CN1823962A - Preparation method of nauclea officinalis powder medicine for injection - Google Patents
Preparation method of nauclea officinalis powder medicine for injection Download PDFInfo
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- CN1823962A CN1823962A CN 200610000227 CN200610000227A CN1823962A CN 1823962 A CN1823962 A CN 1823962A CN 200610000227 CN200610000227 CN 200610000227 CN 200610000227 A CN200610000227 A CN 200610000227A CN 1823962 A CN1823962 A CN 1823962A
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- radix naucleae
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Abstract
A process for preparing the powder fatheadtree injection includes such steps as extracting in water, filtering, concentrating, adding gypsum powder, stirring, vacuum drying, pulverizing, extracting in alcohol 3 times, collecting liquid extract, cold storage, laying aside for 24 hr, taking supernatant, recovering alcohol, adding the water for injection, cooling, using diluted hydrochloric acid to regulate pH value, cold storage, laying aside for 24 hr, filtering, using the solution of sodium hydroxide to regulate pH value, cold storage, filtering, adding water, and vacuum drying.
Description
Technical field
The present invention relates to a kind of method of from the plant Lignum et Radix Naucleae, extracting the medicine injection powder pin of the Lignum et Radix Naucleae extract that obtains.
Background technology
Lignum et Radix Naucleae has the function of heat-clearing and toxic substances removing, is used for the treatment of the acute tonsillitis, acute pharyngolaryngitis, acute conjunctivitis and upper respiratory tract infection.The Lignum et Radix Naucleae injection that has only the Lignum et Radix Naucleae extract tablet at present and use for intramuscular injection.Lignum et Radix Naucleae extract tablet disintegration time is long, absorbs slowly, and effect is slow; The Lignum et Radix Naucleae injection is fast not as the intravenous injection effect relatively, can not with prestissimo pathogenic bacteria be play a part to kill as directly entering blood for vein with injection powder injection.Simultaneously, the Lignum et Radix Naucleae injection for intramuscular injection is used wherein is added with adjuvants such as cosolvent Tween 80, the people is known from experience produce some adverse consequencess, and put procedure is easy to generate precipitation, the quality instability.Number of patent application is: the patent of " Lignum et Radix Naucleae freeze-dried powder and preparation method thereof " of No. 200410023036.8, a kind of manufacture method of Lignum et Radix Naucleae freeze-dried powder is disclosed, this manufacture method is lyophilization what adopt when liquid dried becomes solid, according to those skilled in the art in the conventional treatment that lyophilization is carried out, cryodesiccated temperature generally arrives 40 degrees below zero subzero 30, adopt the routine techniques of this making injectable powder, not only dry slow, and it is time-consuming bothersome, be unfavorable for increasing productivity, and cause the waste of the energy.
Summary of the invention
At the shortcoming that above-mentioned prior art exists, the object of the present invention is to provide a kind ofly to have identical curative effect, but technical process is saved the preparation method of a kind of nauclea officinalis powder medicine for injection of the energy more simply, more.
The technical solution used in the present invention is: a kind of preparation method of nauclea officinalis powder medicine for injection, and made by following steps: (1) is extracted and is concentrated: get the Lignum et Radix Naucleae extracting in water, extracting solution is filtered, and be concentrated into the clear paste of surveying relative density 1.18～1.19 60 ℃ of heat; (2) absorption, drying under reduced pressure, extraction: add 4 times of amount gessoes in above-mentioned clear paste, stir evenly, 70～80 ℃ of drying under reduced pressure were pulverized 50 mesh sieves then, the ethanol of adding 85% stirs and extracts three times, merges ethanol liquid, cold preservation, left standstill 24 hours, and got supernatant, reclaim ethanol to there not being pure abnormal smells from the patient; (3) add water, adjusting pH value: adding injection water to 50 a ℃ heat survey relative density is 1.02～1.03, puts and is chilled to room temperature, regulates pH value to 2.0～3.0 with dilute hydrochloric acid, cold preservation, left standstill 24 hours, and filtered, filtrate is regulated pH value to 7.0～7.2 with 20% sodium hydroxide solution, (4) cold preservation is 12 hours, filter, add water and make every 1ml and contain Lignum et Radix Naucleae extract and count the solution of 6mg, by the specification requirement packing with rutin, 60-70 ℃ of drying under reduced pressure, promptly.
The preparation method of described nauclea officinalis powder medicine for injection adds water with Lignum et Radix Naucleae and puts hot reflux and follow that to be extracted into extracting solution in the extraction pot faint yellow or almost colourless.
The preparation method of described nauclea officinalis powder medicine for injection adds water with Lignum et Radix Naucleae, puts in the multi-function extractor, decocts with water three times, decocted 2 hours for the first time, and second and respectively 1.5 hours for the third time, collecting decoction.
Because the Lignum et Radix Naucleae main component is flavone compound and alkaloid compound, generally unaffected below 100 ℃, no matter be existing " the Lignum et Radix Naucleae injection " of list marketing, still above-mentioned " Lignum et Radix Naucleae freeze-dried powder " and the originally technology of " Lignum et Radix Naucleae injection powder pin ", its pre-treatment all is to decoct with decocting method to extract more than 3 hours, extracting solution afterwards also will continue heating and concentrate, heated time is very long, the temperature of this heating process all is more than 100 ℃, two more than ten years of list marketing " Lignum et Radix Naucleae injection " uses proof, and 100 ℃ of heating do not influence the curative effect of Lignum et Radix Naucleae.Certainly, after being condensed into thick paste, if use 100 ℃ of oven dry, because be in drying regime, if temperature control is bad, it is inhomogeneous to be heated, and not only drying time is long, and some effective ingredient is also had certain influence, the preparation method of nauclea officinalis powder medicine for injection of the present invention is compared with manufacture method of the prior art, and the drying means that this technology is used is the drying under reduced pressure 60-70 ℃ of temperature, the injectable powder of making has the injectable powder made from the manufacture method of prior art and compares, curative effect is identical, but it is simpler to make the technology that this injectable powder adopts, and drying is more prone to control, and can save the energy, reduce cost.
The present invention is described in further detail below in conjunction with specific embodiment.
The specific embodiment
Embodiment one
Make the method for this medicine, get Lignum et Radix Naucleae and add water, put hot reflux and follow that to be extracted into extracting solution in the extraction pot faint yellow or almost colourless, extracting solution filters, be concentrated into the clear paste of relative density 1.18～1.19 (60 ℃ of heat are surveyed), add 4 times of amount gessoes, stir evenly 70～80 ℃ of drying under reduced pressure, pulverized 50 mesh sieves, the ethanol of adding 85% stirs and extracts three times, merges ethanol liquid, cold preservation, left standstill 24 hours, get supernatant, reclaim ethanol to there not being pure abnormal smells from the patient, adding injection water to relative density is 1.02～1.03 (50 ℃ of heat are surveyed), put and be chilled to room temperature, regulate pH value to 2.0～3.0 with dilute hydrochloric acid, cold preservation was left standstill 24 hours, filter, filtrate is regulated pH value to 7.0～7.2 with 20% sodium hydroxide solution, and cold preservation 12 hours filters, adding water makes every 1ml and contains Lignum et Radix Naucleae extract is counted 6mg with rutin solution, be sub-packed in the vial, 60-70 ℃ of drying under reduced pressure, promptly.Per 10 milliliters of vials contain Lignum et Radix Naucleae extract and calculate with anhydrous rutin, are 6.0mg.
Embodiment two
Make the method for this medicine, get Lignum et Radix Naucleae and add water, put hot reflux and follow that to be extracted into extracting solution in the extraction pot faint yellow or almost colourless, extracting solution filters, be concentrated into the clear paste of relative density 1.18～1.19 (60 ℃ of heat are surveyed), add 4 times of amount gessoes, stir evenly 70～80 ℃ of drying under reduced pressure, pulverized 50 mesh sieves, the ethanol of adding 85% stirs and extracts three times, merges ethanol liquid, cold preservation, left standstill 24 hours, get supernatant, reclaim ethanol to there not being pure abnormal smells from the patient, adding injection water to relative density is 1.02～1.03 (50 ℃ of heat are surveyed), put and be chilled to room temperature, regulate pH value to 2.0～3.0 with dilute hydrochloric acid, cold preservation was left standstill 24 hours, filter, filtrate is regulated pH value to 7.0～7.2 with 20% sodium hydroxide solution, and cold preservation 12 hours filters, adding water makes every 1ml and contains Lignum et Radix Naucleae extract is counted 6mg with rutin solution, be sub-packed in the vial, 60-70 ℃ of drying under reduced pressure, promptly.Per 10 milliliters of vials contain Lignum et Radix Naucleae extract and calculate with anhydrous rutin, are 12.0mg.
Embodiment three
Make the method for this medicine, get Lignum et Radix Naucleae and add water, put in the multi-function extractor, decoct with water three times, decocted 2 hours for the first time, second and respectively 1.5 hours for the third time, collecting decoction filters, and is concentrated into the clear paste of relative density 1.18～1.19 (60 ℃ of heat are surveyed), add 4 times of amount gessoes, stir evenly 70～80 ℃ of drying under reduced pressure, pulverized 50 mesh sieves, the ethanol of adding 85% stirs and extracts three times, merges ethanol liquid, cold preservation, left standstill 24 hours, get supernatant, reclaim ethanol to there not being pure abnormal smells from the patient, adding injection water to relative density is 1.02～1.03 (50 ℃ of heat are surveyed), put and be chilled to room temperature, regulate pH value to 2.0～3.0 with dilute hydrochloric acid, cold preservation was left standstill 24 hours, filter, filtrate is regulated pH value to 7.0～7.2 with 20% sodium hydroxide solution, and cold preservation 12 hours filters, adding water makes every 1ml and contains Lignum et Radix Naucleae extract is counted 6mg with rutin solution, be sub-packed in the vial, 60-70 ℃ of drying under reduced pressure, promptly.Per 10 milliliters of vials contain Lignum et Radix Naucleae extract and calculate with anhydrous rutin, are 6.0mg.
Embodiment four
Make the method for this medicine, get Lignum et Radix Naucleae and add water, put in the multi-function extractor, decoct with water three times, decocted 2 hours second and each 1.5 hours for the third time collecting decoction for the first time, filter, be concentrated into the clear paste of relative density 1.18～1.19 (60 ℃ of heat are surveyed), add 4 times of amount gessoes, stir evenly, 70～80 ℃ of drying under reduced pressure were pulverized 50 mesh sieves, the ethanol of adding 85%, stir and extract three times, merge ethanol liquid, cold preservation, left standstill 24 hours, get supernatant, reclaim ethanol to there not being pure abnormal smells from the patient, adding injection water to relative density is 1.02～1.03 (50 ℃ of heat are surveyed), put and be chilled to room temperature, regulate pH value to 2.0～3.0 with dilute hydrochloric acid, cold preservation was left standstill 24 hours, filter, filtrate is regulated pH value to 7.0～7.2 with 20% sodium hydroxide solution, and cold preservation 12 hours filters, adding water makes every 1ml and contains Lignum et Radix Naucleae extract is counted 6mg with rutin solution, be sub-packed in the vial, 60-70 ℃ of drying under reduced pressure, promptly.Per 10 milliliters of vials contain Lignum et Radix Naucleae extract and calculate with anhydrous rutin, are 6.0mg.
Claims (3)
1, a kind of preparation method of nauclea officinalis powder medicine for injection is characterized in that: made by following steps: (1) is extracted and is concentrated: get the Lignum et Radix Naucleae extracting in water, extracting solution is filtered, and be concentrated into the clear paste of surveying relative density 1.18～1.19 60 ℃ of heat; (2) absorption, drying under reduced pressure, extraction: add 4 times of amount gessoes in above-mentioned clear paste, stir evenly, 70～80 ℃ of drying under reduced pressure were pulverized 50 mesh sieves then, the ethanol of adding 85% stirs and extracts three times, merges ethanol liquid, cold preservation, left standstill 24 hours, and got supernatant, reclaim ethanol to there not being pure abnormal smells from the patient; (3) add water, adjusting pH value: adding injection water to 50 a ℃ heat survey relative density is 1.02～1.03, puts and is chilled to room temperature, regulates pH value to 2.0～3.0 with dilute hydrochloric acid, cold preservation was left standstill 24 hours, filtered, filtrate is regulated pH value to 7.0～7.2 with 20% sodium hydroxide solution, (4) cold preservation, filtration, the decompression oven dry: cold preservation 12 hours filters, adding water makes every 1ml and contains Lignum et Radix Naucleae extract is counted 6mg with rutin solution, by after the specification requirement packing, 60-70 ℃ of drying under reduced pressure, promptly.
2, the preparation method of nauclea officinalis powder medicine for injection according to claim 1 is characterized in that: Lignum et Radix Naucleae is added water put hot reflux and follow that to be extracted into extracting solution in the extraction pot faint yellow or almost colourless.
3, the preparation method of nauclea officinalis powder medicine for injection according to claim 1 is characterized in that: Lignum et Radix Naucleae added water, puts in the multi-function extractor, decoct with water three times, decocted 2 hours for the first time, and second and respectively 1.5 hours for the third time, collecting decoction.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610000227 CN1823962A (en) | 2006-01-06 | 2006-01-06 | Preparation method of nauclea officinalis powder medicine for injection |
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| CN 200610000227 CN1823962A (en) | 2006-01-06 | 2006-01-06 | Preparation method of nauclea officinalis powder medicine for injection |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104017103A (en) * | 2014-06-20 | 2014-09-03 | 海南制药厂有限公司 | Water-soluble nauclea officinalis polysaccharide as well as preparation method and application thereof |
| CN108938773A (en) * | 2018-08-29 | 2018-12-07 | 海南森祺制药有限公司 | A kind of sugar-free nauclea officinalis oral solution and preparation method thereof |
-
2006
- 2006-01-06 CN CN 200610000227 patent/CN1823962A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104017103A (en) * | 2014-06-20 | 2014-09-03 | 海南制药厂有限公司 | Water-soluble nauclea officinalis polysaccharide as well as preparation method and application thereof |
| CN104017103B (en) * | 2014-06-20 | 2016-02-10 | 海南制药厂有限公司 | A kind of nauclea officinalis water-soluble polysaccharide and preparation method thereof and application |
| CN108938773A (en) * | 2018-08-29 | 2018-12-07 | 海南森祺制药有限公司 | A kind of sugar-free nauclea officinalis oral solution and preparation method thereof |
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