CN1836673A - Chinese medicinal soft capsule and method for preparing and controlling the quality of Chinese medicinal soft capsule - Google Patents
Chinese medicinal soft capsule and method for preparing and controlling the quality of Chinese medicinal soft capsule Download PDFInfo
- Publication number
- CN1836673A CN1836673A CN 200510200164 CN200510200164A CN1836673A CN 1836673 A CN1836673 A CN 1836673A CN 200510200164 CN200510200164 CN 200510200164 CN 200510200164 A CN200510200164 A CN 200510200164A CN 1836673 A CN1836673 A CN 1836673A
- Authority
- CN
- China
- Prior art keywords
- solution
- reference substance
- soft capsule
- capsule
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The present invention discloses Jinshuibao soft capsule prepared with fermented aweto powder as main medicine component and containing diluent and softening agent. The soft capsule has relatively high stability. In addition, the preparation process and its quality control method is also disclosed.
Description
Technical field
The medicine that the invention discloses a kind of Chinese medicinal soft capsule is formed, and the medicine that especially discloses the JINSHUIBAO soft capsule a kind of is formed, and belongs to the field of Chinese medicines.Simultaneously, the invention also discloses this preparation of soft capsule method and method of quality control.
Background technology
Fermented Cordyceps powder be from the fresh Cordyceps in Qinghai, separate the section ergot fungus cordyceps sinensis obtain asexual generation one Synnematum sinense Yin et Shen sp. Now strain through the mycelial dried powder of liquid fermentation and culture gained, effect with tonifying the lung kidney, beneficial vital essence can be used for the auxiliary treatment of diseases such as cough that deficiency of both the lung and kidney causes, asthma, spitting of blood, aching pain in waist and back and chronic bronchitis.Clinically be made into multiple dosage form, comprise tablet, capsule, oral liquid, as the JINSHUIBAO sheet.These medicines have been brought into play bigger effect in the application of treatment deficiency of both the lung and kidney disease.
But because of the characteristic of Cordyceps powder, that existing preparation all exists is easily mouldy, the moisture absorption, rotten shortcoming, needs a kind of better dosage form to replace; On the other hand, soft capsule has good leak tightness, dispersion of medicine, cover bad smell, advantage such as be easy to preserve and carry, and just becoming the emerging dosage form of the field of Chinese medicines, and it represents the new developing direction of Chinese patent medicine.Thereby if the Cordyceps powder preparation can be made soft capsule, will be great progress.Because the prescriptions of Chinese medicine complexity, the Chinese medicinal soft capsule formulation method does not have unified standard, and each medicine all will systematically be studied, fermented Cordyceps powder is no exception, so far find no the document that is made into soft capsule, reach this purpose, must pay work.
Summary of the invention
The technological difficulties of soft capsule are mainly in the preparation of capsule liquid, and general capsule liquid is made up of medicine, diluent and softening agent, and in order to determine its ratio, the inventor studies.
One, the selection of diluent: the selection of pharmaceutical diluents is one of key of development soft capsule, and it should be able to guarantee the accuracy and the stability of formulation of content, thereby guarantees the safety and effectiveness of medicine.Diluent at present commonly used has vegetable oil and Polyethylene Glycol-400 (PEG-400), the inventor by experiment to above the two screen.
Get two parts of fermented Cordyceps powder, add the vegetable oil and the Polyethylene Glycol-400 of capacity respectively, fully mix after colloid mill ground 20 minutes, put in 3000 rev/mins the centrifuge centrifugal 30 minutes, the precipitation situation of observing two mixed liquors the results are shown in following table.
The different diluent sedimentation of table 1 situation result of the test
| Diluent | The sedimentation situation |
| Vegetable oil | Sedimentation fully, vegetable oil and medicated powder layering are obvious |
| Polyethylene Glycol-400 | Precipitation, the not layering of Polyethylene Glycol and medicated powder do not appear |
By table 1 result as can be known, be the content good stability of diluent gained with Polyethylene Glycol-400, be difficult for layering and separate out, be diluent so determine to select for use Polyethylene Glycol-400.
Two, the selection of diluent ratio: the consumption of diluent directly has influence on the loading amount and the content uniformity of soft capsule.Diluent ratio is low excessively, and then medicinal liquid is mobile bad, and content uniformity is bigger.Diluent ratio is excessive, and drug dose increases, the inconvenience of taking medicine.Therefore screen the diluent of different proportion, thereby determined optimal proportion.Get the medicated powder of three parts of mix homogeneously, add not commensurability Polyethylene Glycol-400 respectively, fully mix, observe its state, the results are shown in following table after colloid mill ground 20 minutes.
The selection result of the test of table 2 diluent ratio
| Diluent | The medicinal liquid situation |
| ?1∶1 | The medicinal liquid thickness, mobile bad |
| ?3∶2 | Medicinal liquid is even, and is better mobile |
| ?2∶1 | Medicinal liquid is rarer, good fluidity |
By result in the table as can be known, when the ratio of diluent and medicated powder was 3: 2, the flowability of medicinal liquid can satisfy the requirement of soft capsule pressing, so determine that the ratio of diluent and Chinese caterpillar fungus fermentation mycopowder is 3: 2.
Three, the selection of softening agent: in the process of preparation sample, find, through washing ball, the softgel shell hardening after placement a period of time (about 10 days) of exsiccant soft capsule finished product, the disintegration of soft capsule is elongated, the inventor thinks after the characteristic of each material by analysis: the PEG-400 in the capsule liquid can absorb the moisture in the softgel shell, so cause the softgel shell hardening, the disintegration of soft capsule is elongated, change this situation, should add an amount of softening agent and suppress the moisture that capsule liquid absorbs softgel shell in capsule liquid.Afterwards, the inventor found that propylene glycol had the effect of moisture between balance softgel shell capsule liquid, so its ratio is studied.When preparing sample again, substitute part Polyethylene Glycol-400 with accounting for a certain proportion of propylene glycol of total medication amount, made sample is observed its variation placing a period of time (T=14～20 ℃, RH=40%～60%) back, and experimental result sees the following form.
The different prescription of table 3 capsule liquid is to EFFECT OF CORK STOPPER
| Diluent | Disintegration (0 day) | Disintegration (30 days) |
| PEG-400 | 19 minutes | 37 minutes |
| The PEG-400+5% propylene glycol | 18 minutes | 30 minutes |
| The PEG-400+8% propylene glycol | 15 minutes | 17 minutes |
| The PEG-400+10% propylene glycol | 14 minutes | 15 minutes |
As can be seen from the above table, after the propylene glycol ratio reaches 8%, reached requirement disintegration.So determine in the prescription of soft capsule, should add the propylene glycol of total medication amount 8%, prolong to prevent soft capsule hardening and disintegration.
Four, preparation process: according to the research contents in early stage, JINSHUIBAO preparation of soft capsule process has finally been formulated in invention.That is: get fermented Cordyceps powder, add propylene glycol in proportion and add Polyethylene Glycol-400, mix homogeneously is pressed into soft capsule.Its mixed process can be ground with colloid mill, so that medicinal liquid reaches uniform and smooth.
Five, method of quality control: in order effectively to control product quality, the inventor has also formulated quality standard, and this standard comprises qualitative identification and assay two parts, and following content is arranged.
Differentiate: (1) gets adenine reference substance and adenosine reference substance, adds Diluted Alcohol and makes the solution that every 1ml contains 10ug respectively, in contrast product solution.Test according to high performance liquid chromatography, with octadecylsilane chemically bonded silica is filler, phosphate buffer solution [0.066mol/L potassium dihydrogen phosphate-0.066mol/L disodium phosphate soln (4: 6)] with 0.5% oxolane is a mobile phase, the detection wavelength is 260nm, draw [assay] item need testing solution and each 20ul of above-mentioned reference substance solution down, inject high performance liquid chromatograph, in the test sample chromatograph, with the corresponding position of reference substance chromatograph on, corresponding chromatographic peak is arranged.
(2) get this product content 5g, put in the 10ml centrifuge tube, in 12000 rev/mins centrifuge centrifugal 30 minutes, discard upper strata liquid, precipitation adds water 10ml, is heated to and boils, and filters, and gets subsequent filtrate as need testing solution.Other gets the alanine reference substance, adds water and makes the solution that every 1ml contains alanine 1mg, in contrast product solution.Test according to thin layer chromatography, draw need testing solution 3ul, reference substance solution 2ul, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, be developing solvent with n-butyl alcohol-glacial acetic acid-water (4: 1: 1), launch, take out, dry, spray is with ninhydrin solution, and it is clear to be heated to speckle colour developing.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(3) get the mannitol reference substance, add Diluted Alcohol and make the solution that every 1ml contains 9mg, in contrast product solution.Test according to thin layer chromatography, draw need testing solution and each 2ul of above-mentioned reference substance solution under the item of [discriminating] (2), put respectively on same silica gel g thin-layer plate, with isopropyl alcohol-ethyl acetate-water (9: 6: 2) is developing solvent, launch, take out, dry, spray is with 2% potassium permanganate solution, and it is clear that hot blast blows to the speckle colour developing.In the test sample chromatograph, with the stratographic relevant position of reference substance on, show the speckle of same color.
Assay: according to high effective liquid chromatography for measuring.
Chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; Phosphate buffer solution [0.066mol/L potassium dihydrogen phosphate-0.066mol/L disodium phosphate soln (4: 6)] with 2% oxolane is a mobile phase; The detection wavelength is 260nm, and number of theoretical plate is pressed the adenosine peak and calculated, and should be not less than 3000.
The preparation of the reference substance solution 105 ℃ of drying under reduced pressure of learning from else's experience are an amount of to the adenosine reference substance of constant weight, accurately claim surely, add Diluted Alcohol and make the solution that every 1ml contains 40ug, and precision pipettes 2ml, puts in the 10ml measuring bottle, adds mobile phase to scale, shakes up, promptly.
The content under the content uniformity item is got in the preparation of need testing solution, and mixing is got 2.5g, and accurate the title decides, put in the ground triangular flask, precision adds Diluted Alcohol 50ml, claims to decide weight, supersound process (power 250W, frequency 40KHz) 30 minutes, put coldly, claim to decide weight again, supply the weight that subtracts mistake with Diluted Alcohol, shake up, filter, precision pipettes subsequent filtrate 2ml, puts in the 10ml measuring bottle, adds mobile phase to scale, shake up, filter with microporous filter membrane (0.45um), promptly.
Accurate respectively reference substance solution and each 20 Ma of need testing solution drawn of algoscopy inject high performance liquid chromatograph, measure, promptly.
Beneficial effect
This bright JINSHUIBAO soft capsule is adopted medicinal aluminium-plastic bubble plate packing.With room temperature reserved sample observing method sample is observed: (T=14～20 ℃, RH=40%～60%) at ambient temperature, carry out continuous six months study on the stability at the appointed time.The investigation index is: character, identification check, assay, microbial limit, and test method is by method of quality control of the present invention; Limit test of microbe is by " Chinese pharmacopoeia appendix XIII C limit test of microbe method operation in 2000.The results are shown in following table.
Table 4 JINSHUIBAO soft capsule stability experiment result
The result meets the regulation of current domestic drug standard.The present invention has reached purpose.
The specific embodiment
Embodiment 1:
Prescription: fermented Cordyceps powder 1.8kg, Polyethylene Glycol-400 2.4kg, propylene glycol 0.35kg
Method for making: get fermented Cordyceps powder, add propylene glycol and Polyethylene Glycol-400, cross colloid mill and ground 20 minutes, on encapsulating machine, be pressed into soft capsule.
Embodiment 2:
Prescription: fermented Cordyceps powder 2.2kg, Polyethylene Glycol-400 2.8kg, propylene glycol 0.45kg, ethyl hydroxybenzoate 0.1kg
Method for making: get fermented Cordyceps powder, add propylene glycol, Polyethylene Glycol-400 and ethyl hydroxybenzoate, cross colloid mill and ground 20 minutes, on encapsulating machine, be pressed into soft capsule.
Embodiment 3:
Prescription: fermented Cordyceps powder 2kg, Polyethylene Glycol-400 2.6kg, propylene glycol 0.4kg
Method for making: get fermented Cordyceps powder, add propylene glycol and Polyethylene Glycol-400, mix homogeneously is made 10000 of soft capsules.
Quality standard:
Adenine reference substance and adenosine reference substance are got in discriminating (1), add Diluted Alcohol and make the solution that every 1ml contains 10ug respectively, in contrast product solution.Test according to high performance liquid chromatography (appendix VID of Chinese Pharmacopoeia version in 2000), with octadecylsilane chemically bonded silica is filler, phosphate buffer solution [0.066mol/L potassium dihydrogen phosphate-0.066mol/L disodium phosphate soln (4: 6)] with 0.5% oxolane is a mobile phase, the detection wavelength is 260nm, draw " assay " item need testing solution and each 20ul of above-mentioned reference substance solution down, inject high performance liquid chromatograph, in the test sample chromatograph, with the corresponding position of reference substance chromatograph on, corresponding chromatographic peak is arranged.
(2) get this product content 5g, put in the 10ml centrifuge tube, in 12000 rev/mins centrifuge centrifugal 30 minutes, discard upper strata liquid, precipitation adds water 10ml, is heated to and boils, and filters, and gets subsequent filtrate as need testing solution.Other gets the alanine reference substance, adds water and makes the solution that every 1ml contains alanine 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw need testing solution 3ul, reference substance solution 2ul, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, be developing solvent with n-butyl alcohol-glacial acetic acid-water (4: 1: 1), launch, take out, dry, spray is with ninhydrin solution, and it is clear to be heated to speckle colour developing.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(3) get the mannitol reference substance, add Diluted Alcohol and make the solution that every 1ml contains 9mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw need testing solution and each 2ul of above-mentioned reference substance solution under " differentiating (2) " item, put respectively on same silica gel g thin-layer plate, with isopropyl alcohol-ethyl acetate-water (9: 6: 2) is developing solvent, launch, take out, dry, spray is with 2% potassium permanganate solution, and it is clear that hot blast blows to the speckle colour developing.In the test sample chromatograph, with the stratographic relevant position of reference substance on, show the speckle of same color.
Assay is measured according to high performance liquid chromatography (appendix VID of Chinese Pharmacopoeia version in 2000).
Chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; Phosphate buffer solution [0.066mol/L potassium dihydrogen phosphate-0.066mol/L disodium phosphate soln (4: 6)] with 2% oxolane is a mobile phase; The detection wavelength is 260nm, and number of theoretical plate is pressed the adenosine peak and calculated, and should be not less than 3000.
The preparation of the reference substance solution 105 ℃ of drying under reduced pressure of learning from else's experience are an amount of to the adenosine reference substance of constant weight, accurately claim surely, add Diluted Alcohol and make the solution that every 1ml contains 40ug, and precision pipettes 2ml, puts in the 10ml measuring bottle, adds mobile phase to scale, shakes up, promptly.
The content under the content uniformity item is got in the preparation of need testing solution, and mixing is got 2.5g, and accurate the title decides, put in the ground triangular flask, precision adds Diluted Alcohol 50ml, claims to decide weight, supersound process (power 250W, frequency 40KHz) 30 minutes, put coldly, claim to decide weight again, supply the weight that subtracts mistake with Diluted Alcohol, shake up, filter, precision pipettes subsequent filtrate 2ml, puts in the 10ml measuring bottle, adds mobile phase to scale, shake up, filter with microporous filter membrane (0.45um), promptly.
Accurate respectively reference substance solution and each 20 Ma of need testing solution drawn of algoscopy inject high performance liquid chromatograph, measure, promptly.
Every of this product contains adenosine (C
10H
13N
5O
4) should be 0.36～0.60mg.
Claims (7)
1. a JINSHUIBAO soft capsule contains a certain proportion of fermented Cordyceps powder, Polyethylene Glycol and propylene glycol in its capsule liquid, it is characterized in that three's weight ratio is: 180～220 parts of fermented Cordyceps powder, 240～280 parts of Polyethylene Glycol, 35～45 parts of propylene glycol.
2. soft capsule according to claim 1 is characterized in that the weight ratio of three kinds of components is: 200 parts of fermented Cordyceps powder, 260 parts of Polyethylene Glycol, 40 parts of propylene glycol.
3. as soft capsule as described in the claim 2, it is characterized in that in capsule liquid, can also adding an amount of suspending agent and antiseptic.
4. as soft capsule as described in the claim 1,2 or 3, it is characterized in that used Polyethylene Glycol is a Polyethylene Glycol-400 in the capsule liquid.
5. as preparation of soft capsule method as described in the claim 4, it is characterized in that this method comprises the process of being prepared as follows: get fermented Cordyceps powder, add propylene glycol and Polyethylene Glycol, mix homogeneously is pressed into soft capsule.
6. as the method for quality control of soft capsule as described in the claim 4, it is characterized in that this method comprises one or more in the following discriminating:
A. get capsule liquid, 2.5g, the accurate title, decide, put in the ground triangular flask, precision adds Diluted Alcohol 50ml, claims to decide weight, supersound process 30 minutes is put coldly, claims to decide weight again, supply the weight that subtracts mistake with Diluted Alcohol, shake up, filter, precision pipettes subsequent filtrate 2ml, puts in the 10ml measuring bottle, adds mobile phase to scale, shake up, filter, make sample with the 0.45um microporous filter membrane; Get adenine reference substance and adenosine reference substance, add Diluted Alcohol and make the solution that every 1ml contains 10ug respectively, in contrast product solution; Test according to high performance liquid chromatography, with octadecylsilane chemically bonded silica is filler, phosphate buffer solution with 0.5% oxolane is a mobile phase, the detection wavelength is 260nm, draw sample solution and each 20ul of reference substance solution, inject high performance liquid chromatograph, in the test sample chromatograph, with the corresponding position of reference substance chromatograph on, corresponding chromatographic peak is arranged;
B. get capsule liquid 5g, put in the 10ml centrifuge tube, in 12000 rev/mins centrifuge centrifugal 30 minutes, discard upper strata liquid, precipitation adds water 10ml, is heated to and boils, and filters, and gets subsequent filtrate as need testing solution; Other gets the alanine reference substance, adds water and makes the solution that every 1ml contains alanine 1mg, in contrast product solution; According to the thin layer chromatography test, draw need testing solution 3ul, reference substance solution 2ul, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with n-butyl alcohol-glacial acetic acid of 4: 1: 1-water is developing solvent, launches, and takes out, dry, spray is with ninhydrin solution, and it is clear to be heated to the speckle colour developing, in the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color;
C. get the mannitol reference substance, add Diluted Alcohol and make the solution that every 1ml contains 9mg, in contrast product solution; Test according to thin layer chromatography, drawing need testing solution and each 2ul of above-mentioned reference substance solution under the b item, put respectively on same silica gel g thin-layer plate, is developing solvent with isopropyl alcohol-ethyl acetates of 9: 6: 2-water, launch, take out, dry, spray is with 2% potassium permanganate solution, it is clear that hot blast blows to the speckle colour developing, in the test sample chromatograph, with the stratographic relevant position of reference substance on, show the speckle of same color.
7. the method for quality control of soft capsule as claimed in claim 6 is characterized in that this method comprises following content assaying method:
Chromatographic condition and system suitability test are filler with octadecylsilane chemically bonded silica; Phosphate buffer solution with 2% oxolane is a mobile phase; The detection wavelength is 260nm, and number of theoretical plate is pressed the adenosine peak and calculated, and should be not less than 3000;
The preparation of the reference substance solution 105 ℃ of drying under reduced pressure of learning from else's experience are an amount of to the adenosine reference substance of constant weight, accurately claim surely, add Diluted Alcohol and make the solution that every 1ml contains 40ug, and precision pipettes 2ml, puts in the 10ml measuring bottle, adds mobile phase to scale, shakes up, promptly;
Capsule liquid 2.5g is got in the preparation of need testing solution, and accurate the title decides, and puts in the ground triangular flask, precision adds Diluted Alcohol 50ml, claims to decide weight, supersound process 30 minutes, put coldly, claim again to decide weight, supply the weight that subtracts mistake with Diluted Alcohol, shake up, filter, precision pipettes subsequent filtrate 2ml, put in the 10ml measuring bottle, add mobile phase, shake up to scale, filter with the 0.45um microporous filter membrane, promptly;
Accurate respectively reference substance solution and each 20 Ma of need testing solution drawn of algoscopy inject high performance liquid chromatograph, measure, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510200164A CN100582771C (en) | 2005-03-23 | 2005-03-23 | Chinese medicinal soft capsule effective ingredient detection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510200164A CN100582771C (en) | 2005-03-23 | 2005-03-23 | Chinese medicinal soft capsule effective ingredient detection method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1836673A true CN1836673A (en) | 2006-09-27 |
| CN100582771C CN100582771C (en) | 2010-01-20 |
Family
ID=37014267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200510200164A Expired - Fee Related CN100582771C (en) | 2005-03-23 | 2005-03-23 | Chinese medicinal soft capsule effective ingredient detection method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100582771C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102445514A (en) * | 2011-09-26 | 2012-05-09 | 江西济民可信集团有限公司 | Detection method of traditional Chinese medicine preparation jinshuibao capsule |
| CN108535372A (en) * | 2018-03-21 | 2018-09-14 | 江西国药有限责任公司 | The construction method and its finger-print of fermentation cordyceps and preparation sterols HPLC finger-prints |
| CN108693276A (en) * | 2018-06-29 | 2018-10-23 | 江西济民可信药业有限公司 | A kind of fingerprint atlas detection method of Jinshuibao piece |
| CN109172616A (en) * | 2018-11-29 | 2019-01-11 | 江西济民可信金水宝制药有限公司 | A kind of soft capsule and preparation method thereof |
| CN109172618A (en) * | 2018-11-29 | 2019-01-11 | 江西济民可信金水宝制药有限公司 | A kind of pulsatile capsules |
-
2005
- 2005-03-23 CN CN200510200164A patent/CN100582771C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102445514A (en) * | 2011-09-26 | 2012-05-09 | 江西济民可信集团有限公司 | Detection method of traditional Chinese medicine preparation jinshuibao capsule |
| CN102445514B (en) * | 2011-09-26 | 2014-08-20 | 江西济民可信集团有限公司 | Detection method of traditional Chinese medicine preparation jinshuibao capsule |
| CN108535372A (en) * | 2018-03-21 | 2018-09-14 | 江西国药有限责任公司 | The construction method and its finger-print of fermentation cordyceps and preparation sterols HPLC finger-prints |
| CN108535372B (en) * | 2018-03-21 | 2020-10-09 | 江西国药有限责任公司 | Fermented cordyceps sinensis powder and preparation sterol HPLC fingerprint construction method and fingerprint thereof |
| CN108693276A (en) * | 2018-06-29 | 2018-10-23 | 江西济民可信药业有限公司 | A kind of fingerprint atlas detection method of Jinshuibao piece |
| CN109172616A (en) * | 2018-11-29 | 2019-01-11 | 江西济民可信金水宝制药有限公司 | A kind of soft capsule and preparation method thereof |
| CN109172618A (en) * | 2018-11-29 | 2019-01-11 | 江西济民可信金水宝制药有限公司 | A kind of pulsatile capsules |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100582771C (en) | 2010-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101167788B (en) | Quality control method of traditional Chinese medicine 'zhenqi fuzheng' containing glossy privet fruit and radix astragali for strengthening the body resistance for aeipathia deficiency damage and qi | |
| CN104398642A (en) | Preparation and quality detection method of compound prescription cortex phellodendri chinensis fluid | |
| CN1876040B (en) | Detection method of pharmaceutical composition for treating hepatitis | |
| CN1836673A (en) | Chinese medicinal soft capsule and method for preparing and controlling the quality of Chinese medicinal soft capsule | |
| CN101301425B (en) | Formulation for treating diabetes and promoting coronary circulation and quality control method | |
| CN106265641B (en) | A kind of pharmaceutical composition and preparation method thereof containing vildagliptin and melbine | |
| CN104161847A (en) | Quality detection method of traditional Chinese medicinal composition for curing diabetic retinopathy | |
| CN107315061B (en) | A kind of detection method of alizarin root of Dahurian angelica Chinese materia medica preparation that treating uterus bleeding | |
| CN101502549B (en) | Notoginsen triterpenes capsule as well as preparation method thereof and method for measuring content | |
| CN100408051C (en) | Chinese medicine composition and its prepn process and quality control method | |
| CN100594034C (en) | Blood-sugar lowering A preparation for treating diabetes, its preparation method and quality-control method | |
| CN108057046A (en) | A kind of Jinshuibao piece preparation method using direct powder compression | |
| CN101361869B (en) | Quality control method of tables for treating asthma | |
| CN101439083B (en) | Detection method of Chinese medicine soft capsules for clearing wind heat and clearing nasal passage | |
| CN100540037C (en) | A kind of detection method of infantile lung clearing phlegm transforming preparation | |
| CN1772084A (en) | Tongshu oral cavity refreshing tablet and its prepn | |
| CN100560069C (en) | A kind of Mitiglinide calcium preparation and detection method thereof | |
| CN1951388A (en) | Betamethasone sodium phosphate powder injection and preparation method thereof | |
| CN101029890A (en) | Method for inspecting Chinese-medicinal preparation Kaiyinwan | |
| CN108267537A (en) | A kind of method of Cortex Phellodendri in discriminating shangqing pill | |
| CN1679785A (en) | Chinese medicine preparation for treating inflammation preparation and quality control thereof | |
| CN112618630A (en) | Compound thrombus-invigorating soft capsule and quality detection method thereof | |
| CN1762373A (en) | 'Xueshuantong' soft capsule and its preparation | |
| Huang et al. | Simultaneous determination of thirteen main components and identification of eight major metabolites in Xuebijing Injection by UPLC/Q-TOF | |
| CN1323676C (en) | Method for preparing traditional Chinese medicine capsule for treating weakness of spleen and stomach, and its quality control method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100120 Termination date: 20150323 |
|
| EXPY | Termination of patent right or utility model |