CN1939310A - Composition for losing weight - Google Patents
Composition for losing weight Download PDFInfo
- Publication number
- CN1939310A CN1939310A CN 200610116717 CN200610116717A CN1939310A CN 1939310 A CN1939310 A CN 1939310A CN 200610116717 CN200610116717 CN 200610116717 CN 200610116717 A CN200610116717 A CN 200610116717A CN 1939310 A CN1939310 A CN 1939310A
- Authority
- CN
- China
- Prior art keywords
- berberine
- oryzanol
- hypertension
- medicine
- jin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
A medical composition for losing weight and preventing and treating the diseases associated with obesity is prepared from berberine and oryzanol in weight ratio of (8-8.5):1.
Description
Technical field
A kind of dietetic composition of the present invention relates to a kind of with berberine and the oryzanol combined preparation compositions as fat-reducing, also relates to simultaneously said composition is used for the treatment of and obesity and diseases associated thereof.
Technical background
Berberine is a kind of isoquinoline alkaloid that extracts from Ranunculaceae Coptis root stock, to various bacteria, as dysentery bacterium, tubercule bacillus, streptococcus pneumoniae, Bacillus typhi and diphtheria corynebacterium etc. inhibitory action is arranged all, wherein the strongest to the dysentery bacterium effect, be commonly used to treat digestive tract disease such as bacillary gastroenteritis, dysentery.Because oral absorption difference therefore traditional Chang Zuowei antibiotics is used for the treatment of intestinal infection disease berberine.Oryzanol is usually used in diseases such as autonomic nervous dysfunction, pre-menstrual period nercousness and climacteric syndrome, such as: gastric ulcer, irritable bowel syndrome, chronic gastritis, gastroptosis.
But, the poorly soluble of berberine hydrochloride and berberine tannate.
Zoopery in 2006, the Korea S scholar finds in the metabolic effect of research berberine to insulin resistant and two treated animal models that insulin is responded, berberine can alleviate its body weight under the immovable situation of mice intake, the Wistar mice that same berberine can make high fat diet feed loses weight, reduces plasma triglyceride.Berberine can be reduced the gene expression of lipogenesis, raises the gene expression that fatty tissue and muscular energy consume.Confirm that berberine can improve diabetes and fat effect by stimulating the AMPK activity to have.
The influence of adipose cell 3T3-LI cell strain cell differentiation before research such as the endocrine institute Zhou Libin of Shanghai Second Emdical University in 2003, find that berberine obviously suppresses the preceding adipose cell of 3T3-LI cell and is divided into adipose cell, berberine suppresses lipogenesis, be gene expression by inhibition PPAR γ 2, and the differentiation of adipose cell before suppressing.
Fudan University's combination of Chinese and Western medicine institute in 2004, the Wang Shuhai of endocrine diabetes study institute etc. find that also berberine suppresses the expression of adipose cell differentiation and PPAR γ and C/EBP α mRNA in the influence of research berberine to adipose cell carbohydrate metabolism and cell differentiation.Can not cause gathering of body fat and cause weight increase.
Jiangsu college of traditional Chinese medicine chief editor's Chinese medicine voluminous dictionary states clearly, and the berberine therapeutic dose is quite safe, and few side effects is taken for a long time and do not seen any obstacle, once oral 2 gram berberine or take Rhizoma Coptidis powder 100 grams and do not see any side effect.Pointing out also when the complete works of berberine dosage of chief editor's clinical applications such as Sun Chen is the 0.6-1.0 gram that this product is oral has no side effect.The new pharmacology of Chen Xinqian etc. chief editor latest edition, 0.06 three months courses of treatment of gram of oryzanol oral every day, oral only have stomach discomfort, xerostomia, alopecia, a fat secretion etc.Therefore the application of berberine and oryzanol composition is quite safe.
Summary of the invention
The purpose of a kind of dietetic composition of the present invention is to provide a kind of fat-reducing medicine and food that comprises berberine and oryzanol.
Another purpose of a kind of dietetic composition of the present invention is to provide the purposes of this fat-reducing medicine.
A kind of dietetic composition of the present invention is achieved through the following technical solutions: a kind of dietetic composition, comprise berberine and oryzanol, the weight ratio of berberine and oryzanol is 8～8.5: 1, the consumption of oryzanol is 180～300 milligrams/people. day, the consumption of oryzanol is selected to use according to patient's the body constitution and the different situations of the state of an illness.Said composition also includes excipient or carrier.
On the such scheme basis, the preferable weight ratio of described berberine and oryzanol comprises 8.0: 1,8.1: 1, and 8.2: 1,8.3: 1,8.4: 1, in 8.5: 1 one group, the consumption of oryzanol is 180～300 milligrams/people. day.
Further, the more excellent weight ratio of described berberine and oryzanol comprises 8.30: 1,8.31: 1, and 8.32: 1,8.33: 1,8.34: 1,8.35: 1,8.36: 1,8.37: 1,8.38: 1,8.39: in 1 one group, the consumption of oryzanol is 180～300 milligrams/people. day.
In the present invention, described berberine is berberine hydrochloride or berberine tannate, can be commercially available berberine hydrochloride or berberine tannate, also can be berberine hydrochloride or berberine tannate by the known method preparation, but, do not comprise sulphuric acid, phosphoric acid or citric acid berberine.
Among the present invention, described dietetic composition is used to prepare medicine, and this medicine is used to prevent with obesity diseases related or symptom.With obesity diseases related or symptom common disease or the symptom in this area normally, as cardiovascular and cerebrovascular disease and diabetic symptom, such as: fatty liver, hypertension, blood sugar increasing, coronary heart disease, myocardial infarction, apoplexy etc.
In the present invention, described excipient or carrier are excipient or carrier commonly used in pharmacy or the field of food, as diluent, disintegrating agent, lubricant etc.
Pharmacology explanation: because the dissolubility of berberine hydrochloride or berberine tannate is low, be not easy to absorption of human body, and oryzanol be a kind of triterpene alcohol Wei acid esters mixture, fat-soluble strong, itself and berberine hydrochloride combination, the absorption of promotion berberine.And, the long half time of the compound preparation that berberine hydrochloride or berberine tannate and oryzanol are made, medicine are eliminated in the body slower, make human body have time enough fully to absorb the drug, the strong blood drug level of certain level in keeping body strengthens the curative effect of berberine.
The beneficial effect of a kind of dietetic composition of the present invention is: the compositions of using berberine hydrochloride or berberine tannate and oryzanol, significantly reduce hyperlipemia patient's serum cholesterol, serum triglycerides, low-density lipoprotein cholesterol, apolipoprotein B and fasting glucose, reduce patient's body weight significantly, thereby reach fat-reducing effect.Simultaneously, the side effect of this dietetic composition is little, medicament sources is abundant, with low cost, meets China's actual conditions.This has very important clinical significance for reducing the cardiovascular and cerebrovascular vessel incident.
The specific embodiment
Embodiment 1
A kind of dietetic composition comprises berberine and oryzanol, and the weight ratio of berberine and oryzanol is selected 8.1: 1, and 8.2: 1,8.3: 1,8.4: 1,8.5: 1, the consumption of oryzanol was 180～300 milligrams/people. day.
In the present embodiment, described berberine is berberine hydrochloride or berberine tannate, can be commercially available berberine hydrochloride or berberine tannate, also can be berberine hydrochloride or berberine tannate by the known method preparation, but, do not comprise sulphuric acid, phosphoric acid or citric acid berberine.
In the present embodiment, described excipient or carrier are excipient or carrier commonly used in pharmacy or the field of food, as diluent, disintegrating agent, lubricant etc.
Dietetic composition described in the present embodiment can be used as the medicine of prevention and obesity diseases related or symptom, as cardiovascular and cerebrovascular disease and diabetic symptom, such as: fatty liver, hypertension, blood sugar increasing, coronary heart disease, myocardial infarction, apoplexy etc.Through check, the rate of losing weight is not less than 90%.
Embodiment 2
A kind of dietetic composition comprises berberine and oryzanol, the weight ratio of berberine and oryzanol 8.30: 1,8.31: 1,8.32: 1,8.33: 1,8.34: 1,8.35: 1,8.36: 1,8.37: 1,8.38: 1,8.39: 1, the consumption of oryzanol is 180～300 milligrams/people. day.
Berberine is to use berberine hydrochloride, 60 routine hyperlipidemia patients are followed up a case by regular visits to, monitored, find: in the time of rate and blood-lipid decreased, also significantly reduced patient's body weight, this group hyperlipemia patient, Body Mass Index more than or equal to 25 35 routine patients in, wherein 29 routine patients' body weight drops to 66.93 ± 1.9 kilograms of (scope is the 2-12.5 kilogram) significant differences especially significantly (P＜0.001) by 71.41 ± 2.08 kilograms, rate of descent reaches 83%.Wherein 19 routine weight loss equal or exceed 5 kilograms, account for to have 66% in fat-reducing effect 29 examples.Body Mass Index less than 25 25 routine patients in, 2 routine patients' weight loss 1.5-2 kilogram.Rate of descent is 8%.Significant difference (P＜0.01) is arranged between two groups of statistical datas of body weight 〉=25 and body weight＜25, show that the present invention is more obvious to overweight person's fat-reducing.Observe to show that fat-reducing generally is from abdominal part, buttocks, gradually prolong gradually and whole body and internal organs that observation shows, after the rate and blood-lipid decreased, case the earliest can have the body weight change of dominance about first quarter moon, promptly has obviously in general about 2-3 month to lose weight.If keep life style and dietary structure constant, then body weight can maintain the reduced levels after the fat-reducing.If further take healthy lifestyles and dietary structure and continue to take medicine by effective dose, body weight then shows carrying out property and alleviates tendency.The most tangible patient of fat-reducing effect loses weight 12.5 kilograms.This group data also shows, abnormal liver function before the 16 routine patient treatments, and risings such as transaminase (ALT, AST) and γ-GT are reduced to normal after the treatment.The prompting fatty infiltration of liver improves.Be to be a fat-reducing effect part.
60 routine hyperlipemia patients blood fat after berberine hydrochloride and oryzanol composition treatment has had obvious decline.As showing:
| TCH | TG | LDL-C | HDL-C | -B | SG＞6 | SG＜6 | |
| Treatment back t p before the treatment | N＝50 6.42±0.26 4.57±0.18 14.27 ＜0.0001 | N＝46 4.67±1.37 2.49±0.7 3.26 ＜0.001 | N＝58 3.64±0.13 2.72±0.08 7.73 ＜0.0001 | N＝55 1.43±0.1 1.29±0.06 2.34 ＜0.05 | N＝43 1.01±0.1 0.77±0.1 7.88 ＜0.0001 | N＝15 7.68±0.68 6.29±0.31 2.43 ＜0.05 | N＝34 5.29±0.07 5.34±0.06 0.64 ＞0.05 |
This group has fat-reducing effect staff list and fat-reducing situation catalog:
| The woman | More than 60 one full year of life | The patient | Age | Disease | The fat-reducing effect |
| Lee | 63 | Hypertension | Take medicine 3-4 month 133 → 121 jin | ||
| The gold certain | 68 | Hypertension | Take medicine 4 months 114 → 110 jin | ||
| Chen | 71 | Hypertension | Take medicine 3 months 154 → 134 jin | ||
| Zhu | 72 | The hypertension cerebral infarction | Take medicine 2 months 130 → 120 jin | ||
| Xu certain | 63 | Hypertension | Take medicine 3 months 138 → 118 jin | ||
| Appoint certain | 73 | The hypertension cerebral infarction | Take medicine 3 months 134 → 118 jin | ||
| Lu | 77 | The hyperlipemia fatty liver | Take medicine and reduced 4 jin in 3 months | ||
| Yao | 67 | The hypertension cerebral infarction | 3 months 130-112 jin of taking medicine |
| 60 one full year of life following (containing for 60 one full year of life) | Xu certain | 60 | The hypertension wind heart | Take medicine 3 months 160 → 150 jin | |
| Zhao | 30 | Hypertension | Take medicine 2 months 135 → 125 jin | ||
| Money | 55 | Hypertension | Take medicine 3 months 118 → 108 jin | ||
| Poplar | 52 | The hypertension wind heart | Take medicine and reduced 4 jin in 1.5 months | ||
| Thank certain | 54 | Hypertension | Take medicine and reduced 4 jin in 2 months | ||
| Jiang | 53 | The hypertension cerebral infarction | Take medicine 3 months 130 → 118 jin | ||
| Wang certain | 53 | Hypertension | Take medicine and reduced 5 jin in 2 months | ||
| Chen | 52 | The hypertension fatty liver | Take medicine 24 days 195 → 183 jin | ||
| The man | More than 55 one full year of life | Thank certain | 72 | The hypertension cerebral infarction | Take medicine 3 months 138 → 113 jin |
| Answer certain | 65 | The hypertension fatty liver | Take medicine 4 months 114 → 110 jin | ||
| Chapter | 57 | The hypertension fatty liver | Take medicine 2 months 172 → 163 jin | ||
| Lee | 80 | Hypertension | Obey 2 months 173 → 163 jin | ||
| Fourth | 58 | The gout fatty liver | Take medicine 2 months 160 → 150 jin | ||
| Lee | 65 | Hypertension | Take medicine 2 months 126 → 122 jin | ||
| The father-in-law | 50 | The hypertension fatty liver | Take medicine 2 months 160 → 147 jin | ||
| Permitted certain | 44 | The hypertension fatty liver | Take medicine 3 months 168 → 148 jin |
| 55 one full year of life following (containing for 55 one full year of life) | The land | 55 | Hypertension fatty liver hepatitis | Take medicine 2 months 160 → 148 jin | |
| Zhu | 52 | Hypertension | Take medicine 4 months 138 → 128 jin | ||
| Shen | 48 | Hypertension | Take medicine 2 months 155 → 148 jin | ||
| Grandson | 52 | Hypertension | Take medicine and reduced 4 jin in 3 months | ||
| Wei | 38 | Hypertension | Take medicine 1.5 months 127 → 115 jin |
Embodiment 3
A kind of dietetic composition of the present invention, the weight ratio of berberine and oryzanol is 8.20: 1,8.21: 1,8.22: 1,8.23: 1,8.24: 1,8.25: 1,8.26: 1,8.27: 1,8.28: 1,8.29: 1, the consumption of oryzanol is 180～300 milligrams/people. day, berberine is berberine hydrochloride or berberine tannate, can be commercially available berberine hydrochloride or berberine tannate, also can be berberine hydrochloride or berberine tannate by the known method preparation, but, do not comprise sulphuric acid, phosphoric acid or citric acid berberine.
Dietetic composition described in the present embodiment is used to prepare the medicine of a kind of prevention and obesity diseases related or symptom, as cardiovascular and cerebrovascular disease and diabetic symptom, such as: fatty liver, hypertension, blood sugar increasing, coronary heart disease, myocardial infarction, apoplexy etc.
In the present embodiment, excipient that is added or carrier are excipient or carrier commonly used in pharmacy or the field of food, as diluent, disintegrating agent, lubricant etc.
The typical case patient introduces:
1. should 64 years old college professor's hypertension diabetic hyperlipidemia fatty liver of certain man more than 20 year, three times on the one cholesterol of clothes berberine oryzanol composition 0.5 gram drop to the 3.99mmol/L triglyceride by 5.09mmol/L and drop to 2.05mmol/L by 3.18mmol/L, and body weight drops to 56.5 kilograms by 69.
2. 63 years old hypertension hyperlipemia of woman Lee once taken stanin fat-reducing, take the fat-reducing of the whole bag of tricks and various China and foreign countries slimming medicine all obviously not prove effective, after taking berberine and oryzanol composition 3-4 month, cholesterol drops to 4.57mmol/L by 7.17mmol/L, body weight is reduced to 60.5 kilograms by 66.5 kilograms, body weight is by rising 2.5-3 kilogram after drug withdrawal February, and the body weight of taking medicine again continues again to descend.
3. Chen woman hypertension height is 1.50 meters, 75 kilograms of body weight, typical case's abdominal obesity, the fat auntie of nickname, take 1 first quarter moon behind the berberine complex, cholesterol drops to 3.84mmol/L by 6.64mmol/L, and triglyceride drops to 1.68mmol/L by 3.98mmol/L, body weight drops to 70 kilograms by 77 kilograms, and weight loss to 68 kilogram continues to take medicine.
4. permitted certain male popular taxi driver's hypertension hyperlipemia fatty liver and previously suffered from multiple disease, conscious weak, dizzy, after abnormal liver function was taken berberine and oryzanol composition, the constant activity of diet was constant, and GOT is by 37U/L, reduce to 28 gradually, 26U/L Γ GT by 116U/L drop to 70 gradually, 58U/L, cholesterol drops to 3.94mmol/L by 6.93mmol/L, and triglyceride drops to 1.61mmol/L by 4.12mmol/L, and body weight drops to 76.5 kilograms by 84 kilograms
Application examples
The present composition made be used for the treatment of and obesity-related disease.
Experiment shows that berberine and oryzanol composition are used, and not only hyperlipemia are had reliable curative effect, can reduce serum cholesterol and triglyceride simultaneously, more can significantly alleviate patient's body weight, and definite fat-reducing effect is arranged.Body Mass Index is more than or equal among 25 the patient, and the weight loss rate reaches 83%, and wherein 61% patient body weight descends above 5 kilograms.
Experiment shows, during observing treatment 2-17 month (average 12.4 ± 6.8 months) in, except the part patient have gastrointestinal reaction through improve medication dose, method, after the time and continue to find no other cardiovascular and nervous system untoward reaction the treatment.
I am to 100 routine hyperlipemia blood fat reducing treatments and reach nearly 2 years clinical observation research, find that application berberine treatment rate and blood-lipid decreased, body weight significantly alleviate, and Rhizoma Coptidis have definite antiobesity action.
Test demonstration, abnormal liver function before the 16 routine Patients with Fatty Liver treatments, risings such as transaminase are reduced to normally after the treatment.The prompting fatty infiltration of liver improves, and is to be a fat-reducing effect part.Therefore the present invention is of value to the fatty liver treatment.
Claims (10)
1. a dietetic composition comprises berberine and oryzanol.
2. a kind of dietetic composition according to claim 1 is characterized in that: berberine is berberine hydrochloride or berberine tannate.
3. a kind of dietetic composition according to claim 1 and 2 is characterized in that: described compositions also includes excipient or carrier.
4. a kind of dietetic composition according to claim 3 is characterized in that: the weight ratio of berberine and oryzanol is 8～8.5: 1, and the consumption of oryzanol is 180～300 milligrams/people. day.
5. a kind of dietetic composition according to claim 4 is characterized in that: the weight ratio of berberine and oryzanol comprises 8: 1,8.1: 1, and 8.2: 1,8.3: 1,8.4: 1, in 8.5: 1 one group, the consumption of oryzanol is 180～300 milligrams/people. day.
6. a kind of dietetic composition according to claim 5, it is characterized in that: the weight ratio of berberine and oryzanol comprises 8.30: 1,8.31: 1, and 8.32: 1,8.33: 1,8.34: 1,8.35: 1,8.36: 1,8.37: 1,8.38: 1,8.39: in 1 one group, the consumption of oryzanol is 180～300 milligrams/people. day.
7. according to claim 1,2,4,5 or 6 described a kind of dietetic compositions, its purposes is: described dietetic composition is used to prepare the medicine of treatment and prevention of obesity.
8. a kind of dietetic composition according to claim 3, its purposes is: described dietetic composition is used to prepare the medicine of treatment and prevention of obesity.
9. according to claim 1,2,4,5 or 6 described a kind of dietetic compositions, its purposes is: described dietetic composition is used to prepare the medicine or the food of treatment and prevention and obesity-related disease.
10. a kind of dietetic composition according to claim 3, its purposes is: described dietetic composition is used to prepare the medicine or the food of treatment and prevention and obesity-related disease.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101167178A CN100435800C (en) | 2006-09-29 | 2006-09-29 | Composition for losing weight |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101167178A CN100435800C (en) | 2006-09-29 | 2006-09-29 | Composition for losing weight |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1939310A true CN1939310A (en) | 2007-04-04 |
| CN100435800C CN100435800C (en) | 2008-11-26 |
Family
ID=37958015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101167178A Expired - Fee Related CN100435800C (en) | 2006-09-29 | 2006-09-29 | Composition for losing weight |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100435800C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101574343B (en) * | 2008-05-07 | 2011-06-01 | 吉林大学 | Medicament composition for treating diabetes |
| US8003795B2 (en) | 2007-06-22 | 2011-08-23 | Cvi Pharmaceuticals Limited | Compounds and compositions for reducing lipid levels |
| CN103356611A (en) * | 2013-06-24 | 2013-10-23 | 上海交通大学医学院附属瑞金医院 | Application of berberine in preparation of weight-loss drug |
| CN108853050A (en) * | 2018-08-29 | 2018-11-23 | 北京荣祥再生医学研究所有限公司 | A kind of pharmaceutical carrier is preparing the application in antidiabetic compositions |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111146A (en) * | 1994-12-12 | 1995-11-08 | 杨创劳 | Chinese herbal medicinal 'Weiyanling' for treatment of gastropathy |
| CN1365676A (en) * | 2001-01-18 | 2002-08-28 | 杨孟君 | Nano medicine 'Compound berberine' and its preparing process |
-
2006
- 2006-09-29 CN CNB2006101167178A patent/CN100435800C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8003795B2 (en) | 2007-06-22 | 2011-08-23 | Cvi Pharmaceuticals Limited | Compounds and compositions for reducing lipid levels |
| US8815900B2 (en) | 2007-06-22 | 2014-08-26 | Cvi Pharmaceuticals Limited | Compounds and compositions for reducing lipid levels |
| CN101574343B (en) * | 2008-05-07 | 2011-06-01 | 吉林大学 | Medicament composition for treating diabetes |
| CN103356611A (en) * | 2013-06-24 | 2013-10-23 | 上海交通大学医学院附属瑞金医院 | Application of berberine in preparation of weight-loss drug |
| CN108853050A (en) * | 2018-08-29 | 2018-11-23 | 北京荣祥再生医学研究所有限公司 | A kind of pharmaceutical carrier is preparing the application in antidiabetic compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100435800C (en) | 2008-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2020063646A1 (en) | Strain for preventing and treating metabolic diseases and use thereof | |
| CN110623182A (en) | Probiotic plant solid beverage for treating hyperuricemia and gout | |
| Long et al. | Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine | |
| CN100435800C (en) | Composition for losing weight | |
| CN114259507A (en) | Application of Klebsiella minutissima in preparing medicine for treating and/or preventing hyperuricemia-related diseases | |
| CN108938622B (en) | Composition and application thereof in preparing anti-inflammatory drugs | |
| CN102078315A (en) | Application of ampelopsin in preparing medicines for treating obesity | |
| CN104606487A (en) | Fermented traditional Chinese medicine preparation as well as preparation method and application thereof | |
| CN110354228A (en) | Application containing soil material in preparation prevention and/or treatment metabolism class disease medicament or health care product | |
| CN101879162A (en) | Weight-losing medicament formed by matching alpha-ricinoleic acid ethyl ester with berberine | |
| CN101264091A (en) | Blood-fat reducing composition and uses thereof | |
| CN101411781A (en) | Use of pu'er tea in preparing medicament for treating or preventing diabetes | |
| CN109453169A (en) | The purposes of bulleyaconitine A | |
| CN112294893A (en) | Traditional Chinese medicine composition and application thereof in preparation of IR (infrared radiation) treatment medicine | |
| CN105535947A (en) | Pharmaceutical composition for treating II-type diabetes and preparation method of pharmaceutical composition | |
| CN110314160A (en) | Berbamine prevents and treats the application in medicine for treating diabetic nephropathy in preparation | |
| CN1299676C (en) | Anti-anoxia medicinal composition | |
| WO2023155865A1 (en) | Use of morinda officinalis oligosaccharides and composition thereof in prevention or treatment of depression | |
| CN113559166B (en) | Traditional Chinese medicine composition for treating diabetes and preparation method and application thereof | |
| CN1575803A (en) | Application method of Aloe vera L. extract in preventing and curing diabetes | |
| CN112741872B (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
| WO2023204364A1 (en) | Composition for prevention, amelioration or treatment of allergic respiratory diseases comprising alpinia officinarum hance extract as active ingredient | |
| CN112168861A (en) | Astragalus granules and preparation method thereof | |
| CN102283832B (en) | Medicinal composition for preventing or treating hypertensive obese patient and application thereof | |
| CN102552481A (en) | Traditional Chinese medicinal composition with effects of smoothing collaterals and lowering blood pressure and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081126 Termination date: 20180929 |