CN1872077A - Medicine for treating cardiac insufficiency - Google Patents
Medicine for treating cardiac insufficiency Download PDFInfo
- Publication number
- CN1872077A CN1872077A CN 200510013614 CN200510013614A CN1872077A CN 1872077 A CN1872077 A CN 1872077A CN 200510013614 CN200510013614 CN 200510013614 CN 200510013614 A CN200510013614 A CN 200510013614A CN 1872077 A CN1872077 A CN 1872077A
- Authority
- CN
- China
- Prior art keywords
- adjuvant
- drop pill
- adoniside
- starch
- xylitol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008117 stearic acid Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
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Abstract
A medicine for acute or chronic cardiac disfunction is disclosed. Its advantages are high natural level and safety and low toxic by-effect.
Description
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is the pharmaceutical preparation of the acute and chronic cardiac insufficiency of the raw material treatment of making.
Background technology
Adoniside is the total glycosides that extracts among the cohosh Amur Adonis Herb Adonis amurensis Regel et Radde, has heart tonifying, diuresis, and calmness, the effect of decreased heart rate is used for acute and chronic cardiac insufficiency.
Adoniside (Adonlsldum) bitter in the mouth, have draw moist, easily molten in water, but its disintegration of tablet time is long, dissolution and dissolution rate are low, absorption difference, and bioavailability is low, the supplementary product consumption ratio is big, also has bibliographical information that adoniside and an amount of polyethylene glycol 6000, Macrogol 4000, polyethylene glycol 1500, cetomacrogol 1000, sodium stearate, glycerin gelatine, poloxamer, stearic acid, glycerol monostearate acid, insect wax etc. are made drop pill.Dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The medicine that the purpose of this invention is to provide the acute and chronic cardiac insufficiency of a kind of treatment with new type natural substrate adjuvant preparation.
Another object of the present invention provides a kind of preparation method for the treatment of the medicine of acute and chronic cardiac insufficiency.
The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is low, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
The consumption of drug component of the present invention and the selection of adjuvant thereof also grope to sum up to draw through the inventor in a large number, this medicine is formed and is comprised: adoniside, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, filler wherein is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
The adjuvant of further preferred drug component of the present invention is selected from the natural adjuvant of following one or more plant origins for the filler adjuvant: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose;
Further the adjuvant of preferred drug component of the present invention for the filler adjuvant is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum;
Best substrate adjuvant of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Adjuvant is 1: 0.1～1: 1 with the ratio of the weight of adoniside in the pharmaceutical composition of the present invention;
Adjuvant is 1: 0.1～1: 0.6 with the ratio of the weight of adoniside in the preferred pharmaceutical composition of the present invention;
Adjuvant is 1: 0.2～1: 0.4 with the ratio of the weight of adoniside in the best pharmaceutical composition of the present invention.
Medicine mesostroma adjuvant of the present invention and amount of drug are than being the scope that allows on the galenic pharmacy, and medicine described here can be that crude drug also can be the effective ingredient extract.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method; make common any preparation at present; but, preferably adopt following method to be prepared into dropping pill formulation, but this can not limit protection scope of the present invention in order to make each crude drug of this medicine bring into play drug effect better.
The preparation method of medicine of the present invention is as follows:
(a) get adoniside, adjuvant is standby;
(b) in appropriate amount of auxiliary materials, add adoniside, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Further preferred manufacturing procedure is:
The mixture heated melt temperature is 60～85 ℃ in the step (b), and mixing time is 10～30 minutes, and dripping a system temperature and be 60～85 ℃, dropper bore is 1.1～3.5 millimeters, and condensing agent is 0～18 ℃ liquid paraffin or a methyl-silicone oil.
Best preparation method is:
The mixture heated melt temperature is 64 ℃ in the step (b), and dripping a system temperature and be 64 ℃, dropper bore is 1.2～2.5 millimeters, and condensing agent is 0 ℃ a methyl-silicone oil.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, for example: selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis substrate adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of drop pill taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, makes drug effect faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill that this adjuvant is made can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
The present invention is under instruction of Chinese Medicine theory, preparation technology's test that process is a large amount of and pharmacology, the resulting preparation of pharmacodynamics test.Reasonable recipe of the present invention, poisonous side effect of medicine is low, overcome that the acute and chronic cardiac insufficiency toxic and side effects of western medicine is big, expense is high, the Chinese medicine curative effect is low, flavour of a drug are many, the shortcoming of incompatibility large-scale production, is the medicine of the acute and chronic cardiac insufficiency of the treatment determined of a kind of economy, material benefit, curative effect.
To those skilled in the art, technology contents disclosed according to the present invention, those skilled in the art will very clear other embodiment of the present invention, and the embodiment of the invention is only as example.Under the situation of not violating purport of the present invention and scope, can carry out various changes and improvements to the present invention.For example, use different crude drug or extract or active constituents of medicine or effective ingredient and adjuvant provided by the present invention to make various different preparations, particularly drop pill, but as long as use adjuvant of the present invention, all within protection domain of the present invention.
In order to understand the present invention better, the drop pill made from the new substrate of the present invention (prepares according to embodiment 1 method below, hereinafter to be referred as new Amur Adonis Herb aglycone dropping pill) test explanation advantages of the present invention with the drop pill of making for the main matrix adjuvant with the Polyethylene Glycol dissolve scattered time limit of (according to application number be: 200310100940.X embodiment 1 method prepares, hereinafter to be referred as old adoniside drop pill), drop pill soft durometer, the sticking ball of drop pill etc.
Test example 1: dissolve scattered time limit, weight differential contrast experiment's example
In vitro tests
New Amur Adonis Herb aglycone dropping pill and old adoniside drop pill compare, and by measuring dissolve scattered time limit, investigate its good releasing effect; By measuring indexs such as the ball method of double differences is different, whether ripe, whether be fit to suitability for industrialized production if investigating its preparation technology.
1. test medication: new Amur Adonis Herb aglycone dropping pill, old adoniside drop pill.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
Three batches in table 1 with new Amur Adonis Herb aglycone dropping pill and old adoniside drop pill dissolve scattered time limit, weight differential relatively
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | |
| Dissolve scattered time limit (newly) (old) | 3′15″ 4′29″ | 3′15″ 4′30″ | 3′17″ 4′31″ | 3′14″ 4′34″ | 3′20″ 4′28″ | 3′19″ 4′32″ | 3′19″ 4′33″ | |
| 2 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (old) | 3′13″ 4′30″ | 3′14″ 4′26″ | 3′16″ 4′35″ | 3′15″ 4′32″ | 3′14″ 4′32″ | 3′17″ 4′31″ | 3′17″ 4′33″ | |
| 3 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (old) | 3′12″ 4′29″ | 3′13″ 4′31″ | 3′16″ 4′31″ | 3′16″ 4′32″ | 3′20″ 4′33″ | 3′20″ 4′31″ | 3′19″ 4′31″ | |
Above-mentioned experimental data shows that the older adoniside drop pill of dissolve scattered time limit of new Amur Adonis Herb aglycone dropping pill is few, different being controlled in the pharmacopeia prescribed limit of the ball method of double differences of new Amur Adonis Herb aglycone dropping pill, old adoniside drop pill.The result of the test explanation, the new Amur Adonis Herb aglycone dropping pill that the new medium adjuvant is made is more conducive to medicine and plays a role in the shortest time, different all being controlled in the pharmacopeia prescribed limit of new, the old adoniside drop pill ball method of double differences, but suitability for industrialized production.
Test example 2: the comparative observation of new Amur Adonis Herb aglycone dropping pill and old adoniside drop pill soft durometer, the sticking ball of drop pill
Compare by new Amur Adonis Herb aglycone dropping pill and old adoniside drop pill, measure indexs such as above-mentioned, investigate its effect.
1. test medication: new Amur Adonis Herb aglycone dropping pill is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; Old adoniside drop pill prepares according to document.
2. method and result:
Get each three batches of new Amur Adonis Herb aglycone dropping pill and old adoniside drop pill, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches of old adoniside drop pill reserved sample observings of table 2.1 relatively
| 0 month | 1 | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly | |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 2 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 3 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
Table 2.2: three batches of new Amur Adonis Herb aglycone dropping pills and old adoniside drop pill character observation are relatively
| 0 month | January | February | March | June | December | 18 months | ||
| Criterion | The result | |||||||
| 1 batch | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | Hard slightly (old) be hard (newly) slightly | |
| 2 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
| 3 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly |
Table 2.1,2.2 test data show that new Amur Adonis Herb aglycone dropping pill soft durometer changes similar to old adoniside drop pill, strong slightly; New Amur Adonis Herb aglycone dropping pill glues the ball variation, firmness change is similar to old adoniside drop pill.The result of the test explanation, the sticking ball of new, old adoniside drop pill changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
(a) get adoniside 5.8g, xylitol 19.6g, starch 6.7g is standby;
(b) get xylitol and starch mix homogeneously, adding above-mentioned adoniside fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 2
(a) get adoniside 2.0g, lactose 17.8g, starch 4.2g is standby;
(b) get lactose and starch mix homogeneously, adding above-mentioned adoniside fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 3
(a) get adoniside 4.0g, xylitol 25.9g, arabic gum 7.1g is standby;
(b) get xylitol and arabic gum mix homogeneously, adding above-mentioned adoniside fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 4
(a) get adoniside 1.5g, xylitol 28.0g, xanthan gum 2.0g is standby;
(b) get xylitol and xanthan gum mix homogeneously, adding above-mentioned adoniside fully mixes, mixture stirs at 45～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～70 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in-10～10 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 5
(a) get adoniside 2.5g, xylitol 16.5g, starch 7.0g is standby;
(b) get xylitol and starch mix homogeneously, add above-mentioned adoniside, mixture stirs at 45～115 ℃ of heating and meltings, and mixing time is 1～30 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 6
(a) get adoniside 1.5g, erythritol 29.5g is standby;
(b) get erythritol and add above-mentioned adoniside, mixture is at 55～75 ℃ of heating and meltings, stir, mixing time is 5～12 minutes, and insulation is 1.20～3.0 millimeters at 55～75 ℃ of temperature following system, dropper bore, splash in 0～15 ℃ the liquid paraffin, make 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly
Embodiment 7
(a) get adoniside 3.0g, xylitol 24.0g, Lac 6.0g is standby;
(b) get xylitol and Lac mixing mixing, add above-mentioned adoniside, mixture stirs at 45～115 ℃ of heating and meltings, mixing time is 5～20 minutes, and insulation is dripped system 58～70 ℃ of insulations, splash in 12 ℃ of liquid paraffin, make 1000 drop pill of drop pill, promptly.
Embodiment 8
(a) get adoniside 4.0g, xylitol 19.9g, starch 4.1g is standby;
(b) get xylitol and starch mix homogeneously, add above-mentioned adoniside, mixture stirs at 60～75 ℃ of heating and meltings, and mixing time is 10～60 minutes, insulation, at 55～65 ℃ of temperature following system, dropper bore is 1.0～3.5 millimeters, splashes in-20～25 ℃ the vegetable oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 9
(a) get adoniside 6.5g, lactose 16.6g, starch 3.4g is standby;
(b) get mixing of lactose and starch, add above-mentioned adoniside, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 10
(a) get adoniside 7.0g, xylitol 16.5g, arabic gum 15.5g is standby;
(b) get the mixing mixing of xylitol and arabic gum, add above-mentioned adoniside, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splashes in 0～18 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 11
(a) get adoniside 9.5g, xylitol 18.0g, trehalose 2.0g is standby;
(b) get xylitol and trehalose mixing mixing, add above-mentioned adoniside, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 60～85 ℃ of temperature following system, dropper bore is 1.21～3.5 millimeters, splashes in 0～15 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 12
(a) get adoniside 8.0g, xylitol 26.6g, tragakanta 3.4g is standby;
(b) get xylitol and tragakanta mix homogeneously, add above-mentioned adoniside, mixture stirs at 60～85 ℃ of heating and meltings, and mixing time is 10～20 minutes, insulation, at 60～75 ℃ of temperature following system, dropper bore is 1.5～3.5 millimeters, splashes in 10～18 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 13
(a) get adoniside 7.5g, lactose 24.0g, xanthan gum 6.0g is standby;
(b) get lactose and xanthan gum mix homogeneously, add above-mentioned adoniside, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 62～67 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 4 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 14
(a) get adoniside 15.5g, xylitol 18.5g, arabic gum 3.5g is standby;
(b) get xylitol and arabic gum mix homogeneously, add above-mentioned adoniside, mixture stirs at 55～85 ℃ of heating and meltings, and mixing time is 5～30 minutes, insulation, at 58～68 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 15
(a) get adoniside 6.0g, lactose 37.0g, tragakanta 9.0g is standby;
(b) getting lactose and tragakanta mixes, add above-mentioned adoniside, fully mix, mixture is at 64 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, and insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splash in 0 ℃ the methyl-silicone oil, make 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 16
(a) get adoniside 7.0g, xylitol 26.0g, Furcellaran 4.0g is standby;
(b) get xylitol and Furcellaran mixing, adding above-mentioned adoniside fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 17
(a) get adoniside 15g, sorbitol 25g, starch 11.5g is standby;
(b) get sorbitol and starch mixing, add above-mentioned adoniside and fully mix, make 100 by method for preparing tablet thereof, promptly.
Embodiment 18
(a) get adoniside 10.5g, xylitol 14.5g, xanthan gum 8.0g is standby;
(b) get xylitol and xanthan gum mixing, adding above-mentioned adoniside fully mixes, mixture stirs at 60～70 ℃ of heating and meltings, and mixing time is 15～25 minutes, insulation, at 62～66 ℃ of temperature following system, dropper bore is 1.21～2.5 millimeters, splashes in 0～15 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 19
(a) get adoniside 1g, xylitol 183.3g, starch 16.7g is standby;
(b) get xylitol and starch mix homogeneously, add above-mentioned adoniside and fully mix, make 10000 capsules, promptly.
Embodiment 20
(a) get adoniside 0.5g, xylitol 13.3g, starch 6.7g is standby;
(b) get xylitol and starch mix homogeneously, adding above-mentioned adoniside fully mixes, mixture stirs at 75 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 75 ℃ of temperature following system, dropper bore is 1.25～2.5 millimeters, splashes in 5 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 21
(a) get adoniside 0.5g, xylitol 15g, arabic gum 5g is standby;
(b) get xylitol and arabic gum mix homogeneously, adding above-mentioned adoniside fully mixes, mixture stirs at 64 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splashes in 0 ℃ the methyl-silicone oil, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Embodiment 22
(a) get adoniside 0.5g, lactose 17g, starch 3g is standby;
(b) get lactose and starch mix homogeneously, adding above-mentioned adoniside fully mixes, mixture stirs at 80 ℃ of heating and meltings, and mixing time is 10～30 minutes, insulation, at 64 ℃ of temperature following system, dropper bore is 1.25～2.5 millimeters, splashes in 5 ℃ the liquid paraffin, makes 1000 drop pill, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
Claims (10)
1, a kind ofly treat acute and drop pill chronic cardiac insufficiency, it is characterized in that this medicine composition comprises: adoniside, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, filler wherein is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
2, drop pill as claimed in claim 1, it is characterized in that this medicine composition comprises: adoniside, appropriate amount of auxiliary materials, wherein adjuvant comprises filler and plasticity substrate, filler adjuvant wherein is selected from the natural adjuvant of following one or more plant origins: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose.
3, drop pill as claimed in claim 1 is characterized in that wherein filler adjuvant is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
4, drop pill as claimed in claim 2 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Perhaps be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Perhaps be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
5, drop pill as claimed in claim 1 or 2 is characterized in that the adjuvant and the ratio of the weight of adoniside are 1: 0.1～1: 1.
6, drop pill as claimed in claim 1 or 2, it is characterized in that adjuvant and adoniside the ratio of weight be 1: 0.1～1: 0.6.
7, drop pill as claimed in claim 1 or 2, it is characterized in that adjuvant and adoniside the ratio of weight be 1: 0.2～1: 0.4.
8, a kind of preparation method of drop pill is characterized in that this method comprises the steps:
(a) get adoniside, adjuvant is standby;
(b) in appropriate amount of auxiliary materials, add adoniside, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, with the drop pill drop to the greatest extent and wipe liquid coolant, promptly.
9, as the preparation method of drop pill as described in the claim 8, it is characterized in that the mixture heated melt temperature is 60～85 ℃, mixing time is 10～30 minutes, and dripping a system temperature and be 60～85 ℃, dropper bore is 1.1～3.5 millimeters, and condensing agent is 0～18 ℃ liquid paraffin or a methyl-silicone oil.
10, the preparation method of drop pill as claimed in claim 9 is characterized in that the mixture heated melt temperature is 64 ℃, and dripping a system temperature and be 64 ℃, dropper bore is 1.2～2.5 millimeters, and condensing agent is 0 ℃ a methyl-silicone oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100136144A CN1872077B (en) | 2005-06-01 | 2005-06-01 | Medicine for treating cardiac insufficiency |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2005100136144A CN1872077B (en) | 2005-06-01 | 2005-06-01 | Medicine for treating cardiac insufficiency |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1872077A true CN1872077A (en) | 2006-12-06 |
| CN1872077B CN1872077B (en) | 2011-02-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005100136144A Expired - Fee Related CN1872077B (en) | 2005-06-01 | 2005-06-01 | Medicine for treating cardiac insufficiency |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1528318A (en) * | 2003-10-06 | 2004-09-15 | 南昌弘益科技有限公司 | Herba adonidis aglycone drop pill and preparing method thereof |
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2005
- 2005-06-01 CN CN2005100136144A patent/CN1872077B/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1872077B (en) | 2011-02-16 |
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