such as blood vessel; skeleton; muscles etc. compensate and retain the increment of collagen protein and effectively protected benefited protected simultaneously because of the timely capacity of new synthetic collagen protein; so be the benefited property of whole body; thereby accomplished to take stopgap measures and effect a permanent cure; these are not only extremely important; yet existing collagen product is not accomplished its importance and its science and technology; economical; social benefit is healthy self-evident with the good society influence as alleviating aging psychological feelings and pressure with the value place.

3, the present invention uses legal medicine-food two-purpose and property of medicine Wen Ping, the full medicine of compound Chinese medicine that the many organs of cardiopulmonary Liver and kidney the intestines and stomach are taken into account is simultaneously made filler, QI and blood marrow power is prosperous and powerful comprehensively, no matter so its safety, the widely all legal identification of the suitability of effect and crowd, and, the inventive method saves operation because of need not to add filler more in addition, cost and no extraction and technology and do not have waste residue and the residual potential hazard of hazardous solvent, and it is environmental and significantly energy-conservation, water saving has also kept the full explosive component of Chinese medicine and because of pulverizing, compacting waits and significantly reduces the Chinese medicine volume and improve same units volume herbal function.These are very important, because of national Eleventh-Five Year Plan outline draft has all been made hard and fast rule to the energy-saving and water-saving environmental protection, though the more important thing is fact proved that the distinguishing feature Chinese medicine volume of Chinese medicine and Western medicine is big, extract to effectively reduce its effect of volume be low and single far beyond full medicine again and the more important thing is its extract also far beyond the stability under full medicine state for poor.

4, the commodity collagen protein stimulates the irritated extreme high purity that requires of initiation for reducing foreign body as far as possible at present, must cause purifying repeatedly and make technique process complicated and so-called " activity " have a greatly reduced quality unavoidably because of albuminous degeneration and accumulation, cycle is long have high input and recovery rate low, energy-conservation water-saving consumption-reduction environmental protection difficulty is very big during the envoy, the strictness that adds raw material sources limits as so-called " same derived collagen ' Placenta Hominis ' " because of resource scarcity, expensive so the cost height, though also can utilize 3 α-peptide chain height advolution typical [sweet-X-Y (X of collagen protein, Y represents other aminoacid respectively)] 337 (Gan-X-Y-is sweet-X-Y-sweet-) the regular texture people of n controls synthetic collagen protein, but it is higher so more expensive to there is no other any advantage and cost except that purity is more accurate, the synergetic result of these factors also must cause product extremely expensive, as every of present injection only 0.5 milliliter in common beauty parlor price just up to surprising 4000-5000 yuan, more than gold expensive tens of times and even Radix Achyranthis Bidentatae, everyone need expend at least 2 (facial slight wrinkles) once such beauty treatment, (general) also can be found everywhere surplus in the of 20 at most, be not rarely seen, in other words be exactly that everyone each level of consumption is all more than ten thousand yuan even 100,000 yuan, that is be equivalent to China per capita gross annual output value 1-10 doubly more than, more mirable is that such high consumption level does not only lack consumer, unexpectedly also " going after in a swarm " even must shift to an earlier date reservation last month and frequent " selling supply shortage " and need a few days and even wait in line just can buy last month on the contrary, it is more worth that what show great attention to is that this also basic just women consumes the public sentiment, as suitably take into account in advance again must take place and need not oversize wait unlike the adding gradually and even comprehensively of the male consumer group of women and consuming capacity difference thereof, its market prospect is difficult to estimate really! The present invention has not only solved above-mentioned such as resource price, serial problems such as environmental protection fall in joint, and enriched general collagenic protein and aminoacid supply and synthetic simultaneously, reduce the negative nitrogen balance degree comprehensively and significantly slowed down protein degradation speed and the degradation amount that comprises collagen protein, that is be equivalent to increase collagen protein reserve capabillity and storage level, the more important thing is that having solved the external macromole absorbs few skin corium that especially is in the real resisting age of skin of deep layer and absorb great difficult problems such as still less reaching easy allergy, its market prospect and science and technology, the society and economy benefit needn't be underestimated really.

Test and effect: because of the present invention is not that medicine need not be tested and effect, but still demonstration test and effect data are as follows from scientific and technological angle.Extensively representative because of product function and purposes tool, so the experimenter originates wide voluntary participation.Product of the present invention because of effect good and have no side effect and crowd's branch, so the test period short and receive excellent in efficiency, make test be easy to just satisfactorily be finished.Now further be explained as follows (only for reference) under the prerequisite of necessary KNOW-HOW and business secret and please understand: because of the objective and directly perceived sign of collagen protein number is that especially face skin wrinkle and the depth thereof show and gain public acceptance skin allow keeping in Patent Law about situation, so this test serves as observation with it also and passes judgment on the main body reference standard, specifically asks for an interview as described below.Totally 40 of the experimenters of different sexes, age (25-35 year because of its be main body and main consumer group), it is 2 groups that 20 people are divided into for one group: one group is used with product of the present invention and usage and dosage, and one group need not, compare; Test number and time on test reach 2 first quarter moons, all the event of tool statistical significance has suitable representativeness and credibility.The result is as follows: none the routine wrinkle of test group personnel with product of the present invention is deepened, and 3 people's no changes are arranged, and has 17 people to improve; It is that wrinkle shoals even complete obiteration that more shallow and age of wrinkle promptly is significantly improved after January than the lighter; No matter the matched group experimenter finds the age person of increasing the weight of 16 people, 4 people feel no significant change, none improver.Prompting: do not deepen to be controlled, be that product of the present invention is effective, improve illustrating that the direction that the state of an illness is become better reverses, is that effect of the present invention is remarkable with regard to having proved absolutely.

Claims (3)

1. composition collagen, amino acid, vitamine Chinese medicine eatable resistant to crushing cosmetic is by hydrolytic collagen aminoacids complex 10-30 part; Compound vitamin 0.5-1 part, wherein VA0.1-0.3 part, VC10-15 part, VE0.5-1 part; Compound Chinese medicine 1-3 part, wherein Radix Polygoni Multiflori 3-5 part, Radix Angelicae Sinensis 1.5-3 part, Radix Rehmanniae Preparata 3-5 part, Radix Glycyrrhizae Preparata 0.5-2 part are formed.

2. the manufacture method of the described composition collagen, amino acid, vitamine Chinese medicine of claim 1 eatable resistant to crushing cosmetic is as follows:

The amino acid hydrolyticsolution that the manufacturing of a hydrolytic collagen aminoacids complex will directly adopt the conventional processes well known method of hydrochloric acid hydrolysis collagen protein, sodium hydroxide neutralizing hydrolysis liquid to be prepared from, be concentrated in vacuo to dry matter content 35-45%, be spray dried into water content below 5%, airtight standby;

Being manufactured in the sterilizing room of b compound vitamin got VA0.1-0.3 part, VC10-15 part, VE0.5-1 part, joins in the nonmetal mortar evenly porphyrize 1-2 minute, and be airtight standby;

Being manufactured in the sterilizing room of c compound Chinese medicine got Radix Polygoni Multiflori 3-5 part, Radix Angelicae Sinensis 1.5-3 part, Radix Rehmanniae Preparata 3-5 part, Radix Glycyrrhizae Preparata 0.5-2 part, pulverizes jointly, crosses the 200-300 mesh sieve, and be airtight standby;

Being manufactured in the sterilizing room of d composition collagen, amino acid, vitamine Chinese medicine eatable resistant to crushing cosmetic got hydrolytic collagen aminoacids complex 10-30 part; Compound vitamin 0.5-1 part; Compound Chinese medicine 1-3 part; Join jointly in the stainless steel equipment of belt stirrer, mixed thoroughly 3-5 minute for 20-60 rev/min, get product.

3. the purposes of the described composition collagen, amino acid, vitamine Chinese medicine of claim 1 eatable resistant to crushing cosmetic: as the host or the additive of food, cosmetic skin care product; As food, every day for oral administration three times, each 1-3 gram; As the cosmetic skin care product, every day three times, each 0.3-0.5 gram are smeared in the facial external of consumption.