CN1956689A - Wound contact device - Google Patents

Wound contact device Download PDF

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Publication number
CN1956689A
CN1956689A CN 200580011312 CN200580011312A CN1956689A CN 1956689 A CN1956689 A CN 1956689A CN 200580011312 CN200580011312 CN 200580011312 CN 200580011312 A CN200580011312 A CN 200580011312A CN 1956689 A CN1956689 A CN 1956689A
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China
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wound
plurality
surface
structural member
article according
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CN 200580011312
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Chinese (zh)
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约翰·R·柏林格
约翰·卡尔波夫伊兹
阿米塔巴·米特拉
克里斯多佛·L·拉德尔
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柏林格实验室有限公司
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Publication of CN1956689A publication Critical patent/CN1956689A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00Drainage appliances for wounds or the like, i.e. wound drains, implanted drains

Abstract

本发明提供一种用于促进哺乳动物体上伤口愈合的治疗用品。 The present invention provides a method for promoting wound healing treatment of mammalian body supplies. 示例性用品包括一个具有多个形成在其表面上的凹处的渗透性结构件。 Exemplary articles comprise a permeable structure is formed on the surface thereof a plurality of recesses having. 在使用中,将具有凹处的表面邻接伤口表面安置。 In use, the surface having a recess disposed adjacent to the wound surface. 一种处理伤口的方法,包括以下步骤:提供一个渗透性结构件,该结构件包括多条随机布置的纤维并且具有i)多个设置在结构件端部之间的伤口表面接触元件以及ii)多个由所述接触元件界定的空隙;将渗透性结构件敷贴到伤口的至少一个表面上。 A method of wound treatment, comprising the steps of: providing a permeable structure, the structure comprising a plurality of randomly arranged fibers and having a wound surface i) a plurality of structural member disposed between the end portion of the contact element and ii) a plurality of voids defined by the contact member; applicator member on the permeable structured to at least one surface of a wound.

Description

伤口接触用品 The wound contact supplies

相关申请本申请要求申请日为2004年4月13日的美国临时专利申请第60/561,745号的优先权,该专利申请的内容通过引用而结合在本申请中。 RELATED APPLICATIONS This application claims the benefit of US Provisional Patent Application April 13, 2004 No. 60 Priority / No. 561,745, the content of which is hereby incorporated herein by reference.

技术领域 FIELD

本发明涉及一种处理伤口的用品和方法。 The present invention relates to a method of processing and supplies a wound. 更加具体地,本发明涉及一种治疗伤口的接触用品。 More particularly, the present invention relates to a method of treating a wound contacting supplies.

背景技术 Background technique

伤口愈合是一种基本的人体复原过程。 Wound healing is a fundamental human healing process. 用适宜的材料对伤口进行敷贴有助于身体自然的再生过程这一点早已公知。 The wound applicator helps the body's natural regenerative process which is already known with a suitable material. 历史上,这些材料由棉花纤维制成;如纱布。 Historically, these materials are made of cotton fiber; such as gauze. 这些敷片对愈合过程有益处,原因为,所述敷片使损伤组织与外部污染物隔离、以及所述敷片移除掉潜在性有害的伤口渗出物。 The cladding sheet beneficial healing process, because of the cladding sheet and the external tissue damage isolating contaminants, and removal of the applicator sheet off potentially harmful wound exudate.

许多研究得出伤口愈合取决于涉及细胞增生、迁移、粘附连同血管生成的复杂机理的相互作用。 Wound healing depends on many research results involving cell proliferation, migration, adhesion interactions together with the complex mechanisms of angiogenesis. 传统型纱布或其他基本上平齐的材料的敷贴对于这些机理来说实质上不是最为理想。 Applicator or other conventional gauze material substantially flush substantially not ideal for these mechanisms is. 生物体外的伤口愈合研究在确保细胞功能的细胞培养介质中进行。 Studies ensuring cellular function in a cell culture medium in vitro wound healing. 因此,在伤口愈合的研究中,理想做法为提供细胞培养的等同物或者生物反应器系统,以使细胞的增生、迁移和粘附功能的相互作用最佳化。 Thus, in wound healing research, it is desirable practice to provide a cell culture or the equivalents bioreactor system so that the proliferation, migration and interaction optimum adhesion function of cells. 另外,还必须加入其他身体功能,其中所述功能促进纤维粘连蛋白、血浆蛋白质、氧、血小板、生长因子、免疫化学物质等等物质的供应。 Must also be added to other body functions, wherein the function to boost the supply fibronectin, plasma proteins, oxygen, platelets, growth factors, immune chemicals like substances.

随着科学和医学的发展进步,结合到伤口愈合用品中的技术已经大大地得到改进。 With the advancement of science and medicine, incorporated into products in wound healing technology has been greatly improved. 能够吸收是其自身重量许多倍的液体的高吸收性伤口敷片得到使用。 Which is capable of absorbing superabsorbent wound many times its own weight of liquid cladding sheet to be used. 已经获得了暂时密封住伤口以及利用吸力以排掉渗出物的系统。 A temporary seal has been obtained by suction to the wound and drain system exudates. 结合有抗菌剂和生物愈合剂的敷片也已通用。 Binding cladding sheet has antibacterial and healing of biological agents have also been common. 令已发现提供湿润的伤口环境、以促进愈合的用品的用处。 So that has been found to provide a moist wound environment to promote healing of supplies of use.

尽管在伤口愈合用品及敷片方面获得了某些技术成就,但是不少人仍在忍受着慢性伤口带来的痛苦。 Despite some success in wound healing technology supplies and deposited films, but many people continue to endure the pain caused by chronic wounds. 这些慢性伤口令人身体虚弱、并可持续数年,从而大大地降低了人的生命质量。 These chronic wounds debilitating and can last for several years, which greatly reduces the quality of human life. 这些伤口经常会导致截肢。 These wounds often lead to amputation. 个别人甚至还会死于比如感染等的并发症。 Few people will even die from complications such as infection and the like.

因此,极度需要有更加有效的伤口愈合用品和方法。 Thus, the need for extremely more effective wound healing supplies and methods.

发明内容 SUMMARY

为了促进伤口的愈合,本发明提供一种伤口接触材料、一种用于制造该伤口接触材料的方法以及一种利用该伤口接触材料的处理方法。 In order to promote wound healing, the present invention provides a wound contact material, a method for manufacturing the wound contact material and a processing method using the wound contact material used.

依据本发明的一个示例性实施方式,提供一种用于在哺乳动物体上促进伤口愈合的治疗用品。 According to an exemplary embodiment of the present invention, there is provided a method for the treatment of promoting wound healing in mammalian body supplies. 该用品包括一个具有形成在其表面上的多个凹处的渗透性基体或结构件,其中,具有所述凹处的所述表面被安置成与伤口处于表面接触状态。 The article comprises a permeable base structure or a plurality of recesses formed on its surface has, wherein said surface having the recess is arranged to be in surface contact with the wound.

依据本发明的另一个示例性实施方式,提供一种用于在哺乳动物体上促进伤口愈合的治疗用品。 According to another exemplary embodiment of the present invention, there is provided a method for the treatment of promoting wound healing in mammalian body supplies. 该用品包括一个渗透性结构件,该结构件具有多个设置在结构件的端部之间的伤口表面接触元件、以及具有多个由所述接触元件所界定的空隙。 The article comprises a permeable structure, the structure having a plurality of voids disposed between the contact surface of the wound element end structure, and a plurality of contact elements by the bounded.

依据本发明的又一个示例性实施方式,提供一种用于促进哺乳动物体上伤口愈合的治疗用品,该用品包括一个渗透性结构件,该结构件包括多条彼此联结纤维,其中所述结构件具有多个设置在结构件端部之间的伤口表面接触元件以及多个由所述接触元件界定的空隙。 According to yet another exemplary embodiment of the present invention, wherein the structure of a mammalian body for promoting wound healing therapeutic article that includes a permeable structure, the structure comprising a plurality of fibers are coupled, a contact member having a plurality of voids and a plurality of elements from the surface of the wound structure between the ends of the contact element defined.

依据本发明的再一个示例性实施方式,提供一种用于促进哺乳动物体上伤口愈合的治疗用品,该用品包括一聚合物毡片,该毡片具有多个设置在结构件端部之间的伤口表面接触元件以及多个由所述接触元件界定的空隙。 According to yet another exemplary embodiment of the present invention, there is provided a method for promoting wound healing mammalian body treatment article that comprises a polymer mat, the mat having a structural member disposed between a plurality of end portions wound surface contact element by the contact element and defining a plurality of voids.

依据本发明的又一个示例性实施方式,提供一种制造用于促进哺乳动物体上伤口愈合的治疗用品的方法,包括步骤:提供一熔融的基体材料;提供一界定并形成多个凹处和多个接触元件的模子;以及将熔融的基体材料涂(applying)到模子上。 According to yet another exemplary embodiment of the present invention, there is provided a method for the treatment of wound healing mammalian body manufactured articles for promoting, comprising the steps of: providing a molten matrix material; providing a plurality of recesses are formed and defined and a plurality of contact elements of the mold; and the molten matrix material is coated (Applying) to the mold.

依据本发明一个更进一步的示例性实施方式,提供一种制造用于促进哺乳动物体上伤口愈合的治疗用品的方法,包括步骤:提供一渗透性结构件;以及在所述渗透性结构件的表面中形成多个凹处。 According to the present invention, a still further exemplary embodiment, there is provided a method for producing mammalian body for promoting wound healing, treating article, comprising the steps of: providing a permeable structure; and in the permeability of the structure a plurality of recesses formed in the surface.

依据本发明的另一个示例性实施方式,提供一种处理伤口的方法,包括步骤:提供一渗透性结构件,其中所述结构件包括多个设置在结构件端部之间的伤口表面接触元件以及多个由所述接触元件界定的空隙;将渗透性结构件敷贴到伤口的至少一个表面上;以及将力施加到结构件上,以保持结构件与伤口表面紧密接触。 According to another exemplary embodiment of the present invention, there is provided a method of treating a wound, comprising the steps of: providing a permeable structure, wherein said structure comprises a plurality of wound surface member disposed between the structural member in contact with the end portion and a plurality of voids defined by the contact member; applicator member on the permeability of the wound structure at least one surface; and a force is applied to the structural member, to maintain the structural member in intimate contact with the wound surface.

通过以下的描述部分,以上所述的、以及其他的方面和目的将变得显而易见。 Portion of the following description, the above and other aspects and objects will become apparent.

附图说明 BRIEF DESCRIPTION

当以参照附图的方式通读以下的详细描述部分时,可最有效地理解本发明。 When referring to the accompanying drawings by way of the following detailed description of the read section, can be most efficiently understand the present invention. 要强调的是,按照通常的做法,附图中的各个特征部件并不是按比例绘制。 It is emphasized that, according to common practice, the various features member figures not drawn to scale. 相反,出于清楚目的而随意扩大或缩小各个特征的尺寸。 In contrast, for purposes of clarity arbitrarily expanded or reduced dimensions of the various features. 其中所述附图包括:图1为依据本发明第一示例性实施方式的设有槽道的伤口接触敷片的立体图;图2A为依据本发明第二示例性实施方式的设有槽道的伤口接触组件的立体图;图2B为依据图2A所示的第二示例性实施方式的设有槽道的伤口接触组件的剖面图;图3A为依据本发明第三示例性实施方式的设有凹孔的伤口敷片的立体图;图3B为如图3A所示的设有凹孔的伤口敷片的俯视图;图3C为如图3A所示的设有凹孔的伤口敷片的仰视图;图3D为如图3A所示的设有凹孔的伤口敷片的剖面图;图4A、4B、4C示出了如图3A所示的设有凹孔的伤口敷片的使用情形;图5A为依据本发明第四示例性实施方式的不规则伤口接触敷片的立体图;图5B为如图5A所示的不规则伤口接触敷片的剖面图。 The drawings wherein: Figure 1 a perspective view of a contact sheet for wound dressing is provided with a channel according to a first exemplary embodiment of the present invention; FIG. 2A is provided according to a second exemplary embodiment of the present invention, a channel a perspective view of a wound contact assembly; FIG. 2B is provided with a wound contact assembly according to the channel cross-sectional view of a second exemplary embodiment shown in FIG. 2A; FIG. 3A according to a third exemplary embodiment of the present invention is provided with a recess a perspective view of a wound dressing sheet hole; FIG. 3B is a plan view of a wound is provided with recesses 3A, cladding sheet; FIG. 3C is a bottom view of the wound is provided with recesses 3A, the cladding sheet; FIG. 3D is a sectional view of a recessed hole wound dressing sheet shown in FIG. 3A; FIG. 4A, 4B, 4C illustrate usage of the wound dressing is provided with recesses sheet shown in FIG. 3A; FIG. 5A is a exemplary embodiments according to the fourth embodiment of the present invention, a perspective view of an irregular wound contacting sheet applicator; FIG. 5B is a cross-sectional view shown in FIG. 5A irregular wound contact dressing sheet.

具体实施方式 Detailed ways

一种具有断续接触层的伤口敷片,具有如下优点,即在伤口表面接触元件的作用下而促进组织的生长,并且通过在断续处设置供后续的组织生长所需的空隙体积(void volume)而使得组织能够生长。 A wound contact layer having a cladding sheet intermittent, has the advantage that the contact surface of the wound under the action of elements promote growth of tissue, and by the intermittent supply is provided subsequent tissue growth required void volume (void Volume) so that tissue can grow. 理想地,接触材料的结构在实体上要足够皱褶,以在将力施加到材料上时能够抵抗而不会被展平,所述力为将材料压到伤口表面所需。 Ideally, the structure of the contact material is physically enough to fold, in order to apply a force to be able to resist without being flattened, the force pressing the material on the material to a desired surface wounds.

材料理想为当被暴露到水流体或其他体液上时能够保持其结构。 Material is over when exposed to the aqueous fluid or other body fluids can maintain its structure. 许多传统型敷片材料在受潮时变软,使得其几何形状发生变化。 Many traditional cladding sheet material softens when exposed to moisture, such that a change in its geometry. 接触层为可渗透性,使得下面的伤口能够透气,并且使得能够对伤口进行引流。 Permeable contact layer, such that the following breathable wound, and enables the wound drainage. 接触层的吸收性不应当过大,因为过大会导致结构损坏。 The absorbent layer should not be in contact with too large, resulting in damage to the structure because Excessive. 所述层由这样的基底材料构成,即所述基底材料在湿气和水性液体的存在下可抵抗变化的发生。 The base layer is made of such material, i.e. the substrate material in the presence of moisture and resistant to the aqueous liquid changes.

在当前实施方式中,当将结构件(structure)压到伤口表面上时,保留在伤口表面上的空隙的大小优选为至少0.1mm。 In the present embodiment, when the structure (Structure) when pressed onto the wound surface, voids that remain on the wound surface is preferably a size of at least 0.1mm. 由邻近空隙的接触元件所界定的空隙的宽度优选为大于0.1mm。 The width of the contact element adjacent the gap defined by voids preferably greater than 0.1mm. 更加优选的宽度为在大约0.5到10mm之间,而更加优选的高度则为在大约0.2到5mm之间。 More preferably a width of between about 0.5 to 10mm, and more preferably between about 0.2 height compared to 5mm.

伤口愈合被视为是复杂的过程。 Wound healing is a complex process is considered. 当将如所描述的伤口接触材料压到伤口表面上时,认为会发生一些生物学过程。 When wound contact material as described pressed onto the wound surface, a number of biological processes that occur. 机械应力施加到下面的组织上。 Mechanical stress to the underlying tissue. 接触表面中的断续处将导致悬链形状(catenary shape)的力加压在组织上。 At intermittent contact surface will result in a force catenary shape (catenary shape) pressure on the tissue. 这些机械应力促进细胞成活以及血管生成,而断续处则开始被填以颗粒状的组织(granular tissue)。 These mechanical stresses to promote cell survival and angiogenesis, and is interrupted at the start filled with a particulate tissue (granular tissue). 过量的流体从伤口转移出来,而组织则以这样的方式及模式生长,即使得在拆除接触表面后、对新生长的组织所造成的破损达到最小。 Excess fluid from the wound out, and tissue growth mode and places this manner, even after the contact surfaces have in the removal of damaged tissue caused by the growth of new minimum.

纤维基体或结构件具有纺造工艺技术所带来的各种灵活适应性。 Or a fibrous matrix having structural elements made of various flexible and adaptable spinning technology brings. 可通过一些在所属领域公知的方法,将纤维织物制成用于本发明的结构件。 Some in the art by well-known methods, formulated for the fabric structure of the present invention. 在这些方法中,有针织法、纺织法、刺绣法、编织法、毡织法、纺粘法、熔喷法、熔纺法。 In these methods, there knitting method, a textile process, method embroidery, weaving, mat weaving, spun bonding, melt blowing, melt spinning. 可进一步使这些方法中的每一种方法适于生产出其结构与本发明的材料结构相匹配的材料。 These processes may be further each of the methods suitable for producing the material of the present invention, the structure of which matches. 对于熔喷法,可通过例如将熔融材料直接喷涂到模子上而在结构件的生产过程中得到理想的结构。 For meltblowing, for example, by directly spraying the molten material into the mold obtained during the production of the desired configuration of the structural member. 可供选择地,可通过在生产之后对已成形的结构件进行加工而制成所述结构,例如通过热冲压或真空成形法。 Alternatively, after producing can be processed in the formed structural member is made of the structure, for example by vacuum forming or hot stamping. 此外,可使纤维混合上粘合剂,并将其喷洒到刻纹表面上。 Further, the fibers mixed with a binder can, and spray it onto the threaded surface.

纤维织物的多功能性还延及其在组合应用方面的容易适应性。 The fabric also extends versatility and easy adaptability in application of the combination. 可改变单纤维材料以优化物理参数,比如刚性或柔韧性。 Filamentary materials may be varied to optimize the physical parameters, such as rigid or flexible. 还可针对单纤维材料有助于伤口愈合的公知性能而对其进行选择。 It may also contribute to the wound healing properties of known single fiber material for its selection. 这些纤维材料的例子为藻酸钙和胶原。 Examples of such materials are calcium alginate fibers and collagen. 可供选择地,可用公知的伤口愈合剂对纤维进行处理,比如透明质酸或抗菌银(antimicrobial silver)。 Alternatively, using well-known wound healing agent fibers can be treated, such as hyaluronic acid or a silver antibacterial (antimicrobial silver). 可改变纤维材料的比率,以适合伤口的需要。 The ratio of fiber material can be varied to suit the needs of a wound. 依据本发明的一个令人满意的方面,可根据需要,添加上具有各种各样伤口愈合特性的不同纤维。 A satisfactory accordance with aspects of the present invention, according to need, the fibers having different characteristics on a variety of wound healing is added.

其他预计作为有益添加物的纤维结构件包括:1、吸收流体的纤维2、非吸收剂类纤维3、生物可吸收纤维4、对伤口表面进行引流的芯吸式纤维5、具有公知的愈合作用的纤维,比如藻酸钙6、用于按受控的方式释放出固化剂的生物可侵蚀纤维7、用于传输电荷或电流的传导性纤维8、用于选择性地将不良组织、物质或微生物去除的粘附性纤维9、用于保护脆弱组织的非粘附性纤维图1示出了本发明的一个示例性实施方式。 Other additives useful as expected the fiber structure comprises: 1, the fluid absorbent fibers 2, 3 non-absorbent fibers, bioabsorbable fibers 4, 5 for draining a fiber wick type of wound surface, has a known healing fibers such as calcium alginate 6, for releasing a biological curing agent in a controlled manner erodible fibers 7, current for charge transport or conductive fibers 8, for selectively undesirable tissue, or substances microbial removal bondable fibers 9 for nonadherent protect fragile tissue fibers FIG. 1 illustrates an exemplary embodiment of the present invention. 如图1所示,设有槽道的伤口敷片100由一大体具有贴合性的聚合物毡片材料102构成。 As shown in FIG. 1, the wound dressing is provided with a channel 100 formed of a sheet having a substantially polymeric material bonded mat of 102. 可供选择的其他织物也可适用于多数的应用,比如针织、纺织或编织织物。 Alternatively the fabric can be applied to most other applications, such as knit, woven or knitted fabrics. 也可考虑使用具有类似物理特性的聚烯烃以及聚氨酯,所述聚烯烃比如聚乙烯或聚丙烯,而所述聚氨酯比如尼龙。 Also contemplated having similar physical properties of polyolefins and polyurethanes, the polyolefin such as polyethylene or polypropylene, and a polyurethane such as nylon. 尤其需要的是聚合物所具有的蠕变阻力。 Particularly desirable is a polymer having a creep resistance. 空隙槽道104切入到毡片材料102中,以提供促进新组织向上生长的断续处。 Void channels 104 cut into the mat material 102 to provide intermittent upward at promoting the growth of new tissue. 在使用中,将设有槽道的伤口敷片100压到伤口上,使其与受伤的组织紧密接触。 In use, the wound dressing is provided with a channel piece 100 is pressed onto the wound, into close contact with the injured tissue. 理想地,将0.1psi或更大的力施加到接触层上,以将接触元件压到伤口表面上。 Ideally, the 0.1psi or greater force is applied to the contact layer to the contact element is pressed onto the wound surface. 伤口接触元件106因而与受伤的组织处于紧密接触状态。 The contact member 106 thus wound with the injured tissue in close contact.

图2A和2B示出了伤口敷片组件200,由设有槽道的敷片100和一水汽可渗透的粘合性背片202构成。 2A and 2B illustrate a wound dressing sheet assembly 200, constituted by cladding sheet provided with the channel 100 and the adhesive backing sheet 202 a vapor permeable. 一般地,粘合性水汽可渗透的背片在所属领域为公知技术,并且认为所述背片通过保持相对于某些特定伤口的最佳潮湿度而有助于伤口的愈合。 Generally, the adhesive water vapor permeable backsheet is well known in the art techniques, and that the backing sheet by maintaining optimum moisture degree with respect to certain wound healing of the wound and help. 在使用中,将敷片组件200放置在伤口表面上,使其设有槽道的敷片部分100与伤口接触。 In use, the dressing plate assembly 200 is placed on the wound surface, so that the channel is provided with cladding portion 100 contact with the wound sheet. 粘合性片202覆盖住设有槽道的敷片100,并且粘合到邻近伤口的皮肤上。 Adhesive cover sheet 202 is provided with channels cladding sheet 100 and adhered to the skin adjacent the wound. 组件200提供了设有槽道的敷片100所具有的优点。 Assembly 200 is provided with channels cladding sheet 100 has the advantage. 附加地,在使潮湿水汽能够传送的同时,粘合性片202对组件200进行紧固、并且保护伤口使其免受细菌感染等等。 Additionally, when the moisture vapor can be transmitted at the same time, the adhesive sheet 202 pairs of fastening assembly 200, and protect the wound from bacterial infection and so it.

图3A、3B、3C和3D示出了本发明另一令人满意的实施方式。 FIGS. 3A, 3B, 3C and 3D illustrate another embodiment of the present invention satisfactorily. 用于设有凹孔的伤口敷片300的基体或结构件可由类似于在设有槽道的敷片100中所利用的材料以及按与其类似的生产方法构造而成。 Provided with recesses for wound dressing sheet material of the substrate or structural member 300 may be provided with similar channels in the cladding sheet 100 is constructed and utilized by the production methods analogous thereto. 图3A绘出了设有凹孔的敷片300的立体图,图中其接触表面320位于上面。 Figure 3A depicts a perspective view of a cladding sheet is provided with recesses 300, 320 in FIG located above the contact surface thereof. 图3D所示为设有凹孔的敷片300的剖面图,图中最佳地示出了数个接触元件332与凹孔空隙330。 FIG. 3D is a cross-sectional view of the cladding sheet is provided with recesses 300, best shown in FIG several contact elements 332 with recesses 330 voids. 优选地,总的凹孔空隙面积占据总敷片面积的至少25%。 Preferably, the total void area of ​​the recessed holes occupy at least 25% of the total area of ​​the cladding sheet. 更加优选地,总的凹孔空隙面积占据总敷片面积的至少50%。 More preferably, the total void area of ​​the recessed holes occupy at least 50% of the total area of ​​the cladding sheet. 凹孔空隙330由侧壁332局部界定。 Void recesses 330 defined by a side wall 332 partially. 侧壁332则起到部分地提供刚性的作用,其中所述刚性为抵抗凹孔式敷片300被压实所需。 Sidewall 332 functions to provide rigidity of the part, wherein the recesses of formula rigid to resist compacted cladding sheet 300 desired. 优选地,接触元件被构造成具有弓形接触表面。 Preferably, the contact element is configured to have an arcuate contact surface. 在一优选的实施方式中,接触半径(radius ofcontact)在大约0.1mm到1mm之间。 In a preferred embodiment, the contact radius (radius ofcontact) between about 0.1mm to 1mm.

可将凹孔空隙330制成多种规则或不规则的形状。 The recesses 330 may be formed voids various regular or irregular shapes. 优选地,将凹孔空隙构造成使其不是“底切(undercut)”,从而使得每一孔口的周边小于相应的内空隙的周边。 Preferably, the recesses are not configured so that the gap "undercut (undercut)", so that the periphery of each aperture is smaller than the corresponding inner peripheral voids. “底切”或网状空隙结构在拆除敷片300时可造成组织破损,原因在于当将材料从伤口上除去时,会撕裂掉已经长进空隙中的任何组织。 Can cause tissue damage, because when the material is removed from the wound, tear away any tissue void has maturity when "undercut" void structure or a mesh sheet 300 in the removal of plating. 附加地,底切或网状的空隙结构更有可能导致敷片材料脱落到新生长的伤口组织中。 Additionally, undercuts or net void structure more likely to lead to a wound dressing sheet material off the new growth of tissue.

在一优选的实施方式中,用于敷片300的基底材料为Masterflo RTM,由美国麻省Wakefield的BBA集团制造。 In a preferred embodiment, the substrate sheet for dressing material 300 is Masterflo RTM, manufactured by BBA Group in Wakefield, Massachusetts, USA. 在该示例性实施方式中,基底材料的厚度大约为1.0mm。 In the exemplary embodiment, the thickness of the base material is about 1.0mm. 使凹孔空隙330热冲压到基底材料中,其深度大约为0.75mm、其直径则大约为2mm。 Recesses of the voids 330 punched into the hot base material, to a depth of about 0.75mm, the diameter of about 2mm.

由于一般接触层每过几天就被更换,因此重要之处在于考虑到使新形成的组织与新接触层的空隙对准的可能性。 Since the contact layer is generally replaced every few days, and therefore it is important that the consideration of the possibility that the newly formed tissue void layer in contact with the new alignment. 因而,依据本发明的示例性实施方式:1)可对凹孔空隙330进行随机布置,使得每次更换敷片后凹孔间隙330不与新的组织生长物排齐;2)可提供具有不同直径的凹孔的不同接触层;或者3)每一次对材料进行更换时可使用不同间隔的凹孔。 Thus, according to an exemplary embodiment of the present invention: 1) of the recesses may be randomly arranged voids 330, such that each time after the application of replacement sheets clearance recesses 330 are not aligned with the new growths of tissue; 2) can provide a different different contact layer recessed hole diameter; or 3) may be used at different intervals of recesses each time the material replacement.

图3B和3C分别示出了设有凹孔的敷片300的相应的俯视图和仰视图。 3B and 3C illustrate a cladding sheet provided with recesses corresponding to the top and bottom 300 of FIG. 另可想象得到该实施方式的一个变化形式,即具有同时设置在设有凹孔的敷片300的顶部和底部上的凹孔空隙330和/或接触元件322。 Another conceivable that a variation of this embodiment, i.e., simultaneously provided with recesses on the top and bottom of the sheet cladding is provided with recesses 300, voids 330 and / or the contact element 322. 还可想象得到有关设有凹孔的伤口敷片300的第二变化形式,其中,凹孔空隙330的一些或全部为穿过结构件整个厚度的孔眼所替代,使得该变化形式的俯视图和仰视图将会看似如图3B所示的视图。 Also imagine wound about the cladding sheet is provided with recesses 300 in a second variant, wherein the recesses 330 of some or all of the void is through the eyelet entire thickness of the structural element is replaced, so that a plan view and a bottom view of the variant FIG 3B will appear to the view shown in FIG.

在一个示例性实施方式中,凹孔空隙330可部分地被填充上治疗物质。 In one exemplary embodiment, the recesses 330 may voids partially filled with a therapeutic substance. 例如,可将杀菌物质放置在空隙330中,以对受感染的伤口进行处理。 For example, the sterilizing material can be placed in the gap 330, the infected wound to be treated. 此外,可将生物愈合剂传输到空隙中,以提高新组织的形成速率。 Further, the biological healing agent may be transmitted to the void, to increase the rate of formation of new tissue. 在又一示例性实施方式中,敷片300的层体可在每一侧部上具有不同的功能。 In yet another exemplary embodiment, the cladding sheet 300 may have different functions on each side. 例如,敷片300的一侧可针对新组织的生长进行优化,而另一侧则可针对抗菌剂的传输进行优化。 For example, one side of the cladding sheet 300 may be optimized for the growth of new tissue, while the other side may be optimized for the transmission of the antimicrobial agent.

设有凹孔的敷片的使用由图4A、4B和4C所示出。 Use provided with recesses cladding sheet shown in FIG. 4A, 4B and 4C. 图4A所示为伤口表面400。 4A is a wound surface 400 shown in FIG. 注意,伤口表面400可以代表深的组织伤口的小的内部部分、或浅的表面伤口中的大多数。 Note that, the wound surface 400 may be representative of deep tissue wounds of small internal part, surface or shallow wounds most. 图4B所示为将设有凹孔的敷片300应用到伤口表面400上,以及位于凹孔空隙330中的相应的组织生长物410。 FIG 4B shows the sheet cladding is provided with recesses 300 is applied to the wound surface 400, and the tissue located in the corresponding recesses 330 in the gap 410 growth. 最后在图4C中,示出了将设有凹孔的敷片300拆除掉而只留有组织生长物410。 Finally, in Figure 4C, it shows a cladding sheet 300 is provided with the recessed hole removal leaving out only the growth of tissue 410. 如将在以下详细论及,理想为提供一用于使敷片300保持压到伤口表面上的外力。 As will be addressed in detail hereinafter, is provided over a cladding sheet 300 for holding the external force to press the wound surface.

图5A和5B示出了本发明的另一实施方式,即粗糙的不规则敷片500。 5A and 5B illustrate another embodiment of the present invention, i.e., a rough irregular cladding sheet 500. 参看立体图,图5A绘出了不规则敷片500具有不规则空隙510以及不规则接触表面520的情形,其中所述接触表面520起到“钩形”元件的作用、其在将基体放置在伤口中时能够接触并且粘接到坏死组织上。 Referring to a perspective view, FIG. 5A depicts a case where irregular irregular cladding sheet 500 having a void 510 and 520 of the irregular surface of the contact, wherein the contact surface 520 act as a "hook" elements, in which the substrate is placed in a wound when capable of contacting and bonded to the necrotic tissue. 当将基体从伤口上拆除时,由于坏死组织粘接到钩形突起部520上,从而可将其从伤口上移除。 When the substrate is removed from the wound, due to the necrotic tissue adhered to the hook-shaped projection portion 520, so that it can be removed from the wound. 基体的拆除对伤口进行了清除。 Removal of the matrix of the wound was removed. 坏死组织的移除是使伤口愈合的重要部分。 Removal of necrotic tissue is an important part of wound healing. 敷片500的基体可由聚合物毡片或絮状物(batting)制成。 The base substrate 500 may be deposited polymer mats or floc (batting) is made. 在一个示例性实施方式中,用热空气使所述毡片烧焦,从而一定百分比的纤维熔融而形成具有一些钩状元件520的刻纹表面。 In one exemplary embodiment, the mat with hot air blackened, so that a certain percentage of the fibers to form a melt having a number of hook elements 520 sculptured surface. 另一个合适的构形可以是例如与钩状或环状织物一同使用的钩状材料(hook material)。 Another suitable configuration may be, for example, hook material (hook material) with the hook fabric used in conjunction or cyclic.

尽管所使用的方法和基体有利于新组织的生长,但在适当移除掉坏死组织后,伤口仍会受到感染并可以用例如包括抗菌银的物质对其进行处理,其中所述物质在杀死细菌方面起到作用。 Although the method used and the substrate is conducive to the growth of new tissue, but after appropriate removal of necrotic tissue away, and the wound may still be infected with, for example, comprise an antimicrobial silver-treated substance thereof, wherein said substance kills bacteria play a role.

一般地,新组织形成的伤口愈合阶段指的是增生阶段。 Generally, the new wound healing tissue formation stage refers to the stage of proliferation. 一旦在增生阶段伤口充分愈合,并且细菌量充分下降,则可使用不含抗菌银的、以及任选地含有生长促进材料的基体,以利于新细胞组织的连续增生。 Once sufficient proliferative phase of wound healing, and sufficiently reduced the amount of bacteria may be used without antimicrobial silver, and optionally a matrix containing growth promoting material to facilitate the continuous proliferation of new cells and tissues.

图5B所示为不规则敷片500的随机横剖面。 Figure 5B is a cross-sectional random irregular cladding sheet 500. 可通过使合适的基体经过处于基体组成材料的熔点或熔点附近的对流热的下面,而制成不规则敷片500的粗糙化表面。 The surface may be roughened by a suitable substrate through convection heat in the vicinity below the melting point or melting point of the composition of the matrix material, it is made irregular cladding sheet 500. 例如,聚合物材料通常在从大约250摄氏度到大约290摄氏度的范围中熔融。 For example, a molten polymeric material is typically in the range of from about 250 degrees Celsius to about 290 degrees Celsius. 在该范围下操作的短暂经过对流热源下面的聚合物毡片材料将历经表面熔融以及随后的位于其表面上的聚合物丝线的熔合过程。 Operating at short range after the heat convection following polymeric mat over the surface of the molten material and subsequent fusing of the polymer threads located on the surface. 可通过温度和暴露时间而控制表面熔融的程度,以生成具有展示出不规则空隙510和不规则接触元件的理想粗糙度的表面。 The degree of melting can be controlled by the surface temperature and exposure time, to generate a void 510 and exhibits an irregular roughness of the surface irregularities over the contact element. 尽管所示出的不规则敷片500仅具有一个粗糙化表面,但是本发明并未受此限限,原因为可同样地对上表面和下表面均进行粗糙化。 Although shown irregular cladding sheet 500 having a roughened surface only, but the present invention is not limited by this limit, for reasons to be in the same manner both upper and lower surfaces roughened. 这样的敷片在对受损的伤口进行治疗时将相当有用。 Such cladding sheet would be quite useful in the treatment of impaired wound.

如上所述,使用本伤口绷带发明进行的处理包括压下创造性绷带,使其与伤口表面处于紧密接触状态。 As described above, using the process of the present invention comprises a wound dressing inventive pressure bandages, wound surface and it is in intimate contact state. 一般地,所述力应当至少0.1psi。 Generally, the force should be at least 0.1 psi. 可想象得到用于保持所述紧密接触状态的各种方法和系统。 Conceivable that the various methods and systems for maintaining the state of close contact. 这些方法和系统可包括:将粘合膜贴在创造性绷带上、以及贴在邻近伤口表面之处;使绷带缠在敷片上并使其缠绕着受伤区域;以及将气袋或其他可膨胀囊状物紧固到结构件上,使囊状物充上气体或液体。 The method and system may comprise: an adhesive film onto the inventive bandage, and attached adjacent the surface of the wound; bandage wrapped around the cladding sheet wrapped around the injured area and allowed; and the air bag or other inflatable bladder was secured to the structural member, so that the bladder filled gas or liquid. 在一示例性实施方式中,间歇地将压力施加到囊状物上。 In an exemplary embodiment, the pressure is applied intermittently to the bladder. 可将贴合性密封件放置在伤口上,并使其接触结构件,接着再将刚性密封件紧固在伤口的上面,与结构件接触,从而使力传递到接触结构件上。 May be bonded seal is placed over the wound and brought into contact structure, and then again fastened on top of the rigid seal wounds, contact with the structural member so that the contact force is transmitted to the structural member. 接着在刚性密封件和柔韧性密封件之间施加压力,使接触结构件压到伤口表面上。 Then applying a pressure seal between the rigid and flexible seal member, the contact structure pressed onto the wound surface. 可通过使用贴合性护罩密封住伤口区域同时施加吸力而提高紧密接触。 Suction may be applied by using a bonding shroud seal the wound area while simultaneously improving intimate contact. 当使用吸力时,设有凹孔的伤口敷片300尤其良好地适用于所述应用。 When using suction, is provided with recessed hole wound dressing sheet 300 is particularly well suited to the application. 一般地,吸力的大小范围在0.25PSI和5psi之间。 In general size range, and the suction between 0.25PSI 5psi. 通过将伤口包扎材料包扎到敷片的背面上,可进一步改进吸力的使用。 By packing material wound dressing to the back of the sheet cladding can be further improved using suction. 一种此类合适的伤口包扎材料描述在美国临时专利申请第60/554,158号中,其申请日为2004年3月18日。 One such suitable wound dressing materials are described in US Provisional Patent Application No. 60 / 554,158, filed its March 18, 2004.

范例分析1患者A,70岁,男性,右臀部二级褥疮,明显溃烂。 Examples of analysis 1 patient A, 70 years old, male, right hip two bed sores, canker significantly. 将本发明的接触结构件敷贴到伤口上,将粘合膜放置在伤口上面,并且与结构件接触。 The contact structure according to the invention the applicator member to the wound, the wound adhesive film is placed above and in contact with the structural member. 在粘合膜的下面施加1.1psi的吸力,以将力传递到接触结构件上。 Applying suction below 1.1psi adhesive film, to transfer a force to the contact structure. 大体上持续保持吸力。 Generally continue to maintain suction. 每隔两到四天更换接触材料。 Every two to four days to replace the contact material. 在使用该用品30天后,伤口的溃烂部分基本愈合,伤口的开口区域从66平方厘米缩小到45平方厘米。 In the article the use of 30 days, the wound is substantially healed ulcers portion, the wound opening area is reduced from 66 cm2 to 45 cm2. 对伤口进行多层皮肤移植。 The wound multilayer skin graft.

范例分析2患者B,50岁,男性,右踝部骨折(facture),露出骨头。 Examples of analysis of patient B, 50 years old, male, right ankle fracture (facture), exposing the bone. 使用板以进行骨折复位,并且进行游离腹直肌皮瓣处理,覆盖住露出的骨头及硬体(hardware)。 For fractures using a plate, and performs the processing of the free TRAM flap, covering the exposed bone and hardware (hardware). 皮瓣仅部分存活,导致形成带有露出的骨头及硬物的、具有开口的伤口。 Only part of the flap survival, results in the formation of bone and is exposed with a hard object, having an opening of a wound. 将本发明的接触结构件敷贴到伤口上,以及将粘合膜放置在伤口的上面并使其接触结构件。 The contact structure according to the invention the applicator member to the wound, and the adhesive film is placed over the wound and brought into contact structure. 通过使极好的绷带缠绕着踝部,或通过吸力的应用而将力施加到接触结构件上。 By the excellent ankle bandage, or by the contact force is applied to the structural member by applying suction. 一般地,施加吸力大约半天,并且在当天的剩余时间中保持住绷带包套的力,若干天后,仅使用绷带包套以提供力。 Generally, suction is applied about half a day, and hold the bandage wrap force rest of the day, several days, only the bandage wrap in order to provide a force. 当通过吸力提供力时,使用1到2psi之间的吸力。 When provided by suction force using a suction between 1 to 2psi. 不到两星期,新组织已经在露出的硬物上长出。 Less than two weeks, the new organization has grown on the exposed hard object. 在7个星期的时间段中,伤口区域从50平方厘米缩小到28平方厘米。 In the seven-week period, the wound area is reduced from 50 cm2 to 28 cm2.

尽管已经在本申请文件中显示及描述了本发明的优选实施方式,但是应可理解,提供这些实施方式仅出于示例作用。 While there has been shown and described preferred embodiments of the present invention in this document, it should be understood that these embodiments are merely examples for effect. 所属领域的技术人员可想象得到许多不偏离本发明的精神的变化、修改和替换方案。 Those skilled in the art can imagine many without departing from the spirit of the present invention, variations, modifications, and alternatives. 因此,权利要求书将涵盖所有落入本发明的范围和精神之内的所述变化方案。 Accordingly, the appended claims to cover all variations within the scope of the invention and fall within the spirit.

Claims (42)

1.一种用于促进哺乳动物体上伤口愈合的治疗用品,所述用品包括:一个渗透性结构件,其具有多个形成在其表面上的凹处;其中,具有所述多个凹处的所述表面被安置成与伤口的至少一个表面接触,且至少在伤口中存在有流体的情况下,所述结构件可基本上保持住预定构形。 1. A method for promoting wound healing mammalian body treatment products, said article comprising: a permeable structure having a plurality of recesses formed on its surface; wherein said plurality of recesses having the surface is placed in contact with at least one surface of the wound, and the presence of fluid at least in the case of a wound, the structural member can retain substantially the predetermined configuration.
2.根据权利要求1所述的用品,其中,所述结构件包括合成聚合物。 2. The article according to claim 1, wherein said structural member comprises a synthetic polymer.
3.根据权利要求2所述的用品,其中,所述合成聚合物包括聚烯烃。 3. The article according to claim 2, wherein said synthetic polymer comprises a polyolefin.
4.根据权利要求3所述的用品,其中,所述聚烯烃是聚乙烯或聚丙烯的一种。 4. The article according to claim 3, wherein the polyolefin is a polyethylene or polypropylene.
5.根据权利要求2所述的用品,其中,所述合成聚合物包括聚氨酯。 5. The article according to claim 2, wherein the synthetic polymer comprises a polyurethane.
6.根据权利要求4所述的用品,其中,所述聚氨酯是尼龙。 6. Products according to claim 4, wherein the polyurethane is nylon.
7.根据权利要求2所述的用品,其中,所述合成聚合物包括聚酯。 7. The article according to claim 2, wherein said synthetic polymer comprises a polyester.
8.根据权利要求1所述的用品,其中,所述结构件包括纺织材料。 8. The article according to claim 1, wherein said structural member comprises a textile material.
9.根据权利要求1所述的用品,其中,所述结构件包括针织材料。 9. The article according to claim 1, wherein said structural member comprises a knit material.
10.根据权利要求1所述的用品,其中,所述结构件包括编织材料。 10. The article according to claim 1, wherein said structural member comprises a woven material.
11.根据权利要求1所述的用品,其中,所述结构件包括刺绣材料。 11. The article according to claim 1, wherein said structural member comprises a needlework material.
12.根据权利要求1所述的用品,其中,所述结构件包括毡织材料。 12. The article according to claim 1, wherein said structural member comprises a woven felt material.
13.根据权利要求1所述的用品,其中,所述结构件包括纺粘的材料。 13. The article according to claim 1, wherein said structural member comprises a spunbond material.
14.根据权利要求1所述的用品,其中,所述结构件包括熔喷材料。 14. The article according to claim 1, wherein said structural member comprises a meltblown material.
15.根据权利要求1所述的用品,其中,所述结构件包括熔纺材料。 15. The article according to claim 1, wherein said structural member comprises a melt-spun material.
16.根据权利要求1所述的用品,其中,所述结构件包括纤维材料,所述纤维材料包括至少一条纤维。 16. The article according to claim 1, wherein said structural member comprises a fibrous material, the fibrous material comprises at least one fiber.
17.根据权利要求16所述的用品,其中,所述纤维进一步包括愈合剂。 17. The article according to claim 16, wherein said fiber further comprises a healing agent.
18.根据权利要求17所述的用品,其中,所述愈合剂为透明质酸和/或抗菌银中的至少一种。 18. The article according to claim 17, wherein the healing agent is hyaluronic acid and / or at least one antimicrobial silver.
19.根据权利要求16所述的用品,其进一步包括一条第二纤维,该第二纤维包括选自于胶原和藻酸钙的愈合材料。 19. The article according to claim 16, further comprising a second fiber, the second fiber comprises a healing material is selected from collagen and calcium alginate.
20.根据权利要求1所述的用品,其进一步包括联结到渗透性结构件的至少一部分上的粘合膜。 20. The article according to claim 1, further comprising an adhesive film on at least a portion of the structural member coupled to the permeability.
21.一种用于促进哺乳动物体上伤口愈合的治疗用品,所述用品包括:一渗透性结构件,其具有:多个设置在结构件端部之间的伤口表面接触元件,以及多个由所述接触元件界定的空隙,其中,至少在伤口中存在有流体的情况下,所述结构件可大体保持住预定构形。 21. A method for promoting wound healing mammalian body treatment products, said article comprising: a permeable structure, comprising: a plurality of contact elements disposed between the surface of the wound structure end portions, and a plurality of void defined by the contact element, wherein at least the fluid present case, the structural member can hold a predetermined configuration substantially in the wound.
22.根据权利要求21所述的用品,其中,所述结构件包括具有第一表面区域的第一侧部以及具有第二表面区域的第二侧部。 22. The article according to claim 21, wherein said structural member comprises a first portion having a first side and a second surface region of the side surface portion of the second region.
23.根据权利要求22所述的用品,其中,所述多个空隙设置在所述第一侧部和/或所述第二侧部中的至少一个上。 23. The article according to claim 22, wherein the plurality of voids disposed on the first side portion and / or the second side portion of at least one.
24.根据权利要求23所述的用品,其中,所述多个空隙占据的面积大于其所在侧部的表面积的大约25%。 24. The article according to claim 23, wherein said plurality of voids greater than the area it occupies about 25% of the surface area of ​​the side portion.
25.根据权利要求23所述的用品,其中,所述多个空隙占据的面积大于其所在侧部的表面积的大约50%。 25. The article according to claim 23, wherein said plurality of voids in it is larger than the area occupied by the surface area of ​​the side portion is approximately 50%.
26.一种用于促进哺乳动物体上伤口愈合的治疗用品,所述用品包括:一渗透性结构件,该结构件包括多条彼此联结的、随机布置的纤维并且具有:多个设置在结构件端部之间的伤口表面接触元件;以及多个由所述接触元件界定的空隙。 26. A method for promoting wound healing mammalian body treatment products, said article comprising: a permeable structure, the structure comprising randomly arranged fibers coupled to each other and having a plurality of: a plurality of structures arranged wound surface between the contact element end portion; and a plurality of contact elements defined by the voids.
27.一种用于促进哺乳动物体上伤口愈合的治疗用品,所述用品包括:一聚合物毡片,该毡片具有多个设置在结构件端部之间的伤口表面接触元件;以及多个由所述接触元件界定的空隙。 27. A method for promoting wound healing mammalian body treatment products, said article comprising: a polymer mat, the surface of the wound mat having a plurality of structural member disposed between the end portions of the contact elements; and a plurality a contact element defined by the voids.
28.一种制造用于促进哺乳动物体上伤口愈合的治疗用品的方法,包括以下步骤:提供一熔融的基体材料;提供一界定形成多个凹处和多个接触元件的模子;将熔融的基体材料涂到模子上;冷却所述熔融的基体材料;以及将成形的用品从模子中取出。 28. A method of manufacturing a mammalian body for promoting wound healing treatment article, comprising the steps of: providing a molten matrix material; providing a mold defining a plurality of recesses are formed and a plurality of contact elements; melted matrix material applied to the mold; cooling the molten matrix material; and the formed articles removed from the mold.
29.一种制造用于促进哺乳动物体上伤口愈合的治疗用品的方法,包括以下步骤:提供一渗透性结构件;以及在所述渗透性结构件的表面中形成多个凹处。 29. A method of manufacturing a mammalian body for promoting wound healing treatment article, comprising the steps of: providing a permeable structure; and forming a plurality of recesses in a surface of said permeable structural member.
30.根据权利要求29所述的方法,其中,所述形成多个凹处的步骤包括热冲压。 Step 30. The method of claim 29, wherein said recess comprises a plurality of hot stamping.
31.根据权利要求29所述的方法,其中,所述形成多个凹处的步骤包括真空成形。 Step 31. The method of claim 29, wherein said recess comprises a plurality of vacuum forming.
32.根据权利要求29所述的方法,其中,所述形成多个凹处的步骤包括模压加工。 Step 32. The method of claim 29, wherein said recess comprises a plurality of embossing.
33.根据权利要求29所述的方法,其中,所述形成多个凹处的步骤包括切割加工。 Step 33. A method according to claim 29, wherein said recess comprises a plurality of cutting.
34.根据权利要求29所述的方法,其中,所述形成多个凹处的步骤包括传输对流热越过结构件的其中至少一个表面上,其中所述对流热大概处于结构件材料的熔点温度。 Step 34. A method according to claim 29, wherein said plurality of recesses comprises forming a convective heat transfer across the structural member wherein the at least one surface, wherein said convective heat at about the melting temperature of the structural member material.
35.一种处理伤口的方法,包括以下步骤:提供一渗透性结构件,所述结构件包括多条纤维并且具有:i)多个设置在结构件端部之间的伤口表面接触元件;ii)多个由所述接触元件界定的空隙;将渗透性结构件敷贴到伤口的至少一个表面上。 35. A method of treating a wound, comprising the steps of: providing a permeable structure, said structure comprises a plurality of fibers and having: I) a plurality of wound surface structural member disposed between the end portions of the contact elements; ii ) a plurality of voids defined by the contact member; applicator member on the permeable structured to at least one surface of a wound.
36.根据权利要求35所述的方法,其进一步包括以下步骤:将粘合膜贴到渗透性结构件的至少一部分上,该部分与接触元件相对;以及使用粘合膜可解除地保持渗透性结构件与伤口表面紧密接触。 36. The method according to claim 35, further comprising the step of: the adhesive film attached to at least a portion of the permeable structure, the portion of the contact member opposite; and using an adhesive film releasably retained permeability structure element in close contact with the wound surface.
37.根据权利要求35所述的方法,其进一步包括使用绷带包套可解除地保持渗透性结构件与伤口表面紧密接触的步骤。 37. The method according to claim 35, further comprising using bandage wrap for releasably retaining step permeable structure in close contact with the wound surface.
38.根据权利要求35所述的方法,其进一步包括使用吸力可解除地保持渗透性结构件与伤口表面紧密接触的步骤。 38. The method according to claim 35, further comprising using a suction releasably holding step permeable structure in close contact with the wound surface.
39.根据权利要求35所述的方法,其进一步包括使用伤口包扎件可解除地保持渗透性结构件与伤口表面紧密接触的步骤。 39. The method according to claim 35, further comprising the use of a wound dressing member releasably holding step permeable structure in close contact with the wound surface.
40.根据权利要求35所述的方法,其进一步包括使用充气型囊状物可解除地保持渗透性结构件保持与伤口表面紧密接触的步骤。 40. The method according to claim 35, further comprising using inflatable bladder structure for releasably retaining the permeability of the step holder in close contact with the wound surface.
41.一种处理伤口的方法,包括以下步骤:提供一个第一渗透性结构件,其包括:i)多个设置在结构件端部之间的伤口表面接触元件;ii)多个由所述接触元件界定的空隙;将第一渗透性结构件敷贴到伤口上,使得接触元件中的至少一部分与伤口表面的一部分接合;在一个预定的时间段后,将第一渗透性结构件从伤口上拆下,连同拆下的是联结到接触元件中的多个元件上的、坏死组织中的至少一部分;提供一个第二渗透性结构件,该第二渗透性结构件包括基于伤口状况的药剂;以及在一个第二预定时间段后,将第二渗透性结构件从伤口上拆下。 41. A method of treating a wound, comprising the steps of: providing a first permeable structure, which comprises: i) a plurality of contact elements disposed between the surface of the wound structure end; ii) a plurality of said the contact element defines a void; the first structural member permeable to wound applicator, so that at least a portion of the engagement portion of the wound contacting surface of the element; after a predetermined period of time, the permeability of the first structure from the wound detached, together with at least a portion of the removed elements is coupled to the plurality of the contact elements, necrotic tissue; providing a second permeable structural member, the second member comprises a permeable structure-based drug wound condition ; and after a second predetermined period of time, the permeability of the second structural member is removed from the wound.
42.根据权利要求41所述的方法,其进一步包括以下步骤:将一个第三渗透性结构件敷贴到伤口上,所述第三结构件具有多个形成在其表面上的凹处。 42. The method according to claim 41, further comprising the steps of: a third structural member permeable to wound applicator, said third structural member having a plurality of recesses formed on its surface.
CN 200580011312 2004-04-13 2005-03-10 Wound contact device CN1956689A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008141228A1 (en) 2007-05-10 2008-11-20 Kci Licensing Inc. Reduced pressure wound dressing having a wound contact surface with columnar protrusions
CN103480048A (en) * 2008-05-30 2014-01-01 凯希特许有限公司 Reduced-pressure, compression systems and apparatuses for use on joints
CN105193553A (en) * 2015-08-12 2015-12-30 万龙 Water-absorbent non-woven fabric and preparation method thereof as well as medical non-woven fabric

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008141228A1 (en) 2007-05-10 2008-11-20 Kci Licensing Inc. Reduced pressure wound dressing having a wound contact surface with columnar protrusions
EP2144643A4 (en) * 2007-05-10 2018-01-03 KCI Licensing, Inc. Reduced pressure wound dressing having a wound contact surface with columnar protrusions
CN103480048A (en) * 2008-05-30 2014-01-01 凯希特许有限公司 Reduced-pressure, compression systems and apparatuses for use on joints
CN103480048B (en) * 2008-05-30 2016-07-06 凯希特许有限公司 For use on pressure compression system and the joint means
CN105193553A (en) * 2015-08-12 2015-12-30 万龙 Water-absorbent non-woven fabric and preparation method thereof as well as medical non-woven fabric

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