CN1814158A - Powder for treating stomach-ache and preparing method - Google Patents
Powder for treating stomach-ache and preparing method Download PDFInfo
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- CN1814158A CN1814158A CNA2005101306246A CN200510130624A CN1814158A CN 1814158 A CN1814158 A CN 1814158A CN A2005101306246 A CNA2005101306246 A CN A2005101306246A CN 200510130624 A CN200510130624 A CN 200510130624A CN 1814158 A CN1814158 A CN 1814158A
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a stomachache curing powder and the preparing method thereof, prepared of the following raw materials in weight shares: White Paeony Root 4-8 shares, Rhizoma Cyperi 3-6 shares ,costus root 2-4 shares,Rhizoma Corydalis 3-6 shares, Corium stomachichum galli 3-6 shares, Cuttlebone 6-12 shares,Liquorice Root 2-4 shares, Thunberg Fritillary Bulb 3- 6 shares, and Sanchi 1.6-3.2 shares. And its preparing method includes a process flow as follows: taking the raw materials, selecting and rinsing clean parts and drying them at low temperature, crushing and passing through 100-mesh sieve, sterilizing, capsulizing, and checking the quality. It can promote the secretion of gastric juice and obviously raise the acidity of gastric juice and the activity of pepsin and steapsin, promote concrescence of gastric ulcer, strenghten digestion, and effectively cure patients with atrophic gastritis.
Description
Technical field
The present invention relates to a kind of medicine of preventing and treating gastritis and preparation method thereof, particularly a kind of medicine of preventing and treating atrophic gastritis and preparation method thereof.
Background technology
The M ﹠ M of gastric cancer occupies first of all kinds of tumors in China, is the prevention of I level and reduce the effective method of gastric cancer mortality, promptly when gastric mucosa is in the state that might transform aspect gastric cancer, will treat.Chronic atrophic gastritis and gastric cancer, especially the intestinal-type gastric cancer incidence rate is remarkable positive correlation, how understand chronic atrophic gastritis (CAG) to the gastric cancer development, seek a kind of effective means blocking-up CAG, and can reverse the focus that its atrophy is Chinese scholars research always.
Chronic atrophic gastritis is the class in the chronic gastritis, be divided into A type and Type B, except that the pathological changes of seeing chronic superficial gastritis, but sick damage gland involvement, the body of gland atrophy, decreased number, mucomembranous skin is common to be thickened, because body of gland atrophy or disappearance, gastric mucosa has attenuation in various degree, in the gastric mucosa of chronic atrophic gastritis, common have pylorus glandular metaplasia and an intestinal gland metaplasia.Intestinal epithelial metaplasia often starts from the gastric pits cervical region, and upwards development can be prolonged and the top layer epithelium, and dividing a word with a hyphen at the end of a line downwards to reach the deep of body of gland.The advantage of limiting to the tissue regeneration process sometimes, the meat that then can live, even can produce canceration.Because the secretory function of the major part disappearance stomach function regulating of body of gland lowers, the pepsic secretion of hydrochloric acid all reduces.
Most of patients has the full vexed or pain of middle epigastrium, loss of appetite, nausea and vomiting, belch etc. clinically, anemia can be arranged, becomes thin, glossitis, atrophy of tongue, diarrhoea etc.
Prevent that this disease from should in different phase, different levels, adopt multiple measure at different onset mechanism, integrated control is not reaching gastric cancer in earlier stage, takes the positive prevention in footpath.
The medicine of a lot of control atrophic gastritis of present development, owing to be chemosynthesis, what have has certain side effect, clinical effectiveness is not good, at present, still do not have the medicine of satisfied treatment chronic atrophic gastritis clinically, therefore await developing a kind of medicine, can overcome existing deficiency, the effectively preventing atrophic gastritis with medicine.
Summary of the invention
The object of the present invention is to provide a kind of powder for stomachache and preparation method thereof,, prevent and treat chronic atrophic gastritis in order to overcome existing deficiency with medicine.
To achieve these goals, powder for stomachache provided by the present invention, it is characterized in that, counting proportioning by following various raw material medicaments in part by weight forms: Radix Paeoniae Alba RADIX PAEONIAE ALBA 4-8 part, Rhizoma Cyperi RHIZOMACYPERI 3-6 part, Radix Aucklandiae (Radix Vladimiriae) RADIX AUCKLANDIAE 2-4 part, Rhizoma Corydalis RHIZOMA CORYDALIS3-6 part, Endothelium Corneum Gigeriae Galli ENDOTHELIUM CORNEUM GLGERIAE GALLI 3-6 part, Endoconcha Sepiae ENDOCONCHA SEPIAE 6-12 part, Radix Glycyrrhizae RADIX GLYCYRRHIZAE2-4 part, Bulbus Fritillariae Thunbergii BULBUSFRITILLARIAE THUNBERGII 3-6 part, Radix Notoginseng RADIX NOTOGISENG 1.6-3.2 part.
And, be preferably 6 parts of the Radix Paeoniae Albas, 4.5 parts of Rhizoma Cyperis, 3 parts of Radix Aucklandiae (Radix Vladimiriae), 4.5 parts of Rhizoma Corydalis, 4.5 parts of Endothelium Corneum Gigeriae Galli, 9 parts of Endoconcha Sepiaes, 3 parts in Radix Glycyrrhizae, 4.5 parts of Bulbus Fritillariae Thunbergiis, 2.4 parts of Radix Notoginsengs.
And, for achieving the above object, the method for preparing powder for stomachache provided by the present invention, its technological process is for getting described various crude drug, cleans that the back is clean with the drinking water rinsing, after the cold drying, pulverizes 100 mesh sieves, sterilization, encapsulating capsule, quality examination.
The parts by weight proportioning of described various crude drug is: 6 parts of the Radix Paeoniae Albas, 4.5 parts of Rhizoma Cyperis, 3 parts of Radix Aucklandiae (Radix Vladimiriae), 4.5 parts of Rhizoma Corydalis, 4.5 parts of Endothelium Corneum Gigeriae Galli, 9 parts of Endoconcha Sepiaes, 3 parts in Radix Glycyrrhizae, 4.5 parts of Bulbus Fritillariae Thunbergiis, 2.4 parts of Radix Notoginsengs.
Described dry run is to adopt the oven dry of hot air circulation drying baker, between 45-60 ℃ of the control temperature, dries 24 hours.
Described sterilization process is to adopt ultraviolet radiation sterilization 2 times, each sterilization time 30-40 minute.
Powder for stomachache provided by the present invention is natural animal and plant medicine; has antiinflammatory; analgesia; calmness and inhibition ulcer, the effect of protection gastric mucosa can promote gastric secretion and gastric acidity obviously to increase; and can increase the activity of pepsin and pancreatic lipase; synthesizing after the healing of promotion gastric ulcer and gastric mucosa fall, the enhancing of facilitating digestion function obtains the effective treatment the atrophic gastritis disease of patient.
The specific embodiment
In the prescription of the present invention, the white peony root's total glycoside in the Radix Paeoniae Alba has analgesic activity, and Radix Paeoniae has obvious preventive and therapeutic effect for stress ulcer.The extract cyperol of Rhizoma Cyperi has tangible analgesia and antiinflammatory action.Radix Aucklandiae (Radix Vladimiriae) can suppress the generation of gastric ulcer, and gastric mucosa is had protective effect.Rhizoma Corydalis has significant analgesia role and sedation.Rhizoma Corydalis total alkaloids has significantly the anti-gastric-ulcer effect, and the effect that suppresses gastric juice, pepsin, gastric acid secretion is also arranged simultaneously.Endothelium Corneum Gigeriae Galli can impel gastric secretion and gastric acidity obviously to increase, and can increase pepsin, pancreatic lipase activity, and the gastrointestinal propulsion functions is had facilitation, thereby promotes that gastrointestinal emptying speeds up.Radix Glycyrrhizae has calmness and antiinflammatory action, and has the obvious suppression ulcer function, can reduce gastric acid and the significant excretory effect of gastric acid inhibitory.The Bulbus Fritillariae Thunbergii of Bulbus Fritillariae Thunbergii have the effect that promotes enterokinesia.Radix Notoginseng has significant analgesia role, and Radix Notoginseng all has obvious suppression standby for multiple active chronic inflammation.Endoconcha Sepiae has remarkable facilitation to the healing of experimental gastric ulcer, can reduce total acidity gastric juice with the gastric acid vitro reactions, can increase gastric tissue CAMP content, can also promote gastric mucosa PGF
2Synthetic.
Embodiment 1-3 is the preparation of medicine of the present invention:
The plant origin of the used various raw medicinal materials of the present invention is described as follows:
Radix Paeoniae Alba RADIX PAEONIAE ALBA is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..
Rhizoma Cyperi RHIZOMA CYPERI is the dry rhizome of Cyperaceae Cyperus rotundus L..
Radix Aucklandiae (Radix Vladimiriae) RADIX AUCKLANDIAE is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne.
Rhizoma Corydalis RHIZOMA CORYDALIS is the dry tuber of papaveraceae plant corydalis CorydalisyanhusuoW.T.Wang.
Endothelium Corneum Gigeriae Galli ENDOTHELIUM CORNEUM GLGERIAE GALLI is the dry inner wall of sandbag of the chicken Gallusgallus domesticus Brisson of Phasianidae animal man.
Endoconcha Sepiae ENDOCONCHA SEPIAE is the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune Sepiella maindronide Rochebrune or golden cuttlefish Sepia esculenta Hoyle.
Radix Glycyrrhizae RADIX GLYCYRRHIZAE is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensisFisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabraL..
Bulbus Fritillariae Thunbergii BULBUS FRITILLARIAE THUNBERGII is the dry bulb of liliaceous plant Bulbus Fritillariae Thunbergii Fritillaria thnubergii Miq..
Radix Notoginseng RADIX NOTOGISENG is the dry root of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen
Embodiment 1
Get Radix Paeoniae Alba 4g Rhizoma Cyperi 3g Radix Aucklandiae (Radix Vladimiriae) 2g Rhizoma Corydalis 3g Endothelium Corneum Gigeriae Galli 3g Endoconcha Sepiae 6g Radix Glycyrrhizae 2g Bulbus Fritillariae Thunbergii 3g Radix Notoginseng 1.6g.
Get the decoction pieces of said medicine, with drinking water rinsing twice decoction pieces clean after, adopt the oven dry of hot air circulation drying baker, between 45-60 ℃ of the control temperature, dried 24 hours, dry back mixed powder is broken into fine powder, crosses 100 mesh sieves, mixing adopts ultraviolet radiation sterilization 2 times, each sterilization time 30-40 minute.Powder after the sterilization pours in No. 0 capsule of international standard with NJP800C type fully-automatic capsule filling machine.Make regular check on selective examination in batches before every batch of medicine clinical practice.Warehouse-in is stored in shady and cool dry place, temperature 18-20 ℃, between the humidity 30-45%, preserves 3 years.
Embodiment 2
Get Radix Paeoniae Alba 6g Rhizoma Cyperi 4.5g Radix Aucklandiae (Radix Vladimiriae) 3g Rhizoma Corydalis 4.5g Endothelium Corneum Gigeriae Galli 4.5g Endoconcha Sepiae 9g Radix Glycyrrhizae 3g Bulbus Fritillariae Thunbergii 4.5g Radix Notoginseng 2.4g.
Get the decoction pieces of said medicine, with drinking water rinsing twice decoction pieces clean after, adopt the oven dry of hot air circulation drying baker, between 45-60 ℃ of the control temperature, dried 24 hours, dry back mixed powder is broken into fine powder, crosses 100 mesh sieves, mixing adopts ultraviolet radiation sterilization 2 times, each sterilization time 30-40 minute.Powder after the sterilization pours in No. 0 capsule of international standard with NJP800C type fully-automatic capsule filling machine.Make regular check on selective examination in batches before every batch of medicine clinical practice.Warehouse-in is stored in shady and cool dry place, temperature 18-20 ℃, between the humidity 30-45%, preserves 3 years.
Embodiment 3
Get Radix Paeoniae Alba 8g Rhizoma Cyperi 6g Radix Aucklandiae (Radix Vladimiriae) 4g Rhizoma Corydalis 6g Endothelium Corneum Gigeriae Galli 6g Endoconcha Sepiae 12g Radix Glycyrrhizae 4g Bulbus Fritillariae Thunbergii 6g Radix Notoginseng 3.2g.
Get the decoction pieces of said medicine, with drinking water rinsing twice decoction pieces clean after, adopt the oven dry of hot air circulation drying baker, between 45-60 ℃ of the control temperature, dried 24 hours, dry back mixed powder is broken into fine powder, crosses 100 mesh sieves, mixing adopts ultraviolet radiation sterilization 2 times, each sterilization time 30-40 minute.Powder after the sterilization pours in No. 0 capsule of international standard with NJP800C type fully-automatic capsule filling machine.Make regular check on selective examination in batches before every batch of medicine clinical practice.Warehouse-in is stored in shady and cool dry place, temperature 18-20 ℃, between the humidity 30-45%, preserves 3 years.
Embodiment 4
Present embodiment is clinical diagnosis case history and curative effect efficient
(1) physical data:
1, this group patient 100 examples, women 28 examples, male 72 examples, age: 25-89 year, use medicine 12-24 week.
2, above case is all through gastroscopy, and pathological diagnosis is the indication of this technology.
Choice criteria:
The national gastritis treasure that holds of Chongqing controls " the pathological diagnosis standard of the classification of chronic gastritis and fibergastroscope diagnostic criteria and atrophic gastritis " (tentative program) that forum is formulated with reference to nineteen eighty-two, and with reference to gastritis Sydney system of newly classifying.
(1) syndrome of deficiency of spleen qi and stomach qi: 1. gastral cavilty feeling of fullness, food postemphasis; 2. gastral cavilty is latent sick, likes warm pain relieved by pressing; 3. anorexia loose stool; 4. spiritlessness and weakness, lusterless complexion or sallow; 5. pale tongue or tooth seal is arranged, thready and weak pulse or heavy thin.(2) stomach network Blood stasis: 1. gastral cavilty twinges tenderness; 2. localized pain; 3. pain does not heal for a long time; 4. have a stomachache night very; 5. dimly red tongue or purple are dark, or petechia, ecchymosis are arranged, the purple varicose of the sublingual vein stasis of blood, hesitant pulse.(3) taste heat stagnation card: the 1. scorching hot distending pain of gastral cavilty; 2. xerostomia, bitter taste, halitosis; 3. yellowish or reddish urine; 4. constipation with dry stool; 5. red tongue, yellow fur is thick or greasy, stringy and rolling pulse or number.All possess 3 of syndrome of deficiency of spleen qi and stomach qi, 2 of stomach network blood stasis symptoms, and 2 persons of taste heat stagnation card can be diagnosed as qi-asthenia fever stagnation of the blood blood stasis syndrome.
Meet chronic atrophic gastritis (CAG) the companion's intestinalization and/or the dysplasia person of above-mentioned Western medicine diagnose standard and differential diagnosis in tcm standard, can be selected in.
(2) treatment and observational technique:
1. Therapeutic Method
The treatment group: powder for stomachache capsule (Radix Paeoniae Alba, Bulbus Fritillariae Thunbergii, Rhizoma Cyperi, Radix Notoginseng, Radix Glycyrrhizae etc.) by Mongolian medicinal preparation chamber in my institute according to the preparation of the formulation of embodiment 2, each 5 to 10, every day 3 times, oral.
Matched group: MOLUO DAN (Handan Pharmaceutical Co., Ltd purchases usefulness), every day 3 times, each ball is oral.
Be a course of treatment all, take medicine 2 courses of treatment with 3 months.Withdraw the medicine that all influence this research during the treatment.
2. observation index
Clinical symptoms: adopt clinical manifestations such as the record patient stomachache before medication of unified form, feeling of fullness, poor appetite, weak, belch, pantothenic acid, noisy, loose stool, constipation, xerostomia hardship, body of the tongue, tongue fur, sublingual vein, pulse condition, 1-2 week record is once at interval later on.
Gastroscopy: press diagnostic criteria under the CAG mirror, mainly observe the gastric mucosa color change, blood vessel is seen thoroughly, and extent of disease etc. according to its degree difference, are kept the score respectively by gastric antrum, the curved order of body of stomach size.
Pathology: be divided into routine pathology, HP evaluation and classification and SABC pathology.HP checks and gets biopsy at patient's gastric antrum, body of stomach respectively, should check after after patient's drug withdrawal one month.
3. statistical method: data adopts t to check X
2Significance analysis is carried out in check.
(3) therapeutic outcome: (table 1)
Criterion of therapeutical effect: efficacy assessment standard is formulated with reference to the Ministry of Public Health " the clinical research guideline of new Chinese medicine treatment atrophic gastritis " and the curative effect determinate standard of Liaoning, Jiangxi College of Traditional Chinese Medicine and the formulation of atrophic gastritis research association of Affiliated Hospital of Hebei College of Traditional Chinese Medicine in 1984, is divided into clinical basic healing, effective, invalid.
Table 1
| Group | The example number | Clinical cure | Effectively | Invalid | Total effective rate |
| The treatment group | 100 | 72 | 23 | 5 | 95％ |
| Matched group | 100 | 48 | 42 | 10 | 90％ |
As shown in table 1: two groups of cure rates compare, and there were significant differences (P＜0.05) through X 2 test.
Applicable cases: 100 routine chronic atrophic gastritis patients, after taking the powder for stomachache preparation, effectively controlled the state of an illness, alleviated pain, improve HP and infect, improve the gastric mucosa blood circulation.
Therefore, powder for stomachache energy effectively preventing atrophic gastritis provided by the present invention, by systematic research, summary, analysis, for clinical practice provides feasible scientific basis, and good economic benefits and social benefit have been created, in being adapted at, the mongolian medicine fecund I distinguish exploitation, also be adapted at the whole nation and use.
Certainly; the present invention also can have other various embodiments; under the situation that does not deviate from spirit of the present invention and essence thereof; those of ordinary skill in the art work as can make various corresponding changes and distortion according to the present invention, but these corresponding changes and distortion all should belong to the protection domain of the appended claim of the present invention.
Claims (7)
1. a powder for stomachache is characterized in that, counts proportioning by following various raw material medicaments in part by weight and forms: Radix Paeoniae Alba 4-8 part, Rhizoma Cyperi 3-6 part, Radix Aucklandiae (Radix Vladimiriae) 2-4 part, Rhizoma Corydalis 3-6 part, Endothelium Corneum Gigeriae Galli 3-6 part, Endoconcha Sepiae 6-12 part, Radix Glycyrrhizae 2-4 part, Bulbus Fritillariae Thunbergii 3-6 part, Radix Notoginseng 1.6-3.2 part.
2. powder for stomachache according to claim 1, it is characterized in that the parts by weight proportioning of described various crude drug is: 6 parts of the Radix Paeoniae Albas, 4.5 parts of Rhizoma Cyperis, 3 parts of Radix Aucklandiae (Radix Vladimiriae), 4.5 parts of Rhizoma Corydalis, 4.5 parts of Endothelium Corneum Gigeriae Galli, 9 parts of Endoconcha Sepiaes, 3 parts in Radix Glycyrrhizae, 4.5 parts of Bulbus Fritillariae Thunbergiis, 2.4 parts of Radix Notoginsengs.
3. one kind prepares the method for powder for stomachache according to claim 1, it is characterized in that, its technological process is for getting described various crude drug, cleans that post rinse is clean, after the cold drying, pulverizes 100 mesh sieves, sterilization, encapsulating capsule, quality examination.
4. the method for preparing powder for stomachache according to claim 3, it is characterized in that, the weight fraction proportioning of the various crude drug of getting is Radix Paeoniae Alba 4-8 part, Rhizoma Cyperi 3-6 part, Radix Aucklandiae (Radix Vladimiriae) 2-4 part, Rhizoma Corydalis 3-6 part, Endothelium Corneum Gigeriae Galli 3-6 part, Endoconcha Sepiae 6-12 part, Radix Glycyrrhizae 2-4 part, Bulbus Fritillariae Thunbergii 3-6 part, Radix Notoginseng 1.6-3.2 part.
5. the method for stating according to claim 4 for preparing powder for stomachache, it is characterized in that the parts by weight proportioning of described various crude drug is: 6 parts of the Radix Paeoniae Albas, 4.5 parts of Rhizoma Cyperis, 3 parts of Radix Aucklandiae (Radix Vladimiriae), 4.5 parts of Rhizoma Corydalis, 4.5 parts of Endothelium Corneum Gigeriae Galli, 9 parts of Endoconcha Sepiaes, 3 parts in Radix Glycyrrhizae, 4.5 parts of Bulbus Fritillariae Thunbergiis, 2.4 parts of Radix Notoginsengs.
6. according to claim 3, the 4 or 5 described methods that prepare powder for stomachache, it is characterized in that described dry run is to adopt the oven dry of hot air circulation drying baker, between 45-60 ℃ of the control temperature, dried 24 hours.
7. according to claim 3, the 4 or 5 described methods that prepare powder for stomachache, it is characterized in that described sterilization process is to adopt ultraviolet radiation sterilization 2 times, each sterilization time 30-40 minute.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102139058A (en) * | 2011-03-10 | 2011-08-03 | 龚定军 | Traditional Chinese medicine for treating stomach diseases |
| CN103610925A (en) * | 2013-11-28 | 2014-03-05 | 山西丰源药业有限公司 | Chinese medicinal herb preparation for treating chronic gastric diseases and preparation method thereof |
| CN104383442A (en) * | 2014-11-19 | 2015-03-04 | 王顺正 | Medicine for treating gastral cavity pain |
| CN105920297A (en) * | 2016-05-13 | 2016-09-07 | 晋利华 | Combined medicine for treating antral gastritis through combination of traditional Chinese medicine and western medicine |
| CN105944089A (en) * | 2016-04-27 | 2016-09-21 | 迟彩霞 | Capsule for treating atrophic gastritis and preparation method thereof |
| CN108210868A (en) * | 2018-03-07 | 2018-06-29 | 付国强 | Stomach living dissipates |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546066A (en) * | 2003-09-15 | 2004-11-17 | 史 忠 | Gastrointestinal ulcer treating Chinese traditional medicine |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102139058A (en) * | 2011-03-10 | 2011-08-03 | 龚定军 | Traditional Chinese medicine for treating stomach diseases |
| CN102139058B (en) * | 2011-03-10 | 2012-10-10 | 龚定军 | Traditional Chinese medicine for treating stomach diseases |
| CN103610925A (en) * | 2013-11-28 | 2014-03-05 | 山西丰源药业有限公司 | Chinese medicinal herb preparation for treating chronic gastric diseases and preparation method thereof |
| CN103610925B (en) * | 2013-11-28 | 2016-01-06 | 山西丰源药业有限公司 | Treat Chinese herbal and crude drugs preparations of old gastropathy and preparation method thereof |
| CN104383442A (en) * | 2014-11-19 | 2015-03-04 | 王顺正 | Medicine for treating gastral cavity pain |
| CN105944089A (en) * | 2016-04-27 | 2016-09-21 | 迟彩霞 | Capsule for treating atrophic gastritis and preparation method thereof |
| CN105920297A (en) * | 2016-05-13 | 2016-09-07 | 晋利华 | Combined medicine for treating antral gastritis through combination of traditional Chinese medicine and western medicine |
| CN108210868A (en) * | 2018-03-07 | 2018-06-29 | 付国强 | Stomach living dissipates |
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