CN1931390A - Class D amplifier driven external deep brain stimulator - Google Patents
Class D amplifier driven external deep brain stimulator Download PDFInfo
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- CN1931390A CN1931390A CN 200610016107 CN200610016107A CN1931390A CN 1931390 A CN1931390 A CN 1931390A CN 200610016107 CN200610016107 CN 200610016107 CN 200610016107 A CN200610016107 A CN 200610016107A CN 1931390 A CN1931390 A CN 1931390A
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Abstract
The present invention relates to deep brain stimulator and belongs to the field of medical equipment. The class D amplifier driven external deep brain stimulator includes one in vivo signal stimulating part, one in vitro signal generating and controlling part, and one signal coupling module for signal coupling between the two foregoing parts. The in vivo signal stimulating part includes one pair of stimulating electrodes; and the in vitro signal generating and controlling part includes one class D amplifier and pulse driver module, one micro controller module. The pulse signal the micro controller module generates is amplified in the class D amplifier and pulse driver module and introduced with the signal coupling module to body to excite the stimulating electrode pair. The present invention has the advantages of low power consumption and high efficiency. The in vivo inducing output coil and stimulating electrodes are implanted via once operation and need no power source.
Description
Technical field
The present invention relates to a kind of brain depth stimulator, belong to medical instruments field.
Technical background
Brain depth stimulator is commonly called as brain pacemaker, and English name is Deep Brain Stimulator, is called for short DBS.DBS has obtained in the dyskinetic disorder using widely in treatment, is the method for the most promising at present treatment parkinson disease (Parkinson ' s Disease--PD).
Parkinson disease (Parkinson ' s Disease, be a kind of common person in middle and old age's nervous system degeneration disease PD), frequently-occurring disease is after 60 years old, it is slow mainly to show as patient motion, symptoms such as other parts of trick or health are trembled, and health loses flexibility, and it is stiff to become.In China, more than 170 ten thousand Parkinsonians are arranged among the old people more than 55 years old approximately, prevalence and American-European countries are approaching, and disease presents the trend of patient's rejuvenation.
At present, be among the continuous research at Parkinsonian Therapeutic Method always.Traditional Drug therapy is constantly to replenish dopamine, and it is main increasing the brain DOPAMINE CONTENT IN RABBIT, and common drug has levodopa (L-dopa) and some can activate the medicine of dopamine receptor.Except Drug therapy, surgical operation therapy also can play better curative effect, and common method has: brain cell transplantation art, damage art and brain depth stimulator are brain pacemaker.Though brain cell transplantation art and gene therapy have obtained very ten-strike in zoopery,, should not generally adopt because the ideal transplanted tissue of clinical shortage still rests on laboratory stage at present.Damaging art is to utilize the galvanocautery method to destroy function exaltation nuclear group in the brain, though effect generally acknowledged, have destructive operation, higher, an easy recurrence of complication as a kind of, and also higher to requirements such as patient's age, indications, there is obvious weak point.Brain deep electrical stimulation technology is to utilize brain stereotactic operation a certain special position implant electrode in brain, restrains the neuron of abnormal electrical activity by high-frequency electrical stimulation, thereby plays the effect of treatment.The characteristics of this technology maximum are determined curative effect, safety, can control by the postoperative adjustment, and side effect is little, does not destroy cerebral tissue, does not influence the treatment of other new methods from now on.Therefore, at present the DBS technology has replaced substantially and has damaged the first-selection that art becomes the parkinson disease surgical intervention.
At present, the DBS of Shi Yonging is by exclusive make (ActivaTherapy) of Medtronic Inc. (Medtronic Inc.) of the U.S. clinically, its structure mainly comprises four parts, implants that the patient is intravital to be: nerve stimulator, brain pacemaker lead, extended line, outer body are controlling magnet.The shortcoming of this brain pacemaker is that the supplying cell of the DBS of implant into body can not can only disposablely use from external for its electric energy supplement, and its life-span was in 5～8 years.In a single day battery power exhausts, and patient can only undergo surgery once more, takes out DBS to change, and has both increased patient's misery, has increased the weight of its financial burden again.And many places implantation foreign body also causes skin ulceration easily in the body.In addition, owing to the monopoly position of Medtronic Inc. in occupation of brain pacemaker, the price of its product is difficult to bear for the patient of China.
External deep brain stimulator can overcome above-mentioned deficiency, farthest shift out each ingredient of brain depth stimulator external, reduce patient's wound area, fundamentally solve present product needed and frequently change the problem of battery, but still there is the problem of inefficiency in the circuit that adopts bipolar transistor to drive.
Summary of the invention
The objective of the invention is to overcome the above-mentioned deficiency of prior art, a kind of low-power consumption, high efficiency external deep brain stimulator are provided, this kind brain depth stimulator is introduced drive circuit with the D class A amplifier A, receives good effect.
The present invention adopts following technical scheme: the external deep brain stimulator that a kind of D of employing class A amplifier A drives comprises intravital signal stimulus part and external signal generation and control section and is used for the coupled signal coupling module of two parts of signals; Intravital signal stimulus partly comprises pair of stimulating electrodes; External signal produces with control section and comprises D class A amplifier A pulsed drive module, micro controller module; After the amplification of pulse signal by the micro controller module generation, import in the body, encourage intravital pair of stimulating electrodes by the signal coupling module through D class A amplifier A pulsed drive module.
Signal coupling module of the present invention can adopt following structure: comprise excitation coil that links to each other with D class A amplifier A pulsed drive module and the induction output winding that links to each other with pair of stimulating electrodes.Induction output winding wherein is preferably circular planar disk-like.The signal coupling module preferably also has the alignment device of following structure: comprise be arranged on external and near the permanent magnet of excitation coil, be arranged on the magnetic core in the excitation coil and be arranged on magnetic core in the induction output winding.
Brain depth stimulator of the present invention preferably also comprises power supply monitoring and the charging module that is subjected to micro controller module control.
DBS of the present invention has following beneficial effect:
(1) pulse driving circuit has adopted the D class A amplifier A, this amplifier is used as audio frequency amplifier at first, because inner transistor (field effect transistor) only is operated in saturated or cut-off state, the linear properties pair amplifier is influence not, therefore the D class A amplifier A has characteristics such as low in energy consumption, efficient height.Native system adopts efficient that the D class A amplifier A drives and significantly improves when adopting bipolar transistor driving circuit, brings up to now 5.6% by original 7/10000ths, reaches the needs of external DBS substantially.Simultaneously, because the raising of switching speed, the pulsewidth of the pulse signal of generation also reaches the requirement of brain deep electricity irritation.
(2) insert intravital induction output winding and stimulating electrode and need not the power supply power supply, therefore only need once operation to implant and get final product.And output winding is designed to circular planar disk-like, reduces the thickness at intracranial.
(3) in excitation coil and induction the autoregistration device that the magnetic core by permanent magnet material and coil inside constitutes is housed between the output winding, two coils can be found accurately in the 10mm scope automatically, because the thickness of human brain parietal bone has only about 5mm, therefore can reach the needs that find accurately automatically the scalp both sides fully, keep higher coupling efficiency.
Description of drawings
Fig. 1 is a system architecture diagram of the present invention.
Fig. 2 is the structured flowchart of D class A amplifier A pulse driving circuit.
Fig. 3 is a signal coupling module structural representation of the present invention.Among the figure: 1 is excitation coil (primary coil); 2 is the magnetic core in the excitation coil; 3 is the excitation coil permanent magnet; 4 are induction output winding (secondary coil); 5 is the magnetic core in the secondary coil.
The specific embodiment
Below in conjunction with drawings and Examples the present invention is further described.
Fig. 1 is a system architecture diagram of the present invention.External deep brain stimulator of the present invention is divided into intravital signal stimulus part with brain depth stimulator and external signal produces and control section, and two parts transmit signal by signal coupling module coupling coil.
The core of D class A amplifier A drive circuit is a PWM pulsewidth modulation part.Its structure chart as shown in Figure 2.By frequency of internal oscillator clock generating is that 125kHz, amplitude are the sawtooth waveforms of 3V, by voltage comparator circuit the pulse signal modulation that single-chip microcomputer produces is become pulsewidth and the proportional pulse signal of voltage magnitude, the conducting of two groups of MOSFET of this pulse-width signal control rear end H bridge and ending, make the power of signal obtain amplifying, after the passive low ventilating filter demodulation becomes stimulation pulse signal, be coupled in the body by excitation coil.
The signal coupling module constitutes with external a pair of coil 1,4 and alignment device by being separately positioned in the body as shown in Figure 2.Intravital stimulation part only keeps an induction output winding and pair of stimulating electrodes; External signal produces with control section and comprises D class A amplifier A pulsed drive module, micro controller module, button and display module, power supply monitoring and charging module, excitation coil and alignment device thereof.Pulse signal is produced by micro controller module, excitation coil 1 links to each other with the pulsed drive module, obtain pulse-width signal, excitation coil 1 has constituted low-pass filter circuit jointly with induction output winding 4 and electric capacity, makes the pulse-width signal demodulation obtain required stimulation pulse signal.Permanent magnet 3 can make iron core 2 and 5 magnetization in the coil, and the three inhales mutually, finishes and finds the location accurately.Display is used for showing each parameter of excitation coil moderate stimulation pulse, and operator (doctor or patient) as feedback, constantly adjusts controller parameter by keyboard with this, to obtain the optimal stimulus effect.Power supply monitoring links to each other with micro controller module, display, keyboard and D class A amplifier A pulsed drive module with charging module, be above-mentioned module for power supply, by micro controller module control, monitor self electric quantity in real time simultaneously, electric weight gives the alarm when not enough, shows by display.
Intravital induction output winding and stimulating electrode need not the power supply power supply, therefore only need once operation to implant and get final product.Respond to the boost pulse that output winding coupling excitation coil sends, and stimulus signal is directed into the target area through stimulating electrode, the target area neuron is produced stimulation.This output winding is designed to circular planar disk-like, reduces the thickness at intracranial.
After DBS of the present invention implants, produce a pulse signal by external pulse driving circuit, this drive circuit has adopted the D class audio amplifier, has improved the work efficiency and the switching speed of circuit greatly.The frequency, amplitude and the pulsewidth that produce pulse can be regulated by button and controller, show by display module, signal is aligned with it induction output winding in excitation coil is coupled to body, and the target spot of patient's intracranial being chosen in advance by stimulating electrode stimulates.The power supply monitoring module is monitored in real time to the electric weight of battery simultaneously, and electric weight gives the alarm when not enough, and shows on display, reminds patient's charging or changes battery.
The design of pulse driving circuit is the design's a key, selects suitable D class A amplifier A, can produce the boost pulse that has certain energy and meet the particular stimulation parameter on excitation coil.The MAX4295 that the D class A amplifier A that the design selects can adopt SSM2301 that ADI (ADI) produces or U.S. letter company to produce.The MAX4295D class A amplifier A has low-power consumption and high efficiency advantages such as (efficient are up to 87%), and interior part running clock has four kinds of patterns, because stimulus frequency about 100Hz, therefore selects minimum frequency of oscillation pattern (125kHz) to get final product.The inductance and the electric capacity of signal coupling module serve as passive low ventilating filter, be to reduce electromagnetic interference (EMI), can be at excitation coil again and connect an electric capacity.
The present invention is on software design, and system can reserve several groups of stimulus parameters commonly used, for patient's selection of the different state of an illness and the course of disease.The interface of whole system is very succinctly easy to operate, makes things convenient for the Parkinsonian to regulate voluntarily.
Claims (5)
1. external deep brain stimulator that adopts the D class A amplifier A to drive comprises intravital signal stimulus part and external signal generation and control section and is used for the coupled signal coupling module of two parts of signals; Intravital signal stimulus partly comprises pair of stimulating electrodes; External signal produces with control section and comprises D class A amplifier A pulsed drive module, micro controller module; After the amplification of pulse signal by the micro controller module generation, import in the body, encourage intravital pair of stimulating electrodes by the signal coupling module through D class A amplifier A pulsed drive module.
2. external deep brain stimulator according to claim 1 is characterized in that, described signal coupling module comprises excitation coil that links to each other with D class A amplifier A pulsed drive module and the induction output winding that links to each other with pair of stimulating electrodes.
3. external deep brain stimulator according to claim 2 is characterized in that, described induction output winding is a circular planar disk-like.
4. external deep brain stimulator according to claim 2, it is characterized in that, described signal coupling module also comprise be arranged on external and near the permanent magnet of excitation coil, be arranged on the magnetic core in the excitation coil and be arranged on magnetic core in the induction output winding, this three constitutes alignment device.
5. external deep brain stimulator according to claim 1 is characterized in that, described brain depth stimulator also comprises power supply monitoring and the charging module that is subjected to micro controller module control.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100161070A CN100522285C (en) | 2006-10-08 | 2006-10-08 | Class D amplifier driven external deep brain stimulator |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100161070A CN100522285C (en) | 2006-10-08 | 2006-10-08 | Class D amplifier driven external deep brain stimulator |
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| CN1931390A true CN1931390A (en) | 2007-03-21 |
| CN100522285C CN100522285C (en) | 2009-08-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2006100161070A Expired - Fee Related CN100522285C (en) | 2006-10-08 | 2006-10-08 | Class D amplifier driven external deep brain stimulator |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622468A (en) * | 2013-11-14 | 2015-05-20 | 先健科技(深圳)有限公司 | Deep brain stimulation system with predication function |
| CN111643812A (en) * | 2020-06-17 | 2020-09-11 | 科斗（苏州）脑机科技有限公司 | Wireless stimulation device |
-
2006
- 2006-10-08 CN CNB2006100161070A patent/CN100522285C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104622468A (en) * | 2013-11-14 | 2015-05-20 | 先健科技(深圳)有限公司 | Deep brain stimulation system with predication function |
| CN104622468B (en) * | 2013-11-14 | 2020-04-07 | 先健科技(深圳)有限公司 | Deep brain stimulation system with external prediction function |
| CN111643812A (en) * | 2020-06-17 | 2020-09-11 | 科斗（苏州）脑机科技有限公司 | Wireless stimulation device |
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| Publication number | Publication date |
|---|---|
| CN100522285C (en) | 2009-08-05 |
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Granted publication date: 20090805 Termination date: 20111008 |