CN1883676A - Preparation for treating rhinitis - Google Patents
Preparation for treating rhinitis Download PDFInfo
- Publication number
- CN1883676A CN1883676A CNA2006100851945A CN200610085194A CN1883676A CN 1883676 A CN1883676 A CN 1883676A CN A2006100851945 A CNA2006100851945 A CN A2006100851945A CN 200610085194 A CN200610085194 A CN 200610085194A CN 1883676 A CN1883676 A CN 1883676A
- Authority
- CN
- China
- Prior art keywords
- preparation
- rhinitis
- volatile oil
- add
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to an external-use preparation for treating rhinitis, which can be prepared into liquid or solid form, and is prepared from raw material herbs including oak-apple, Smilax china L. root, seed of nuxvomica, Cotula hemisphaerica seeds, Os Sepiae, black catechu and coral.
Description
Technical field
The present invention relates to a kind of medicine for external use preparation for treating rhinitis that is used for the treatment of signs such as nasal obstruction due to acute and chronic rhinitis, the allergic rhinitis, watery nasal discharge.
Background technology
Rhinitis is a commonly encountered diseases, the systemic factor of its pathogenic factor and body, and local factor, occupation is relevant with living environment, and especially climate variability sickness rate in season is more.Along with the progress of society, the developing rapidly of heavy industry etc., atmospheric pollution increases the weight of, and the sickness rate that makes primary disease is ascendant trend year by year, and is particularly remarkable over nearly more than 20 years, more obvious in developed country.And also be so in China, the complex area of weather extreme drought in addition, rain is few, and wind is many, and the sickness rate of rhinitis obviously rises in recent years.
Doctor trained in Western medicine mainly adopts antihistamine drug at present, sodium cromoglicate, and steroid hormone, nasal decongestant and specific immunity desensitization fire subtract therapies such as quick, but the radical cure difficulty, the relapse rate height, and side effect is big.Therefore, seek the new natural and the novel form thereof of efficient, quick and easy, as to meet clinical practice needs treatment of allergic rhinitis, become important problem in the clinical and scientific research of prenasal section.
Uygur's medical science is thought, rhinitis is that the inside and outside disease factor can make the unbalance and makings of body fluid cause the natural agent of quilt domination organs such as lung to go down unusually, thereby make unusual phlegmatic temperament be trapped in nasal cavity, the infringement nasal mucosa, local blood circulation is obstructed and causes rhinitis, adopts clinically and removes unusual phlegmatic temperament, adjust makings, the ventilation of clear chamber, the dehumidifying detumescence, convergence antiinflammatory etc. are treated for basic principle.
Summary of the invention
The object of the invention is, develops a kind of medicine for external use preparation for treating rhinitis that is used for the treatment of signs such as nasal obstruction due to acute and chronic rhinitis, the allergic rhinitis, watery nasal discharge.Said preparation comprises spray or nasal drop, is to be made by crude drug Galla Turcica (Galla Helepensis), European Radix Smilacis Chinae, Semen Strychni, Fructus Coriandri, Semen Nigellae, Endoconcha Sepiae, catechu, Corallium Japonicum Kishinouye, tween 80; Said preparation is brown to brown xanchromatic liquid, gas perfume (or spice).Said preparation has removes partial unusual bile matter and deteriorated blood, restrain astringent or styptic treatment for spontaneous sweating, effects such as antipruritic pain relieving.Be used for the sign such as nasal obstruction, watery nasal discharge due to acute and chronic rhinitis, the allergic rhinitis.
The medicine for external use preparation for treating rhinitis that is used for the treatment of acute and chronic rhinitis, allergic rhinitis of the present invention, said preparation comprises the liquid or solid preparation, is to be made by crude drug Galla Turcica (Galla Helepensis) 150-250g, European Radix Smilacis Chinae 150-250g, Semen Strychni 50-150g, Fructus Coriandri 50-150g, Semen Nigellae 50-150g, Endoconcha Sepiae 50-150g, catechu 50-150g, Corallium Japonicum Kishinouye 50-150g; Said preparation is brown to brown xanchromatic liquid or solid, abnormal smells from the patient perfume (or spice).
The preparation method of preparation for treating rhinitis follows these steps to carry out:
A, get ceriander seed, Semen Nigellae two flavor medical materials and add 10 times of water gagings, the way of distillation was extracted volatile oil 6 hours, and it is standby to collect volatile oil, and the aqueous solution that extracted volatile oil filters, and centrifugal, supernatant is standby, and medicinal residues discard;
B, all the other Galla Turcica (Galla Helepensis)s, European Radix Smilacis Chinae, Semen Strychni, Endoconcha Sepiae, catechu, Corallium Japonicum Kishinouye are mixed add 8 times of water gagings, adjust pH 7 decocted 2 times, each 2 hours, filter, merging filtrate and standby supernatant concentrate, with ethanol precipitation, concentration to 80%, get supernatant, reclaim ethanol, be concentrated into d=1.15, add the volatile oil of extraction and 1% tween 80, mixing, regulating pH with 10% sodium hydroxide is 5.5-7.5, add to 1000ml with distilled water, or spray drying is made granule promptly.
Preparation for treating rhinitis is in the purposes of the medicine of preparation treatment acute and chronic rhinitis, allergic rhinitis.
Using method of the present invention: with preparation for treating rhinitis drip in right amount in or sparge nasal cavity, get final product for 3-4 time on the one.
The pharmacological properties of preparation for treating rhinitis of the present invention:
The preparation for treating rhinitis stability test:
Experimental technique and result:
The acceleration environment stability test: with three batches of lot numbers is that 050301,050302 and 050303 test sample adopts aluminium foil and the hard sheet of polrvinyl chloride (PVC), adopt blister package, place in the growth cabinet, adjust the temperature to 40 ℃ ± 2 ℃, relative humidity RH75% ± 5%, stored 6 months, respectively at the 0th, 1,2,3, June timing sampling, carry out the inspection of character, discriminating, pH value, content uniformity, aseptic, microbial limit according to this product quality standard, the results are shown in Table 1, table 2, table 3.
Preparation preliminarily stabilised test under table 1 acceleration environment
Sample: dimension medicine preparation for treating rhinitis, lot number: 050301
Preparation preliminarily stabilised test report under table 2 acceleration environment
Sample: dimension medicine preparation for treating rhinitis, lot number: 050302
Preparation preliminarily stabilised test report under table 3 acceleration environment
Sample: dimension medicine preparation for treating rhinitis, lot number: 050303
Conclusion:
Three batches of test samples of dimension medicine preparation for treating rhinitis adopt aluminium foil and the hard sheet of polrvinyl chloride (PVC), adopt blister package, storage 6 months under acceleration environment, room temperature condition were stored 6 months, check according to this product quality standard, significant change does not all take place in each index such as the character of sample, discriminating, pH value, content uniformity, aseptic, microbial limit, show this preparation under selected packing material, steady quality.
The antibacterial action research of dimension medicine preparation for treating rhinitis:
For understanding fully the effect of Uigurs medicine preparation for treating rhinitis, adopt the in vitro tests method that it has been carried out experimental study.
Trial drug: dimension medicine preparation for treating rhinitis
Strain and culture medium: staphylococcus aureus, escherichia coli, Candida albicans, bacillus pyocyaneus provide by medicine inspecting institute of autonomous region.Broth bouillon, nutrient agar, sabouraud medium, all method preparations in accordance with regulations, packing sterilization back is stand-by.
Method and result:
The Plating antibacterial tests: get 5 in test tube of sterilization preparation variable concentrations, than your river of the unexpected rival dilute liquid medicine that looses, make the pastille plating medium, its concentration is respectively 0.1000,0.0500,0.0250,0.0125,0.0063 and 0.0032g/ml.With actication of culture, select colonies typical to be inoculated in broth bouillon and the sabouraud medium, cultivate 16～18h, streak inoculation is in the zones of different of each pastille flat board, cultivate 24h for 37 ℃, observe the growing state of the medicine flat board of different bacterium variable concentrations, the results are shown in Table 1.
Table 1 looses to the Plating antibacterial tests result of encountered pathogenic bacteria than your river of unexpected rival
| Strain | The drug dilution degree | MIC(g/ml) |
| Staphylococcus aureus e coli bacillus pyocyaneus Candida albicans | 1∶640 1∶160 1∶80 1∶20 | 0.0032 0.0125 0.0250 0.0500 |
The test tube method antibacterial tests: 10 in test tube, with dimension medicine preparation for treating rhinitis (1g/ml) compounding pharmaceutical concentration be 0.5000,0.2500,0.12500,0.0010g/ml, establish the culture medium that does not contain medicine and compare.Various bacterium are seeded in the fluid medium 37 ℃ cultivated 16～18 hours, be diluted to 1023 concentration with fluid medium, every pipe inoculation 0.1ml cultivated 24 hours at 37 ℃, the results are shown in Table 2
Table 2 looses to the test tube method antibacterial tests result of encountered pathogenic bacteria than your river of unexpected rival
| Strain | The drug dilution degree | MIC(g/ml) |
| Staphylococcus aureus e coli bacillus pyocyaneus Candida albicans | 1∶512 1∶32 1∶16 1∶2 | 0.0020 0.0312 0.0625 0.5000 |
Discuss: by Plating and two kinds of method tests of test tube method, dimension medicine preparation for treating rhinitis all has inhibitory action to antibacterials such as staphylococcus aureus, escherichia coli, bacillus pyocyaneus, Candida albicans, and is wherein very strong to aureus with inhibition.
The specific embodiment
Embodiment 1
A, get ceriander seed 50g, Semen Nigellae 50g two flavor medical materials and add 10 times of water gagings, the way of distillation was extracted volatile oil 6 hours, and it is standby to collect volatile oil, and the aqueous solution that extracted volatile oil filters, and centrifugal, supernatant is standby, and medicinal residues discard;
B, all the other Galla Turcica (Galla Helepensis) 150g, European Radix Smilacis Chinae 150g, Semen Strychni 50g, Endoconcha Sepiae 50g, catechu 50g, Corallium Japonicum Kishinouye 50g mixed add 8 times of water gagings, adjust pH 7, decocted 2 times, each 2 hours, filter, merging filtrate and standby supernatant, concentrate, with ethanol precipitation, concentration to 80%, get supernatant, reclaim ethanol, be concentrated into d=1.15, add the volatile oil of extraction and 1% tween 80, mixing, regulating pH with 10% sodium hydroxide is 5.5, add to 1000ml with distilled water, or spray drying is made granule promptly.
Using method: with preparation for treating rhinitis drip in right amount in or sparge nasal cavity, can be used for the treatment of the purposes of the medicine of acute and chronic rhinitis, allergic rhinitis 3-4 time on the one.Said preparation is brown to brown xanchromatic liquid or solid, abnormal smells from the patient perfume (or spice).
Embodiment 2
A, get ceriander seed 100g, Semen Nigellae 100g two flavor medical materials and add 10 times of water gagings, the way of distillation was extracted volatile oil 6 hours, and it is standby to collect volatile oil, and the aqueous solution that extracted volatile oil filters, and centrifugal, supernatant is standby, and medicinal residues discard;
B, all the other Galla Turcica (Galla Helepensis) 200g, European Radix Smilacis Chinae 200g, Semen Strychni 100g, Endoconcha Sepiae 100g, catechu 100g, Corallium Japonicum Kishinouye 100g are added 8 times of water gagings, adjust pH 7, decocted 2 times, each 2 hours, filter, merging filtrate and standby supernatant, concentrate, with ethanol precipitation, concentration to 80%, get supernatant, reclaim ethanol, be concentrated into d=1.15, add the volatile oil of extraction and 1% tween 80, mixing, regulating pH with 10% sodium hydroxide is 6.0, add to 1000ml with distilled water, or spray drying is made granule promptly.
Using method: with preparation for treating rhinitis drip in right amount in or sparge nasal cavity, can be used for the treatment of the purposes of the medicine of acute and chronic rhinitis, allergic rhinitis 3-4 time on the one.Said preparation is brown to brown xanchromatic liquid or solid, abnormal smells from the patient perfume (or spice).
Embodiment 3
A, get ceriander seed 150g, Semen Nigellae 150g two flavor medical materials and add 10 times of water gagings, the way of distillation was extracted volatile oil 6 hours, and it is standby to collect volatile oil, and the aqueous solution that extracted volatile oil filters, and centrifugal, supernatant is standby, and medicinal residues discard.
B, all the other Galla Turcica (Galla Helepensis) 250g, European Radix Smilacis Chinae 250g, Semen Strychni 150g, Endoconcha Sepiae 150g, catechu 150g, Corallium Japonicum Kishinouye 150g are added 8 times of water gagings, adjust pH 7, decocted 2 times, each 2 hours, filter, merging filtrate and standby supernatant, concentrate, with ethanol precipitation, concentration to 80%, get supernatant, reclaim ethanol, be concentrated into d=1.15, add the volatile oil of extraction and 1% tween 80, mixing, regulating pH with 10% sodium hydroxide is 7.5, add to 1000ml with distilled water, or spray drying is made granule promptly.
Using method: with preparation for treating rhinitis drip in right amount in or sparge nasal cavity, can be used for the treatment of the purposes of the medicine of acute and chronic rhinitis, allergic rhinitis 3-4 time on the one.Said preparation is brown to brown xanchromatic liquid or solid, abnormal smells from the patient perfume (or spice).
Embodiment 4
A, get ceriander seed 120g, Semen Nigellae 120g two flavor medical materials and add 10 times of water gagings, the way of distillation was extracted volatile oil 6 hours, and it is standby to collect volatile oil, and the aqueous solution that extracted volatile oil filters, and centrifugal, supernatant is standby, and medicinal residues discard;
B, all the other Galla Turcica (Galla Helepensis) 230g, European Radix Smilacis Chinae 230g, Semen Strychni 120g, Endoconcha Sepiae 120g, catechu 120g, Corallium Japonicum Kishinouye 120g are added 8 times of water gagings, adjust pH 7, decocted 2 times, each 2 hours, filter, merging filtrate and standby supernatant, concentrate, with ethanol precipitation, concentration to 80%, get supernatant, reclaim ethanol, be concentrated into d=1.15, add the volatile oil of extraction and 1% tween 80, mixing, regulating pH with 10% sodium hydroxide is 6.5, add to 1000ml with distilled water, or spray drying is made granule promptly.
Using method: with preparation for treating rhinitis drip in right amount in or sparge nasal cavity, can be used for the treatment of the purposes of the medicine of acute and chronic rhinitis, allergic rhinitis 3-4 time on the one.Said preparation is brown to brown xanchromatic liquid or solid, abnormal smells from the patient perfume (or spice).
Embodiment 5
A, get ceriander seed 80g, Semen Nigellae 80g two flavor medical materials and add 10 times of water gagings, the way of distillation was extracted volatile oil 6 hours, and it is standby to collect volatile oil, and the aqueous solution that extracted volatile oil filters, and centrifugal, supernatant is standby, and medicinal residues discard;
B, all the other Galla Turcica (Galla Helepensis) 180g, European Radix Smilacis Chinae 180g, Semen Strychni 80g, Endoconcha Sepiae 80g, catechu 80g, Corallium Japonicum Kishinouye 80g are added 8 times of water gagings, adjust pH 7, decocted 2 times, each 2 hours, filter, merging filtrate and standby supernatant, concentrate, with ethanol precipitation, concentration to 80%, get supernatant, reclaim ethanol, be concentrated into d=1.15, add the volatile oil of extraction and 1% tween 80, mixing, regulating pH with 10% sodium hydroxide is 7.0, add to 1000ml with distilled water, or spray drying is made granule promptly.
Using method: with preparation for treating rhinitis drip in right amount in or sparge nasal cavity, can be used for the treatment of the purposes of the medicine of acute and chronic rhinitis, allergic rhinitis 3-4 time on the one.Said preparation is brown to brown xanchromatic liquid or solid, abnormal smells from the patient perfume (or spice).
Claims (3)
1, a kind of medicine for external use preparation for treating rhinitis that is used for the treatment of acute and chronic rhinitis, allergic rhinitis, it is characterized in that said preparation comprises the liquid or solid preparation, is to be made by crude drug Galla Turcica (Galla Helepensis) 150-250g, European Radix Smilacis Chinae 150-250g, Semen Strychni 50-150g, Fructus Coriandri 50-150g, Semen Nigellae 50-150g, Endoconcha Sepiae 50-150g, catechu 50-150g, Corallium Japonicum Kishinouye 50-150g; Said preparation is brown to brown xanchromatic liquid or solid, abnormal smells from the patient perfume (or spice).
2, the preparation method of medicine preparation for treating rhinitis according to claim 1 is characterized in that following these steps to carrying out:
A, get ceriander seed, Semen Nigellae two flavor medical materials and add 10 times of water gagings, the way of distillation was extracted volatile oil 6 hours, and it is standby to collect volatile oil, and the aqueous solution that extracted volatile oil filters, and centrifugal, supernatant is standby, and medicinal residues discard;
B, all the other Galla Turcica (Galla Helepensis)s, European Radix Smilacis Chinae, Semen Strychni, Endoconcha Sepiae, catechu, Corallium Japonicum Kishinouye are mixed add 8 times of water gagings, adjust pH 7 decocted 2 times, each 2 hours, filter, merging filtrate and standby supernatant concentrate, with ethanol precipitation, concentration to 80%, get supernatant, reclaim ethanol, be concentrated into d=1.15, add the volatile oil of extraction and 1% tween 80, mixing, regulating pH with 10% sodium hydroxide is 5.5-7.5, add to 1000ml with distilled water, or spray drying is made granule promptly.
3, medicine preparation for treating rhinitis according to claim 1 is in the purposes of the medicine of preparation treatment acute and chronic rhinitis, allergic rhinitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100851945A CN1883676A (en) | 2006-05-30 | 2006-05-30 | Preparation for treating rhinitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100851945A CN1883676A (en) | 2006-05-30 | 2006-05-30 | Preparation for treating rhinitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1883676A true CN1883676A (en) | 2006-12-27 |
Family
ID=37582060
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006100851945A Pending CN1883676A (en) | 2006-05-30 | 2006-05-30 | Preparation for treating rhinitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1883676A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102458383A (en) * | 2009-05-18 | 2012-05-16 | 雀巢产品技术援助有限公司 | Opioid receptors stimulating compounds (thymoquinone, nigella sativa) and food allergy |
| CN103830355A (en) * | 2014-02-28 | 2014-06-04 | 田易玲 | Black cumin seed oil nose drop and preparation method thereof |
| CN109288997A (en) * | 2018-12-06 | 2019-02-01 | 新疆维吾尔自治区维吾尔医药研究所 | A kind of compound medicine and its preparation method and application for treating rhinitis |
-
2006
- 2006-05-30 CN CNA2006100851945A patent/CN1883676A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102458383A (en) * | 2009-05-18 | 2012-05-16 | 雀巢产品技术援助有限公司 | Opioid receptors stimulating compounds (thymoquinone, nigella sativa) and food allergy |
| CN103830355A (en) * | 2014-02-28 | 2014-06-04 | 田易玲 | Black cumin seed oil nose drop and preparation method thereof |
| CN103830355B (en) * | 2014-02-28 | 2016-03-09 | 徐凌川 | Oleum Nigellae nasal drop and preparation method thereof |
| CN109288997A (en) * | 2018-12-06 | 2019-02-01 | 新疆维吾尔自治区维吾尔医药研究所 | A kind of compound medicine and its preparation method and application for treating rhinitis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105496944A (en) | Chitosan gel and preparation method thereof | |
| CN1883676A (en) | Preparation for treating rhinitis | |
| CN114652748A (en) | Preparation method and application of medical gynecological lotion containing stem cell bacteriostatic factors | |
| Dasht et al. | Comparing the effect of ethanol extracts of Descurainia sophia (L.) seed and Althaea officinalis root on Streptococcus pyogenes | |
| CN105748398A (en) | Oral care solution and preparation method thereof | |
| CN117281839A (en) | Application of bacteroides sally CSP6 in preparing medicine and/or food for treating and/or preventing inflammatory bowel disease | |
| CN108586626B (en) | Preparation method and application of tetrastigma hemsleyanum Diels et Gilg oligosaccharide | |
| CN112245325A (en) | Health-care antibacterial gel and preparation method thereof | |
| Nosáľová et al. | Antitussive activity of an extracellular Rhodella grisea proteoglycan on the mechanically induced cough reflex | |
| CN111905058A (en) | Pharmaceutical composition for skin mucosa nursing and wound repair and preparation method thereof | |
| CN106867674B (en) | Extraction, purification and detection method of bean curd vegetable volatile oil and application thereof | |
| CN105325466B (en) | A kind of composition for inducing plant disease-resistant and coordinate plant growth, and its preparation method and application | |
| CN104686518B (en) | A kind of biological complex preparation containing m-methoxybenzoic acid and amino-oligosaccharide and its application | |
| CN113509493B (en) | Antibacterial ointment for promoting wound healing and preparation method thereof | |
| Manurung et al. | MIC, MBIC, MBEC analyses of garlic extract (Allium sativum) from Indonesian variety against Streptococcus mutans | |
| CN103040897B (en) | Application of Qingkailing active component radix isatidis extract in preparation of anti-multidrug-resistant bacterium medicine | |
| CN105663359B (en) | A kind of Chinese medicine composition and preparation method thereof for layer of green-shell egg In Vitro Bacteriostasis | |
| CN111838167A (en) | Smearing preparation for preventing and treating kiwifruit canker | |
| CN104906132A (en) | Plaster preparation for preventing and treating lamb stomatitis | |
| CN116036174B (en) | Medicine for treating pulmonary nodules and preparation method thereof | |
| CN1304023C (en) | Extractive of rosemary, preparation method and application | |
| CN101095707B (en) | Use of bupleurum root total polyoses in the preparing of medicine for preventing and treating acute respiratory distress syndrome | |
| CN104983724B (en) | A kind of collagen film and preparation method thereof | |
| CN114917285B (en) | Application of polysaccharide compound in medicine for preventing and treating respiratory tract virus infection | |
| Agarwal et al. | Comparative evaluation of antimicrobial efficacy of clove and thyme essential oil against Enterococcus faecalis: An in vitro study |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |