CN1911281A - Medicine for treating cervix erosio - Google Patents
Medicine for treating cervix erosio Download PDFInfo
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- CN1911281A CN1911281A CN 200610105023 CN200610105023A CN1911281A CN 1911281 A CN1911281 A CN 1911281A CN 200610105023 CN200610105023 CN 200610105023 CN 200610105023 A CN200610105023 A CN 200610105023A CN 1911281 A CN1911281 A CN 1911281A
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- cervical erosion
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Abstract
A Chinese medicine for treating cervical erosion is prepared from brucea fruit oil and the extract of corydalis tuber.
Description
(1) technical field
The present invention relates to a kind of Amino-Cerv thing, relate in particular to a kind of medicine that is used for the treatment of cervical erosion.
(2) background technology
Cervical erosion is married woman's commonly encountered diseases and frequently-occurring disease, and sickness rate accounts for about 60% of gynecological's outpatient service.Improve the cure rate of cervical erosion, significant to the generation that prevents cervical cancer.
Treatment cervical erosion has several different methods at present, wherein naturopathy is to use a kind of very widely Therapeutic Method at present, and method commonly used has electricity to press therapy, laser therapy, cryotherapy etc., but it needs certain device, the expense height, and in various degree complication is arranged.The Chinese patent medicine of treatment cervical erosion is employed clinically, but is patient's self-medication, and the course of treatment, long (need 5～7 days per course of treatment, totally 2～3 courses of treatment) uncertain therapeutic efficacy was cut.
The main pathology of cervical erosion is that the local normal squamous epithelial cancer of cervix uteri comes off, and is covered by columnar epithelium.The dominant mechanism (method) of treatment cervical erosion is to dispel columnar epithelium, as long as columnar epithelium is dispeled, normal squamous epithelial cancer will cover cervix uteri, the healing of cervical erosion that Here it is again.
The present invention is that we sum up medicine of the present invention and dispel endometrial experience, inspired by its thinking, the initiative Chinese medicine preparation is dispeled the columnar epithelium of cervical erosion face, to have corrosion wart, direct killing hyperplastic tissue cell, impel apoptotic Chinese medicine preparation to make suitable dosage form, the doctor has opened up the new way of treatment by Chinese herbs cervical erosion with the disposable cervix uteri treatment cervical erosion that is positioned over of preparation of the present invention.
(3) summary of the invention
The object of the invention is to provide a kind of short treating period, and determined curative effect is cheap, and it is convenient to use, and medicine directly can be positioned over the cervix uteri of pathological changes, a kind of treatment cervical erosion medication of disposable placement.
Chinese medicine preparation of the present invention is to be the preparation that raw material is made with following pharmaceutical composition:
Oleum Fructus Bruceae 20～40% Rhizoma Corydalis extracts 10～20%
Above-mentioned Chinese medicine composition among the present invention is the active constituents of medicine of preparation medicine of the present invention.Fructus Bruceae hardship, cold has the effect of heat-clearing and toxic substances removing, corrosion wart.Modern pharmacological research shows that the Main Ingredients and Appearance of Oleum Fructus Bruceae is a unsaturated fatty acid, and they can directly enter cancerous cell, destroys plasma membrane system and mitochondrion, makes tumor cell disintegrate, death.Be widely used in clinical with abnormal cell proliferative diseases such as treatment malignant tumor and condyloma acuminatum.Rhizoma Corydalis suffering, hardship, temperature.Have invigorate blood circulation, effect such as circulation of qi promoting, pain relieving.
Aforementioned pharmaceutical compositions of the present invention when being prepared into pharmaceutically dosage form, can add conventional medicine excipient, for example solvent, binding agent, filler, disintegrating agent, antiseptic, solubilizing agent etc.
Aforementioned pharmaceutical compositions of the present invention according to the preparation process of routine, can be made any pharmaceutical dosage form that is suitable for clinical use, for example tablet, suppository, unguentum, powder, pill, capsule etc.
Prescription and technology that pharmaceutical composition of the present invention is made tablet are:
Prescription: Oleum Fructus Bruceae 20～40% Rhizoma Corydalis extracts 10～20%
Method for making (1): above two flavors, Rhizoma Corydalis extract and Oleum Fructus Bruceae mixing, it is an amount of that other gets glycerol gelatin matrix, puts in the water-bath and heat, and after waiting to dissolve, adds Rhizoma Corydalis extract and Oleum Fructus Bruceae mixture, fully stir, mixing, perfusion, cooling, promptly.
Method for making (2): get Oleum Fructus Bruceae and Tween-80 mixing, other gets Myrj 45 or semi-synthetic fatty acid ester or glycerin gelatine or Polyethylene Glycol, puts in the water-bath in right amount and melts, and adds the Rhizoma Corydalis extract, stir evenly, add above-mentioned oil solution again, fully stir, perfusion, cooling, promptly.
The indication of medicine of the present invention is: reach dissimilar cervical erosion in various degree.
To be the doctor directly be positioned over the cervix uteri of pathological changes with pharmaceutical preparation targeting of the present invention to the advantage of medicine of the present invention, and disposable placement treatment cervical erosion has been opened up the new way of treatment by Chinese herbs cervical erosion.Have short treating period (disposable), determined curative effect, cheap, use advantages such as convenient.
The clinical research of experimental example Drug therapy cervical erosion of the present invention
In the process of the present invention's development, the applicant uses compound recipe Oleum Fructus Bruceae bolt treatment cervical erosion and has carried out clinical preliminary observation with reference to the related content of State Food and Drug Administration's " new drug (Chinese medicine) clinical guidance principle " and " obstetrics and gynecology " (sixth version).
1 object and method:
1.1 diagnostic criteria: the cervix uteri surface takes on a red color, and is that squamous epithelial cancer comes off, replaced by columnar epithelium, and the result that last veins beneath the skin appears, rotten to the corn face and normal squamous epithelial cancer on every side have clearly boundary, and it is not painted to be coated with iodine solution.Size and inflammation degree according to rotten to the corn face respectively are divided into 3 types.
Be divided into according to area:
(1) slight rotten to the corn: the cervical erosion face accounts for the cervix uteri area and is less than 1/3.
(2) moderate erosion: the cervical erosion face accounts for 1/3～2/3 of cervix uteri area.
(3) severe erosion: the cervical erosion face accounts for 2/3 of cervix uteri area.
Cervix uteri inflammation degree is divided into:
(1) simple type: at the inflammation initial stage, rotten to the corn face is that simple columnar epithelium covers, and has an even surface.
(2) granular pattern: because the hypertrophy of a cervix uteri glandular epithelium hyperplasia and a matter, rotten to the corn face is uneven, is graininess.
(3) mastoid process type: the obvious hypertrophy of matter between glandular epithelium reaches, surface irregularity is more remarkable, forms the mastoid process sample.
1.2 the object of observation: this group data is totally 80 examples, is the outpatient.Be divided into observation group and matched group at random.Observation group's 50 examples, matched group 30 examples, at the fermentation basically identicals such as size, inflammation degree and pathologic finding of age, the course of disease, rotten to the corn face, feature does not relatively have significant difference (P＞0.05) between group between two groups.
1.3 method: in the clean back of menstruation 2-3d, expose cervix uteri with vaginal speculum, compound recipe Oleum Fructus Bruceae bolt is put into the cervix uteri mouth for 1 piece, the vaginal plugging sterile gauze takes out gauze and gets final product behind the 24h.Prohibitive life and bath in a tub during the treatment finish afterwards to carry out respectively in January, February efficacy evaluation the course of treatment.
1.4 curative effect determinate standard: recovery from illness: the cervical erosion face disappears, and cervix uteri is smooth; Effectively: the severe erosion transfers the moderate erosion to, the moderate erosion transfers slight erosion to; Invalid: rotten to the corn face no change before and after the treatment.
2 results:
| Total routine number | Recovery from illness | Effectively | Invalid | Total effective rate | |||||
| n | ％ | n | ％ | n | ％ | n | ％ | ||
| Observation group's matched group | 50 30 | 38 7 | 76.0 23.3 | 9 15 | 18.0 50.0 | 3 8 | 6.0 26.7 | 47 22 | 94.0 73.3 |
Total effective rate relatively has utmost point significant difference (P＜0.01) between two groups
The explanation of this paper data, Drug therapy cervical erosion curative effect of the present invention affirms that short treating period is not found significant complications, the patient is easy to accept.
(4) specific embodiment
The present invention is further described below in conjunction with embodiment:
The present invention with following raw material and the method for making of making tablet is:
Raw material: Oleum Fructus Bruceae 20～40% Rhizoma Corydalis extracts 10～20%
Method for making (1): above two flavors, Rhizoma Corydalis extract and Oleum Fructus Bruceae mixing, it is an amount of that other gets glycerol gelatin matrix, puts in the water-bath and heat, and after waiting to dissolve, adds Rhizoma Corydalis extract and Oleum Fructus Bruceae mixture, fully stir, mixing, perfusion, cooling, promptly.
Method for making (2): get Oleum Fructus Bruceae and Tween-80 mixing, other gets Myrj 45 or semi-synthetic fatty acid ester or glycerin gelatine or Polyethylene Glycol, puts in the water-bath in right amount and melts, and adds the Rhizoma Corydalis extract, stir evenly, add above-mentioned oil solution again, fully stir, perfusion, cooling, promptly.
Embodiment 2
Raw material: Oleum Fructus Bruceae 25～35% Rhizoma Corydalis extracts 15～20%
Method for making is the same.
Claims (2)
1. one kind is used for the treatment of the cervical erosion medicine, it is characterized in that being made by following raw materials according by weight percentage:
Oleum Fructus Bruceae 20～40% Rhizoma Corydalis extracts 10～20%.
2. a kind of cervical erosion medicine that is used for the treatment of according to claim 1 is characterized in that being made by the following raw materials according material by weight percentage:
Oleum Fructus Bruceae 25～35% Rhizoma Corydalis extracts 15～20%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610105023 CN1911281A (en) | 2006-08-10 | 2006-08-10 | Medicine for treating cervix erosio |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610105023 CN1911281A (en) | 2006-08-10 | 2006-08-10 | Medicine for treating cervix erosio |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1911281A true CN1911281A (en) | 2007-02-14 |
Family
ID=37720444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610105023 Pending CN1911281A (en) | 2006-08-10 | 2006-08-10 | Medicine for treating cervix erosio |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1911281A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829253A (en) * | 2010-05-25 | 2010-09-15 | 耿福能 | Medicine composite for treating cervical erosion and preparation method thereof |
| CN102641310A (en) * | 2011-02-17 | 2012-08-22 | 广东药学院 | Khosam oil suppository |
-
2006
- 2006-08-10 CN CN 200610105023 patent/CN1911281A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101829253A (en) * | 2010-05-25 | 2010-09-15 | 耿福能 | Medicine composite for treating cervical erosion and preparation method thereof |
| CN102641310A (en) * | 2011-02-17 | 2012-08-22 | 广东药学院 | Khosam oil suppository |
| CN102641310B (en) * | 2011-02-17 | 2013-11-13 | 广东药学院 | Khosam oil suppository |
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