CN1883665A - Orally administered tablet, capsule, pills with eight ingredients and preparation method thereof - Google Patents
Orally administered tablet, capsule, pills with eight ingredients and preparation method thereof Download PDFInfo
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- CN1883665A CN1883665A CN 200610020842 CN200610020842A CN1883665A CN 1883665 A CN1883665 A CN 1883665A CN 200610020842 CN200610020842 CN 200610020842 CN 200610020842 A CN200610020842 A CN 200610020842A CN 1883665 A CN1883665 A CN 1883665A
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Abstract
Disclosed is a Chinese medicament in the form of oral tablets, capsules and pills, wherein the constituents include (by weight ratio) cow-bezoar 1-800 parts, sandalwood 100-800 parts, tabasheer 100-800 parts, safflower 100-800 parts, rabbit ear grass 100-800 parts, filling agent 0-200 parts, wetting agent 0-200 parts, bonding agent 0-200 parts, crumbling agent 0-200 parts and lubricating agent 0-200 parts.
Description
One, technical field
The invention belongs to and contain the pharmaceutical preparation that eight flavor medical materials are made, be specifically related to capsule, pill or tablet of containing eight flavor medical materials such as Calculus Bovis, Lignum Santali Albi, Concretio Silicea Bambusae, Herba Swertiae bimaculatae, Flos Carthami, BAXIAGA, Radix Pecteilis susannae, list loud, high-pitched sound and preparation method thereof.
Two, background technology
Eight flavor principal agents of existing national standard are diffusing to be that pulverizing medicinal materials is become fine powder, and sieving makes, and because of existing medicine is a powder, medicine profusely disorderly bored when the patient swallowed, and be unfavorable for taking, and medicine directly contacts generation stimulation taste with the oral cavity and quality standard is lower.The present invention packs medicine in the softgel shell into, or coating makes tablet, or makes pill and can address the aforementioned drawbacks, and cover the medicine stink, and outward appearance is clean and tidy, attractive in appearance, has improved the compliance of clinical use.Have again became 100 purpose fine powders to incapsulate in the shell pulverizing medicinal materials or granulate after incapsulate in the shell, capsulae vacuus dissolving back medicine disperses in gastrointestinal tract, stripping, and no disintegrating procedue is compared with powder, capsule, tablet, pill have take, easy to carry, loading amount is more accurate.The selection of multiple dosage form is provided for clinical application.
Eight flavor principal agent capsules, tablet, pill are made up of Chinese medicine such as Calculus Bovis, Lignum Santali Albi, Concretio Silicea Bambusae, Herba Swertiae bimaculatae, Flos Carthami, BAXIAGA, Radix Pecteilis susannae, list loud, high-pitched sound and Tibetan medicine.Principal agent Flos Carthami, Herba Swertiae bimaculatae have the effect of blood circulation promoting and blood stasis dispelling, depressed liver-energy dispersing and function of gallbladder promoting, and being equipped with Calculus Bovis, Radix Pecteilis susannae, list loud, high-pitched sound can eliminating inflammation and expelling toxin, alleviate pathological reactions such as blood capillary edema, biliary ductuli obstruction, and reaches the effect of heat-clearing and toxic substances removing.
Three, summary of the invention
The objective of the invention is to overcome the deficiency that above-mentioned prior art exists, prepare a kind of eight flavor principal agent capsules, tablet, pill, make it both taking conveniences, again can the masking agents stink, the preparation method of a kind of eight flavor principal agent capsules, tablet, pill is provided simultaneously.
Oral capsule definition of the present invention refers to the hard capsule under the appendix I L capsule item under an appendix rules of preparations of Chinese Pharmacopoeia version in 2005 item; Tablet refers to oral ordinary tablet, chewable tablet, the Film coated tablets under an appendix ID of Chinese Pharmacopoeia version in 2005 the tablet item; Pill refers to water pill, honeyed pill, concentrated pill under 2005 editions one appendix IH item of Chinese Pharmacopoeia etc.
Realize the object of the invention by the following technical solutions:
A kind of capsule, tablet, pill that contains eight ignorant Chinese medicines such as Calculus Bovis, Lignum Santali Albi, Concretio Silicea Bambusae, Herba Swertiae bimaculatae, Flos Carthami, BAXIAGA, Radix Pecteilis susannae, list loud, high-pitched sound and Tibetan medicine; or also contain at least a pharmaceutic adjuvant in filler, lubricant, binding agent, disintegrating agent or the lubricant, it is characterized in that the weight proportion of each component is:
100～800 parts of seven flavor medicine material fine powders such as 1～800 part of Calculus Bovis, Lignum Santali Albi, Concretio Silicea Bambusae, Herba Swertiae bimaculatae, Flos Carthami, BAXIAGA, Radix Pecteilis susannae, list loud, high-pitched sound
0～200 part of filler
0～200 part of wetting agent
0～200 part of binding agent
0～200 part of disintegrating agent
0～200 part of lubricant
Filler is: starch, dextrin, cane sugar powder, lactose, Mel, calcium sulfate, calcium bicarbonate, magnesium oxide, magnesium sulfate, microcrystalline Cellulose, mannitol or sorbitol.
Wetting agent and binding agent are: distilled water, ethanol, starch slurry, dextrin, Arabic religion, gelatin, 30 POVIDONE K 30 BP/USP 30, hypromellose or hyprolose.
Disintegrating agent is: dried starch, carboxymethylstach sodium, low-substituted hydroxypropyl cellulose, microcrystalline Cellulose, crosslinked carboxymethylstach sodium or polyvinylpolypyrrolidone.
Lubricant is: silicon dioxide, magnesium stearate, stearic acid, calcium stearate or Pulvis Talci.
The present invention's eight flavor principal agent capsules, tablet, pill become fine powder to be packed in the capsule shells after sterilization eight flavor pulverizing medicinal materials, the medical material fine powder that perhaps crushes and the filler of selection, binding agent, disintegrating agent mixing, add wetting agent and make soft material, granulate, dry, granulate, encapsulated, make capsule; In drying, add the moderate lubrication agent behind the granulate, tabletting, coating makes sheet; Or make pill.
The eight flavor principal agent capsules, tablet, the pill that make according to said method, according under the appendix IH pill item under an appendix rules of preparations of Chinese Pharmacopoeia version in 2005 item, IL capsule item down and the every Content inspection under the appendix ID tablet item, capsule outward appearance, moisture, content uniformity, disintegration, microbial limit etc. are all up to specification; Tablet appearance, weight differential, disintegration, microbial limit etc. are all up to specification; Pill outward appearance, weight differential, disintegration, microbial limit.Prove that described preparation method technological design is reasonable, can effectively control product quality, make eight flavor principal agent capsules, tablet, pill mass industrialized production become possibility.
Compared with prior art, advantage of the present invention is: the medicine filling in Capsules or add the in blocks or general one-tenth pill of appropriate amount of auxiliary materials compacting, has been solved powder and taken, stores and carry inconvenient defective.Provide the more selection of multi-pharmaceutics for clinician and patient simultaneously, can satisfy oral administration patient's different demands and selection.The invention belongs to State Food and Drug Administration's new drug management project, its down described new technology needs scientific experimentation repeatedly in a large number, and the prescription of new drug, quality standard also are brand-new.
Claims (6)
1; a kind of eight flavor Orally administered tablets; capsule; pill; contain Calculus Bovis; Lignum Santali Albi; Concretio Silicea Bambusae; Herba Swertiae bimaculatae; Flos Carthami; BAXIAGA; Radix Pecteilis susannae; eight flavor medical materials such as list loud, high-pitched sound; or also contain filler; wetting agent; binding agent; disintegrating agent; at least a pharmaceutic adjuvant in the lubricant; the weight portion proportioning that it is characterized in that each combination is: 1～800 part of Calculus Bovis; 100～800 parts of Concretio Silicea Bambusaes; 100～800 parts of Herba Swertiae bimaculataes; 100～800 parts in Lignum Santali Albi; 100～800 parts of BAXIAGA; 100～800 parts of list loud, high-pitched sounds; 100～800 parts of Radix Pecteilis susannae; 100～800 parts on Flos Carthami; 0～200 part of filler; 0～200 part of wetting agent, 0～200 part of binding agent; 0～200 part of disintegrating agent; 0～200 part of lubricant.
2, according to the described a kind of eight flavor Orally administered tablets of claim 1, capsule, pill, it is characterized in that said filler is starch, dextrin, cane sugar powder, lactose, Mel, calcium sulfate, magnesium oxide, magnesium carbonate, mannitol or sorbitol, optional wherein at least a or do not select.
3, according to the described a kind of eight flavor Orally administered tablets of claim 1, capsule, pill, it is characterized in that said lubricant and binding agent are distilled water, ethanol, starch slurry, dextrin, arabic gum, Mel, gelatin, 30 POVIDONE K 30 BP/USP 30, hyprolose or hypromellose, optional wherein at least a or do not select.
4, according to described a kind of eight flavor Orally administered tablets, the capsules of claim 1, pill, it is characterized in that said disintegrating agent is pregelatinized Starch, carboxymethylstach sodium or microcrystalline Cellulose, optional wherein at least a or do not select.
5, according to described a kind of eight flavor Orally administered tablets, the capsules of claim 1, pill, it is characterized in that said lubricant is a silicon dioxide, magnesium stearate or Pulvis Talci, optional wherein at least a.
6, a kind of preparation method for preparing the described eight flavor Orally administered tablets of claim 1, capsule, pill; it is characterized in that: according to each ingredients weight parts proportional quantity of eight flavor Orally administered tablet, pill or capsules; Calculus Bovis, Lignum Santali Albi, Concretio Silicea Bambusae, Herba Swertiae bimaculatae, Flos Carthami, BAXIAGA, Radix Pecteilis susannae, list loud, high-pitched sound are ground into fine powder; sieve; mixing, directly filled capsules.Pulverizing medicinal materials is become fine powder, add suitable quantity of water, general ball makes pill.Or with the filler of above eight flavor medical materials and selections, binding agent, disintegrating agent mixes, and pulverizes, and sieves, and adds wetting agent and makes soft material, granulation, drying, granulate; Add lubricant again, tabletting, coating makes tablet, or in drying, the direct encapsulated capsule that makes behind the granulate.Or after making soft material, make pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610020842 CN1883665A (en) | 2006-05-18 | 2006-05-18 | Orally administered tablet, capsule, pills with eight ingredients and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610020842 CN1883665A (en) | 2006-05-18 | 2006-05-18 | Orally administered tablet, capsule, pills with eight ingredients and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1883665A true CN1883665A (en) | 2006-12-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610020842 Pending CN1883665A (en) | 2006-05-18 | 2006-05-18 | Orally administered tablet, capsule, pills with eight ingredients and preparation method thereof |
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| Country | Link |
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| CN (1) | CN1883665A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103028038A (en) * | 2013-01-08 | 2013-04-10 | 严斯文 | Smoking control tablet |
| CN104096108A (en) * | 2014-07-18 | 2014-10-15 | 那生桑 | Mongolian medicine for treating painful subacute thyroiditis and preparation method thereof |
-
2006
- 2006-05-18 CN CN 200610020842 patent/CN1883665A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103028038A (en) * | 2013-01-08 | 2013-04-10 | 严斯文 | Smoking control tablet |
| CN104096108A (en) * | 2014-07-18 | 2014-10-15 | 那生桑 | Mongolian medicine for treating painful subacute thyroiditis and preparation method thereof |
| CN104096108B (en) * | 2014-07-18 | 2017-12-22 | 乌苏日乐特 | It is a kind of to treat scorching anaesthetic of painful methylene and preparation method thereof |
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