CN1840143A - Composite preparation for resisting oxidation, preventing and treating senile dementia and preparation method thereof - Google Patents
Composite preparation for resisting oxidation, preventing and treating senile dementia and preparation method thereof Download PDFInfo
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- CN1840143A CN1840143A CN 200610000923 CN200610000923A CN1840143A CN 1840143 A CN1840143 A CN 1840143A CN 200610000923 CN200610000923 CN 200610000923 CN 200610000923 A CN200610000923 A CN 200610000923A CN 1840143 A CN1840143 A CN 1840143A
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Abstract
The invention discloses a compound preparation for resisting oxidation and senile dementia, wherein the active constituents include (by weight portions) curcuma longa 10-47.5 parts, ginkgo leaves flavones 0-5 parts, and American ginseng saponin 0-5 parts.
Description
Technical field
The present invention relates to a kind of antioxidation, prevent and treat compound preparation of senile dementia and preparation method thereof.
Background technology
Scientific research shows that oxidative damage is the precipitating factor of alzheimer disease.Because old people's self oxidation resistance weakens, so add the development that antioxidant (being free radical scavenger) may delay primary disease in good time.More and more studies show that, the sudden change of disease that ageing-related and gene, all the damage with free radical is relevant as cancer, arteriosclerosis, coronary heart disease, diabetes, cataract, senile dementia, arthritis etc.In view of this, keep enough antioxidant of body, in time remove free radical and be defying age and one of the important means that keep fit.Replenishing of antioxidant or antioxidant also is subject to people's attention more and more.
Natural plants is a kind of natural anti-oxidation resource that has potentiality.The medicine that the development and utilization pure natural plant extracts antioxidation, prevent and treat senile dementia becomes a new problem.
Summary of the invention
The technical issues that need to address of the present invention just are a kind of antioxidation to be provided, to prevent and treat compound preparation of senile dementia and preparation method thereof.
For addressing the above problem, the present invention adopts following technical scheme:
A kind of antioxidation of the present invention, prevent and treat the compound preparation of senile dementia, the weight portion proportioning of the active component that it is contained is: curcumin 10-47.5 part, Folium Ginkgo flavone 0-5 part, total panaquilon 0-5 part.
Preferably, the weight portion proportioning of the active component that the present invention is contained is: curcumin 15-30 part, Folium Ginkgo flavone 1-3 part, total panaquilon 1-3 part.
Further preferably, the weight portion proportioning of the active component that the present invention is contained is: 15 parts of curcumins, 1 part of Folium Ginkgo flavone, 1 part of total panaquilon.
Curcumin of the present invention derives from Rhizoma Curcumae Longae extract, and the weight content of curcumin is 30-95% in the described Rhizoma Curcumae Longae extract.Described Folium Ginkgo flavone derives from Semen Ginkgo extrac, and the weight content of Folium Ginkgo flavone is 2-24% in the described Semen Ginkgo extrac.Described total panaquilon derives from Radix Panacis Quinquefolii extract, and the total panaquilon weight content is 2-80% in the described Radix Panacis Quinquefolii extract.
The present invention provides a kind of method for preparing described antioxidation, prevents and treats the compound preparation of senile dementia simultaneously, and it comprises the steps:
A, the weight content that is equipped with curcumin are the Rhizoma Curcumae Longae extract of 30-95%;
The weight content of B, preparation Folium Ginkgo flavone is the Semen Ginkgo extrac of 2-24%;
C, preparation total panaquilon weight content are the Radix Panacis Quinquefolii extract of 2-80%;
D, above-mentioned three kinds of extracts are mixed back and pharmaceutically acceptable carrier or excipient
Be prepared into various dosage forms.
The preparation method of Rhizoma Curcumae Longae extract of the present invention is: Rhizoma Curcumae Longae cleaned to make meets requirement of Chinese Pharmacopoeia version in 2005, and the coarse powder that curcuma powder is broken into about 20 orders is standby; The Rhizoma Curcumae Longae coarse powder is packed in the barrel of supercritical extraction unit, again barrel is put into extraction kettle, during 50 ℃ of design temperatures, open CO
2Steel cylinder pressurizes to system by high-pressure pump, regulates CO when extraction kettle and separating still pressure are respectively 36MPa and 6.0MPa
2The about 150kg/h of flow keeps the state extraction 3h of constant temperature, constant voltage, constant current amount, emits turmeric oil, the Rhizoma Curcumae Longae coarse powder is proceeded curcumin extract, and still carries out according to above-mentioned parameter, promptly during 50 ℃ of temperature, opens CO
2Steel cylinder pressurizes to system by high-pressure pump, regulates CO when extraction kettle and separating still pressure are respectively 36MPa and 6.0MPa
2The about 150kg/h of flow is at CO
2In add edible 95% ethanol of entrainer of 20% amount, keep the state extraction 4h of constant temperature, constant voltage, constant current amount, isolate curcumin alcoholic solution and Rhizoma Curcumae Longae and extract residue, emit the curcumin alcoholic solution; The above-mentioned curcumin alcoholic solution that obtains is put decompression recycling ethanol in the triple effect concentrator, and temperature is lower than 60 ℃, emits, and filters; Obtain containing small amount of moisture curcumin solution, 80 ℃ of vacuum decompression dryings, that is, wherein the content of curcumin is 30-95%.
The preparation method of Semen Ginkgo extrac of the present invention is: the Folium Ginkgo coarse powder adds 8 times of amount 95% ethanol extractions 3 times, and merge extractive liquid, filters, 70 ℃ of decompression recycling ethanols of filtrate, be concentrated into and be equivalent to crude drug 1.2g/ml Folium Ginkgo crude extract, extract is suspended in 10 times of amount 20% ethanol, filter, get filtrate, with 70 ℃ of decompression and solvent recoveries of filtrate, the density when being concentrated into 60 ℃ is 1.26～1.28,60 ℃ of drying under reduced pressure, that is, wherein the weight content of Folium Ginkgo flavone is 2-24%.
The preparation method of Radix Panacis Quinquefolii extract of the present invention is: 1, will cut to 1～2 centimetre Radix Panacis Quinquefolii must 100kg with cut to 1～2 centimetre of segment Radix Panacis Quinquefolii 100kg, amounting to Radix Panacis Quinquefolii 200kg drops in the extraction pot, add for the first time 95% edible ethanol 842kg, add water 760kg, be mixed with concentration and be 50 ± 1% 1600kg alcoholic solution, open pump circulation 20 minutes, soaked 4 hours, keep extraction pot jacket steam pressure must not be higher than 0.02MPa, temperature is 60 ± 5 ℃ in jar, extracted 2 hours, and put medicinal liquid through filter; 2, add 95% edible ethanol 526kg for the second time, add water 475kg, be mixed with concentration and be 50 ± 1% 1000kg alcoholic solution, open pump circulation 20 minutes, soaked 4 hours, and kept extraction pot jacket steam pressure must not be higher than 0.02MPa, temperature is 60 ± 5 ℃ in jar, extracted 2 hours, and put medicinal liquid through filter; 3, will put to agitator tank with the medicinal liquid merging second time for the first time, squeezed into the settling tank precipitation afterwards 24 hours, filtering supernatant, reclaim ethanol, vacuum is-0.04MPa, treat ethanol reclaim finish after, transfer vacuum be-0.06～-0.08MPa concentrates, thickening temperature is no more than 90 ℃, is the clear paste of 1.16～1.17g/ml when being concentrated into 60 ℃ of proportions; 4, the above-mentioned clear paste that obtains is-0.06 in vacuum～-carrying out vacuum drying under the condition of 0.08MPa, baking temperature is no more than 90 ± 2 ℃, pulverizes, mixes promptly, and wherein the total panaquilon weight content is 2-80%.
The active component of compound preparation of the present invention is made up of active component curcumin, Folium Ginkgo flavone and total panaquilon in Rhizoma Curcumae Longae extract, Semen Ginkgo extrac, the Radix Panacis Quinquefolii extract, three kinds of mutual coordinative roles of active component, wherein curcumin is a monarch drug, is aided with Folium Ginkgo flavone and total panaquilon and reaches antioxidation, prevents and treats senile dementia.
It is clear that the present invention chooses in three kinds of main antioxidant contents structure, the plant extract side of combining that antioxidation mechanism is understood, try hard to from the different chemical constituent of phytochemical, different action pathway combined effect in each target spot of antioxidation, select simultaneously curcumin again for use based on liposoluble, select water solublity is better, antioxidation is strong Folium Ginkgo crude extract, Radix Panacis Quinquefolii extract again, to strengthen antioxidative effect of the present invention.
Curcumin is widely used in food additive.Studies show that curcumin is at the external lipid peroxidation that can suppress rat liver microsomes, suppress the answering of neutrophilic leukocyte and stop the generation of oxygen-derived free radicals, reduce the generation of hydroxy radical in the Fenton reaction during high concentration.Confirm that by experiment mouse peritoneal injection curcumin is after 7 days, the MDA content of blood plasma obviously reduces, the effect of heavy dose of group smaller dose group is stronger, present certain dose-dependence, and MDA content reduces obviously in the cerebral tissue, but the changes of contents of MDA is not obvious in the hepatic tissue.Simultaneously, the SOD activity of curcumin group mice plasma, liver and cerebral tissue is significantly increased, and is dose dependent.Cur generates O to the NBT/PMS/NADH system
2 -Remarkable scavenging action is arranged, and it partly removes concentration SC50 is 82.5 μ mol/L, is equivalent to the SOD vigor of 10.3U.Curcumin (the erythrocyte oxidisability haemolysis that 120 μ mol/L can suppress to be brought out by AAPH effectively (suppressing more than 2 hours)
Homogenate Total antioxidant capacity and SOD activity, activity of glutathione peroxidase, promote liver and adrenal gland metabolism to low density lipoprotein, LDL and lipoprotein (a), increasing gallbladder drains low density lipoprotein, LDL, suppress the picked-up of spleen to low density lipoprotein, LDL, the content of low density lipoprotein, LDL and lipoprotein (a) in the blood is reduced, thereby play blood fat reducing and study of anti-atherogenic effect, its effect for reducing fat in vivo also may be the metabolism that has changed fatty acid.In addition, the curcumol extract also can resist the oxidative modification effect of low density lipoprotein, LDL (LDL).
Curcumin can make the inductive rat ischaemic ECG change of isoproterenol alleviate, and suppresses serum CPK, the active rising of LDH, GOT and free serum fatty acid and raises, and also reduces the content of ischemic myocardium MDA simultaneously.In addition, curcumin also can improve the rat heart muscle hypoxia-bearing capability, and the ischemia injury of rat heart muscle is had the certain protection effect.Curcumin also can suppress the generation, SOD activity improving of MDA of ischemia-reperfusion rat cerebral tissue and inferior hydrochlorate slightly, effectively remove superoxide anion (O
2 -), thereby ischemical reperfusion injury is had protective effect.
A large amount of research reports confirm that Folium Ginkgo extract has stronger antioxidation, and Folium Ginkgo extract is multiple free radical scavenger and strong antioxidant, can improve antioxidase activity such as SOD, GSH-Px, can directly remove O simultaneously
2 -, OH, lipid peroxidation free radical.Domestic Zhou Shi utilizes 61 routine patient with angina pectoris to take Folium Ginkgo flavone (taponin) continuously and tests discovery after 1 month, in patient's body and the O in the blood
2 -Number of free radical such as OH and LPO (serum lipid peroxide), malonaldehyde, conjugated diene isoreactivity material concentration all have reduction, and SOD, GSH-PX are active to be increased, and blood plasma lipid peroxide and erythrocyte lipid peroxide content significantly reduce.Show that Folium Ginkgo flavone has free radicals such as removing active oxygen and the obvious effect that slows down pathologic lipid peroxidation, anti peroxidation of lipid damage.The antioxidant effect of Shanghai Chen Shi has utilized chemoluminescence method and studies on Spectrophotometric Determination Folium Ginkgo flavone water solublity and pure dissolubility flavone, the result shows that water miscible flavone and pure dissolubility flavone can not only be removed O effectively
- 2H
2O
2, and can suppress lipid peroxidation, and the two all might remove LOLOO and O
2Tianjin Zhang Shi utilizes the effect research that experimentizes to oxidation of ginkgo leaf extractive of drosophila survival experiment and quick aging model mice, tests crystallization and shows that really Folium Ginkgo extract has antioxidation.
It is generally acknowledged that the antioxidation of Folium Ginkgo extract mainly is the Folium Ginkgo flavone glycosides in the Folium Ginkgo extract, and the main effect of the bilobalide in the Folium Ginkgo extract is an antagonism platelet activating factor optionally.The result of study of external Joyeux etc. shows that it is irrelevant that Folium Ginkgo extract is removed free radical and antioxidation and Folium Ginkgo terpene lactones, and relevant with Folium Ginkgo flavone.Wuhan Hu Shi adopts Folium Ginkgo extract removing OH effect in colorimetric method for determining deoxyribose-ferrum system, and chemoluminescence method detects Folium Ginkgo extract removing O in hypoxanthine oxidase-luminol system
- 2Effect.The result shows that ginkgo biloba crude extract (total flavonoid glycoside content 7%) is removed OH and O
- 2Effect all be better than ginkgo leaf extract extract (total flavonoid glycoside content 24% contains the Semen Ginkgo terpene lactones).
Modern study shows, ginsenoside Rb
1Snperoxiaized influence of rats'liver brain microgranule body constitution and vitamin E are compared, find Rb
1Can obviously suppress by vitamin C-NADOH and Fe
3-Propylhomoserin brings out liver, brain malonaldehyde (MDA) content reduces, and shows a certain amount of effect relationship, and the inhibitory action intensity of Rb1 is roughly similar with vitamin E.
The present invention has powerful antioxidation and antiinflammatory action.The pathological characteristics of senile dementia is that the outer a large amount of senile plaques of brain cell are piled up and the interior neural thread protein NTP matter of neurocyte is tangled.Such pathological process is accompanied by the interior environment change of brain, as chronic inflammatory disease (inflammatory factor increase, as IL-1beta) and _ interior environment Metabolic disorder (free radical increases) or the like.These factors cause neurocyte dead gradually together, and Web Grafiti between the neurocyte produces senile dementia.Utilize the animal model of senile dementia mice, proved the middle postadolescence mice (the 10-16 month) that curcumin is raised, can antioxidation (brain peroxidating protein level descends 61.5% sick Mus), antiinflammatory (inflammatory factor IL-1beta descends 61.8% sick Mus), and the senile plaque of sick Mus forms and descends 43%.Curcumin can directly combine with the senile plaque denatured protein in the external test tube and in the tissue slice of senile dementia, below fluorescence microscope, provide fluorescence, external test-tube model proves that successfully curcumin is not only in conjunction with the senile plaque denatured protein, stop and continue to form denatured protein, and have the senile plaque denatured protein that dissolving has formed.Extremely old mouse model (the 16-22 month in the prime of life of adopting curcumin to raise, at this moment there has been senile plaque in mouse brain, to pile up), fully consistent with the external model result, intravascular injection or raising can both be passed through blood brain barrier and be combined with senile plaque denatured protein in the brain, provide fluorescence, stop and continue to form denatured protein (senile plaque forms and descends 85%), the senile plaque denatured protein that dissolving has formed (established senile plaque degraded 32.5%).Now in the world, still do not have the method for treatment and prevention senile dementia, experimental animal model successfully proves, energy antioxidation, antiinflammatory and prevention, treatment senile dementia.
Curcumin proved as crowd's medication do not have toxicity and very low poison to pay effect since thousands of years.The present invention's prescription is a monarch drug with the curcumin exactly, is aided with the possible poison of ministerial drug alleviation curcumin and pays effect, increases some antioxidation target spots, improves the monarch drug function.Animal and human group's test shows that the present invention can obviously improve rat or blood in human body in oar polyphenoils dismutase vigor, reduces malonaldehyde and lipid peroxide content.
In the table for the old people take the present invention's (compound turmeric cellulose capsule) back serum MDA, SOD, GSH-PX testing result (± s)
| Group | The example number | MDA(mmol/L) | SOD(U/ml) | GSH-PX(U/ml) |
| After testing before the experiment | 30 30 | 5.3±0.9 3.0±1.0 ▲ | 44.8±7.3 62.2±21.6 ▲ | 54.1±9.6 66.5±10.3 ▲ |
Annotate: relatively preceding with experiment
▲P＜0.01;
The specific embodiment
The preparation of embodiment 1 Rhizoma Curcumae Longae extract
Rhizoma Curcumae Longae cleaned to make meet requirement of Chinese Pharmacopoeia version in 2005, Rhizoma Curcumae Longae is cleaned to make meet requirement of Chinese Pharmacopoeia version in 2005, the coarse powder that curcuma powder is broken into about 20 orders is standby; The Rhizoma Curcumae Longae coarse powder is packed in the barrel of supercritical extraction unit, again barrel is put into extraction kettle, during 50 ℃ of design temperatures, open CO
2Steel cylinder pressurizes to system by high-pressure pump, regulates CO when extraction kettle and separating still pressure are respectively 36MPa and 6.0MPa
2The about 150kg/h of flow keeps the state extraction 3h of constant temperature, constant voltage, constant current amount, emits turmeric oil, the Rhizoma Curcumae Longae coarse powder is proceeded curcumin extract, and still carries out according to above-mentioned parameter, promptly during 50 ℃ of temperature, opens CO
2Steel cylinder pressurizes to system by high-pressure pump, regulates CO when extraction kettle and separating still pressure are respectively 36MPa and 6.0MPa
2The about 150kg/h of flow is at CO
2In add edible 95% ethanol of entrainer of 20% amount, keep the state extraction 4h of constant temperature, constant voltage, constant current amount, isolate curcumin alcoholic solution and Rhizoma Curcumae Longae and extract residue, emit the curcumin alcoholic solution; The above-mentioned curcumin alcoholic solution that obtains is put decompression recycling ethanol in the triple effect concentrator, and temperature is lower than 60 ℃, emits, and filters; Obtain containing small amount of moisture curcumin solution, 80 ℃ of vacuum decompression dryings, that is, wherein the content of curcumin is 30-95%.
The preparation of embodiment 2 Folium Ginkgo extract
The Folium Ginkgo coarse powder adds 8 times of amount 95% ethanol extractions 3 times, and merge extractive liquid, filters, 70 ℃ of decompression recycling ethanols of filtrate, be concentrated into and be equivalent to crude drug 1.2g/ml Folium Ginkgo crude extract, extract is suspended in 10 times of amount 20% ethanol, filter, get filtrate, with 70 ℃ of decompression and solvent recoveries of filtrate, the density when being concentrated into 60 ℃ is 1.26～1.28,60 ℃ of drying under reduced pressure, that is, wherein the weight content of Folium Ginkgo flavone is 2-24%.
The preparation of embodiment 3 Radix Panacis Quinquefolii extracts
American ginseng medicine must meet every specification requirement of " Jilin Chinese herbal medicine processing standard ".
With cut after the assay was approved to 1～2 centimetre Radix Panacis Quinquefolii must 100kg with cut to 1～2 centimetre of segment Radix Panacis Quinquefolii 100kg, amount to 200kg and drop into 3m
3In the comprehensive extraction pot.
Add for the first time 95% edible ethanol 842kg, add qualified process water 760kg, be mixed with concentration (50 ± 1) %1600kg alcoholic solution, open pump circulation 20 minutes, soaked 4 hours, keep extraction pot jacket steam pressure must not be higher than 0.02MPa, temperature was extracted 2 hours for 60 ± 5 ℃ in jar, put medicinal liquid through filter.
Add for the second time 95% edible ethanol 526kg, add qualified process water 475kg, be mixed with concentration (50 ± 1) %1000kg alcoholic solution, open pump circulation 20 minutes, soaked 4 hours, keep extraction pot jacket steam pressure must not be higher than 0.02MPa, temperature was extracted 2 hours for 60 ± 5 ℃ in jar, put medicinal liquid through filter.
Put to agitator tank with the medicinal liquid merging second time for the first time, squeezed into the settling tank precipitation afterwards 24 hours, filter supernatant through kieselguhr and plate basket filter, reclaim ethanol with the triple effect concentrator, vacuum should be-0.04MPa, treat ethanol reclaim finish after, transfer vacuum be-0.06～-0.08MPa concentrates, thickening temperature should not surpass 90 ℃, the cocnentration factor 1.16～1.17g/ml (60 ℃ of measurements) that weighs.
The above-mentioned clear paste that obtains is-0.06 in vacuum～-carrying out vacuum drying under the condition of 0.08MPa, baking temperature should not surpass 90 ± 2 ℃, can not be distinguished the flavor of by gelatinizing, through check, pulverizing is mixed in qualified back, mixes promptly again after the pulverizing, and wherein the total panaquilon weight content is 2-80%.
Embodiment 4 antioxidation, prevent and treat the preparation of the compound capsule of senile dementia
Rhizoma Curcumae Longae extract, Semen Ginkgo extrac and the Radix Panacis Quinquefolii extract of embodiment 1,2 and 3 preparations are mixed, make the weight portion proportioning of contained active component be: 10 parts of curcumins, 1 part of Folium Ginkgo flavone, 1 part of total panaquilon is with gained mixture drying, pulverize, make granule, and then dry, granulate, incapsulate, promptly get capsule.
Embodiment 5 antioxidation, prevent and treat the preparation of the compound buccal lozenge of senile dementia
Rhizoma Curcumae Longae extract, Semen Ginkgo extrac and the Radix Panacis Quinquefolii extract of embodiment 1,2 and 3 preparations are mixed, make the weight portion proportioning of contained active component be: 9.5 parts of curcumins, 1 part of Folium Ginkgo flavone, 1 part of total panaquilon is made dried cream with mixture, and dried cream powder is broken into dried cream powder, add cane sugar powder, dextrin 100g, protein sugar, granulate drying, granulate, add Mentholum, magnesium stearate, mixing, tabletting promptly gets buccal tablet.
Embodiment 6 antioxidation, prevent and treat the preparation of the compound oral liquid of senile dementia
Rhizoma Curcumae Longae extract, Semen Ginkgo extrac and the Radix Panacis Quinquefolii extract of embodiment 1,2 and 3 preparations are mixed, make the weight portion proportioning of contained active component be: 47.5 parts of curcumins, 1 part of Folium Ginkgo flavone, 1 part of total panaquilon, mixture is made clear paste, get sucrose and make syrup, merge with above-mentioned clear paste, stir evenly cooling; Get Mentholum, benzoic acid is received, and essence is an amount of, behind 70% dissolve with ethanol, adds in the above-mentioned medicinal liquid, stirs evenly, and leaves standstill, filter, and embedding, sterilization promptly gets oral liquid.
Embodiment 7 antioxidation, prevent and treat the preparation of the compound recipe sugar-free granule of senile dementia
Rhizoma Curcumae Longae extract, Semen Ginkgo extrac and the Radix Panacis Quinquefolii extract of embodiment 1,2 and 3 preparations are mixed, make the weight portion proportioning of contained active component be: 2 parts of curcumins, 1 part of Folium Ginkgo flavone, 1 part of total panaquilon, mixture is made extractum, add dextrin or dextrin and stevioside, again through granulating, dry, the granulate branch bag of packing into becomes granule.
Embodiment 8 antioxidation, prevent and treat the preparation of the compound capsule of senile dementia
With the Rhizoma Curcumae Longae extract drying of embodiment 1 preparation, pulverize, make granule, and then dry, granulate incapsulates, and promptly gets capsule.
Embodiment 9 antioxidation, prevent and treat the preparation of the compound capsule of senile dementia
Rhizoma Curcumae Longae extract, the Semen Ginkgo extrac of embodiment 1 and 2 preparations are mixed, make the weight portion proportioning of contained active component be: 15 parts of curcumins, 1 part of Folium Ginkgo flavone is with gained mixture drying, pulverize, make granule, and then dry, granulate incapsulates, and promptly gets capsule.
Embodiment 10 antioxidation, prevent and treat the preparation of the compound capsule of senile dementia
Rhizoma Curcumae Longae extract, the Radix Panacis Quinquefolii extract of embodiment 1 and 3 preparations are mixed, make the weight portion proportioning of contained active component be: 15 parts of curcumins, 1 part of total panaquilon is with gained mixture drying, pulverize, make granule, and then dry, granulate incapsulates, and promptly gets capsule.
Embodiment 11 antioxidation, prevent and treat the preparation of the compound capsule of senile dementia
Rhizoma Curcumae Longae extract, Semen Ginkgo extrac and the Radix Panacis Quinquefolii extract of embodiment 1,2 and 3 preparations are mixed, make the weight portion proportioning of contained active component be: 15 parts of curcumins, 1 part of total panaquilon, with gained mixture drying, pulverize, make granule, and then it is dry, granulate incapsulates, and promptly gets capsule.
Embodiment 12 antioxidation, prevent and treat the preparation of the compound capsule of senile dementia
Rhizoma Curcumae Longae extract, Semen Ginkgo extrac and the Radix Panacis Quinquefolii extract of embodiment 1,2 and 3 preparations are mixed, make the weight portion proportioning of contained active component be: 30 parts of curcumins, 1 part of Folium Ginkgo flavone, 1 part of total panaquilon is with gained mixture drying, pulverize, make granule, and then dry, granulate, incapsulate, promptly get capsule.
Embodiment 13 antioxidation, prevent and treat the preparation of the compound capsule of senile dementia
Rhizoma Curcumae Longae extract, Semen Ginkgo extrac and the Radix Panacis Quinquefolii extract of embodiment 1,2 and 3 preparations are mixed, make the weight portion proportioning of contained active component be: 5 parts of curcumins, 1 part of Folium Ginkgo flavone, 1 part of total panaquilon is with gained mixture drying, pulverize, make granule, and then dry, granulate, incapsulate, promptly get capsule.
The invention is not restricted to above-mentioned most preferred embodiment, anyone draws identical with the present invention or akin product under enlightenment of the present invention, all belong to protection domain of the present invention.
Claims (10)
1, a kind of antioxidation, prevent and treat the compound preparation of senile dementia, it is characterized in that the weight portion proportioning of the active component that it is contained is: curcumin 10-47.5 part, Folium Ginkgo flavone 0-5 part, total panaquilon 0-5 part.
2, antioxidation as claimed in claim 1, prevent and treat the compound preparation of senile dementia, it is characterized in that the weight portion proportioning of the active component that it is contained is: curcumin 15-30 part, Folium Ginkgo flavone 1-3 part, total panaquilon 1-3 part.
3, antioxidation as claimed in claim 1, prevent and treat the compound preparation of senile dementia, it is characterized in that: the weight portion proportioning of the active component that it is contained is: 15 parts of curcumins, 1 part of Folium Ginkgo flavone, 1 part of total panaquilon.
4, as the arbitrary described antioxidation of claim 1-3, prevent and treat the compound preparation of senile dementia, it is characterized in that: described curcumin derives from Rhizoma Curcumae Longae extract, the weight content of curcumin is 30-95% in the described Rhizoma Curcumae Longae extract.
5, as the arbitrary described antioxidation of claim 1-3, prevent and treat the compound preparation of senile dementia, it is characterized in that: described Folium Ginkgo flavone derives from Folium Ginkgo extract, the weight content of Folium Ginkgo flavone is 2-24% in the described Folium Ginkgo extract.
6, as the arbitrary described antioxidation of claim 1-3, prevent and treat the compound preparation of senile dementia, it is characterized in that: described total panaquilon derives from Radix Panacis Quinquefolii extract, the total panaquilon weight content is 2-80% in the described Radix Panacis Quinquefolii extract.
7, a kind of preparation is characterized in that as the arbitrary described antioxidation of claim 1-6, the method for preventing and treating the compound preparation of senile dementia it comprises the steps:
The weight content of A, preparation curcumin is the Rhizoma Curcumae Longae extract of 30-95%;
The weight content of B, preparation Folium Ginkgo flavone is the Semen Ginkgo extrac of 2-24%;
C, preparation total panaquilon weight content are the Radix Panacis Quinquefolii extract of 2-80%;
D, above-mentioned three kinds of extracts are mixed the back be prepared into various dosage forms with pharmaceutically acceptable carrier or excipient.
8, preparation method as claimed in claim 7 is characterized in that the preparation method of described Rhizoma Curcumae Longae extract is: the coarse powder that curcuma powder is broken into about 20 orders is standby; The Rhizoma Curcumae Longae coarse powder is packed in the barrel of supercritical extraction unit, again barrel is put into extraction kettle, during 50 ℃ of design temperatures, open CO
2Steel cylinder pressurizes to system by high-pressure pump, regulates CO when extraction kettle and separating still pressure are respectively 36MPa and 6.0MPa
2The about 150kg/h of flow keeps the state extraction 3h of constant temperature, constant voltage, constant current amount, emits turmeric oil, the Rhizoma Curcumae Longae coarse powder is proceeded curcumin extract, and still carries out according to above-mentioned parameter, promptly during 50 ℃ of temperature, opens CO
2Steel cylinder pressurizes to system by high-pressure pump, regulates CO when extraction kettle and separating still pressure are respectively 36MPa and 6.0MPa
2The about 150kg/h of flow is at CO
2In add edible 95% ethanol of entrainer of 20% amount, keep the state extraction 4h of constant temperature, constant voltage, constant current amount, isolate curcumin alcoholic solution and Rhizoma Curcumae Longae and extract residue, emit the curcumin alcoholic solution; The above-mentioned curcumin alcoholic solution that obtains is put decompression recycling ethanol in the triple effect concentrator, and temperature is lower than 60 ℃, emits, and filters; Obtain containing small amount of moisture curcumin solution, 80 ℃ of vacuum decompression dryings, that is, wherein the content of curcumin is 30-95%.
9, preparation method as claimed in claim 7, the preparation method that it is characterized in that described Semen Ginkgo extrac is: the Folium Ginkgo coarse powder adds 8 times of amount 95% ethanol extractions 3 times, merge extractive liquid,, filter, 70 ℃ of decompression recycling ethanols of filtrate, be concentrated into and be equivalent to crude drug 1.2g/ml Folium Ginkgo crude extract, extract is suspended in 10 times of amount 20% ethanol, filter, get filtrate, 70 ℃ of decompression and solvent recoveries of filtrate, density when being concentrated into 60 ℃ is 1.26～1.28,60 ℃ of drying under reduced pressure, that is, wherein the weight content of Folium Ginkgo flavone is 2-24%.
10, preparation method as claimed in claim 7, the preparation method that it is characterized in that described Radix Panacis Quinquefolii extract is: 1, with cut to 1～2 centimetre Radix Panacis Quinquefolii must 100kg with cut to 1～2 centimetre of segment Radix Panacis Quinquefolii 100kg, amounting to Radix Panacis Quinquefolii 200kg drops in the extraction pot, add for the first time 95% edible ethanol 842kg, add water 760kg, be mixed with concentration and be 50 ± 1% 1600kg alcoholic solution, open pump circulation 20 minutes, soaked 4 hours, keep extraction pot jacket steam pressure must not be higher than 0.02MPa, temperature is 60 ± 5 ℃ in jar, extracts 2 hours, puts medicinal liquid through filter; 2, add 95% edible ethanol 526kg for the second time, add water 475kg, be mixed with concentration and be 50 ± 1% 1000kg alcoholic solution, open pump circulation 20 minutes, soaked 4 hours, and kept extraction pot jacket steam pressure must not be higher than 0.02MPa, temperature is 60 ± 5 ℃ in jar, extracted 2 hours, and put medicinal liquid through filter; 3, will put to agitator tank with the medicinal liquid merging second time for the first time, squeezed into the settling tank precipitation afterwards 24 hours, filtering supernatant, reclaim ethanol, vacuum is-0.04MPa, treat ethanol reclaim finish after, transfer vacuum be-0.06～-0.08MPa concentrates, thickening temperature is no more than 90 ℃, is the clear paste of 1.16～1.17g/ml when being concentrated into 60 ℃ of proportions; 4, the above-mentioned clear paste that obtains is-0.06 in vacuum～-carrying out vacuum drying under the condition of 0.08MPa, baking temperature is no more than 90 ± 2 ℃, pulverizes, mixes promptly, and wherein the total panaquilon weight content is 2-80%.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599098A (en) * | 2013-11-15 | 2014-02-26 | 山西省中医药研究院 | Composition of compatibility of curcumin and bilobalide B, and application of composition |
| CN105054076A (en) * | 2015-08-25 | 2015-11-18 | 广州施健生物科技有限公司 | Alzheimer's disease improving nutritional composition and application thereof |
| CN105166896A (en) * | 2015-09-06 | 2015-12-23 | 吉林大学 | Health-care food capable of improving memory in auxiliary manner |
| CN106420796A (en) * | 2016-12-26 | 2017-02-22 | 哈尔滨工业大学（威海） | Composition for preventing or treating Alzheimer's disease |
| CN109045216A (en) * | 2018-09-17 | 2018-12-21 | 横琴绿环科技有限公司 | A kind of protect liver brain tonic composition and preparation method thereof preventing and treating senile dementia disease |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1231244C (en) * | 2002-10-01 | 2005-12-14 | 粟明 | Health foods for tonification, being sturdy and postponing senility |
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2006
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599098A (en) * | 2013-11-15 | 2014-02-26 | 山西省中医药研究院 | Composition of compatibility of curcumin and bilobalide B, and application of composition |
| CN103599098B (en) * | 2013-11-15 | 2015-07-15 | 山西省中医药研究院 | Composition of compatibility of curcumin and bilobalide B, and application of composition |
| CN105054076A (en) * | 2015-08-25 | 2015-11-18 | 广州施健生物科技有限公司 | Alzheimer's disease improving nutritional composition and application thereof |
| CN105166896A (en) * | 2015-09-06 | 2015-12-23 | 吉林大学 | Health-care food capable of improving memory in auxiliary manner |
| CN106420796A (en) * | 2016-12-26 | 2017-02-22 | 哈尔滨工业大学（威海） | Composition for preventing or treating Alzheimer's disease |
| CN109045216A (en) * | 2018-09-17 | 2018-12-21 | 横琴绿环科技有限公司 | A kind of protect liver brain tonic composition and preparation method thereof preventing and treating senile dementia disease |
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