CN1931088A - Detection method with blood pressure monitor and korotkoff sound delaying and pulse wave conducting time signal generator - Google Patents
Detection method with blood pressure monitor and korotkoff sound delaying and pulse wave conducting time signal generator Download PDFInfo
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Abstract
The present invention is blood pressure monitor detecting method and Korotkoff sound delaying and pulse wave conducting time signal generator. The detection method includes outputting several analog signals through digital synthesis on the computer stored data of respiration, cardioelectric, pulse wave and Korotkoff sound signals; setting computer controlled cuff pulse wave pressure generator, and determining the amplitudes and relations of the essential signals based on the relevant blood pressure detecting principle to form simulating human body signals essential for detecting blood pressure monitor and corresponding Korotkoff sound delaying and pulse wave conducting time signals; and feeding these signals to the blood pressure monitor to inspect the identity between the detection results of the blood pressure monitor and the set data of the signal generator.
Description
Technical field
The invention belongs to a kind of detection method and device, be specifically related to a kind of detection method and device the arteriotony monitoring device to armarium.
Background technology
In the blood pressure measurement technical field, by what people generally admitted be: pulse wave translation time can be used as a kind of method of noinvasive continuous blood pressure measuring, pulse wave translation time is meant the time that pulse wave is propagated between 2 of human body artery system, as far back as nineteen twenty-two, promptly the someone finds that pulse wave conduction speed (PWTV) or conduction time (PWTT) are relevant with arteriotony, also relevant with the vessel wall elasticity amount with capacity of blood vessel; Nineteen fifty-seven, the someone proposes within the specific limits again, and is linear between PWTT and the arteriotony BP.PWTT and by shooting between the arteriotony BP relation can be expressed as:
BP＝a+b*PWTT ……(A)
Wherein BP is an arteriotony, PWTT is a pulse wave translation time, a and b are regression coefficient undetermined, a, the size of b varies with each individual, but same individuality is at short notice, this numerical value is determined, utilize the individuation regression technique that undetermined coefficient a, b are proofreaied and correct, can realize utilizing the METHOD FOR CONTINUOUS DETERMINATION of pulse wave translation time PWTT to estimate each individual successive arteriotony BP, and the correction of this regression coefficient never has method preferably.
Applicant is found first: have corresponding relation between korotkoff ' s sound delay time and the human blood-pressure, the time of Ke Shi sound due in korotkoff ' s sound delay time is meant from the fixedly reference point consistent with heart beat rhythm to the corresponding cycle, during with traditional auscultation (also claiming Ke Shi sound method) measuring blood pressure, need earlier cuff to be pressurized to above systolic pressure, the compacted closed condition that is in of arterial wall under the cuff does not have the blood flow mistake in the blood vessel at this moment.Begin slow venting then, referring to Fig. 1, when cuff pressure drops to when being lower than systolic pressure slightly, begin to occur first Ke Shi sound, it is constantly open that this Ke Shi sound correspondence tremulous pulse, finds following rule after deliberation: in the open moment, first Ke Shi sound T1 apart from the ecg-r wave distance farthest at a series of tremulous pulse, and Ke Shi sound afterwards apart from ecg-r wave apart from T2, T3 ... more and more nearer, to the last reach to minima during a Ke Shi sound.Equally, if with pulse wave point of climb in the cuff as reference point (referring to Fig. 2), then korotkoff ' s sound delay time TK can be defined as in the cuff pulse wave again and rises and light to the time between appearance place of Ke Shi sound, equally, along with the decline of cuff pressure P, korotkoff ' s sound delay time T1, T2 in each Cardiac cycle, T3 ... more and more littler.The reason that above-mentioned phenomenon occurs is because the rising of intra-arterial pressure wave is not a vertical lifting, but the process of a gradual change, so decline along with the cuff internal pressure, in each cardiac cycle, the more and more morning that arterial wall is open, the time that the Ke Shi sound produces, also more and more early so interior fixedly reference point of each corresponding cycle (as other fixing reference point of pulse wave rising point or setting in cardiac wave R or the cuff) relatively, the time delay of Ke Shi sound was also shorter and shorter.Find again after deliberation: cuff pressure changed the variation of the korotkoff ' s sound delay time that causes when blood pressure was constant, and the korotkoff ' s sound delay time change in elevation that blood pressure causes when constant with cuff pressure is relevant, and it is identical to be similar to size, and direction is opposite.
According to above-mentioned achievement in research, at number of patent application is in the patent application of ZL200510071813.0 and PCT/CN2005/001210, applicant has proposed to ask for this parameter of korotkoff ' s sound delay time the method for aforementioned individuation regression coefficient a undetermined, b, thereby makes the METHOD FOR CONTINUOUS DETERMINATION of utilizing pulse wave translation time PWTT estimate that the method for each individual successive arteriotony BP can be achieved.This patent application has also disclosed the noinvasive continuous detecting device of arteriotony by shooting that adopts this method, this apparatus structure is seen Fig. 3, the using method of this device is: by filling, the venting unit can make cuff internal pressure P raise gradually or reduce gradually, in this process, detect Ke Shi sound due in by korotkoff sound sensor, and be input to microprocessor, by electrocardioelectrode and ecg circuit cardiac cycle signal is input to microprocessor synchronously simultaneously, thereby can measure from fixing reference point (can be ecg-r wave, also pulsation ripple starting point etc. in the cuff) the interval T till the Ke Shi sound starting point place to this cycle of each cardiac cycle
KValue obtains the function T that korotkoff ' s sound delay time changes with cuff pressure thus
K(P); When actual measurement, make cuff internal pressure P remain on a certain known state by the cuff pressure controller again, under this known cuff pressure (Pm) condition, measure korotkoff ' s sound delay time (T
K) value, cuff pressure changes the variation of the korotkoff ' s sound delay time that causes when constant according to blood pressure, and it is identical that the korotkoff ' s sound delay time that blood pressure causes when constant with cuff pressure changes size, and direction is opposite, obtains each T
KThe blood pressure of place cardiac cycle (just obtains T during with respect to initial measurement
K(P) during function) variable quantity of blood pressure, this blood pressure amount with obtain T
K(P) the mean blood pressure value addition that records during function is exactly the actual blood pressure value of this cardiac cycle, utilizes this instrument also can determine the undetermined coefficient b of aforementioned equation A.
Foregoing invention has proposed the brand new ideas that a kind of arteriotony is measured, the same with other armarium, also need it to be carried out verification when making above-mentioned monitoring of blood pressure device, and devices such as existing now electrocardiosignal generator, blood pressure signal generator all can not satisfy above-mentioned blood pressure monitor coordinated and met certain relation mutually to many signals and multiple signal requirement with the relevant detection instrument.
Summary of the invention
The present invention is intended to address the above problem, a kind of detection method and korotkoff ' s sound delay time and pulse wave translation time signal generator to blood pressure monitor is provided, this method and apparatus can be exported multiple mutual coordination and meet the analogue signal of certain relation, detects by the monitor of measuring korotkoff ' s sound delay time and pulse wave translation time monitoring human blood pressure foregoing.
For reaching above-mentioned purpose, the inventive method comprises following content:
Setting is the signal generation apparatus of master controller with the computer, by digital synthesis technology will pre-deposit breathing, electrocardio, the pulse wave of computer, the data of Ke Shi tone signal are output as the analogue signal of corresponding breathing, electrocardio, pulse wave, Ke Shi sound;
Setting is by computer-controlled cuff pulse wave pressure-generating device, in order to produce mimic cuff pulse wave pressure signal;
The data setting that blood pressure monitor will be detected by computer is a known quantity, and according to linear formula: BP=a+b*PWTT between pulse wave translation time and the arteriotony BP, wherein: BP is a pressure value; A, b are the individuation regression coefficient, and PWTT is a pulse wave translation time; And according to blood pressure when constant cuff pressure change the variation of the korotkoff ' s sound delay time that causes, the variation size of the korotkoff ' s sound delay time that blood pressure causes when constant with cuff pressure is identical, opposite this principle of direction, determine the relative amplitude of various signals and the sequential phase relation between the signal, the required human body signal of simulation blood pressure monitor testing process, and the pulse wave translation time and the korotkoff ' s sound delay time signal that meet above-mentioned formula and principle relation, these signals are input to blood pressure monitor, and whether the testing result of check blood pressure monitor conforms to the setting data of signal generation apparatus.
The further scheme of the inventive method comprises:
Described signal generation apparatus is exported the signal of expressing pulsation ripple conduction time (PWTT) as follows: export corresponding pulse wave translation time signal by the interval between two characteristic points controlling statement pulse wave translation time in each cardiac cycle, the pulse wave translation time PWTT size of known set blood pressure is determined by following formula:
PWTT＝(BP-a)/b
Wherein: the pressure value of BP for setting; A, b regression coefficient for setting.
The further scheme of the inventive method comprises:
Korotkoff ' s sound delay time (T is expressed in output as follows
K) signal:
In each cardiac cycle, explain korotkoff ' s sound delay time to the interval of Ke Shi sound due in, korotkoff ' s sound delay time (T by the control permanent datum
K) be according to pressure value of setting and the real-time pressure value in the cuff, and the korotkoff ' s sound delay time of calculator memory storage and the relation curve between the blood pressure obtain.
The further scheme of the inventive method comprises:
Cuff pulse wave signal when the oscillographic method measuring blood pressure is simulated in output as follows:
The cuff of tested blood pressure monitor is inflated to greater than systolic pressure, venting decompression gradually then, signal generation apparatus is according to the change value of pressure of cuff, cuff pulse wave pressure signal when producing simulation oscillographic method measuring blood pressure by computer control cuff pulse wave generating means, its Changing Pattern is: when cuff pressure by the process that drops to greater than systolic pressure less than diastolic pressure in, simulation cuff pulse wave pulse amplitude increases gradually, when cuff pressure equals mean pressure, it is maximum that amplitude reaches, then, with the reduction of cuff pressure, pulse amplitude reduces gradually.
The structure of apparatus of the present invention is: be provided with center-controlling computer, it is characterized in that: be provided with to be used to store and comprise electrocardio, pulse wave, breathing, Ke Shi sound wave shape in interior memory of data, computer is connected with the human body simulation signal output part with the analog signal conditioner circuit by D/A; Also be provided with by computer-controlled cuff pulse wave pressure signal generating device, cuff pulse wave pressure signal generating device is connected with the pressure signal outfan.
At blood pressure monitor according to korotkoff ' s sound delay time and pulse wave translation time monitoring human blood pressure, the inventive method and device can produce the multiple analogue signal that can satisfy the required mutual coordination of this blood pressure monitor observation process and meet corresponding relation, to realize the detection to this quasi-instrument.
The further scheme of the present invention can produce the signal of characteristic parameters such as expressing pulse wave propagate time, korotkoff ' s sound delay time and oscillographic method cuff pulse wave Changing Pattern, finishes come the monitoring human Performance Detection of the pertinent instruments of arteriotony by shooting by pulse wave propagate time and korotkoff ' s sound delay time.
Description of drawings
When descending, Fig. 1, cuff pressure P make the korotkoff ' s sound delay time T of reference point with Electrocardiographic R ripple
KSketch map
When descending, Fig. 2, cuff pressure P make the korotkoff ' s sound delay time TK sketch map of reference point with pulse wave point of climb in the cuff
Fig. 3, arterial blood pressure measuring device embodiment block diagram
Fig. 4, Ke Shi sound of the present invention postpone and pulse wave translation time signal generator example structure sketch map
Fig. 5, the inventive method cuff pulse wave signal generation sketch map
Fig. 6, the inventive method pulse wave translation time PWTT mode signal output sketch map
Fig. 7, the inventive method embodiment mode of operation 1-2 are to the signal waveform sketch map of the detection method generation of blood pressure monitor
Fig. 8, korotkoff ' s sound delay time T
KWith cuff pressure the descend function relation figure change and the secondary T of match
K(P) curve chart
Fig. 9, according to T shown in Figure 8
K(P) dT that draws of matched curve
K/ dP is with the curve chart of cuff pressure P
Figure 10, figure the inventive method embodiment mode of operation 2-2 are to the signal waveform sketch map of the detection method generation of blood pressure monitor
Figure 11: the inventive method embodiment mode of operation 3-2 detects the signal waveform sketch map that blood pressure monitor produces
Specific embodiments
Embodiment 1
This example is to adopt a kind of device-korotkoff ' s sound delay time and the pulse wave translation time signal generator of the inventive method.
This apparatus structure is as shown in Figure 4: be provided with the center control single chip computer, be used to store and comprise electrocardio, pulse wave, breathing, Ke Shi sound wave shape in interior memory of data, single-chip microcomputer is connected with the human body simulation signal output part with signal conditioning circuit by D/A;
The structure of this routine cuff pulse wave pressure signal generating device is: be provided with caisson, its input be connected by monolithic processor controlled inflation motor, outfan is by being connected with cuff by monolithic processor controlled air circuit breaker.
Adopt the generation method of this device physiological signal to be:
Signals such as breathing, electrocardio, pulse wave, korotkoff ' s sound delay time adopt digital synthesis technology to generate.Be specially: on single-chip microcomputer, store breathing, electrocardio, pulse wave, the Ke Shi tone signal signal of each one-period according to certain breathing rate and heart rate in advance, generate each waveform monocycle data according to heart rate and the breathing rate interpolation set then, the phase circulation is exported and through the D/A conversion, is obtained the successive analog waveform of each signal weekly.Each signal is behind modulate circuit, and output obtains the available signal of monitoring of blood pressure instrument, and the amplitude of each signal and mutual sequential phase relation are by computer control.
The formation method of cuff pulse wave is (referring to Fig. 5):
After inflating for the cuff of this signal generator and air accumulator by detected monitoring of blood pressure instrument, turn-off air circuit breaker, in a cardiac cycle, the Single-chip Controlling motor is inflated to air accumulator, time length by inflation, the increasing degree of control air accumulator air pressure, after inflation finishes, according to the particular moment of program setting at next cardiac cycle, open air circuit breaker, gas is along pressure differential, enter cuff by air accumulator, after pressure at two ends equates substantially, turn-off air circuit breaker, open the slow vent valve of cuff then, to emit (when cuff pressure equals to inflate preceding pressure by the gas that air accumulator flows in the cuff, turn-off vent valve), cuff pressure has produced pulse change thus, and this pulse promptly can be used for simulating the cuff pulse wave.Said process is after turn-offing air circuit breaker, and opening motor is the air accumulator inflation, waits for next cardiac cycle, and air circuit breaker is opened, palikinesia, and the amplitude of cuff pulse wave and output timing phase place are controlled by computer.
This example is several concrete implementation pattern of the inventive method.
Several main testing processes of utilizing korotkoff ' s sound delay time and pulse wave translation time monitoring blood pressure at ZL200510071813.0 and PCT/CN2005/001210 patent application announcement, this example has been set the mode of operation of several its different testing processes of adaptation, below it is described one by one:
One, this mode of operation is at the following testing process of blood pressure monitor: behind PWTT coefficient a, the b of blood pressure monitor in obtaining computing formula, calculate pressure value BP by measuring PWTT.
1-1, the summary of blood pressure monitor testing process:
According to PWTT and concern between the arteriotony BP by shooting:
BP＝a+b*PWTT ……(A)
Wherein BP is an arteriotony, and PWTT is a pulse wave translation time, and a and b are regression coefficient
Behind regression coefficient a, the b of blood pressure monitor in obtaining this formula, measure the pulse wave translation time of human body by shooting, thereby obtain the BP of arteriotony by shooting of human body
1-2, at the testing process of the above-mentioned 1-1 of blood pressure monitor, this mode of operation produces the simulation human body standard signal of pulse wave translation time by shooting by signal generator, its method is:
Set a pressure value earlier, signal generator is by this setting value output pulse wave translation time signal corresponding with it, and the production method of this pulse wave translation time is:
Referring to Fig. 6, express pulse wave translation time (PWTT) with the ecg-r wave peak value to the interval of the starting point of pulse wave signal, pick up counting by the output ecg-r wave, when reaching the pulse wave translation time of setting blood pressure, the starting point of output pulse wave and later waveform.Setting the pulse wave translation time size of blood pressure is determined by following formula:
PWTT＝(BP-a)/b
Wherein: the pressure value of BP for setting; A, b coefficient for setting.
Under this mode of operation, signal generator produces signals such as electrocardio, breathing, pulse wave, under the simulation normal condition, when pressure value is stablized, the time relationship of human body electrocardio and pulse wave is explained mimic pulse wave translation time by said method, and this signal is input to instrument for measuring blood pressure, whether the PWTT and the pressure value BP that can detect blood pressure monitor calculating be consistent with the value of signal source setting, thereby judge the performance of instrument for measuring blood pressure.
Each signal waveform sketch map that this 1-2 mode of operation produces as shown in Figure 7, wherein the amplitude of each signal can remain unchanged, and only needs to express pulse wave translation time PWTT by the sequential phase relation of electrocardio and pulse wave.
Two, this mode of operation is at the following testing process of blood pressure monitor: blood pressure monitor obtains the korotkoff ' s sound delay time function curve and obtains systolic pressure, diastolic pressure, the mean pressure that oscillographic method calculates by the cuff pulse wave.
2-1, the summary of blood pressure monitor testing process:
-cuff and cuff distal sensor are fixed on measured's one side upper arm, obtain measured's systolic pressure, diastolic pressure and mean arterial blood pressure value BP with oscillographic method
0, and write down synchronous pulse wave propagate time PWTT
0
-by a series of korotkoff ' s sound delay time T that obtains in the complete deflation course of cuff and corresponding cuff pressure P value (referring to Fig. 1), formation function T
K(P); The discrete data that forms this function is carried out conic fitting, obtain the T that a korotkoff ' s sound delay time T changes with cuff pressure P
K(P) matched curve (see figure 8) is to above-mentioned T
K(P) difference is asked in matched curve, and the variation of corresponding korotkoff ' s sound delay time forms new sequence of function g (P) (see figure 9) when obtaining unit pressure (1mmHg) change.
After obtaining above-mentioned individuation functional relationship, cuff pressure changes the variation of the korotkoff ' s sound delay time that causes when constant according to blood pressure, the variation size of the korotkoff ' s sound delay time that blood pressure causes when constant with cuff pressure is identical, opposite this principle of direction, the korotkoff ' s sound delay time T that can obtain under certain cuff pressure Pm
KmVariable quantity be converted into corresponding arteriotony variable quantity (can be according to g (Pi)=dT
K/ dP=dT
K/ dBpi calculates).
2-2, at the above-mentioned 2-1 testing process of blood pressure monitor, this mode of operation produces the korotkoff ' s sound delay time function curve of simulation human body by signal generator and is used for the cuff pulse wave signal of oscillographic method, its method is:
Signal generator produces signals such as electrocardio, breathing, pulse wave, Ke Shi sound, produce simulation cuff pressure pulse wave simultaneously, to the mutual coordination between each signal, produce the korotkoff ' s sound delay time function curve and the cuff pulse wave signal that is used for oscillographic method of simulation human body by computer;
Wherein the generation method of oscillographic method cuff pulse wave is:
Realize that by the monitoring of blood pressure instrument cuff inflates greater than the systolic pressure and the process of venting gradually, when the monitoring of blood pressure instrument inflate finish and begin venting gradually after, signal generation apparatus is by computer control generation cuff pulse wave; This example adopts the cuff pulse wave generating means of embodiment 1, and the height of cuff pulse wave amplitude changes by the control motor inflates the length control of time, and the time of inflating is long more, and pressure reduction is big more, and pulse amplitude is big more; The time of inflating is short more, and pressure reduction is more little, and pulse amplitude is more little;
The computer of signal generator is according to the real-time cuff pressure value of the blood pressure monitor variation amplitude by following rule control cuff pulse wave: when cuff pressure by the process that drops to greater than systolic pressure less than diastolic pressure in, the pulse amplitude that produces with the pulse pollex in the cuff increases gradually, when cuff pressure equals mean pressure, it is maximum that amplitude reaches, then, with the reduction of cuff pressure, pulse amplitude reduces gradually; For example: the algorithm that this device is chosen according to the monitoring of blood pressure instrument, when cuff pressure being set equaling systolic pressure, 50% when cuff pulse wave amplitude is mean pressure; During mean pressure, the time of inflating is the longest, the pulse maximum of generation; When cuff pressure equals diastolic pressure, 75% when the pulse wave amplitude is mean pressure.
Ke Shiyin T time delay
KSignal is exported as follows:
Express korotkoff ' s sound delay time T with cuff pulse wave starting point to the interval of Ke Shi sound due in
KSignal is picked up counting by output sleeve band pulse wave starting point, when reaching the korotkoff ' s sound delay time of setting blood pressure, and the starting point of output Ke Shi tone signal and later waveform.Referring to Fig. 2, korotkoff ' s sound delay time T
KBe according to pressure value of setting and the real-time pressure value in the cuff, in the relation curve of the blood pressure of Computer Storage and korotkoff ' s sound delay time, table look-up and obtain.
Its process is: at first will deposit the single-chip microcomputer memorizer in after the sampling of korotkoff ' s sound delay time function curve.Do different processing according to the different mode of setting, obtain corresponding korotkoff ' s sound delay time.
For this 2-2 mode of operation be: according to predefined blood pressure systolic pressure, the diastolic pressure force value, the corresponding Ke Shi sound of systolic pressure is postponed maximum, the corresponding Ke Shi sound of diastolic pressure postpones minima, curve pressing force equal proportion is divided, obtain the relation curve of blood pressure and time delay, deposit single-chip microcomputer in tabular form, when cuff real-time pressure during greater than systolic pressure, do not produce the Ke Shi tone signal, when cuff pressure is between systolic pressure and diastolic pressure, in blood pressure of storing and the relation curve of time delay, table look-up, obtain corresponding korotkoff ' s sound delay time, when cuff pressure during less than diastolic pressure, korotkoff ' s sound delay time is the korotkoff ' s sound delay time of constant when equaling diastolic pressure.
Each signal waveform sketch map that this 2-2 mode of operation produces as shown in figure 10.
Behind the signal input blood pressure monitor that said method produces, blood pressure monitor can calculate the korotkoff ' s sound delay time function curve by aforesaid 2-1 testing process, and obtain systolic pressure, diastolic pressure, the mean pressure equivalence that oscillographic method calculates by the cuff pulse wave, korotkoff ' s sound delay time function curve, the systolic pressure of blood pressure, diastolic pressure, mean pressure value that these result of calculations and signal generation apparatus are set are compared, can check the degree of reliability of blood pressure monitor.
Three, this mode of operation is at the following testing process of blood pressure monitor: blood pressure monitor is determined regression coefficient b in the BP=a+b*PWTT formula with korotkoff ' s sound delay time.
The testing process summary of 3-1, tested blood pressure monitor:
Cuff pressure roughly is controlled at average pressure level between systolic pressure and diastolic pressure, obtains the sequence and pairing pulse wave propagate time of each time delay time delay of Ke Shi sound by shooting; In measuring process, allow the measured deeply breathe continuously, take out two groups of data arbitrarily, calculate variation delta T time delay of point-to-point transmission;
The sequence of function T that obtains according to aforementioned korotkoff ' s sound delay time function curve (referring to Fig. 8)
K(P), to T
K(P) difference is asked in matched curve, the variation (referring to Fig. 9) of corresponding korotkoff ' s sound delay time when obtaining unit pressure (1mmHg) change, form new sequence of function g (P), obtain the g value under corresponding cuff pressure, estimate the arteriotony variation delta BP1 of this point-to-point transmission and synchronous pulse wave propagate time Δ PWTT1, can obtain regression coefficient b1=Δ BP1/ Δ PWTT1.
3-2, at the above-mentioned 3-1 testing process of blood pressure monitor, this mode of operation produces signals such as electrocardio, breathing, pulse wave, Ke Shi sound by signal generator, and produces simulation cuff pressure pulse wave; Simulation is worked as cuff pressure and is stabilized between systolic pressure and the diastolic pressure, when causing blood pressure by deeply breathing, and the relation between each signal.
The physical relationship of each signal is: the amplitude of korotkoff ' s sound delay time signal and cuff pulse wave signal is determined by cuff pressure, electrocardio, breathing and pulse wave signal amplitude remain unchanged, by breathing blood pressure signal BP is modulated, blood pressure when simulation is deeply breathed, the pulse wave propagate time is with the blood pressure respective change, when cuff pressure between systolic pressure and diastolic pressure, and when keeping constant substantially, the delay time rate of change of korotkoff ' s sound delay time signal during according to this cuff pressure produces corresponding variation.
Concrete modulator approach is: in each cardiac cycle (R crest value), detect the breath signal amplitude of this moment, produce a blood pressure amount Δ BP with the proportional relation of breathing amplitude then.As previously mentioned, pulse wave translation time changes according to the variation of Δ BP, korotkoff ' s sound delay time also can change according to the variation of Δ BP simultaneously, be pulse wave translation time and korotkoff ' s sound delay time can synchronous DIGEN change according to breathing, thereby simulated that reason is deeply breathed the blood pressure that causes and the pulse wave translation time that causes and the change procedure of korotkoff ' s sound delay time.
Its process is: at first will deposit the single-chip microcomputer memorizer in after the sampling of korotkoff ' s sound delay time function curve.Do different processing according to the different mode of setting, obtain corresponding korotkoff ' s sound delay time.For this 3-2 mode of operation be: the difference curves of at first on single-chip microcomputer, storing blood pressure and korotkoff ' s sound delay time, promptly represent under a certain pressure, unit pressure changes the variable quantity of the korotkoff ' s sound delay time that causes, simultaneously, the described method of 2-2 mode of operation obtains the relation curve of blood pressure and korotkoff ' s sound delay time as described above.The cuff pressure of this moment is between systolic pressure and diastolic pressure, near mean pressure.The variation delta BP of the corresponding proportional relation of breath signal amplitude when adding of the pressure value when the force value BP that calculates pulse wave translation time PWTT this moment is the cuff real-time pressure with this cycle R crest value; And calculate corresponding pulse wave translation time PWTT thus.Table look-up in the relation curve Tk of blood pressure and korotkoff ' s sound delay time (P) by cuff real-time pressure value and to obtain corresponding korotkoff ' s sound delay time Tkb, on difference curves, table look-up then and obtain the korotkoff ' s sound delay time variable quantity of cuff real-time pressure value correspondence, and obtain Δ Tk by the product of Ke Shi sound variable quantity and Δ BP, the korotkoff ' s sound delay time in the corresponding cycle that obtains at last be Δ Tk and Tkb and.The korotkoff ' s sound delay time that so just can simulated respiration causes changes.
After the signal that said method is produced was input to the instrument for measuring blood pressure device, the signal that the monitoring of blood pressure instrument detects by testing process 3-1 can calculate the coefficient b in the pulse wave translation time PWTT computing formula, can calculate coefficient a in conjunction with mode of operation 2-1 again.The setting value of two coefficients and signal source is compared, can check the accuracy of monitoring of blood pressure instrument.
Each signal waveform sketch map that this 3-2 mode of operation produces as shown in figure 11.
Embodiment 3
As different from Example 2: in the 2-2 mode of operation, embodiment 2 expresses korotkoff ' s sound delay time T with cuff pulse wave starting point to the interval of Ke Shi sound due in
KSignal, this example then are to express korotkoff ' s sound delay time T with the ecg-r wave peak value to the interval of Ke Shi sound due in
KSignal (referring to Fig. 1) is picked up counting by the ecg-r wave peak value, when reaching the korotkoff ' s sound delay time of setting blood pressure, and the starting point of output Ke Shi tone signal and later waveform.
This example is with the relation curve T between described korotkoff ' s sound delay time and the blood pressure
K(P) be stored in the computer, its method to set up is: describe relation curve T between korotkoff ' s sound delay time and the blood pressure by Several Parameters and equation
K(P), pre-deposit known curve T
K(P) equation parameter when cuff real-time pressure during greater than systolic pressure, does not produce the Ke Shi tone signal; When cuff pressure is between systolic pressure and diastolic pressure, according to cuff pressure value and curve T
K(P) equation parameter calculates corresponding korotkoff ' s sound delay time; When cuff pressure during less than diastolic pressure, korotkoff ' s sound delay time is a constant, the korotkoff ' s sound delay time when equaling diastolic pressure.
Claims (10)
1, the detection method of blood pressure monitor, it is characterized in that: being provided with the computer is the signal generation apparatus of master controller, by digital synthesis technology will pre-deposit breathing, electrocardio, the pulse wave of computer, the data of Ke Shi tone signal are output as the analogue signal of corresponding breathing, electrocardio, pulse wave, Ke Shi sound;
Setting is by computer-controlled cuff pulse wave pressure-generating device, in order to produce mimic cuff pulse wave pressure signal;
The data setting that blood pressure monitor will be detected by computer is a known quantity, and according to linear formula: BP=a+b*PWTT between pulse wave translation time and the arteriotony BP, wherein: BP is a pressure value; A, b are the individuation regression coefficient, and PWTT is a pulse wave translation time; And according to blood pressure when constant cuff pressure change the variation of the korotkoff ' s sound delay time that causes, the variation size of the korotkoff ' s sound delay time that blood pressure causes when constant with cuff pressure is identical, opposite this principle of direction, determine the relative amplitude of various signals and the sequential phase relation between the signal, the required human body signal of simulation blood pressure monitor testing process, and the pulse wave translation time and the korotkoff ' s sound delay time signal that meet above-mentioned formula and principle relation, these signals are input to blood pressure monitor, and whether the testing result of check blood pressure monitor conforms to the setting data of signal generation apparatus.
2, method according to claim 1, it is characterized in that: described signal generation apparatus is exported the signal of expressing pulsation ripple conduction time (PWTT) as follows: export corresponding pulse wave translation time signal by the interval between two characteristic points controlling statement pulse wave translation time in each cardiac cycle, the pulse wave translation time PWTT size of known set blood pressure is determined by following formula:
PWTT＝(BP-a)/b
Wherein: the pressure value of BP for setting; A, b regression coefficient for setting.
3, method according to claim 2, it is characterized in that: express pulse wave translation time (PWTT) to the interval of the starting point of pulse wave signal with the ecg-r wave peak value, pick up counting by the output ecg-r wave, when reaching the pulse wave translation time of setting blood pressure, the starting point of output pulse wave and later waveform.
4, method according to claim 1 is characterized in that: comprise output as follows and express korotkoff ' s sound delay time (T
K) signal:
In each cardiac cycle, explain korotkoff ' s sound delay time to the interval of Ke Shi sound due in, korotkoff ' s sound delay time (T by the control permanent datum
K) be according to pressure value of setting and the real-time pressure value in the cuff, and the korotkoff ' s sound delay time of calculator memory storage and the relation curve T between the blood pressure
K(P) obtain.
5, method according to claim 4 is characterized in that: express korotkoff ' s sound delay time (T with cuff pulse wave starting point or ecg-r wave peak value to the interval of Ke Shi sound due in
K) signal, pick up counting by output sleeve band pulse wave starting point or ecg-r wave peak value, when reaching the korotkoff ' s sound delay time of setting blood pressure, the starting point of output Ke Shi tone signal and later waveform.
6, method according to claim 4 is characterized in that: with the relation curve T between described korotkoff ' s sound delay time and the blood pressure
K(P) be stored in the computer, its method to set up is: according to predefined blood pressure systolic pressure, the diastolic pressure force value, the corresponding Ke Shi sound of systolic pressure is postponed maximum, the corresponding Ke Shi sound of diastolic pressure postpones minima, curve pressing force equal proportion is divided, obtain the relation curve of blood pressure and time delay, and deposit in the single-chip microcomputer, when cuff real-time pressure during greater than systolic pressure, do not produce the Ke Shi tone signal, when cuff pressure is between systolic pressure and diastolic pressure, in blood pressure of storing and the relation curve of time delay, table look-up, obtain corresponding korotkoff ' s sound delay time, when cuff pressure during less than diastolic pressure, korotkoff ' s sound delay time is the korotkoff ' s sound delay time of constant when equaling diastolic pressure.
7, according to the described method of the arbitrary claim of claim 1-6, it is characterized in that: comprise the cuff pulse wave signal when the oscillographic method measuring blood pressure is simulated in output as follows:
The cuff of tested blood pressure monitor is inflated to greater than systolic pressure, venting decompression gradually then, signal generation apparatus is according to the change value of pressure of cuff, cuff pulse wave pressure signal when producing simulation oscillographic method measuring blood pressure by computer control cuff pulse wave generating means, its Changing Pattern is: when cuff pressure by the process that drops to greater than systolic pressure less than diastolic pressure in, simulation cuff pulse wave pulse amplitude increases gradually, when cuff pressure equals mean pressure, it is maximum that amplitude reaches, then, with the reduction of cuff pressure, pulse amplitude reduces gradually.
8, according to the described method of the arbitrary claim of claim 1-6, it is characterized in that: describedly determine that by computer the physical relationship of each signal comprises following content: blood pressure signal BP is modulated by breath signal, blood pressure during simulated respiration, the pulse wave propagate time changes with blood pressure; When cuff pressure between systolic pressure and diastolic pressure, and when keeping constant substantially, the time delay rate of change of korotkoff ' s sound delay time signal during according to this cuff pressure produces corresponding variation;
Describedly to the synthetic method of blood pressure signal be: in each cardiac cycle, detect the breath signal amplitude of this moment, produce a blood pressure amount (Δ BP) with the proportional relation of breathing amplitude then by breath signal.
9, time-delay of Ke Shi sound and pulse wave translation time signal generator, be provided with center-controlling computer, it is characterized in that: be provided with to be used to store and comprise electrocardio, pulse wave, breathing, Ke Shi sound wave shape in interior memory of data, computer is connected with the human body simulation signal output part with the analog signal conditioner circuit by D/A; Also be provided with by computer-controlled cuff pulse wave pressure signal generating device, cuff pulse wave pressure signal generating device is connected with the pressure signal outfan.
10, Ke Shi sound time-delay according to claim 9 and pulse wave translation time signal generator, it is characterized in that: the structure of described cuff pulse wave pressure signal generating device is: be provided with caisson, its input be connected by monolithic processor controlled inflation motor, outfan is by being connected with cuff by monolithic processor controlled air circuit breaker.
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