CN1927393A - Composite collagen gel - Google Patents
Composite collagen gel Download PDFInfo
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- CN1927393A CN1927393A CN 200510098430 CN200510098430A CN1927393A CN 1927393 A CN1927393 A CN 1927393A CN 200510098430 CN200510098430 CN 200510098430 CN 200510098430 A CN200510098430 A CN 200510098430A CN 1927393 A CN1927393 A CN 1927393A
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- collagen
- collagen gel
- gel
- antibiotic
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Abstract
The invention relates to a kind of compound collagen gel, which is the mixture of collagen and antibiotics. For every gram gel, there is 1-100mg collagen, which is extracted from tendon of the rat tails, swine, or ox, 1-100mg antibiotics, 0.1-1.0mg medical antiseptics, 10-500mg thickening agents, and water. The antibiotics and collagen act cooperatively to be used in the treatment of the following diseases: different kinds of open wound, anabrosis caused by diabetes, skin damage because of venereal disease, hyperkeratesis, cuticularized skin problems such as keratosis palmaris ET plantaris, winter cutitis and ichthyosis. Since the collagen protein in the gel can be easily absorbed to provide threpsis to the diseased region, so it can promote the agglutination very effectively as well as extend the time of releasing time of the antibiotics.
Description
Technical field
The present invention relates to Medicines.
Background technology
With the collagen protein is that raw material adds the composite collagen gel that an amount of antibiotic, thickening agent etc. are made, be applied to wound external Medicines aspect, has the promotion wound healing, anti-inflammation, the characteristics that property of medicine effective time is long, and coat the formed thin film of wound surface and have air permeability and good.Collagen protein in the composite collagen gel has the medicament slow release effect, and antibiotic can slowly be discharged, and makes antibacterial effect more lasting, does not see like product at present on market.
Summary of the invention
The purpose of this invention is to provide a kind of composite collagen gel, this gel contains antibiotic and collagen protein composition, the obstinate concurrent infection wound that suitable various types of open wounds, various diseases cause, the skin malnutrition infringement, the ulcer of diabetes-induced and the skin damage that sexually transmitted disease (STD) causes that cause as circulatory disturbance such as decubital ulcer, arteriosclerosis, symptoms such as hyperkeratosis are used for the treatment of keratosis palmaris et plantaris, winter dermatitis, ichthyosis, send out lichen isogonism voltinism dermatosis.Collagen protein in the gel easily is absorbed, can provides nutrition for diseased region, have the effect of good promotion wound healing, and can prolong antibiotic release time, make in anti-inflammation, have the effect that promotes wound healing, thereby reach excellent curative
The object of the present invention is achieved like this:
A kind of composite collagen gel has collagen protein and antibiotic mixture in its component; Its component and composition weight ratio are: contain in every gram collagen gel
Collagen protein 1-100mg
Antibiotic 1-100mg
Medical antiseptic 0.1-1.0mg
Thickening agent 10-500mg
All the other are distilled water
Described collagen protein extracts from Mus tail or pig, tendon Bovis seu Bubali tendon.
Described antibiotic is a kind of in a kind of or wantonly two kinds of mixture in ofloxacin and the tobramycin.
Described thickening agent is a kind of in hydrophilic tragacanth, carboxymethyl cellulose, chitosan, chitin, sodium alginate, sesbania gum, tara gum, the Ficus elastica, or a kind of in wantonly two kinds of mixture.
The present invention has following actively useful effect:
This product is to be that raw material adds the gel that an amount of antibiotic etc. is made with the collagen protein, this product can be used for: the obstinate that various types of open wounds, various diseases cause, the skin malnutrition infringement that circulatory disturbance such as concurrent infection wound such as decubital ulcer, arteriosclerosis cause, the ulcer of diabetes-induced and skin damage that sexually transmitted disease (STD) causes etc.The moisture-keeping function of collagen protein can improve symptoms such as xerosis cutis, Pruritus, hyperkeratosis, be used for the treatment of keratosis palmaris et plantaris, winter dermatitis, ichthyosis, send out lichen isogonism voltinism dermatosis, its special efficacy is that the collagen protein in the gel has easily and is absorbed, can provides nutrition for diseased region, effect with good promotion wound healing, prolong antibiotic release time, reach good curative effect.
The specific embodiment
Embodiment one:
The component of described composite collagen gel and the part by weight of each component are: contain in every gram composite collagen gel
Collagen protein 4mg
Antibiotic ofloxacin 30mg
Medical antiseptic 0.2mg
Thickening agent tragacanth 30mg
All the other are distilled water
The composite collagen gel of present embodiment is through following test:
Composite collagen gel treatment decubital ulcer, wound, skin ulcer and xerosis cutis, Pruritus, hyperkeratosis be totally 20 examples; Male patient's 13 examples wherein, female patient 7 examples; Age, be 18 months observing time in 8-75 year; Decubital ulcer 4 examples wherein, wound 5 examples, 5 examples of burning (hydrothermal solution scald 2 examples, flame burn 1 example, chemical burn 1 example, electric spark burn 1 example), ulcer 2 examples, xerosis cutis 1 example, Pruritus 2 examples, hyperkeratosis 1 example.
Embodiment two:
The component of described composite collagen gel and the part by weight of each component are: contain in every gram composite collagen gel
Collagen protein 5mg
Antibiotic ofloxacin 40mg
Medical antiseptic 0.2mg
Thickening agent tragacanth 50mg
All the other are distilled water
The composite collagen gel of present embodiment is through following test:
Composite collagen gel treatment decubital ulcer, wound, skin ulcer and xerosis cutis, Pruritus, hyperkeratosis be totally 20 examples; Male patient's 13 examples wherein, female patient 7 examples; Age, be 18 months observing time in 8-75 year; Decubital ulcer 4 examples wherein, wound 5 examples, 5 examples of burning (hydrothermal solution scald 2 examples, flame burn 1 example, chemical burn 1 example, electric spark burn 1 example), ulcer 2 examples, xerosis cutis 1 example, Pruritus 2 examples, hyperkeratosis 1 example.
Embodiment three:
The part by weight of described composite collagen gel component and each component is: contain in every gram composite collagen gel
Collagen protein 6mg
Antibiotic ofloxacin 50mg
Medical antiseptic 0.3mg
Thickening agent tragacanth 70mg
All the other are distilled water
The composite collagen gel of present embodiment is through following test:
Composite collagen gel treatment decubital ulcer, wound, skin ulcer and xerosis cutis, Pruritus, hyperkeratosis be totally 20 examples; Male patient's 12 examples wherein, female patient 8 examples; Age, be 18 months observing time in 8-75 year; Decubital ulcer 4 examples wherein, wound 6 examples, 4 examples of burning (hydrothermal solution scald 4 examples, flame burn 1 example, chemical burn 1 example, electric spark burn 1 example), ulcer 1 example, xerosis cutis 2 examples, Pruritus 1 example, hyperkeratosis 2 examples.
In sum, among the 60 routine patients of application, except that the patient who merges the III0 wound surface, the shallow wound surface of general shallow II0 and dark II0 is all healing in 7-20 days, and the longest is healing in 25 days; Improved significantly in decubital ulcer 4-9 days; Can cure in ulcer 3-6 days; Xerosis cutis, Pruritus, the average 2-5 of hyperkeratosis days have clear improvement; Therapeutic effect is good, has no side effect.
Characteristics of the present invention:
This composite collagen gel mainly is made up of collagen protein, antibiotic, thickening agent and antiseptic, it when user mode gel, collagen protein has the effect that promotes that wound healing and drug slow discharge, have the good penetration effect with the antibiotic coupling, and make the antibiotic time keep permanent.Composite collagen gel forms the gas-pervious protecting film of one deck after the skin surface drying, help wound and airborne microorganism to isolate, but the Nutrition that collagen protein is good simultaneously and the healing of biocompatibility accelerated in wounds.
Described composite collagen gel mainly is made up of collagen protein, antibiotic, thickening agent and antiseptic, the concrete manufacture method of collagen gel: be under aseptic condition with collagen liquid, antibiotic, thickening agent and antiseptic in sequence with mixed after, gel is made in stirring, reinstall in the packing of strict sterilization, filling and sealing under aseptic condition is made composite collagen gel.
The preparation of described composite collagen gel is extracted under aseptic condition, the collagen liquid extracting method: impurity such as tendon Bovis seu Bubali raw material → removal tendon Bovis seu Bubali epidermis, muscle, fat → clean → smash to pieces → acetic acid or hydrochloric acid acid is molten → and pepsin or papain enzymolysis → saltout → water dialysis → collagen liquid; Other material is through the different approaches sterilization treatment, and thickening agent is good with glycerol and water dissolution, adds collagen liquid, stirs, and adds antibiotic solution and antiseptic, is stirred to the viscosity of gel defined, fill then.
The main component of described composite collagen gel is the mixture that collagen protein, an amount of antibiotic also have thickening agent and antiseptic.
The content of mixture of collagen liquid, antibiotic, thickening agent and antiseptic in each container of packing into is identical.
The material of dress composite collagen gel is that medical material is made, and composite collagen gel is full of container.
The function of composite collagen gel:
This product contain abundant active collagen with and broad ectrum antibiotic.Help improving the cytotrophy of diseased region, promote the growth that damage location newly granulates: also help improving the blood vessel circulation of diseased region, promote the formation of fibrocyte and new vessels, make hard pressed blood vessel keep connecting, active collagen is the excellent drug carrier, help medicament slow release, make antibiotic lasting maintenance bactericidal action, be applicable to the treatment keratosis palmaris et plantaris, winter dermatitis, ichthyosis, send out lichen isogonism voltinism dermatosis, improve xerosis cutis, Pruritus, symptoms such as hyperkeratosis, the contained antibiotic composition and the Nutrition of collagen protein are suitable for various types of open wounds, obstinate concurrent infection wound such as decubital ulcer that various diseases causes, the skin malnutrition infringement that circulatory disturbance such as arteriosclerosis cause, the skin damage that the ulcer of diabetes-induced and sexually transmitted disease (STD) cause etc.
Described collagen liquid is: contain collagen protein 2.01～8.01mg in the 1ml collagen liquid, all the other are aqueous solution.
This product using method: remove wound surface earlier, gel is coated on the wound surface, form thin film, coating in a day once basically.
Claims (6)
1. a composite collagen gel has collagen protein and antibiotic mixture in its component, it is characterized in that: its component and composition weight ratio are: contain in every gram collagen gel
Collagen protein 1-100mg
Antibiotic 1-100mg
Medical antiseptic 0.1-1.0mg
Thickening agent 10-500mg
All the other are distilled water
Described collagen protein extracts from Mus tail or pig, tendon Bovis seu Bubali tendon.
2. composite collagen gel as claimed in claim 1 is characterized in that: described component and composition weight ratio are: contain in every gram collagen gel
Collagen protein 4mg
Antibiotic ofloxacin 30mg
Medical antiseptic 0.2mg
Thickening agent tragacanth 30mg
All the other are distilled water.
3. composite collagen gel as claimed in claim 1 is characterized in that: described component and composition weight ratio are: contain in every gram collagen gel
Collagen protein 5mg
Antibiotic ofloxacin 40mg
Medical antiseptic 0.2mg
Thickening agent tragacanth 50mg
All the other are distilled water.
4. composite collagen gel as claimed in claim 1 is characterized in that: its component and composition weight ratio are: contain in every gram collagen gel
Collagen protein 6mg
Antibiotic ofloxacin 50mg
Medical antiseptic 0.2mg
Thickening agent tragacanth 70mg
All the other are distilled water.
5. composite collagen gel as claimed in claim 1 is characterized in that: described antibiotic is a kind of in a kind of or wantonly two kinds of mixture in ofloxacin and the tobramycin.
6. composite collagen gel as claimed in claim 1, it is characterized in that: described thickening agent is a kind of in hydrophilic tragacanth, carboxymethyl cellulose, chitosan, chitin, sodium alginate, sesbania gum, tara gum, the Ficus elastica, or a kind of in wantonly two kinds of mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510098430 CN1927393A (en) | 2005-09-08 | 2005-09-08 | Composite collagen gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510098430 CN1927393A (en) | 2005-09-08 | 2005-09-08 | Composite collagen gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1927393A true CN1927393A (en) | 2007-03-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510098430 Pending CN1927393A (en) | 2005-09-08 | 2005-09-08 | Composite collagen gel |
Country Status (1)
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| CN (1) | CN1927393A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822827A (en) * | 2010-05-13 | 2010-09-08 | 仵小南 | Preparation for cosmetic dermatology and scar repairing |
| CN101829320A (en) * | 2010-05-20 | 2010-09-15 | 佟刚 | Collagen gel and preparation method thereof |
| CN103209592A (en) * | 2010-08-30 | 2013-07-17 | 安伯洛股份有限公司 | Inhibition of biofilm formation and removal of biofilm by use of moss |
| CN101648002B (en) * | 2008-08-13 | 2013-12-25 | 北京和润创新医药科技发展有限公司 | Medicinal composition for treating skin injury and ulcer and application thereof |
| US9795809B2 (en) | 2013-12-23 | 2017-10-24 | Embro Corporation | Use of moss to improve dental health |
| CN109431850A (en) * | 2018-03-16 | 2019-03-08 | 广东众尔健生物科技有限公司 | A kind of application of Collagen type-I in cosmetic field |
| CN110755455A (en) * | 2019-11-15 | 2020-02-07 | 何增义 | Composition for promoting wound healing of diabetic complications and preparation method thereof |
| CN110787288A (en) * | 2019-12-25 | 2020-02-14 | 郑州康金瑞健康产业有限公司 | Medical collagen oral ulcer protective gel and preparation method thereof |
-
2005
- 2005-09-08 CN CN 200510098430 patent/CN1927393A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101648002B (en) * | 2008-08-13 | 2013-12-25 | 北京和润创新医药科技发展有限公司 | Medicinal composition for treating skin injury and ulcer and application thereof |
| CN101822827A (en) * | 2010-05-13 | 2010-09-08 | 仵小南 | Preparation for cosmetic dermatology and scar repairing |
| CN101829320A (en) * | 2010-05-20 | 2010-09-15 | 佟刚 | Collagen gel and preparation method thereof |
| CN101829320B (en) * | 2010-05-20 | 2012-05-23 | 佟刚 | Collagen gel and preparation method thereof |
| CN103209592A (en) * | 2010-08-30 | 2013-07-17 | 安伯洛股份有限公司 | Inhibition of biofilm formation and removal of biofilm by use of moss |
| US9795809B2 (en) | 2013-12-23 | 2017-10-24 | Embro Corporation | Use of moss to improve dental health |
| CN109431850A (en) * | 2018-03-16 | 2019-03-08 | 广东众尔健生物科技有限公司 | A kind of application of Collagen type-I in cosmetic field |
| CN110755455A (en) * | 2019-11-15 | 2020-02-07 | 何增义 | Composition for promoting wound healing of diabetic complications and preparation method thereof |
| CN110787288A (en) * | 2019-12-25 | 2020-02-14 | 郑州康金瑞健康产业有限公司 | Medical collagen oral ulcer protective gel and preparation method thereof |
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